This is a Validated Antibody Database (VAD) review about human DSC2, based on 8 published articles (read how Labome selects the articles), using DSC2 antibody in all methods. It is aimed to help Labome visitors find the most suited DSC2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DSC2 synonym: ARVD11; CDHF2; DG2; DGII/III; DSC3

Invitrogen
mouse monoclonal (7G6)
  • immunohistochemistry; human; loading ...; fig 7a
  • western blot; human; 1:1000; fig 9b
Invitrogen DSC2 antibody (Invitrogen, 326200) was used in immunohistochemistry on human samples (fig 7a) and in western blot on human samples at 1:1000 (fig 9b). Sci Adv (2021) ncbi
mouse monoclonal (7G6)
  • immunocytochemistry; human
  • western blot; human
In order to study the role of desmocollin-2 in adhesive strength and cytoskeleton architecture in esophageal squamous cell carcinoma, Invitrogen DSC2 antibody (Invitrogen, 7G6) was used in immunocytochemistry on human samples and in western blot on human samples . Mol Med Rep (2014) ncbi
mouse monoclonal (7G6)
  • immunohistochemistry - paraffin section; human; fig 3
In order to discuss the mutation that result in arrhythmogenic cardiomyopathy and cardiocutaneous syndromes in the Hutterites, Invitrogen DSC2 antibody (Invitrogen, 32?C6200) was used in immunohistochemistry - paraffin section on human samples (fig 3). Circ Cardiovasc Genet (2013) ncbi
mouse monoclonal (7G6)
  • western blot; human; fig 1
In order to elucidate how the keratin intermediate filament network is involved in the establishment and maintenance of cell polarity, Invitrogen DSC2 antibody (Invitrogen, 7G6) was used in western blot on human samples (fig 1). J Cell Biol (2008) ncbi
mouse monoclonal (7G6)
  • immunocytochemistry; human; fig 5
In order to identify and characterize a new type of adherens junction in human meningiomas, Invitrogen DSC2 antibody (Zymed, 7G6) was used in immunocytochemistry on human samples (fig 5). Cell Tissue Res (2008) ncbi
mouse monoclonal (7G6)
  • immunohistochemistry - frozen section; human
In order to investigate the effect of the plakoglobin mutation in Naxos disease on connexin43, Invitrogen DSC2 antibody (Zymed, 7G6) was used in immunohistochemistry - frozen section on human samples . Heart Rhythm (2004) ncbi
mouse monoclonal (7G6)
  • immunohistochemistry - paraffin section; human; fig 3
  • immunohistochemistry; human; fig 3
In order to describe the pathology of Carvajal syndrome, Invitrogen DSC2 antibody (Zymed, 7G6) was used in immunohistochemistry - paraffin section on human samples (fig 3) and in immunohistochemistry on human samples (fig 3). Cardiovasc Pathol (2004) ncbi
Abcepta
  • immunohistochemistry; human; fig s7
In order to elucidate the contributions of cell-cell adhesion proteins to intercellular force and epithelial tissue dynamics, Abcepta DSC2 antibody (ABGENT, AP16771b) was used in immunohistochemistry on human samples (fig s7). Nat Cell Biol (2015) ncbi
Articles Reviewed
  1. Li K, Wu R, Zhou M, Tong H, Luo K. Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system. Sci Adv. 2021;7:eabg7265 pubmed publisher
  2. Bazellières E, Conte V, Elosegui Artola A, Serra Picamal X, Bintanel Morcillo M, Roca Cusachs P, et al. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nat Cell Biol. 2015;17:409-20 pubmed publisher
  3. Fang W, Liao L, Zeng F, Zhang P, Wu J, Shen J, et al. Desmocollin‑2 affects the adhesive strength and cytoskeletal arrangement in esophageal squamous cell carcinoma cells. Mol Med Rep. 2014;10:2358-64 pubmed publisher
  4. Gerull B, Kirchner F, Chong J, Tagoe J, Chandrasekharan K, Strohm O, et al. Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population. Circ Cardiovasc Genet. 2013;6:327-36 pubmed publisher
  5. Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, et al. The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol. 2008;183:19-28 pubmed publisher
  6. Akat K, Bleck C, Lee Y, Haselmann Weiss U, Kartenbeck J. Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52. Cell Tissue Res. 2008;331:401-12 pubmed
  7. Kaplan S, Gard J, Protonotarios N, Tsatsopoulou A, Spiliopoulou C, Anastasakis A, et al. Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm. 2004;1:3-11 pubmed
  8. Kaplan S, Gard J, Carvajal Huerta L, Ruiz Cabezas J, Thiene G, Saffitz J. Structural and molecular pathology of the heart in Carvajal syndrome. Cardiovasc Pathol. 2004;13:26-32 pubmed