This is a Validated Antibody Database (VAD) review about human Fyn, based on 41 published articles (read how Labome selects the articles), using Fyn antibody in all methods. It is aimed to help Labome visitors find the most suited Fyn antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Fyn synonym: SLK; SYN; p59-FYN

Knockout validation
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1g
  • western blot; rat; loading ...; fig 1e
In order to probe the interaction between STEP and PSD-95, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot knockout validation on mouse samples (fig 1g) and in western blot on rat samples (fig 1e). Proc Natl Acad Sci U S A (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-3)
  • western blot; human; loading ...; fig 3c
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, SC-365913) was used in western blot on human samples (fig 3c). Redox Biol (2017) ncbi
mouse monoclonal
  • western blot; human; 1:1000; loading ...; fig s9b
In order to examine whether p140Cap protein levels in ERBB2-amplified breast cancer patients correlate with survival, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, B-12) was used in western blot on human samples at 1:1000 (fig s9b). Nat Commun (2017) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:1000; loading ...; fig s9b
In order to examine whether p140Cap protein levels in ERBB2-amplified breast cancer patients correlate with survival, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, B-12) was used in western blot on human samples at 1:1000 (fig s9b). Nat Commun (2017) ncbi
mouse monoclonal (E-12)
  • western blot; human; fig s17b
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-271294) was used in western blot on human samples (fig s17b). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (B-12)
  • western blot; rat; loading ...
In order to examine the impact of ischemia/reperfusion injury on sodium potassium ATPase enzymatic and signaling functions, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, Sc-8056) was used in western blot on rat samples . Physiol Rep (2016) ncbi
mouse monoclonal (E-3)
  • western blot; human; loading ...; fig 4c
In order to characterize the molecular changes involved in human aortic smooth muscle cell proliferation, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, SC-365913) was used in western blot on human samples (fig 4c). Sci Rep (2016) ncbi
mouse monoclonal (B-12)
  • western blot; human; fig 2
In order to determine an enrichment in insulin-like growth factor I receptor, c-Src, G-protein-coupled receptor kinases, and focal adhesion kinase in porstate cancer cell exosomes, Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in western blot on human samples (fig 2). J Cell Biochem (2017) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • immunoprecipitation; human; 1:50; fig 4
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; human; 1:200; fig 1
In order to study improvement of the pathology of hypertrophic scar by simultaneous deactivation of FAK and Src, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1), in immunoprecipitation on human samples at 1:50 (fig 4), in immunocytochemistry on human samples at 1:100 (fig 4) and in western blot on human samples at 1:200 (fig 1). Sci Rep (2016) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:200; fig 1
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056;) was used in western blot on human samples at 1:200 (fig 1). Int J Mol Med (2016) ncbi
mouse monoclonal (B-12)
  • western blot; rat; loading ...; fig 8a
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in western blot on rat samples (fig 8a). J Cell Mol Med (2016) ncbi
mouse monoclonal (15)
  • western blot; rat
In order to study how BDNF activation and phosphorylation of Fyn regulate oligodendrocyte myelination, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotech, sc-434) was used in western blot on rat samples . Glia (2016) ncbi
mouse monoclonal (B-12)
  • immunocytochemistry; mouse
In order to investigate the molecular mechanisms involved in TASK1 internalization in PC12 cells, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in immunocytochemistry on mouse samples . Am J Physiol Cell Physiol (2015) ncbi
mouse monoclonal (B-12)
  • western blot; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in western blot on human samples . Mol Cell Endocrinol (2015) ncbi
mouse monoclonal (B-12)
  • western blot; human; 1:1000; fig 5
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056 B-12) was used in western blot on human samples at 1:1000 (fig 5). PLoS ONE (2015) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:50
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc8056) was used in immunohistochemistry - paraffin section on human samples at 1:50. Exp Dermatol (2015) ncbi
mouse monoclonal (B-12)
  • immunocytochemistry; human; 1:50
  • western blot; human; 1:200
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, Sc-8056) was used in immunocytochemistry on human samples at 1:50 and in western blot on human samples at 1:200. Cell Signal (2015) ncbi
mouse monoclonal (B-12)
  • western blot; mouse; fig 8
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on mouse samples (fig 8). J Neurosci (2015) ncbi
mouse monoclonal (FYN-59)
  • western blot; human; loading ...; fig 2c
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, SC-73388) was used in western blot on human samples (fig 2c). Mol Carcinog (2015) ncbi
mouse monoclonal (B-12)
  • western blot; swine
In order to study the effect of ouabain on Src kinase and Na(+)/K(+)-ATPase, Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on swine samples . Biochem Biophys Res Commun (2014) ncbi
mouse monoclonal (B-12)
  • immunohistochemistry - paraffin section; human; 1:150
  • immunoprecipitation; human
  • western blot; human; 1:1000
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in immunohistochemistry - paraffin section on human samples at 1:150, in immunoprecipitation on human samples and in western blot on human samples at 1:1000. Int J Cancer (2014) ncbi
mouse monoclonal (B-12)
  • western blot; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-8056) was used in western blot on human samples . Eur J Cancer (2014) ncbi
mouse monoclonal (B-12)
  • western blot; mouse
Santa Cruz Biotechnology Fyn antibody (Santa Cruz, sc-8056) was used in western blot on mouse samples . J Hepatol (2014) ncbi
mouse monoclonal (15)
  • immunoprecipitation; human
Santa Cruz Biotechnology Fyn antibody (Santa Cruz Biotechnology, sc-434) was used in immunoprecipitation on human samples . J Biol Chem (2013) ncbi
Abnova
mouse monoclonal (3G11-F9)
  • western blot; human; 1:1000; loading ...; fig 2b
Abnova Fyn antibody (Abnova, H00002534-M01) was used in western blot on human samples at 1:1000 (fig 2b). BMC Cancer (2019) ncbi
Abcam
domestic goat polyclonal
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1a
Abcam Fyn antibody (Abcam, ab802) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1a). Mol Cancer Res (2016) ncbi
domestic rabbit monoclonal (EPR5500)
  • western blot; rat
In order to determine the role of miR-125a-3p and Fyn in granulosa cells, Abcam Fyn antibody (Abcam, ab125016) was used in western blot on rat samples . FASEB J (2015) ncbi
mouse monoclonal (FYN-01)
  • western blot; human; 1:1000; tbl 4
Abcam Fyn antibody (Abcam, AB1881) was used in western blot on human samples at 1:1000 (tbl 4). Methods Mol Biol (2014) ncbi
Enzo Life Sciences
mouse monoclonal (FYN-01)
  • western blot; human; 1:1000
Enzo Life Sciences Fyn antibody (Alexis Biochemicals, 804-564-C100) was used in western blot on human samples at 1:1000. Cancer Cell (2011) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 7f
Cell Signaling Technology Fyn antibody (Cell Signaling, 4023T) was used in western blot on human samples (fig 7f). Science (2019) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; 1:500; loading ...; fig 4a
Cell Signaling Technology Fyn antibody (CST, 4023) was used in immunocytochemistry on mouse samples at 1:500 (fig 4a). elife (2019) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6c
Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot on mouse samples at 1:1000 (fig 6c). Nat Commun (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 6a
  • western blot; swine; loading ...; fig 5j
In order to study amyloid precursor protein Tyr phosphorylation in mouse model of Alzheimer's disease, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot on human samples (fig 6a) and in western blot on swine samples (fig 5j). Front Mol Neurosci (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023P) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 1g
  • western blot; rat; loading ...; fig 1e
In order to probe the interaction between STEP and PSD-95, Cell Signaling Technology Fyn antibody (Cell Signaling, 4023) was used in western blot knockout validation on mouse samples (fig 1g) and in western blot on rat samples (fig 1e). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1
Cell Signaling Technology Fyn antibody (Cell signaling, 4023) was used in western blot on human samples (fig 1). FASEB J (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:3000; fig 8
In order to study kinase DYRK1A selective inhibition by targeting its folding process, Cell Signaling Technology Fyn antibody (Cell Signaling Technology, 4023BC) was used in western blot on human samples at 1:3000 (fig 8). Nat Commun (2016) ncbi
BD Biosciences
mouse monoclonal (25/Fyn)
  • western blot; human; loading ...; fig 2e
BD Biosciences Fyn antibody (BD Biosciences, clone 25/Fyn) was used in western blot on human samples (fig 2e). Biol Open (2019) ncbi
mouse monoclonal (25/Fyn)
  • immunohistochemistry - frozen section; rat; loading ...; fig 6h
  • western blot; rat; loading ...; fig 6i
BD Biosciences Fyn antibody (Becton-Dickinson, 610163) was used in immunohistochemistry - frozen section on rat samples (fig 6h) and in western blot on rat samples (fig 6i). Development (2017) ncbi
mouse monoclonal (25/Fyn)
  • immunocytochemistry; rat; 1:500; fig 7
  • western blot; rat; 1:250; fig 5
In order to study how cellular localization affects DHHC5 activity, BD Biosciences Fyn antibody (BD Transduction Laboratories, 610163) was used in immunocytochemistry on rat samples at 1:500 (fig 7) and in western blot on rat samples at 1:250 (fig 5). Nat Commun (2015) ncbi
mouse monoclonal (25/Fyn)
  • western blot; mouse
BD Biosciences Fyn antibody (Transduction Laboratories, 25) was used in western blot on mouse samples . Eur J Immunol (2015) ncbi
mouse monoclonal (25/Fyn)
  • western blot; human; fig 7
BD Biosciences Fyn antibody (BD, 610163) was used in western blot on human samples (fig 7). J Biol Chem (2014) ncbi
mouse monoclonal (25/Fyn)
  • western blot; mouse
In order to study the regulation of adipogenesis by mechanical strain in mesenchymal stem cells and the roles played by Fyn, mTORC2 and RhoA, BD Biosciences Fyn antibody (BD Biosciences, 610163) was used in western blot on mouse samples . Stem Cells (2013) ncbi
Articles Reviewed
  1. Timms R, Zhang Z, Rhee D, Harper J, Koren I, Elledge S. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science. 2019;365: pubmed publisher
  2. Chen J, Huang W, Bamodu O, Chang P, Chao T, Huang T. Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo. BMC Cancer. 2019;19:634 pubmed publisher
  3. Padmanabhan P, Martínez Mármol R, Xia D, Götz J, Meunier F. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. elife. 2019;8: pubmed publisher
  4. Xiong X, Lee C, Li W, Yu J, Zhu L, Kim Y, et al. Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins. Biol Open. 2019;: pubmed publisher
  5. Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
  6. Roberts S, Dun X, Doddrell R, Mindos T, Drake L, Onaitis M, et al. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development. 2017;144:3114-3125 pubmed publisher
  7. Poulsen E, Iannuzzi F, Rasmussen H, Maier T, Enghild J, Jørgensen A, et al. An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients. Front Mol Neurosci. 2017;10:59 pubmed publisher
  8. Chattopadhyay R, Raghavan S, Rao G. Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol. 2017;12:438-455 pubmed publisher
  9. Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, et al. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun. 2017;8:14797 pubmed publisher
  10. Sanchez Martin M, Ambesi Impiombato A, Qin Y, Herranz D, Bansal M, Girardi T, et al. Synergistic antileukemic therapies in NOTCH1-induced T-ALL. Proc Natl Acad Sci U S A. 2017;114:2006-2011 pubmed publisher
  11. Belliard A, Gulati G, Duan Q, Alves R, Brewer S, Madan N, et al. Ischemia/reperfusion-induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+-ATPase: protection by ouabain preconditioning. Physiol Rep. 2016;4: pubmed
  12. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  13. Won S, Incontro S, Nicoll R, Roche K. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. Proc Natl Acad Sci U S A. 2016;113:E4736-44 pubmed publisher
  14. Janjanam J, Rao G. Novel role of cortactin in G protein-coupled receptor agonist-induced nuclear export and degradation of p21Cip1. Sci Rep. 2016;6:28687 pubmed publisher
  15. Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  16. DeRita R, Zerlanko B, Singh A, Lu H, Iozzo R, Benovic J, et al. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017;118:66-73 pubmed publisher
  17. Su L, Li X, Wu X, Hui B, Han S, Gao J, et al. Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar. Sci Rep. 2016;6:26023 pubmed publisher
  18. Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher
  19. Shen F, Zhang Y, Jernigan D, Feng X, Yan J, Garcia F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016;14:518-27 pubmed publisher
  20. Wu X, Yang L, Zheng Z, Li Z, Shi J, Li Y, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med. 2016;37:639-48 pubmed publisher
  21. Peng K, Tian X, Qian Y, Skibba M, Zou C, Liu Z, et al. Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II. J Cell Mol Med. 2016;20:482-94 pubmed publisher
  22. Peckham H, Giuffrida L, Wood R, Gonsalvez D, Ferner A, Kilpatrick T, et al. Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. Glia. 2016;64:255-69 pubmed publisher
  23. Brigidi G, Santyr B, Shimell J, Jovellar B, Bamji S. Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Nat Commun. 2015;6:8200 pubmed publisher
  24. Matsuoka H, Inoue M. Src mediates endocytosis of TWIK-related acid-sensitive K+ 1 channels in PC12 cells in response to nerve growth factor. Am J Physiol Cell Physiol. 2015;309:C251-63 pubmed publisher
  25. Grossman H, Chuderland D, Ninio Many L, Hasky N, Kaplan Kraicer R, Shalgi R. A novel regulatory pathway in granulosa cells, the LH/human chorionic gonadotropin-microRNA-125a-3p-Fyn pathway, is required for ovulation. FASEB J. 2015;29:3206-16 pubmed publisher
  26. Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
  27. Carnesecchi J, Malbouyres M, de Mets R, Balland M, Beauchef G, Vié K, et al. Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. PLoS ONE. 2015;10:e0120672 pubmed publisher
  28. Choi C, Kim Y, Sohn J, Lee H, Kim W. Focal adhesion kinase and Src expression in premalignant and malignant skin lesions. Exp Dermatol. 2015;24:361-4 pubmed publisher
  29. Tamilzhalagan S, Muthuswami M, Periasamy J, Lee M, Rha S, Tan P, et al. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 2015;27:1075-86 pubmed publisher
  30. Sheng L, Leshchyns ka I, Sytnyk V. Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels. J Neurosci. 2015;35:1739-52 pubmed publisher
  31. Gütgemann S, Sandusky M, Wingert S, Claus M, Watzl C. Recruitment of activating NK-cell receptors 2B4 and NKG2D to membrane microdomains in mammalian cells is dependent on their transmembrane regions. Eur J Immunol. 2015;45:1258-69 pubmed publisher
  32. Cox S. Intracellular signaling of CTLs. Methods Mol Biol. 2014;1186:49-63 pubmed publisher
  33. Fenton S, Hutchens K, Denning M. Targeting Fyn in Ras-transformed cells induces F-actin to promote adherens junction-mediated cell-cell adhesion. Mol Carcinog. 2015;54:1181-93 pubmed publisher
  34. Gable M, Abdallah S, Najjar S, Liu L, Askari A. Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase. Biochem Biophys Res Commun. 2014;446:1151-4 pubmed publisher
  35. Fukumoto Y, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, et al. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem. 2014;289:12313-29 pubmed publisher
  36. Bouchekioua Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, et al. LKB1 when associated with methylatedER? is a marker of bad prognosis in breast cancer. Int J Cancer. 2014;135:1307-18 pubmed publisher
  37. Cao M, Hou D, Liang H, Gong F, Wang Y, Yan X, et al. miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. Eur J Cancer. 2014;50:1013-24 pubmed publisher
  38. Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed publisher
  39. Thompson W, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, et al. Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells. 2013;31:2528-37 pubmed publisher
  40. Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher
  41. Eckert M, Lwin T, Chang A, Kim J, Danis E, Ohno Machado L, et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell. 2011;19:372-86 pubmed publisher