This is a Validated Antibody Database (VAD) review about human FTL, based on 23 published articles (read how Labome selects the articles), using FTL antibody in all methods. It is aimed to help Labome visitors find the most suited FTL antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
FTL synonym: LFTD; NBIA3

Knockout validation
Abcam
domestic rabbit monoclonal (EPR5260)
  • immunohistochemistry knockout validation; mouse; fig 3
  • western blot knockout validation; mouse; fig 4
  • immunohistochemistry - paraffin section; mouse; fig 3
In order to use Fth and Ftl knock out mice to study iron metabolism in the brain, Abcam FTL antibody (Abcam, ab109373) was used in immunohistochemistry knockout validation on mouse samples (fig 3), in western blot knockout validation on mouse samples (fig 4) and in immunohistochemistry - paraffin section on mouse samples (fig 3). PLoS ONE (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (D-9)
  • western blot; human; 1:1000; loading ...; fig 2a, 7a
Santa Cruz Biotechnology FTL antibody (Santa Cruz, sc-74513) was used in western blot on human samples at 1:1000 (fig 2a, 7a). Sci Rep (2021) ncbi
mouse monoclonal (D-1)
  • western blot; mouse; loading ...; fig 1d
Santa Cruz Biotechnology FTL antibody (Santa Cruz, sc-390558) was used in western blot on mouse samples (fig 1d). Cell Death Dis (2020) ncbi
mouse monoclonal (D-9)
  • western blot; human; 1:200; loading ...; fig s3a
Santa Cruz Biotechnology FTL antibody (Santa Cruz, sc-74513) was used in western blot on human samples at 1:200 (fig s3a). Sci Adv (2019) ncbi
mouse monoclonal (D-9)
  • western blot; mouse; loading ...; fig 3a
Santa Cruz Biotechnology FTL antibody (Santa, sc-74513) was used in western blot on mouse samples (fig 3a). Biology (Basel) (2019) ncbi
mouse monoclonal (D-9)
  • western blot; mouse; 1:1000; loading ...; fig 2a
Santa Cruz Biotechnology FTL antibody (SantaCruz, sc-74513) was used in western blot on mouse samples at 1:1000 (fig 2a). Redox Biol (2018) ncbi
mouse monoclonal (D-9)
  • western blot; human; 1:1000; loading ...; fig 5a
Santa Cruz Biotechnology FTL antibody (Santa Cruz, sc-74513) was used in western blot on human samples at 1:1000 (fig 5a). Science (2017) ncbi
mouse monoclonal (D-9)
  • western blot; human; 1:1000; loading ...; fig 2c
Santa Cruz Biotechnology FTL antibody (SantaCruz, sc-74513) was used in western blot on human samples at 1:1000 (fig 2c). Mol Cell Biol (2017) ncbi
mouse monoclonal (D-1)
  • western blot; human; 1:1000; loading ...; fig 4b
In order to study the role of mitochondrial ferritin protein in iron-dependent cell death (ferroptosis)., Santa Cruz Biotechnology FTL antibody (Santa Cruz, sc-390558) was used in western blot on human samples at 1:1000 (fig 4b). Front Aging Neurosci (2016) ncbi
mouse monoclonal (D-9)
  • western blot; mouse; 1:1000; loading ...; fig 1c
In order to examine the role of multicopper ferroxidases in the kidney, Santa Cruz Biotechnology FTL antibody (Santa Cruz, sc-74513) was used in western blot on mouse samples at 1:1000 (fig 1c). Sci Rep (2016) ncbi
mouse monoclonal (D-9)
  • immunohistochemistry; mouse; 1:125
Santa Cruz Biotechnology FTL antibody (Santa Cruz Biotechnology, SC-74513) was used in immunohistochemistry on mouse samples at 1:125. Front Neurosci (2015) ncbi
mouse monoclonal (D-1)
  • western blot; human; 1:1000; fig 4
In order to characterize inhibition of neuronal tumor cell proliferation by mitochondrial ferritin, Santa Cruz Biotechnology FTL antibody (Santa Cruz Biotechnology, sc-390558) was used in western blot on human samples at 1:1000 (fig 4). Cell Mol Life Sci (2015) ncbi
mouse monoclonal (D-9)
  • western blot; human; 1:500
Santa Cruz Biotechnology FTL antibody (Santa Cruz Biotechnology, SC-74513) was used in western blot on human samples at 1:500. J Biomol Screen (2014) ncbi
Abcam
domestic rabbit monoclonal (EPR5260)
  • western blot; human; 1:10,000; loading ...; fig 3a
Abcam FTL antibody (Abcam, ab109373) was used in western blot on human samples at 1:10,000 (fig 3a). Oxid Med Cell Longev (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...
Abcam FTL antibody (Abcam, ab69090) was used in western blot on human samples . Theranostics (2021) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; human; fig s7
  • western blot; human; 1:1000; fig s5c
Abcam FTL antibody (Abcam, ab69090) was used in immunocytochemistry on human samples (fig s7) and in western blot on human samples at 1:1000 (fig s5c). Nat Commun (2021) ncbi
domestic rabbit monoclonal (EPR5260)
  • western blot; mouse; loading ...; fig 4c, 4d
Abcam FTL antibody (Abcam, ab109373) was used in western blot on mouse samples (fig 4c, 4d). Cell Death Discov (2020) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1e
Abcam FTL antibody (Abcam, ab69090) was used in immunohistochemistry on mouse samples at 1:500 (fig 1e). Front Cell Neurosci (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:800; loading ...; fig 3a, 3s5a
Abcam FTL antibody (Abcam, ab69090) was used in western blot on human samples at 1:800 (fig 3a, 3s5a). elife (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2e
  • western blot; rat; loading ...; fig 2e
Abcam FTL antibody (Abcam, ab69090) was used in western blot on human samples (fig 2e) and in western blot on rat samples (fig 2e). Cancer Lett (2018) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:5000; loading ...; fig 5
In order to report polyphenols with iron-chelating potential, Abcam FTL antibody (Abcam, AB69090) was used in western blot on human samples at 1:5000 (fig 5). Mol Nutr Food Res (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; fig 2D
In order to report the transcriptomes of thousands of single pancreatic cells, Abcam FTL antibody (Abcam, ab69090) was used in immunohistochemistry on human samples (fig 2D). Cell Syst (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 7a
In order to develop StemID, an algorithm for identifying stem cells among all detectable cell types within a population, Abcam FTL antibody (Abcam, ab69090) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 7a). Cell Stem Cell (2016) ncbi
domestic rabbit monoclonal (EPR5260)
  • immunohistochemistry knockout validation; mouse; fig 3
  • western blot knockout validation; mouse; fig 4
  • immunohistochemistry - paraffin section; mouse; fig 3
In order to use Fth and Ftl knock out mice to study iron metabolism in the brain, Abcam FTL antibody (Abcam, ab109373) was used in immunohistochemistry knockout validation on mouse samples (fig 3), in western blot knockout validation on mouse samples (fig 4) and in immunohistochemistry - paraffin section on mouse samples (fig 3). PLoS ONE (2015) ncbi
Articles Reviewed
  1. Zuo Y, Xie J, Li X, Li Y, Thirupathi A, Zhang J, et al. Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD. Oxid Med Cell Longev. 2021;2021:9961628 pubmed publisher
  2. Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics. 2021;11:5650-5674 pubmed publisher
  3. Goldfarb A, Freeman K, Sahu R, Elagib K, Holy M, Arneja A, et al. Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. Nat Commun. 2021;12:1645 pubmed publisher
  4. Shekoohi S, Rajasekaran S, Patel D, Yang S, Liu W, Huang S, et al. Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth. Sci Rep. 2021;11:5267 pubmed publisher
  5. Zhang X, Gou Y, Zhang Y, Li J, Han K, Xu Y, et al. Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice. Cell Death Discov. 2020;6:113 pubmed publisher
  6. Lee D, Kam M, Lee S, Lee H, Lee D. Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis. 2020;11:204 pubmed publisher
  7. Kjell J, Gotz M. Filling the Gaps - A Call for Comprehensive Analysis of Extracellular Matrix of the Glial Scar in Region- and Injury-Specific Contexts. Front Cell Neurosci. 2020;14:32 pubmed publisher
  8. Pulos Holmes M, Srole D, Juarez M, Lee A, McSwiggen D, Ingolia N, et al. Repression of ferritin light chain translation by human eIF3. elife. 2019;8: pubmed publisher
  9. Wang P, Chen S, Guo M, Peng S, Wang M, Chen M, et al. Nanoscale magnetic imaging of ferritins in a single cell. Sci Adv. 2019;5:eaau8038 pubmed publisher
  10. Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I. Factors that May Protect the Native Hibernator Syrian Hamster Renal Tubular Epithelial Cells from Ferroptosis Due to Warm Anoxia-Reoxygenation. Biology (Basel). 2019;8: pubmed publisher
  11. Chen M, Zheng J, Liu G, Xu E, Wang J, Fuqua B, et al. Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux. Redox Biol. 2018;17:432-439 pubmed publisher
  12. Wang Z, Ding Y, Wang X, Lu S, Wang C, He C, et al. Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT. Cancer Lett. 2018;428:21-33 pubmed publisher
  13. Grillo A, SantaMaria A, Kafina M, Cioffi A, Huston N, Han M, et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017;356:608-616 pubmed publisher
  14. Kerins M, Vashisht A, Liang B, Duckworth S, Praslicka B, WOHLSCHLEGEL J, et al. Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017;37: pubmed publisher
  15. Wang Y, Chang S, Wu Q, Gou Y, Jia L, Cui Y, et al. The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis. Front Aging Neurosci. 2016;8:308 pubmed publisher
  16. Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, et al. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Sci Rep. 2016;6:39470 pubmed publisher
  17. Horniblow R, Henesy D, Iqbal T, Tselepis C. Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. Mol Nutr Food Res. 2017;61: pubmed publisher
  18. Muraro M, Dharmadhikari G, Grün D, Groen N, Dielen T, Jansen E, et al. A Single-Cell Transcriptome Atlas of the Human Pancreas. Cell Syst. 2016;3:385-394.e3 pubmed publisher
  19. Grün D, Muraro M, Boisset J, Wiebrands K, Lyubimova A, Dharmadhikari G, et al. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell Stem Cell. 2016;19:266-277 pubmed publisher
  20. Meadowcroft M, Connor J, Yang Q. Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1ΔE9 mice: a histological perspective. Front Neurosci. 2015;9:255 pubmed publisher
  21. Li W, Garringer H, GOODWIN C, Richine B, Acton A, Vanduyn N, et al. Systemic and cerebral iron homeostasis in ferritin knock-out mice. PLoS ONE. 2015;10:e0117435 pubmed publisher
  22. Shi Z, Shi F, Wang Y, Sheftel A, Nie G, Zhao Y, et al. Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation. Cell Mol Life Sci. 2015;72:983-97 pubmed publisher
  23. Montague C, Fitzmaurice A, Hover B, Salazar N, Fey J. Screen for small molecules increasing the mitochondrial membrane potential. J Biomol Screen. 2014;19:387-98 pubmed publisher