This is a Validated Antibody Database (VAD) review about human FTH1, based on 34 published articles (read how Labome selects the articles), using FTH1 antibody in all methods. It is aimed to help Labome visitors find the most suited FTH1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
FTH1 synonym: FHC; FTH; FTHL6; HFE5; PIG15; PLIF

Abcam
domestic rabbit monoclonal (EPR3004Y)
  • western blot; mouse; loading ...; fig 3d
  • immunohistochemistry; human; loading ...; fig s1b
  • western blot; human; loading ...; fig 1h
Abcam FTH1 antibody (Abcam, ab75973) was used in western blot on mouse samples (fig 3d), in immunohistochemistry on human samples (fig s1b) and in western blot on human samples (fig 1h). Acta Pharm Sin B (2022) ncbi
domestic rabbit monoclonal (EPR18878)
  • western blot; mouse; 1:1000; loading ...; fig 5e
Abcam FTH1 antibody (Abcam, ab183781) was used in western blot on mouse samples at 1:1000 (fig 5e). Front Cardiovasc Med (2022) ncbi
domestic rabbit monoclonal (EPR18878)
  • western blot; human; loading ...; fig 7d
Abcam FTH1 antibody (Abcam, ab183781) was used in western blot on human samples (fig 7d). Front Endocrinol (Lausanne) (2022) ncbi
domestic rabbit monoclonal (EPR18878)
  • western blot; human; 1:10,000; loading ...; fig 3a
Abcam FTH1 antibody (Abcam, ab183781) was used in western blot on human samples at 1:10,000 (fig 3a). Oxid Med Cell Longev (2021) ncbi
domestic rabbit monoclonal (EPR18878)
  • western blot; human; 1:1000; loading ...; fig 6e, s6f
Abcam FTH1 antibody (Abcam, ab183781) was used in western blot on human samples at 1:1000 (fig 6e, s6f). Oncol Lett (2021) ncbi
domestic rabbit monoclonal (EPR3004Y)
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4f
  • western blot; mouse; 1:3000; loading ...; fig 4e
Abcam FTH1 antibody (Abcam, ab75973) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig 4f) and in western blot on mouse samples at 1:3000 (fig 4e). Antioxidants (Basel) (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 7i
Abcam FTH1 antibody (Abcam, ab65080) was used in western blot on human samples (fig 7i). Theranostics (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3d
Abcam FTH1 antibody (Abcam, ab231253) was used in western blot on human samples (fig 3d). Cell Death Dis (2021) ncbi
domestic rabbit monoclonal (EPR18878)
  • western blot; mouse; loading ...; fig 6a
Abcam FTH1 antibody (Abcam, ab183781) was used in western blot on mouse samples (fig 6a). Cell Death Discov (2020) ncbi
domestic rabbit monoclonal (EPR18878)
  • western blot; mouse; 1:2000; loading ...; fig s4-2c
Abcam FTH1 antibody (Abcam, EPR18878) was used in western blot on mouse samples at 1:2000 (fig s4-2c). elife (2020) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4a
Abcam FTH1 antibody (Abcam, ab65080) was used in western blot on mouse samples (fig 4a). Haematologica (2019) ncbi
domestic rabbit monoclonal (EPR3005Y)
  • western blot; rat; loading ...; fig 2e
  • western blot; human; loading ...; fig 2e
Abcam FTH1 antibody (Abcam, ab75972) was used in western blot on rat samples (fig 2e) and in western blot on human samples (fig 2e). Cancer Lett (2018) ncbi
domestic rabbit monoclonal (EPR3004Y)
  • western blot; human; 1:1000; loading ...; fig 8b
In order to find the specific gene signature related to iron metabolism consisting of genes regulating iron uptake, mitochondrial FeS cluster biogenesis and hypoxic response, Abcam FTH1 antibody (Abcam, ab75973) was used in western blot on human samples at 1:1000 (fig 8b). Oncotarget (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (B-12)
  • western blot; mouse; loading ...; fig 1d
Santa Cruz Biotechnology FTH1 antibody (Santa Cruz, sc-376594) was used in western blot on mouse samples (fig 1d). Cell Death Dis (2020) ncbi
mouse monoclonal (B-12)
  • western blot; mouse; loading ...; fig 3a
Santa Cruz Biotechnology FTH1 antibody (Santa, sc-376594) was used in western blot on mouse samples (fig 3a). Biology (Basel) (2019) ncbi
mouse monoclonal (B-12)
  • western blot; human
Santa Cruz Biotechnology FTH1 antibody (Santa Cruz, sc-376594) was used in western blot on human samples . J Biomed Mater Res A (2015) ncbi
Rockland Immunochemicals
domestic rabbit polyclonal
  • immunocytochemistry; human; 1:200; loading ...; fig 1f
Rockland Immunochemicals FTH1 antibody (Rockland, 200-401-090-0100) was used in immunocytochemistry on human samples at 1:200 (fig 1f). Cell Rep (2017) ncbi
domestic rabbit polyclonal
Rockland Immunochemicals FTH1 antibody (Rockland, 200-401-090-0100) was used . elife (2015) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; rat; loading ...; fig 5c
Cell Signaling Technology FTH1 antibody (Cell Signaling Technology, 3998) was used in western blot on rat samples (fig 5c). Redox Biol (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2f, 2g, 2h
  • western blot; human; 1:1000; loading ...; fig s5l
Cell Signaling Technology FTH1 antibody (Cell Signaling, 3998) was used in western blot on mouse samples at 1:1000 (fig 2f, 2g, 2h) and in western blot on human samples at 1:1000 (fig s5l). Cell Death Dis (2022) ncbi
domestic rabbit monoclonal (D1D4)
  • western blot; human; 1:25,000; fig 2e
Cell Signaling Technology FTH1 antibody (Cell Signaling Technology, 4393) was used in western blot on human samples at 1:25,000 (fig 2e). Nat Commun (2021) ncbi
domestic rabbit monoclonal (D1D4)
  • western blot; rat; loading ...; fig 4a, 4c
Cell Signaling Technology FTH1 antibody (Cell Signaling, 4393) was used in western blot on rat samples (fig 4a, 4c). Front Mol Biosci (2021) ncbi
domestic rabbit monoclonal (D1D4)
  • western blot; human; 1:1000; fig s5c
Cell Signaling Technology FTH1 antibody (Cell Signaling Technology, 4393) was used in western blot on human samples at 1:1000 (fig s5c). Nat Commun (2021) ncbi
domestic rabbit monoclonal (D1D4)
  • western blot; mouse; 1:1000; loading ...; fig 5d
Cell Signaling Technology FTH1 antibody (Cell Signaling, 4393) was used in western blot on mouse samples at 1:1000 (fig 5d). Cell Death Differ (2021) ncbi
domestic rabbit monoclonal (D1D4)
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 2c
  • western blot; mouse; loading ...; fig 1b
Cell Signaling Technology FTH1 antibody (Cell Signaling, 4393) was used in immunohistochemistry - paraffin section on mouse samples at 1:500 (fig 2c) and in western blot on mouse samples (fig 1b). Haematologica (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6g
Cell Signaling Technology FTH1 antibody (Cell Signaling, 3998S) was used in western blot on human samples (fig 6g). J Clin Invest (2019) ncbi
domestic rabbit monoclonal (D1D4)
  • western blot; human; 1:1000; loading ...; fig 1g
Cell Signaling Technology FTH1 antibody (Cell Signaling, 4393) was used in western blot on human samples at 1:1000 (fig 1g). Cell Rep (2017) ncbi
domestic rabbit monoclonal (D1D4)
  • western blot; human; 1:500; loading ...; fig 3c
In order to started the linkage of HFE genotype and exosome phenotype in cancer, Cell Signaling Technology FTH1 antibody (Cell Signaling, D1D4) was used in western blot on human samples at 1:500 (fig 3c). Biochim Biophys Acta Gen Subj (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 7B
In order to identify cellular processes that regulate HIF1alpha, Cell Signaling Technology FTH1 antibody (Cell signaling, 3998) was used in western blot on human samples at 1:1000 (fig 7B). elife (2017) ncbi
domestic rabbit monoclonal (D1D4)
  • immunocytochemistry; human; 1:100; fig 5
  • western blot; human; 1:1000; fig 7
Cell Signaling Technology FTH1 antibody (Cell Signaling, 4393) was used in immunocytochemistry on human samples at 1:100 (fig 5) and in western blot on human samples at 1:1000 (fig 7). Nat Cell Biol (2014) ncbi
Genway Biotech
polyclonal
  • immunohistochemistry - paraffin section; human; 4 ug/ml; fig 5
Genway Biotech FTH1 antibody (GenWay, GWB-B74CB5) was used in immunohistochemistry - paraffin section on human samples at 4 ug/ml (fig 5). Acta Neuropathol Commun (2016) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 1a
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5b
MilliporeSigma FTH1 antibody (Sigma-Aldrich, F5012) was used in western blot on human samples at 1:500 (fig 1a) and in immunohistochemistry on mouse samples at 1:100 (fig 5b). Antioxidants (Basel) (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s1b
MilliporeSigma FTH1 antibody (Sigma, F5012) was used in western blot on human samples (fig s1b). J Clin Invest (2019) ncbi
domestic rabbit polyclonal
  • immunoprecipitation; mouse; loading ...; fig 1d
  • western blot; mouse; 1:2000; loading ...; fig 1c
MilliporeSigma FTH1 antibody (Sigma-Aldrich, F5012) was used in immunoprecipitation on mouse samples (fig 1d) and in western blot on mouse samples at 1:2000 (fig 1c). J Clin Invest (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; fig 2
  • western blot; mouse; 1:1000; fig 2
  • western blot; human; 1:1000; fig 5
In order to characterize modulation of retinal iron homeostasis by facilitating the update of transferrin-bound iron by alpha-synuclein which may be a visual manifestation of Parkinson's disease, MilliporeSigma FTH1 antibody (Sigma-Aldrich, F5012) was used in immunohistochemistry - paraffin section on mouse samples (fig 2), in western blot on mouse samples at 1:1000 (fig 2) and in western blot on human samples at 1:1000 (fig 5). Free Radic Biol Med (2016) ncbi
Articles Reviewed
  1. Tong J, Li D, Meng H, Sun D, Lan X, Ni M, et al. Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease. Acta Pharm Sin B. 2022;12:3650-3666 pubmed publisher
  2. Man W, Song X, Xiong Z, Gu J, Lin J, Gu X, et al. Exosomes derived from pericardial adipose tissues attenuate cardiac remodeling following myocardial infarction by Adipsin-regulated iron homeostasis. Front Cardiovasc Med. 2022;9:1003282 pubmed publisher
  3. Ji F, Fu X, Li G, He Q, Qiu X. FTO Prevents Thyroid Cancer Progression by SLC7A11 m6A Methylation in a Ferroptosis-Dependent Manner. Front Endocrinol (Lausanne). 2022;13:857765 pubmed publisher
  4. Kong Y, Akatsuka S, Motooka Y, Zheng H, Cheng Z, Shiraki Y, et al. BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance. Redox Biol. 2022;54:102356 pubmed publisher
  5. Jia F, Li H, Jiao Q, Li C, Fu L, Cui C, et al. Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2. Cell Death Dis. 2022;13:418 pubmed publisher
  6. Ashok A, Chaudhary S, Wise A, Rana N, McDonald D, Kritikos A, et al. Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study. Antioxidants (Basel). 2021;10: pubmed publisher
  7. Zuo Y, Xie J, Li X, Li Y, Thirupathi A, Zhang J, et al. Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD. Oxid Med Cell Longev. 2021;2021:9961628 pubmed publisher
  8. Yao F, Cui X, Zhang Y, Bei Z, Wang H, Zhao D, et al. Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma. Oncol Lett. 2021;22:657 pubmed publisher
  9. Fisher A, Sangkhae V, Balusikova K, Palaskas N, Ganz T, Nemeth E. Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy. Nat Commun. 2021;12:4026 pubmed publisher
  10. Choi E, Jeong J, Jang H, Ahn Y, Kim K, An H, et al. Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia. Antioxidants (Basel). 2021;10: pubmed publisher
  11. Chang B, Guan H, Wang X, Chen Z, Zhu W, Wei X, et al. Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells. Front Mol Biosci. 2021;8:660072 pubmed publisher
  12. Zhang X, Yu K, Ma L, Qian Z, Tian X, Miao Y, et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics. 2021;11:5650-5674 pubmed publisher
  13. Goldfarb A, Freeman K, Sahu R, Elagib K, Holy M, Arneja A, et al. Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. Nat Commun. 2021;12:1645 pubmed publisher
  14. Li L, Zhao S, Liu Z, Zhang N, Pang S, Liu J, et al. Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway. Cell Death Dis. 2021;12:220 pubmed publisher
  15. Bao W, Pang P, Zhou X, Hu F, Xiong W, Chen K, et al. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease. Cell Death Differ. 2021;28:1548-1562 pubmed publisher
  16. Zhang X, Gou Y, Zhang Y, Li J, Han K, Xu Y, et al. Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice. Cell Death Discov. 2020;6:113 pubmed publisher
  17. Lissner M, Cumnock K, Davis N, Vilches Moure J, Basak P, Navarrete D, et al. Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury. elife. 2020;9: pubmed publisher
  18. Lee D, Kam M, Lee S, Lee H, Lee D. Peroxiredoxin 5 deficiency exacerbates iron overload-induced neuronal death via ER-mediated mitochondrial fission in mouse hippocampus. Cell Death Dis. 2020;11:204 pubmed publisher
  19. Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I. Factors that May Protect the Native Hibernator Syrian Hamster Renal Tubular Epithelial Cells from Ferroptosis Due to Warm Anoxia-Reoxygenation. Biology (Basel). 2019;8: pubmed publisher
  20. Crippa S, Rossella V, Aprile A, Silvestri L, Rivis S, Scaramuzza S, et al. Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity. J Clin Invest. 2019;129:1566-1580 pubmed publisher
  21. Maio N, Kim K, Holmes Hampton G, Singh A, Rouault T. Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. Haematologica. 2019;: pubmed publisher
  22. Santana Codina N, Gableske S, Quiles Del Rey M, Małachowska B, Jedrychowski M, Biancur D, et al. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica. 2019;: pubmed publisher
  23. Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed publisher
  24. Wang Z, Ding Y, Wang X, Lu S, Wang C, He C, et al. Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT. Cancer Lett. 2018;428:21-33 pubmed publisher
  25. Goodwin J, Dowdle W, Dejesus R, Wang Z, Bergman P, Kobylarz M, et al. Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9. Cell Rep. 2017;20:2341-2356 pubmed publisher
  26. Mrowczynski O, Madhankumar A, Slagle Webb B, Lee S, Zacharia B, Connor J. HFE genotype affects exosome phenotype in cancer. Biochim Biophys Acta Gen Subj. 2017;1861:1921-1928 pubmed publisher
  27. Ryu M, Zhang D, Protchenko O, Shakoury Elizeh M, Philpott C. PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis. J Clin Invest. 2017;127:1786-1797 pubmed publisher
  28. Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed publisher
  29. Rychtarčíková Z, Lettlova S, Tomkova V, Korenkova V, Langerova L, Simonova E, et al. Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. Oncotarget. 2017;8:6376-6398 pubmed publisher
  30. Baksi S, Tripathi A, Singh N. Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease. Free Radic Biol Med. 2016;97:292-306 pubmed publisher
  31. Koeppen A, Ramirez R, Becker A, Mazurkiewicz J. Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation. Acta Neuropathol Commun. 2016;4:46 pubmed publisher
  32. Mancias J, Pontano Vaites L, Nissim S, Biancur D, Kim A, Wang X, et al. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. elife. 2015;4: pubmed publisher
  33. Dowdle W, Nyfeler B, Nagel J, Elling R, Liu S, Triantafellow E, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014;16:1069-79 pubmed publisher
  34. McNally A, Anderson J. Phenotypic expression in human monocyte-derived interleukin-4-induced foreign body giant cells and macrophages in vitro: dependence on material surface properties. J Biomed Mater Res A. 2015;103:1380-90 pubmed publisher