This is a Validated Antibody Database (VAD) review about human EXOSC4, based on 3 published articles (read how Labome selects the articles), using EXOSC4 antibody in all methods. It is aimed to help Labome visitors find the most suited EXOSC4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
EXOSC4 synonym: RRP41; RRP41A; Rrp41p; SKI6; Ski6p; hRrp41p; p12A; exosome complex component RRP41; exosome complex exonuclease RRP41; exosome component Rrp41; ribosomal RNA-processing protein 41

Proteintech Group
rabbit polyclonal
  • western blot; human; fig 6d
In order to identify residues of Y14 that are needed for binding to the mRNA cap, Proteintech Group EXOSC4 antibody (ProteinTech, 15937-1-AP) was used in western blot on human samples (fig 6d). J Biol Chem (2016) ncbi
Bethyl
rabbit polyclonal
  • western blot; human; fig s3
Bethyl EXOSC4 antibody (Bethyl, A303-774A) was used in western blot on human samples (fig s3). Genes Dev (2016) ncbi
Abcam
rabbit polyclonal
  • western blot; human; loading ...; fig 1c
In order to propose that DGCR8 helps to recruit the exosome complex to RNAs and induce their degradation, Abcam EXOSC4 antibody (Abcam, ab137250) was used in western blot on human samples (fig 1c). Mol Cell (2015) ncbi
Articles Reviewed
  1. Geissler R, Simkin A, Floss D, Patel R, Fogarty E, Scheller J, et al. A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1. Genes Dev. 2016;30:1070-85 pubmed publisher
  2. Chuang T, Lee K, Lou Y, Lu C, Tarn W. A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement. J Biol Chem. 2016;291:8565-74 pubmed publisher
  3. Macias S, Cordiner R, Gautier P, Plass M, Cáceres J. DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs. Mol Cell. 2015;60:873-85 pubmed publisher