This is a Validated Antibody Database (VAD) review about human FANCD2, based on 39 published articles (read how Labome selects the articles), using FANCD2 antibody in all methods. It is aimed to help Labome visitors find the most suited FANCD2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
FANCD2 synonym: FA-D2; FA4; FACD; FAD; FAD2; FANCD

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (FI17)
  • western blot knockout validation; human; 1:200; loading ...; fig s2a
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in western blot knockout validation on human samples at 1:200 (fig s2a). Cell Rep (2019) ncbi
Santa Cruz Biotechnology
mouse monoclonal (FI17)
  • immunohistochemistry; mouse; loading ...; fig 3c
  • western blot; mouse; loading ...; fig 3b
  • immunocytochemistry; human; loading ...; fig 5b
  • immunohistochemistry; human; fig 8c
  • western blot; human; loading ...; fig 2a, 5f
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, 20022) was used in immunohistochemistry on mouse samples (fig 3c), in western blot on mouse samples (fig 3b), in immunocytochemistry on human samples (fig 5b), in immunohistochemistry on human samples (fig 8c) and in western blot on human samples (fig 2a, 5f). Neoplasia (2021) ncbi
mouse monoclonal (FI17)
  • western blot; human; loading ...; fig 3h
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc20022) was used in western blot on human samples (fig 3h). Cell (2019) ncbi
mouse monoclonal (FI17)
  • western blot knockout validation; human; 1:200; loading ...; fig s2a
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in western blot knockout validation on human samples at 1:200 (fig s2a). Cell Rep (2019) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:500; loading ...; fig s1f
Santa Cruz Biotechnology FANCD2 antibody (Santa, sc-20022) was used in western blot on human samples at 1:500 (fig s1f). Sci Adv (2019) ncbi
mouse monoclonal (FI17)
  • western blot; human; loading ...; fig 7a, 8c
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, FI-17) was used in western blot on human samples (fig 7a, 8c). PLoS Genet (2019) ncbi
mouse monoclonal
  • western blot; human; loading ...; fig 7a, 8c
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, FI-17) was used in western blot on human samples (fig 7a, 8c). PLoS Genet (2019) ncbi
mouse monoclonal (FI17)
  • immunocytochemistry; human; loading ...; fig 6C
In order to investigate the role of the PTEN phosphatase in DNA interstrand crosslink repair, Santa Cruz Biotechnology FANCD2 antibody (Santa cruz, sc-20022) was used in immunocytochemistry on human samples (fig 6C). Sci Rep (2016) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:200; tbl s6
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in western blot on human samples at 1:200 (tbl s6). PLoS Genet (2016) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:100; fig s3
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in western blot on human samples at 1:100 (fig s3). Nat Commun (2016) ncbi
mouse monoclonal (FI17)
  • western blot; human; loading ...; fig 2c
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, FI-17) was used in western blot on human samples (fig 2c). Cell Rep (2016) ncbi
mouse monoclonal (FI17)
  • immunocytochemistry; human; fig s2
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in immunocytochemistry on human samples (fig s2). PLoS Genet (2016) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:1000
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz Biotechnology, sc-20022) was used in western blot on human samples at 1:1000. Nat Commun (2016) ncbi
mouse monoclonal (FI17)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, Santa Cruz Biotechnology FANCD2 antibody (SCBT, FI17) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:500; fig 4
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in western blot on human samples at 1:500 (fig 4). Nat Chem Biol (2016) ncbi
mouse monoclonal (FI17)
  • immunocytochemistry; human; fig 5a
  • western blot; human; fig s3
In order to elucidate how genome integrity is protected from R-loops in the fanconi anemia pathway, Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in immunocytochemistry on human samples (fig 5a) and in western blot on human samples (fig s3). PLoS Genet (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:200; fig 4a
Santa Cruz Biotechnology FANCD2 antibody (santa cruz, sc-20022) was used in western blot on human samples at 1:200 (fig 4a). Bioorg Med Chem (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; fig 3
In order to study how the Fanconi anemia pathway promotes homologous recombination at stalled replication forks, Santa Cruz Biotechnology FANCD2 antibody (Santa-Cruz, sc-20022) was used in western blot on human samples (fig 3). Nucleic Acids Res (2016) ncbi
mouse monoclonal (FI17)
  • western blot; human; fig 4
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz Biotechnology, sc-20022) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:1000; fig 3h
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz Biotechnology, sc-20022) was used in western blot on human samples at 1:1000 (fig 3h). Nucleic Acids Res (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; fig 3
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, FI17) was used in western blot on human samples (fig 3). Nucleic Acids Res (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:500; fig 2
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in western blot on human samples at 1:500 (fig 2). Cancer Res (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; loading ...; fig 3e
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, SC-20022) was used in western blot on human samples (fig 3e). Cancer Sci (2015) ncbi
mouse monoclonal (FI17)
  • other; human; 1:100; loading ...; fig 4A
  • western blot; human; loading ...; fig s1a
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, 20022) was used in other on human samples at 1:100 (fig 4A) and in western blot on human samples (fig s1a). Cell Rep (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:1000; fig 2, 3
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc-20022) was used in western blot on human samples at 1:1000 (fig 2, 3). Cell Cycle (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; fig 4
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, FI-17) was used in western blot on human samples (fig 4). Nature (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human; 1:500; fig 5
Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz Biotechnologies, sc-20022) was used in western blot on human samples at 1:500 (fig 5). DNA Repair (Amst) (2015) ncbi
mouse monoclonal (FI17)
  • western blot; human
Santa Cruz Biotechnology FANCD2 antibody (Santa, SC-20022) was used in western blot on human samples . Cell Rep (2014) ncbi
mouse monoclonal (FI17)
  • immunocytochemistry; human; 1:400
  • western blot; human; 1:750; fig s5
Santa Cruz Biotechnology FANCD2 antibody (Santa, sc-20022) was used in immunocytochemistry on human samples at 1:400 and in western blot on human samples at 1:750 (fig s5). Nat Chem Biol (2014) ncbi
mouse monoclonal (FI17)
  • western blot; human
In order to study a novel Fanconi anemia subtype in which SLX4 is mutated, Santa Cruz Biotechnology FANCD2 antibody (Santa Cruz, sc20022) was used in western blot on human samples . Nat Genet (2011) ncbi
Abcam
domestic rabbit monoclonal (EPR2302)
  • western blot; mouse; loading ...; fig 4c
Abcam FANCD2 antibody (Abcam, Ab108928) was used in western blot on mouse samples (fig 4c). Biol Open (2021) ncbi
domestic rabbit monoclonal (EPR2302)
  • western blot; human; 1:2000; loading ...; fig s1a
  • ChIP-Seq; mouse; loading ...; fig s3a
  • western blot; mouse; 1:2000; loading ...; fig s1a
Abcam FANCD2 antibody (Abcam, ab221932) was used in western blot on human samples at 1:2000 (fig s1a), in ChIP-Seq on mouse samples (fig s3a) and in western blot on mouse samples at 1:2000 (fig s1a). Science (2019) ncbi
domestic rabbit monoclonal (EPR2302)
  • western blot; human; fig 7e
Abcam FANCD2 antibody (Abcam, ab108928) was used in western blot on human samples (fig 7e). Cell (2018) ncbi
domestic rabbit monoclonal (EPR2302)
  • western blot; human; loading ...; fig 1a
In order to determine that HPV activates the Fanconi anemia pathway, leading to the accumulation of a key regulatory protein, FANCD2, in large nuclear foci, Abcam FANCD2 antibody (Abcam, ab108928) was used in western blot on human samples (fig 1a). MBio (2017) ncbi
domestic rabbit monoclonal (EPR2302)
  • immunocytochemistry; mouse; 1:50; loading ...; fig 6e
Abcam FANCD2 antibody (Abcam, ab108928) was used in immunocytochemistry on mouse samples at 1:50 (fig 6e). Nat Commun (2017) ncbi
domestic rabbit monoclonal (EPR2302)
  • western blot; mouse; 1:500; loading ...; fig 1d
Abcam FANCD2 antibody (Abcam, ab108928) was used in western blot on mouse samples at 1:500 (fig 1d). Nat Commun (2016) ncbi
domestic rabbit monoclonal (EPR2302)
  • western blot; mouse; 1:200; fig s6
In order to study resolution of DNA interstrand cross-links by cooperation of BRCA2 and MERIT40, Abcam FANCD2 antibody (Abcam, ab108928) was used in western blot on mouse samples at 1:200 (fig s6). Genes Dev (2015) ncbi
domestic rabbit monoclonal (EPR2302)
  • western blot; human; fig 4
In order to report the effects of new temozolomide analogues on glioblastoma multiforme, Abcam FANCD2 antibody (Epitomics, 2986-1) was used in western blot on human samples (fig 4). Mol Cancer Ther (2015) ncbi
domestic rabbit monoclonal (EPR2302)
  • western blot; human; 1:1000
Abcam FANCD2 antibody (Abcam, EPR2302) was used in western blot on human samples at 1:1000. DNA Repair (Amst) (2014) ncbi
domestic rabbit monoclonal (EPR2302)
  • immunocytochemistry; mouse
  • western blot; mouse
Abcam FANCD2 antibody (Abcam, ab108928) was used in immunocytochemistry on mouse samples and in western blot on mouse samples . Nucleic Acids Res (2013) ncbi
Invitrogen
mouse monoclonal (FI-17)
  • western blot; human; loading ...; fig 1a
In order to determine that HPV activates the Fanconi anemia pathway, leading to the accumulation of a key regulatory protein, FANCD2, in large nuclear foci, Invitrogen FANCD2 antibody (Thermo Scientific, MA1-16570) was used in western blot on human samples (fig 1a). MBio (2017) ncbi
Novus Biologicals
mouse monoclonal (FI-17)
  • immunocytochemistry; human; 1:1000; loading ...; fig 4c
Novus Biologicals FANCD2 antibody (Novus Biologicals, nb100-316) was used in immunocytochemistry on human samples at 1:1000 (fig 4c). Nucleic Acids Res (2018) ncbi
Articles Reviewed
  1. Mani C, Tripathi K, Chaudhary S, Somasagara R, Rocconi R, Crasto C, et al. Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition. Neoplasia. 2021;23:1002-1015 pubmed publisher
  2. Qiao F, Law H, Krieger K, Clement E, Xiao Y, Buckley S, et al. Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs. Biol Open. 2021;10: pubmed publisher
  3. Wang H, Xiang D, Liu B, He A, Randle H, Zhang K, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178:135-151.e19 pubmed publisher
  4. Lopez Martinez D, Kupculak M, Yang D, Yoshikawa Y, Liang C, Wu R, et al. Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage. Cell Rep. 2019;27:2990-3005.e5 pubmed publisher
  5. Sonego M, Pellarin I, Costa A, Vinciguerra G, Coan M, Kraut A, et al. USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability. Sci Adv. 2019;5:eaav3235 pubmed publisher
  6. Wienert B, Wyman S, Richardson C, Yeh C, Akçakaya P, Porritt M, et al. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Science. 2019;364:286-289 pubmed publisher
  7. Wang J, Chan B, Tong M, Paung Y, Jo U, MARTIN D, et al. Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway. PLoS Genet. 2019;15:e1007983 pubmed publisher
  8. Slyskova J, Sabatella M, Ribeiro Silva C, Stok C, Theil A, Vermeulen W, et al. Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage. Nucleic Acids Res. 2018;46:9537-9549 pubmed publisher
  9. Hoshii T, Cifani P, Feng Z, Huang C, Koche R, Chen C, et al. A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response. Cell. 2018;172:1007-1021.e17 pubmed publisher
  10. Spriggs C, Laimins L. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. MBio. 2017;8: pubmed publisher
  11. Kang Y, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, et al. Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival. Nat Commun. 2017;8:14013 pubmed publisher
  12. Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed publisher
  13. Mair B, Konopka T, Kerzendorfer C, Sleiman K, Salic S, Serra V, et al. Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity. PLoS Genet. 2016;12:e1006279 pubmed publisher
  14. Liang C, Li Z, Lopez Martinez D, Nicholson W, Venien Bryan C, Cohn M. The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2. Nat Commun. 2016;7:12124 pubmed publisher
  15. Kais Z, Rondinelli B, Holmes A, O Leary C, Kozono D, D Andrea A, et al. FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair. Cell Rep. 2016;15:2488-99 pubmed publisher
  16. Jaber S, Toufektchan E, Lejour V, Bardot B, Toledo F. p53 downregulates the Fanconi anaemia DNA repair pathway. Nat Commun. 2016;7:11091 pubmed publisher
  17. Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed publisher
  18. Passerini V, Ozeri Galai E, de Pagter M, Donnelly N, Schmalbrock S, Kloosterman W, et al. The presence of extra chromosomes leads to genomic instability. Nat Commun. 2016;7:10754 pubmed publisher
  19. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  20. Wanzel M, Vischedyk J, Gittler M, Gremke N, Seiz J, Hefter M, et al. CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol. 2016;12:22-8 pubmed publisher
  21. García Rubio M, Pérez Calero C, Barroso S, Tumini E, Herrera Moyano E, Rosado I, et al. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet. 2015;11:e1005674 pubmed publisher
  22. Fujii N, Evison B, Actis M, Inoue A. A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair. Bioorg Med Chem. 2015;23:6912-21 pubmed publisher
  23. Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed publisher
  24. Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, et al. MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. Genes Dev. 2015;29:1955-68 pubmed publisher
  25. Clark D, Tripathi K, Dorsman J, Palle K. FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation. Oncotarget. 2015;6:28816-32 pubmed publisher
  26. Parplys A, Zhao W, Sharma N, Groesser T, Liang F, Maranon D, et al. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 2015;43:9817-34 pubmed publisher
  27. Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, et al. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. 2015;43:8325-39 pubmed publisher
  28. Stoepker C, Ameziane N, van der Lelij P, Kooi I, Oostra A, Rooimans M, et al. Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer. Cancer Res. 2015;75:3543-53 pubmed publisher
  29. Wang G, Liu Y, Cheng X, Zhou G. Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents. Cancer Sci. 2015;106:902-8 pubmed publisher
  30. Liang C, Zhan B, Yoshikawa Y, Haas W, Gygi S, Cohn M. UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway. Cell Rep. 2015;10:1947-56 pubmed publisher
  31. Raghunandan M, Chaudhury I, Kelich S, Hanenberg H, Sobeck A. FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex. Cell Cycle. 2015;14:342-53 pubmed publisher
  32. Ceccaldi R, Liu J, Amunugama R, Hajdu I, Primack B, Petalcorin M, et al. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature. 2015;518:258-62 pubmed publisher
  33. Stoepker C, Faramarz A, Rooimans M, van Mil S, Balk J, Velleuer E, et al. DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. DNA Repair (Amst). 2015;26:54-64 pubmed publisher
  34. Ramirez Y, Mladek A, Phillips R, Gynther M, Rautio J, Ross A, et al. Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth. Mol Cancer Ther. 2015;14:111-9 pubmed publisher
  35. Schmidt L, Wiedner M, Velimezi G, Prochazkova J, Owusu M, Bauer S, et al. ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress. DNA Repair (Amst). 2014;24:122-130 pubmed publisher
  36. Huang Y, Leung J, Lowery M, Matsushita N, Wang Y, Shen X, et al. Modularized functions of the Fanconi anemia core complex. Cell Rep. 2014;7:1849-57 pubmed publisher
  37. Liang Q, Dexheimer T, Zhang P, Rosenthal A, Villamil M, You C, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014;10:298-304 pubmed publisher
  38. Luebben S, Kawabata T, Akre M, Lee W, Johnson C, O Sullivan M, et al. Helq acts in parallel to Fancc to suppress replication-associated genome instability. Nucleic Acids Res. 2013;41:10283-97 pubmed publisher
  39. Stoepker C, Hain K, Schuster B, Hilhorst Hofstee Y, Rooimans M, Steltenpool J, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-41 pubmed publisher