This is a Validated Antibody Database (VAD) review about human DUSP4, based on 6 published articles (read how Labome selects the articles), using DUSP4 antibody in all methods. It is aimed to help Labome visitors find the most suited DUSP4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DUSP4 synonym: HVH2; MKP-2; MKP2; TYP; dual specificity protein phosphatase 4; MAP kinase phosphatase 2; VH1 homologous phosphatase 2; dual specificity protein phosphatase hVH2; mitogen-activated protein kinase phosphatase 2; serine/threonine specific protein phosphatase

Santa Cruz Biotechnology
mouse monoclonal (F-10)
  • ChIP-Seq; human; fig 1
  • chromatin immunoprecipitation; human; fig 3
  • immunocytochemistry; human; fig 2
  • western blot; human; fig s5
In order to analyze the DUSP family members and their differential roles in epithelial to mesenchymal transition and cancer stem cell regulation in breast cancer, Santa Cruz Biotechnology DUSP4 antibody (Santa Cruz Biotechnology, sc-17821) was used in ChIP-Seq on human samples (fig 1), in chromatin immunoprecipitation on human samples (fig 3), in immunocytochemistry on human samples (fig 2) and in western blot on human samples (fig s5). PLoS ONE (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (D9A5)
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology DUSP4 antibody (Cell Signaling, 5149) was used in western blot on human samples (fig 4c). Cell Res (2018) ncbi
rabbit monoclonal (D9A5)
  • other; human; loading ...; fig 4c
Cell Signaling Technology DUSP4 antibody (Cell Signaling, 5149) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
rabbit monoclonal (D9A5)
  • western blot; human; fig 3b
In order to find a role for IL-4 in promoting breast cancer aggressiveness, Cell Signaling Technology DUSP4 antibody (CST, D9A5) was used in western blot on human samples (fig 3b). Cancer Res (2017) ncbi
rabbit monoclonal (D9A5)
  • immunohistochemistry - paraffin section; human; fig 4
  • western blot; human; fig 4
Cell Signaling Technology DUSP4 antibody (Cell Signaling, 5149) was used in immunohistochemistry - paraffin section on human samples (fig 4) and in western blot on human samples (fig 4). Oncotarget (2015) ncbi
BD Biosciences
mouse monoclonal (48/MKP2)
  • western blot; mouse; fig 5
In order to analyze regulation of NLRP3 inflammasome in adipose tissue by phosphodiesterase 3B (PDE3B), BD Biosciences DUSP4 antibody (BD Biosciences, 610850) was used in western blot on mouse samples (fig 5). Sci Rep (2016) ncbi
Articles Reviewed
  1. Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
  2. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  3. Gaggianesi M, Turdo A, Chinnici A, Lipari E, Apuzzo T, Benfante A, et al. IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition. Cancer Res. 2017;77:3268-3279 pubmed publisher
  4. Ahmad F, Chung Y, Tang Y, Hockman S, Liu S, Khan Y, et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep. 2016;6:28056 pubmed publisher
  5. Boulding T, Wu F, McCuaig R, Dunn J, Sutton C, Hardy K, et al. Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer. PLoS ONE. 2016;11:e0148065 pubmed publisher
  6. Hutchinson K, Johnson D, Johnson A, Sanchez V, Kuba M, Lu P, et al. ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma. Oncotarget. 2015;6:22348-60 pubmed