This is a Validated Antibody Database (VAD) review about human FOXO4, based on 16 published articles (read how Labome selects the articles), using FOXO4 antibody in all methods. It is aimed to help Labome visitors find the most suited FOXO4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
FOXO4 synonym: AFX; AFX1; MLLT7; forkhead box protein O4; fork head domain transcription factor AFX1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7

Knockout validation
Cell Signaling Technology
rabbit polyclonal
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology FOXO4 antibody (Cell signaling, 9472) was used in western blot knockout validation on mouse samples (fig 1). Cell Metab (2014) ncbi
Abcam
rabbit monoclonal (EPR5442)
  • immunocytochemistry; human; loading ...; fig 4c
  • western blot; human; loading ...; fig 1a
Abcam FOXO4 antibody (Abcam, ab128908) was used in immunocytochemistry on human samples (fig 4c) and in western blot on human samples (fig 1a). Oncogene (2018) ncbi
rabbit monoclonal
  • western blot; human; loading ...; fig s3a
Abcam FOXO4 antibody (Abcam, ab126594) was used in western blot on human samples (fig s3a). Oncogene (2018) ncbi
rabbit monoclonal (EPR5442)
  • western blot; human; 1:2000
Abcam FOXO4 antibody (Abcam, ab128908) was used in western blot on human samples at 1:2000. Biochem Biophys Res Commun (2015) ncbi
Bethyl
rabbit polyclonal
  • western blot; human; fig 2c
Bethyl FOXO4 antibody (BETHYL, A302-393A) was used in western blot on human samples (fig 2c). J Interferon Cytokine Res (2015) ncbi
Cell Signaling Technology
rabbit monoclonal (4G6)
  • western blot; mouse; loading ...; fig 4b
Cell Signaling Technology FOXO4 antibody (CST, 2599) was used in western blot on mouse samples (fig 4b). Proc Natl Acad Sci U S A (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology FOXO4 antibody (Cell Signaling, 9471) was used in western blot on human samples (fig 4a). Nat Med (2017) ncbi
rabbit monoclonal (4G6)
  • western blot; mouse; 1:1000; fig 2
Cell Signaling Technology FOXO4 antibody (Cell Signaling, 4G6) was used in western blot on mouse samples at 1:1000 (fig 2). Diabetes Obes Metab (2017) ncbi
rabbit monoclonal (4G6)
  • western blot; human; fig 5
Cell Signaling Technology FOXO4 antibody (Cell Signaling, 2599S) was used in western blot on human samples (fig 5). Biosci Rep (2016) ncbi
rabbit monoclonal (4G6)
  • western blot; human; fig 7
Cell Signaling Technology FOXO4 antibody (Cell Signaling, 2599) was used in western blot on human samples (fig 7). PLoS ONE (2015) ncbi
rabbit monoclonal (4G6)
  • western blot; mouse; fig 1c
In order to describe how PTP1B is a mechanism-based therapeutic target for Rett syndrome, Cell Signaling Technology FOXO4 antibody (Cell Signaling Technology, 2599) was used in western blot on mouse samples (fig 1c). J Clin Invest (2015) ncbi
rabbit monoclonal (4G6)
  • flow cytometry; mouse; fig s8
Cell Signaling Technology FOXO4 antibody (Cell Signaling Technology, 2599S) was used in flow cytometry on mouse samples (fig s8). Nat Immunol (2014) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; fig 1
Cell Signaling Technology FOXO4 antibody (Cell signaling, 9472) was used in western blot knockout validation on mouse samples (fig 1). Cell Metab (2014) ncbi
rabbit monoclonal (4G6)
  • western blot; mouse
  • western blot; rat
In order to investigate the mechanism for the neuroprotective effect of Klotho, Cell Signaling Technology FOXO4 antibody (Cell Signaling, 2599) was used in western blot on mouse samples and in western blot on rat samples . J Biol Chem (2014) ncbi
rabbit monoclonal (4G6)
  • western blot; human; 1:2000
Cell Signaling Technology FOXO4 antibody (Cell Signaling, 2599) was used in western blot on human samples at 1:2000. J Cell Physiol (2015) ncbi
rabbit monoclonal (4G6)
  • western blot; human; fig 5
Cell Signaling Technology FOXO4 antibody (Cell Signaling Technology, 2599) was used in western blot on human samples (fig 5). PLoS ONE (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:500
Cell Signaling Technology FOXO4 antibody (Cell Signaling Technology, 9472) was used in western blot on human samples at 1:500. FEBS J (2014) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 3a
Cell Signaling Technology FOXO4 antibody (Cell Signaling Technology, 9472) was used in western blot on mouse samples at 1:1000 (fig 3a). Sci Signal (2013) ncbi
Articles Reviewed
  1. Du X, de Almeida P, Manieri N, de Almeida Nagata D, Wu T, Harden Bowles K, et al. CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1. Proc Natl Acad Sci U S A. 2018;115:E11731-E11740 pubmed publisher
  2. Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed publisher
  3. Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, et al. Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. Nat Med. 2017;23:1055-1062 pubmed publisher
  4. Möllmann J, Kahles F, Lebherz C, Kappel B, Baeck C, Tacke F, et al. The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism. Diabetes Obes Metab. 2017;19:496-508 pubmed publisher
  5. Weikel K, Cacicedo J, Ruderman N, Ido Y. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016;36: pubmed publisher
  6. Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed publisher
  7. Oteiza A, Mechti N. Control of FoxO4 Activity and Cell Survival by TRIM22 Directs TLR3-Stimulated Cells Toward IFN Type I Gene Induction or Apoptosis. J Interferon Cytokine Res. 2015;35:859-74 pubmed publisher
  8. Krishnan N, Krishnan K, Connors C, Choy M, Page R, Peti W, et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J Clin Invest. 2015;125:3163-77 pubmed publisher
  9. Wang G, Liu G, Ye Y, Fu Y, Zhang X. The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4. Biochem Biophys Res Commun. 2015;459:629-35 pubmed publisher
  10. Backer R, Helbig C, Gentek R, Kent A, Laidlaw B, Dominguez C, et al. A central role for Notch in effector CD8(+) T cell differentiation. Nat Immunol. 2014;15:1143-51 pubmed publisher
  11. Kim Muller J, Zhao S, Srivastava S, Mugabo Y, Noh H, Kim Y, et al. Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice. Cell Metab. 2014;20:593-602 pubmed publisher
  12. Zeldich E, Chen C, Colvin T, Bove Fenderson E, Liang J, Tucker Zhou T, et al. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014;289:24700-15 pubmed publisher
  13. Dudakovic A, Camilleri E, Lewallen E, McGee Lawrence M, Riester S, Kakar S, et al. Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells. J Cell Physiol. 2015;230:52-62 pubmed publisher
  14. Sahlberg S, Spiegelberg D, Glimelius B, Stenerlow B, Nestor M. Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PLoS ONE. 2014;9:e94621 pubmed publisher
  15. Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed publisher
  16. Yang P, Li X, Xu C, Eckert R, Reece E, Zielke H, et al. Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Sci Signal. 2013;6:ra74 pubmed publisher