This is a Validated Antibody Database (VAD) review about human EGLN2, based on 6 published articles (read how Labome selects the articles), using EGLN2 antibody in all methods. It is aimed to help Labome visitors find the most suited EGLN2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
EGLN2 synonym: EIT-6; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1

Knockout validation
Abcam
domestic rabbit monoclonal (EPR2746)
  • immunocytochemistry knockout validation; mouse; loading ...; fig 1
Abcam EGLN2 antibody (Abcam, ab113077) was used in immunocytochemistry knockout validation on mouse samples (fig 1). Gene (2016) ncbi
Abcam
domestic rabbit monoclonal (EPR2746)
  • western blot; human; loading ...; fig 4d
Abcam EGLN2 antibody (Abcam, ab113077) was used in western blot on human samples (fig 4d). Sci Adv (2019) ncbi
domestic rabbit monoclonal (EPR2745)
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1j
  • western blot; human; loading ...; fig 5i
Abcam EGLN2 antibody (Abcam, ab108980) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1j) and in western blot on human samples (fig 5i). Cell Death Dis (2018) ncbi
domestic rabbit monoclonal (EPR2745)
  • western blot; human; loading ...; fig 1d
Abcam EGLN2 antibody (Abcam, Ab108980) was used in western blot on human samples (fig 1d). Oxid Med Cell Longev (2016) ncbi
domestic rabbit monoclonal (EPR2746)
  • immunocytochemistry knockout validation; mouse; loading ...; fig 1
Abcam EGLN2 antibody (Abcam, ab113077) was used in immunocytochemistry knockout validation on mouse samples (fig 1). Gene (2016) ncbi
domestic rabbit monoclonal (EPR2745)
  • immunocytochemistry; human; loading ...; fig s3b
Abcam EGLN2 antibody (Abcam, ab108980) was used in immunocytochemistry on human samples (fig s3b). Arthritis Res Ther (2016) ncbi
R&D Systems
domestic sheep polyclonal
  • western blot; human; 1:1000; loading ...; fig 5e
In order to describe a function for NQO1 in stabilizing HIF-1alpha, R&D Systems EGLN2 antibody (R&D Systems, AF6394) was used in western blot on human samples at 1:1000 (fig 5e). Nat Commun (2016) ncbi
Articles Reviewed
  1. Yang M, Chen P, Liu J, Zhu S, Kroemer G, Klionsky D, et al. Clockophagy is a novel selective autophagy process favoring ferroptosis. Sci Adv. 2019;5:eaaw2238 pubmed publisher
  2. Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, et al. TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer. Cell Death Dis. 2018;9:321 pubmed publisher
  3. Oh E, Kim J, Kim J, Kim S, Lee J, Hong S, et al. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nat Commun. 2016;7:13593 pubmed publisher
  4. Clavijo Cornejo D, Martínez Flores K, Silva Luna K, Martínez Nava G, Fernández Torres J, Zamudio Cuevas Y, et al. The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2. Oxid Med Cell Longev. 2016;2016:1472567 pubmed
  5. Zhu K, Song P, Lai Y, Liu C, Xiao G. Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts. Gene. 2016;594:125-130 pubmed publisher
  6. Zamudio Cuevas Y, Martínez Flores K, Fernández Torres J, Loissell Baltazar Y, Medina Luna D, López Macay A, et al. Monosodium urate crystals induce oxidative stress in human synoviocytes. Arthritis Res Ther. 2016;18:117 pubmed publisher