This is a Validated Antibody Database (VAD) review about human Fra-1, based on 37 published articles (read how Labome selects the articles), using Fra-1 antibody in all methods. It is aimed to help Labome visitors find the most suited Fra-1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Fra-1 synonym: FRA; FRA1; fra-1

Santa Cruz Biotechnology
mouse monoclonal (C-10)
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 4b
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, SC271243) was used in immunohistochemistry on mouse samples at 1:1000 (fig 4b). Cell Biosci (2022) ncbi
mouse monoclonal (E-8)
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1b
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-166940) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 (fig 1b). Dis Model Mech (2022) ncbi
mouse monoclonal (F-8)
  • western blot; mouse; 1:100; loading ...; fig 4b
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-271657) was used in western blot on mouse samples at 1:100 (fig 4b). Int J Mol Med (2021) ncbi
mouse monoclonal (6-2H-2F)
  • western blot; mouse; loading ...; fig 3c
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, sc-447) was used in western blot on mouse samples (fig 3c). Mol Med Rep (2021) ncbi
mouse monoclonal (E-8)
  • western blot; mouse; loading ...; fig 2c
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-166940) was used in western blot on mouse samples (fig 2c). Sci Rep (2021) ncbi
mouse monoclonal (E-8)
  • western blot; rat; loading ...; fig 3c
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, sc-166940) was used in western blot on rat samples (fig 3c). Acta Neuropathol Commun (2021) ncbi
mouse monoclonal (C-10)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4a
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-271243) was used in immunohistochemistry - paraffin section on mouse samples (fig 4a). Oncogene (2021) ncbi
mouse monoclonal (E-8)
  • immunohistochemistry - paraffin section; mouse; 1:150; loading ...; fig 3b
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-166940) was used in immunohistochemistry - paraffin section on mouse samples at 1:150 (fig 3b). Nat Commun (2020) ncbi
mouse monoclonal (E-8)
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 6c
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-166940) was used in immunohistochemistry - free floating section on mouse samples at 1:1000 (fig 6c). J Clin Invest (2021) ncbi
mouse monoclonal (6-2H-2F)
  • western blot; mouse; loading ...; fig 2d
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, sc-447) was used in western blot on mouse samples (fig 2d). Cell Death Dis (2020) ncbi
mouse monoclonal (C-10)
  • immunohistochemistry; rat; 1:250; loading ...
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-271243) was used in immunohistochemistry on rat samples at 1:250. Transl Psychiatry (2020) ncbi
mouse monoclonal (E-8)
  • immunohistochemistry; rat; 1:1000; loading ...
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-166940) was used in immunohistochemistry on rat samples at 1:1000. Transl Psychiatry (2020) ncbi
mouse monoclonal (C-12)
  • immunohistochemistry - paraffin section; human; loading ...; fig 7c
  • western blot; human; loading ...; fig 1a, 1b
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-28310) was used in immunohistochemistry - paraffin section on human samples (fig 7c) and in western blot on human samples (fig 1a, 1b). Cancers (Basel) (2020) ncbi
mouse monoclonal (E-8)
  • immunocytochemistry; human; loading ...; fig 4b
Santa Cruz Biotechnology Fra-1 antibody (Santa, sc-166940) was used in immunocytochemistry on human samples (fig 4b). Cancer Cell Int (2019) ncbi
mouse monoclonal (E-8)
  • immunohistochemistry - frozen section; mouse; loading ...; fig 6c
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, E-8) was used in immunohistochemistry - frozen section on mouse samples (fig 6c). elife (2019) ncbi
mouse monoclonal (E-8)
  • western blot; zebrafish ; 1:100; loading ...; fig 4k
Santa Cruz Biotechnology Fra-1 antibody (SantaCruz, sc-166940X) was used in western blot on zebrafish samples at 1:100 (fig 4k). Genetics (2017) ncbi
mouse monoclonal (C-10)
  • immunohistochemistry; mouse; loading ...; fig 1b
Santa Cruz Biotechnology Fra-1 antibody (SantaCruz, SC-271243) was used in immunohistochemistry on mouse samples (fig 1b). Neuron (2017) ncbi
mouse monoclonal (C-12)
  • chromatin immunoprecipitation; human; loading ...; fig 4c
In order to determine that the transcriptional activities of liver X receptor alpha and beta are activated by raffinose, Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-28310) was used in chromatin immunoprecipitation on human samples (fig 4c). Sci Rep (2017) ncbi
mouse monoclonal (B-10)
  • western blot; human; fig 3a
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-48424) was used in western blot on human samples (fig 3a). Biosci Rep (2017) ncbi
mouse monoclonal (D-3)
  • immunohistochemistry; human; 1:200; fig 3i; 5b
  • western blot; human; 1:500; loading ...; fig S5d
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2g; 5c
In order to report FOSL1 as a common transcriptional signature across mutant KRAS cancers of distinct tissue origin, Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-376148) was used in immunohistochemistry on human samples at 1:200 (fig 3i; 5b), in western blot on human samples at 1:500 (fig S5d) and in immunohistochemistry on mouse samples at 1:500 (fig 2g; 5c). Nat Commun (2017) ncbi
mouse monoclonal (C-10)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4a
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, sc-271243) was used in immunohistochemistry on mouse samples at 1:500 (fig 4a). Dis Model Mech (2017) ncbi
mouse monoclonal (C-12)
  • chromatin immunoprecipitation; human; loading ...; fig 1g
  • western blot; human; loading ...; fig 1j
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-28310) was used in chromatin immunoprecipitation on human samples (fig 1g) and in western blot on human samples (fig 1j). Cell Death Dis (2016) ncbi
mouse monoclonal (C-10)
  • western blot; human; 1:1000; fig 4
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-271243) was used in western blot on human samples at 1:1000 (fig 4). Mol Med Rep (2016) ncbi
mouse monoclonal (E-8)
  • western blot; human; loading ...; fig 9a
In order to demonstrate that both Ras and Rap1 are required for cyclic adenosine monophosphate signaling to extracellular signal-regulated kinase, Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-166940) was used in western blot on human samples (fig 9a). J Biol Chem (2016) ncbi
mouse monoclonal (C-12)
  • immunoprecipitation; human; fig 2d
  • western blot; human; fig 2d
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-28310) was used in immunoprecipitation on human samples (fig 2d) and in western blot on human samples (fig 2d). Oncotarget (2016) ncbi
mouse monoclonal (C-12)
  • western blot; human; 1:500; fig 5
In order to research induction of epithelial-to-mesenchymal transition by Polo-like kinase 1 and promotion of epithelial cell motility by activating CRAF/ERK signaling, Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-28310) was used in western blot on human samples at 1:500 (fig 5). elife (2016) ncbi
mouse monoclonal (6-2H-2F)
  • western blot; mouse; fig 5
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-447) was used in western blot on mouse samples (fig 5). Int J Mol Med (2016) ncbi
mouse monoclonal (C-12)
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
  • western blot; human; fig 2
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-28310) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 2) and in western blot on human samples (fig 2). Oncotarget (2015) ncbi
mouse monoclonal (6-2H-2F)
  • EMSA; human; loading ...; fig 4b
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, sc-447) was used in EMSA on human samples (fig 4b). Int J Mol Med (2015) ncbi
mouse monoclonal (6-2H-2F)
  • western blot; human; fig 2
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-447) was used in western blot on human samples (fig 2). Arch Med Sci (2015) ncbi
mouse monoclonal (E-8)
  • immunohistochemistry - paraffin section; rat; 1:5000
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz, sc-166940) was used in immunohistochemistry - paraffin section on rat samples at 1:5000. Neuroscience (2015) ncbi
mouse monoclonal (C-12)
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3c
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, C12) was used in immunohistochemistry on mouse samples at 1:100 (fig 3c). Development (2014) ncbi
mouse monoclonal (C-10)
  • EMSA; human
Santa Cruz Biotechnology Fra-1 antibody (Santa Cruz Biotechnology, sc271243) was used in EMSA on human samples . Int Immunol (2014) ncbi
Abcam
domestic rabbit monoclonal (EP4711)
  • western blot; human; loading ...; fig 2i
Abcam Fra-1 antibody (Abcam, ab124722) was used in western blot on human samples (fig 2i). Cancers (Basel) (2018) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D80B4)
  • western blot; human; loading ...; fig s6e
Cell Signaling Technology Fra-1 antibody (Cell Signaling, D80B4) was used in western blot on human samples (fig s6e). Cancer Res (2018) ncbi
domestic rabbit monoclonal (D80B4)
  • western blot; mouse; 1:2000; fig 2i
  • western blot; human; 1:2000; loading ...; fig S6i
In order to report FOSL1 as a common transcriptional signature across mutant KRAS cancers of distinct tissue origin, Cell Signaling Technology Fra-1 antibody (Cell Signaling, 5281) was used in western blot on mouse samples at 1:2000 (fig 2i) and in western blot on human samples at 1:2000 (fig S6i). Nat Commun (2017) ncbi
domestic rabbit monoclonal (D22B1)
  • western blot; human; 1:1000; loading ...; fig 2b;
In order to report FOSL1 as a common transcriptional signature across mutant KRAS cancers of distinct tissue origin, Cell Signaling Technology Fra-1 antibody (Cell Signaling, 5841) was used in western blot on human samples at 1:1000 (fig 2b;). Nat Commun (2017) ncbi
domestic rabbit monoclonal (D80B4)
  • immunocytochemistry; human; loading ...; fig 7a
Cell Signaling Technology Fra-1 antibody (Cell Signaling, 5281) was used in immunocytochemistry on human samples (fig 7a). MBio (2017) ncbi
domestic rabbit monoclonal (D80B4)
  • western blot; human; loading ...; fig s2e
Cell Signaling Technology Fra-1 antibody (Cell Signaling, 5281) was used in western blot on human samples (fig s2e). Cell Death Dis (2016) ncbi
domestic rabbit monoclonal (D22B1)
  • western blot; human; fig 3b
Cell Signaling Technology Fra-1 antibody (Cell Signaling, 5841) was used in western blot on human samples (fig 3b). Oncotarget (2016) ncbi
Developmental Studies Hybridoma Bank
mouse monoclonal (PCRP-FOSL1-1E3)
  • western blot; dogs; loading ...; fig 5e
Developmental Studies Hybridoma Bank Fra-1 antibody (Developmental Studies Hybridoma Bank, PCRP-FOSL1-1E3) was used in western blot on dogs samples (fig 5e). Oncogene (2017) ncbi
Articles Reviewed
  1. Singh I, Wang L, Xia B, Liu J, Tahiri A, El Ouaamari A, et al. Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake. Cell Biosci. 2022;12:178 pubmed publisher
  2. Owaki T, Kamimura K, Ko M, Nagayama I, Nagoya T, Shibata O, et al. Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A. Dis Model Mech. 2022;15: pubmed publisher
  3. Liu Y, Lin J, Chen Y, Li Z, Zhou J, Lu X, et al. Omega‑3 polyunsaturated fatty acids inhibit IL‑11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity. Int J Mol Med. 2021;48: pubmed publisher
  4. Kim M, Kim J, Hong S, Kwon B, Kim E, Jung H, et al. Effects of Melandrium firmum Rohrbach on RANKL‑induced osteoclast differentiation and OVX rats. Mol Med Rep. 2021;24: pubmed publisher
  5. Liu Y, Zienkiewicz J, Boyd K, Smith T, Xu Z, Hawiger J. Hyperlipidemic hypersensitivity to lethal microbial inflammation and its reversal by selective targeting of nuclear transport shuttles. Sci Rep. 2021;11:11907 pubmed publisher
  6. Sadeghi M, Hemmati S, Mohammadi S, Yousefi Manesh H, Vafaei A, Zare M, et al. Chronically altered NMDAR signaling in epilepsy mediates comorbid depression. Acta Neuropathol Commun. 2021;9:53 pubmed publisher
  7. Riedel M, Berthelsen M, Cai H, Haldrup J, Borre M, Paludan S, et al. In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun. Oncogene. 2021;40:2437-2447 pubmed publisher
  8. Zhang J, Chen D, Sweeney P, Yang Y. An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake. Nat Commun. 2020;11:6326 pubmed publisher
  9. Borie A, Dromard Y, Guillon G, Olma A, Manning M, Muscatelli F, et al. Correction of vasopressin deficit in the lateral septum ameliorates social deficits of mouse autism model. J Clin Invest. 2021;131: pubmed publisher
  10. Du T, Yan Z, Zhu S, Chen G, Wang L, Ye Z, et al. QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism. Cell Death Dis. 2020;11:330 pubmed publisher
  11. Cohen S, Matar M, Vainer E, Zohar J, Kaplan Z, Cohen H. Significance of the orexinergic system in modulating stress-related responses in an animal model of post-traumatic stress disorder. Transl Psychiatry. 2020;10:10 pubmed publisher
  12. Yun S, Hong H, Yeo S, Kim S, Cho Y, Kim K. Ubiquitin-Specific Protease 21 Promotes Colorectal Cancer Metastasis by Acting as a Fra-1 Deubiquitinase. Cancers (Basel). 2020;12: pubmed publisher
  13. Del Mar Díaz González S, Rodríguez Aguilar E, Meneses Acosta A, Valadez Graham V, Deas J, Gómez Cerón C, et al. Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells. Cancer Cell Int. 2019;19:214 pubmed publisher
  14. Chowdhury S, Hung C, Izawa S, Inutsuka A, Kawamura M, Kawashima T, et al. Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice. elife. 2019;8: pubmed publisher
  15. Qiu L, Wang M, Hu S, Ru X, Ren Y, Zhang Z, et al. Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor. Cancers (Basel). 2018;10: pubmed publisher
  16. Schwab A, Siddiqui A, Vazakidou M, Napoli F, Böttcher M, Menchicchi B, et al. Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells. Cancer Res. 2018;78:1604-1618 pubmed publisher
  17. Pena I, Roussel Y, Daniel K, Mongeon K, Johnstone D, Weinschutz Mendes H, et al. Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency. Genetics. 2017;207:1501-1518 pubmed publisher
  18. Liu J, Conde K, Zhang P, Lilascharoen V, Xu Z, Lim B, et al. Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus. Neuron. 2017;96:897-909.e5 pubmed publisher
  19. Zhang K, Myllymäki S, Gao P, Devarajan R, Kytölä V, Nykter M, et al. Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT. Oncogene. 2017;36:5681-5694 pubmed publisher
  20. Na T, Kim G, Oh H, Lee M, Han Y, Kim K, et al. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep. 2017;7:43823 pubmed publisher
  21. Zhang L, Liu H, Mu X, Cui J, Peng Z. Dysregulation of Fra1 expression by Wnt/β-catenin signalling promotes glioma aggressiveness through epithelial-mesenchymal transition. Biosci Rep. 2017;37: pubmed publisher
  22. Vallejo A, Perurena N, Guruceaga E, Mazur P, Martínez Canarias S, Zandueta C, et al. An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017;8:14294 pubmed publisher
  23. Ladrón de Guevara Miranda D, Millón C, Rosell Valle C, Pérez Fernández M, Missiroli M, Serrano A, et al. Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Dis Model Mech. 2017;10:323-336 pubmed publisher
  24. Cai B, Wu J, Yu X, Su X, Wang R. FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions. MBio. 2017;8: pubmed publisher
  25. Wu J, Sun Y, Zhang P, Qian M, Zhang H, Chen X, et al. The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. Cell Death Dis. 2016;7:e2384 pubmed publisher
  26. Klingbeil O, Lesche R, Gelato K, Haendler B, Lejeune P. Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents. Cell Death Dis. 2016;7:e2365 pubmed publisher
  27. Shang W, Zhao L, Dong X, Zhao Z, Li J, Zhang B, et al. Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways. Mol Med Rep. 2016;14:3620-6 pubmed publisher
  28. Li Y, Dillon T, Takahashi M, Earley K, Stork P. Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. J Biol Chem. 2016;291:21584-21595 pubmed
  29. Hanson R, Brown R, Steele M, Grandgenett P, Grunkemeyer J, Hollingsworth M. Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis. Oncotarget. 2016;7:39996-40011 pubmed publisher
  30. Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher
  31. Kim J, Kim E, Lee B, Min J, Song D, Lim J, et al. The effects of Lycii Radicis Cortex on RANKL-induced osteoclast differentiation and activation in RAW 264.7 cells. Int J Mol Med. 2016;37:649-58 pubmed publisher
  32. Iskit S, Schlicker A, Wessels L, Peeper D. Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival. Oncotarget. 2015;6:43146-61 pubmed publisher
  33. Liu B, Wu S, Han L, Zhang C. β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Int J Mol Med. 2015;36:1572-82 pubmed publisher
  34. Lan G, Yang L, Xie X, Peng L, Wang Y. MicroRNA-490-5p is a novel tumor suppressor targeting c-FOS in human bladder cancer. Arch Med Sci. 2015;11:561-9 pubmed publisher
  35. Liu W, Crews F. Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat. Neuroscience. 2015;293:92-108 pubmed publisher
  36. Delgado Olguín P, Dang L, He D, Thomas S, Chi L, Sukonnik T, et al. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014;141:4610-7 pubmed publisher
  37. Davidson C, Cameron L, Burshtyn D. The AP-1 transcription factor JunD activates the leukocyte immunoglobulin-like receptor 1 distal promoter. Int Immunol. 2014;26:21-33 pubmed publisher