This is a Validated Antibody Database (VAD) review about human EXOSC10, based on 4 published articles (read how Labome selects the articles), using EXOSC10 antibody in all methods. It is aimed to help Labome visitors find the most suited EXOSC10 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
EXOSC10 synonym: PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p; exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; autoantigen PM-SCL; polymyositis/scleroderma autoantigen 100 kDa; polymyositis/scleroderma autoantigen 2

Santa Cruz Biotechnology
mouse monoclonal (B-8)
  • immunocytochemistry; human; 1:500; loading ...; fig 2a
Santa Cruz Biotechnology EXOSC10 antibody (Santa Cruz, 374595) was used in immunocytochemistry on human samples at 1:500 (fig 2a). Nat Commun (2019) ncbi
mouse monoclonal (B-8)
  • western blot; human; loading ...; fig 1f
Santa Cruz Biotechnology EXOSC10 antibody (Santa Cruz, Sc-374595-X) was used in western blot on human samples (fig 1f). Cell Rep (2019) ncbi
Abcam
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3a
Abcam EXOSC10 antibody (Abcam, ab50558) was used in western blot on human samples at 1:1000 (fig 3a). Nat Commun (2019) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1b
Abcam EXOSC10 antibody (abcam, Ab50558) was used in western blot on human samples (fig 1b). Cell Rep (2019) ncbi
rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 1e
  • western blot; human; loading ...; fig 1c
In order to propose that DGCR8 helps to recruit the exosome complex to RNAs and induce their degradation, Abcam EXOSC10 antibody (Abcam, ab50558) was used in immunoprecipitation on human samples (fig 1e) and in western blot on human samples (fig 1c). Mol Cell (2015) ncbi
Invitrogen
rabbit polyclonal
  • western blot; human; fig s1a
In order to identify the enzymes and mechanisms responsible for human telomerase RNA degradation, Invitrogen EXOSC10 antibody (Thermo Fisher, PA5-28672) was used in western blot on human samples (fig s1a). Nat Struct Mol Biol (2016) ncbi
Articles Reviewed
  1. Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, et al. Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis. Nat Commun. 2019;10:2229 pubmed publisher
  2. Davidson L, Francis L, Cordiner R, Eaton J, Estell C, Macias S, et al. Rapid Depletion of DIS3, EXOSC10, or XRN2 Reveals the Immediate Impact of Exoribonucleolysis on Nuclear RNA Metabolism and Transcriptional Control. Cell Rep. 2019;26:2779-2791.e5 pubmed publisher
  3. Shukla S, Schmidt J, Goldfarb K, Cech T, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016;23:286-92 pubmed publisher
  4. Macias S, Cordiner R, Gautier P, Plass M, Cáceres J. DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs. Mol Cell. 2015;60:873-85 pubmed publisher