This is a Validated Antibody Database (VAD) review about human FADD, based on 32 published articles (read how Labome selects the articles), using FADD antibody in all methods. It is aimed to help Labome visitors find the most suited FADD antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
FADD synonym: GIG3; MORT1

Knockout validation
BD Biosciences
mouse monoclonal (1/FADD)
  • western blot knockout validation; human; fig s1g
BD Biosciences FADD antibody (BD, 610399) was used in western blot knockout validation on human samples (fig s1g). Cell Death Differ (2019) ncbi
BD Biosciences
mouse monoclonal (1/FADD)
  • western blot knockout validation; human; 1:1000; loading ...; fig 6d
BD Biosciences FADD antibody (BD Transduction, 610400) was used in western blot knockout validation on human samples at 1:1000 (fig 6d). Mol Cell Biol (2017) ncbi
Abcam
domestic rabbit monoclonal (EPR5030)
  • western blot; mouse; loading ...; fig 4c
Abcam FADD antibody (Abcam, ab124812) was used in western blot on mouse samples (fig 4c). Immunity (2020) ncbi
domestic rabbit monoclonal (EPR5030)
  • western blot; mouse; loading ...; fig 3b
Abcam FADD antibody (Abcam, ab124812) was used in western blot on mouse samples (fig 3b). Proc Natl Acad Sci U S A (2018) ncbi
domestic rabbit monoclonal (EPR5030)
  • western blot; mouse; loading ...; fig 3c
Abcam FADD antibody (Abcam, ab124812) was used in western blot on mouse samples (fig 3c). Proc Natl Acad Sci U S A (2017) ncbi
domestic rabbit monoclonal (EPR4415)
  • western blot; human; 1:1000
In order to investigate the role of repressor element 1-silencing transcription factor in neurodegeneration during ageing, Abcam FADD antibody (EPITOMICS, 2988-1) was used in western blot on human samples at 1:1000. Nature (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-10)
  • immunocytochemistry; human; 1:200; loading ...; fig 6a
  • western blot; human; 1:1000; loading ...; fig 6d
Santa Cruz Biotechnology FADD antibody (Santa Cruz, H-10) was used in immunocytochemistry on human samples at 1:200 (fig 6a) and in western blot on human samples at 1:1000 (fig 6d). Mol Cell Biol (2017) ncbi
mouse monoclonal (H-10)
  • western blot; human; 1:2000; loading ...; fig 8b
Santa Cruz Biotechnology FADD antibody (Santa Cruz, sc-271520) was used in western blot on human samples at 1:2000 (fig 8b). Int J Mol Sci (2016) ncbi
mouse monoclonal (G-4)
  • western blot; human; fig 5b
Santa Cruz Biotechnology FADD antibody (Santa Cruz Biotechnology, sc-271748) was used in western blot on human samples (fig 5b). Oncotarget (2015) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s6a
Cell Signaling Technology FADD antibody (Cell Signaling, 2782) was used in western blot on human samples (fig s6a). Sci Adv (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology FADD antibody (Cell Signaling Technology, 2782) was used in western blot on human samples (fig 3b). Theranostics (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2b
In order to elucidate how high-risk human papillomavirus alters signaling pathways involved in cell death and growth regulation, Cell Signaling Technology FADD antibody (Cell signaling, 2782) was used in western blot on human samples (fig 2b). Front Immunol (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 4c
Cell Signaling Technology FADD antibody (Cell Signaling, 2781) was used in immunohistochemistry on mouse samples (fig 4c). PLoS ONE (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 4b
Cell Signaling Technology FADD antibody (Cell Signaling, 2782) was used in western blot on mouse samples (fig 4b). PLoS ONE (2016) ncbi
BD Biosciences
mouse monoclonal (1/FADD)
  • western blot; human; 1:1000; loading ...; fig 1a
  • western blot; mouse; 1:1000; loading ...; fig 1b
BD Biosciences FADD antibody (BD Biosciences, 610400) was used in western blot on human samples at 1:1000 (fig 1a) and in western blot on mouse samples at 1:1000 (fig 1b). Mol Cell (2019) ncbi
mouse monoclonal (1/FADD)
  • western blot knockout validation; human; fig s1g
BD Biosciences FADD antibody (BD, 610399) was used in western blot knockout validation on human samples (fig s1g). Cell Death Differ (2019) ncbi
mouse monoclonal (A66-2)
  • immunoprecipitation; mouse; loading ...; fig 4b
  • western blot; mouse; loading ...; fig 4b
BD Biosciences FADD antibody (BD Bioscience, 556402) was used in immunoprecipitation on mouse samples (fig 4b) and in western blot on mouse samples (fig 4b). EMBO J (2017) ncbi
mouse monoclonal (1/FADD)
  • western blot knockout validation; human; 1:1000; loading ...; fig 6d
BD Biosciences FADD antibody (BD Transduction, 610400) was used in western blot knockout validation on human samples at 1:1000 (fig 6d). Mol Cell Biol (2017) ncbi
mouse monoclonal (A66-2)
  • western blot; human; loading ...; fig s3
In order to test if TRAIL/TRAIL-R signaling in cancer cells alters the immune microenvironment, BD Biosciences FADD antibody (BD Bioscience, 556402) was used in western blot on human samples (fig s3). Mol Cell (2017) ncbi
mouse monoclonal (A66-2)
  • western blot; human; loading ...; fig 7a
BD Biosciences FADD antibody (BD Pharmingen, 556402) was used in western blot on human samples (fig 7a). Cell Death Differ (2017) ncbi
mouse monoclonal (1/FADD)
  • western blot; human; loading ...; fig 3
BD Biosciences FADD antibody (BD biosciences, 610400) was used in western blot on human samples (fig 3). Oncotarget (2017) ncbi
mouse monoclonal (1/FADD)
  • western blot; human; loading ...; fig 2b
BD Biosciences FADD antibody (BD Biosciences, 610400) was used in western blot on human samples (fig 2b). Mol Cell Biol (2016) ncbi
mouse monoclonal (1/FADD)
  • western blot; human; 1:1000; fig s15
BD Biosciences FADD antibody (BD Transduction, 610399) was used in western blot on human samples at 1:1000 (fig s15). Nat Commun (2016) ncbi
mouse monoclonal (1/FADD)
  • western blot; human; loading ...; fig 1c
BD Biosciences FADD antibody (BD Biosciences, 610399) was used in western blot on human samples (fig 1c). Oncotarget (2016) ncbi
mouse monoclonal (1/FADD)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, BD Biosciences FADD antibody (BD, 1) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (A66-2)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, BD Biosciences FADD antibody (BD, A66-2) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (1/FADD)
  • western blot; human; fig 1
BD Biosciences FADD antibody (BD Biosciences, 610400) was used in western blot on human samples (fig 1). Cell Death Dis (2016) ncbi
mouse monoclonal (A66-2)
  • western blot; human; fig 6
BD Biosciences FADD antibody (BD Biosciences, 556402) was used in western blot on human samples (fig 6). Oncotarget (2015) ncbi
mouse monoclonal (1/FADD)
  • immunoprecipitation; human; loading ...; fig 2b
BD Biosciences FADD antibody (BD Transduction Laboratories, 610399) was used in immunoprecipitation on human samples (fig 2b). BMC Cancer (2015) ncbi
mouse monoclonal (A66-2)
  • western blot; human
In order to investigate if Chal-24 can be combined with cisplatin for better cancer therapy, BD Biosciences FADD antibody (BD Biosciences, 556402) was used in western blot on human samples . Oncotarget (2015) ncbi
mouse monoclonal (1/FADD)
  • western blot; human; fig 1
BD Biosciences FADD antibody (BD Biosciences, 610400) was used in western blot on human samples (fig 1). Cell Death Dis (2015) ncbi
mouse monoclonal (1/FADD)
  • western blot; human
BD Biosciences FADD antibody (BD Transduction Laboratories, 610399) was used in western blot on human samples . Cell Death Dis (2014) ncbi
mouse monoclonal (A66-2)
  • western blot; human
In order to identify a novel anticancer mechanism that functions through autophagy-mediated necroptosis, BD Biosciences FADD antibody (BD Biosciences, 556402) was used in western blot on human samples . Oncogene (2014) ncbi
mouse monoclonal (A66-2)
  • western blot; human
BD Biosciences FADD antibody (BD Bioscience, 556402) was used in western blot on human samples . Mol Cancer Res (2013) ncbi
mouse monoclonal (1/FADD)
  • western blot; human
BD Biosciences FADD antibody (BD Biosciences, 610399) was used in western blot on human samples . Cell Death Differ (2010) ncbi
mouse monoclonal (1/FADD)
  • western blot; human; fig 6
BD Biosciences FADD antibody (BD Transduction Laboratories, 1/FADD) was used in western blot on human samples (fig 6). Br J Cancer (2008) ncbi
mouse monoclonal (1/FADD)
  • western blot; human
BD Biosciences FADD antibody (Pharmingen, 610400) was used in western blot on human samples . Oncogene (2008) ncbi
Articles Reviewed
  1. Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, et al. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021;7: pubmed publisher
  2. Tummers B, Mari L, Guy C, Heckmann B, Rodriguez D, Rühl S, et al. Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis. Immunity. 2020;52:994-1006.e8 pubmed publisher
  3. Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10:3351-3365 pubmed publisher
  4. Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand A, Robertson D, et al. RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell. 2019;73:413-428.e7 pubmed publisher
  5. Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
  6. Meng H, Liu Z, Li X, Wang H, Jin T, Wu G, et al. Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proc Natl Acad Sci U S A. 2018;115:E2001-E2009 pubmed publisher
  7. Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar A, et al. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A. 2017;114:11944-11949 pubmed publisher
  8. Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  9. Iurlaro R, Püschel F, León Annicchiarico C, O Connor H, Martin S, Palou Gramón D, et al. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors. Mol Cell Biol. 2017;37: pubmed publisher
  10. Hartwig T, Montinaro A, von Karstedt S, Sevko A, Surinova S, Chakravarthy A, et al. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell. 2017;65:730-742.e5 pubmed publisher
  11. Tanzer M, Khan N, Rickard J, Etemadi N, Lalaoui N, Spall S, et al. Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell Death Differ. 2017;24:481-491 pubmed publisher
  12. Dufour F, Rattier T, Constantinescu A, Zischler L, Morlé A, Ben Mabrouk H, et al. TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress. Oncotarget. 2017;8:9974-9985 pubmed publisher
  13. Ma W, Tummers B, van Esch E, Goedemans R, Melief C, Meyers C, et al. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNF?-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016;7:496 pubmed
  14. Zhu X, Wang K, Zhang K, Zhang T, Yin Y, Xu F. Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Int J Mol Sci. 2016;17: pubmed
  15. Joo D, Tang Y, Blonska M, Jin J, Zhao X, Lin X. Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31. Mol Cell Biol. 2016;36:3010-3018 pubmed
  16. Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  17. Weyhenmeyer B, Noonan J, Würstle M, Lincoln F, Johnston G, Rehm M, et al. Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide. Oncotarget. 2016;7:61295-61311 pubmed publisher
  18. Li J, Chen K, Li S, Liu T, Wang F, Xia Y, et al. Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PLoS ONE. 2016;11:e0152570 pubmed publisher
  19. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  20. Schirmer M, Trentin L, Queudeville M, Seyfried F, Demir S, Tausch E, et al. Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death Dis. 2016;7:e2052 pubmed publisher
  21. Oh Y, Yue P, Wang D, Tong J, Chen Z, Khuri F, et al. Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling. Oncotarget. 2015;6:41324-38 pubmed publisher
  22. Kharaziha P, Chioureas D, Baltatzis G, Fonseca P, Rodriguez P, Gogvadze V, et al. Sorafenib-induced defective autophagy promotes cell death by necroptosis. Oncotarget. 2015;6:37066-82 pubmed publisher
  23. Selmi T, Alecci C, dell Aquila M, Montorsi L, Martello A, Guizzetti F, et al. ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly. BMC Cancer. 2015;15:357 pubmed publisher
  24. Shi S, Wang Q, Xu J, Jang J, Padilla M, Nyunoya T, et al. Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget. 2015;6:1640-51 pubmed
  25. Morlé A, Garrido C, Micheau O. Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis. 2015;6:e1633 pubmed publisher
  26. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
  27. Pavet V, Shlyakhtina Y, He T, Ceschin D, Kohonen P, Perala M, et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014;5:e1043 pubmed publisher
  28. He W, Wang Q, Srinivasan B, Xu J, Padilla M, Li Z, et al. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene. 2014;33:3004-13 pubmed publisher
  29. Han J, Soletti R, Sadarangani A, Sridevi P, Ramirez M, Eckmann L, et al. Nuclear expression of ?-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013;11:207-18 pubmed publisher
  30. Son J, Varadarajan S, Bratton S. TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ. 2010;17:1288-301 pubmed publisher
  31. Ashley D, Riffkin C, Lovric M, Mikeska T, Dobrovic A, Maxwell J, et al. In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs. Br J Cancer. 2008;99:294-304 pubmed publisher
  32. Jeon Y, Kim I, Hong S, Nan H, Kim H, Lee H, et al. Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling. Oncogene. 2008;27:4344-52 pubmed publisher