This is a Validated Antibody Database (VAD) review about human DR4, based on 25 published articles (read how Labome selects the articles), using DR4 antibody in all methods. It is aimed to help Labome visitors find the most suited DR4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DR4 synonym: APO2; CD261; DR4; TRAILR-1; TRAILR1

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D9S1R)
  • western blot knockout validation; human; 1:1000; loading ...; fig 9e
Cell Signaling Technology DR4 antibody (Cell Signaling, D9S1R) was used in western blot knockout validation on human samples at 1:1000 (fig 9e). Mol Cell Biol (2017) ncbi
BioLegend
mouse monoclonal (DJR1)
  • flow cytometry; human; loading ...; fig s2g
BioLegend DR4 antibody (BioLegend, DJR1) was used in flow cytometry on human samples (fig s2g). Cell Death Dis (2019) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human; loading ...; fig 1b, 1e
BioLegend DR4 antibody (Biolegend, 307206) was used in flow cytometry on human samples (fig 1b, 1e). Front Immunol (2019) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human; loading ...; fig s4d
BioLegend DR4 antibody (Biolegend, 307207) was used in flow cytometry on human samples (fig s4d). Cell (2016) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BioLegend DR4 antibody (BioLegen d, 307206) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human; fig 4
BioLegend DR4 antibody (BioLegend, 307205) was used in flow cytometry on human samples (fig 4). PLoS ONE (2015) ncbi
mouse monoclonal (DJR1)
  • western blot; human; 1:2000
BioLegend DR4 antibody (BioLegend, 307201) was used in western blot on human samples at 1:2000. PLoS ONE (2014) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human
BioLegend DR4 antibody (Biolegend, DJR1) was used in flow cytometry on human samples . Clin Cancer Res (2014) ncbi
Invitrogen
mouse monoclonal (DJR1)
  • flow cytometry; human; loading ...; fig 1d
Invitrogen DR4 antibody (Invitrogen, 12-6644-42) was used in flow cytometry on human samples (fig 1d). Sci Adv (2021) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human; fig 4c
Invitrogen DR4 antibody (eBioscience, 12-6644-41) was used in flow cytometry on human samples (fig 4c). Cell Death Differ (2019) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human; fig s2
Invitrogen DR4 antibody (eBioscience, DJR1) was used in flow cytometry on human samples (fig s2). BMC Biotechnol (2016) ncbi
mouse monoclonal (DJR1)
  • flow cytometry; human
Invitrogen DR4 antibody (eBioscience, DJR1) was used in flow cytometry on human samples . J Biol Chem (2013) ncbi
Abcam
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:50; fig 1g
Abcam DR4 antibody (Abcam, ab-8416) was used in immunohistochemistry on human samples at 1:50 (fig 1g). elife (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1b
Abcam DR4 antibody (Abcam, ab8416) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 1b). PLoS ONE (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 5g
Abcam DR4 antibody (Abcam, ab8416) was used in western blot on human samples at 1:500 (fig 5g). Mol Cancer Res (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (DR4.1)
  • flow cytometry; human; loading ...; fig 3a
Santa Cruz Biotechnology DR4 antibody (Santa Cruz, sc-32255) was used in flow cytometry on human samples (fig 3a). Oncotarget (2016) ncbi
mouse monoclonal (B-9)
  • immunocytochemistry; human; 1:500
Santa Cruz Biotechnology DR4 antibody (Santa, B9) was used in immunocytochemistry on human samples at 1:500. J Biol Chem (2011) ncbi
Aviva Systems Biology
mouse
  • immunocytochemistry; human
In order to determine the interactome of human VPS35, Aviva Systems Biology DR4 antibody (Aviva, OASA01719) was used in immunocytochemistry on human samples . J Cell Sci (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D9S1R)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology DR4 antibody (CST, 42533) was used in western blot on human samples (fig 2a). Cell Death Dis (2020) ncbi
domestic rabbit monoclonal (D9S1R)
  • western blot; human; fig s4f
Cell Signaling Technology DR4 antibody (CST, 42533) was used in western blot on human samples (fig s4f). Cell Death Differ (2019) ncbi
domestic rabbit monoclonal (D9S1R)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology DR4 antibody (Cell Signaling Technology, D9S1R) was used in western blot on human samples (fig 2a). Sci Rep (2017) ncbi
domestic rabbit monoclonal (D9S1R)
  • western blot knockout validation; human; 1:1000; loading ...; fig 9e
Cell Signaling Technology DR4 antibody (Cell Signaling, D9S1R) was used in western blot knockout validation on human samples at 1:1000 (fig 9e). Mol Cell Biol (2017) ncbi
domestic rabbit monoclonal (D9S1R)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology DR4 antibody (Cell Signaling, 42533) was used in western blot on human samples (fig 2a). Int J Biochem Cell Biol (2017) ncbi
Beckman Coulter
mouse monoclonal (2.7A6A3)
  • flow cytometry; human; fig 1
Beckman Coulter DR4 antibody (BD Biosciences, IM2088U) was used in flow cytometry on human samples (fig 1). Cancer Biol Ther (2015) ncbi
mouse monoclonal (2.7A6A3)
  • flow cytometry; human; loading ...; tbl 1
Beckman Coulter DR4 antibody (Immunotech, 2.7A6A3) was used in flow cytometry on human samples (tbl 1). J Transl Med (2014) ncbi
mouse monoclonal (2.7A6A3)
  • flow cytometry; human
Beckman Coulter DR4 antibody (Beckman Coulter, IM2088U) was used in flow cytometry on human samples . Cell Death Dis (2014) ncbi
ProSci
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2a
ProSci DR4 antibody (ProSci, 1139) was used in western blot on human samples (fig 2a). EMBO J (2017) ncbi
Articles Reviewed
  1. Jeong D, Kim H, Kim H, Kang M, Jung H, Oh Y, et al. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. elife. 2021;10: pubmed publisher
  2. Kitamura Y, Kanaya N, Moleirinho S, Du W, Reinshagen C, Attia N, et al. Anti-EGFR VHH-armed death receptor ligand-engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers. Sci Adv. 2021;7: pubmed publisher
  3. Ding B, Yuan F, Damle P, Litovchick L, Drapkin R, Grossman S. CtBP determines ovarian cancer cell fate through repression of death receptors. Cell Death Dis. 2020;11:286 pubmed publisher
  4. Jun B, Lee W, Jang J, Jeong S, Chang Y, Lee S, et al. Relation of fibroblast growth factor receptor 2 expression to hepatocellular carcinoma recurrence after liver resection. PLoS ONE. 2020;15:e0227440 pubmed publisher
  5. Chollat Namy M, Ben Safta Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy. Cell Death Dis. 2019;10:695 pubmed publisher
  6. Staniek J, Lorenzetti R, Heller B, Janowska I, Schneider P, Unger S, et al. TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes. Front Immunol. 2019;10:951 pubmed publisher
  7. Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
  8. Zhao L, Zhang B. Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. Sci Rep. 2017;7:44735 pubmed publisher
  9. Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  10. Iurlaro R, Püschel F, León Annicchiarico C, O Connor H, Martin S, Palou Gramón D, et al. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors. Mol Cell Biol. 2017;37: pubmed publisher
  11. Dimberg L, Towers C, Behbakht K, Hotz T, Kim J, Fosmire S, et al. A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance. Mol Cancer Res. 2017;15:382-394 pubmed publisher
  12. Park S, Jwa E, Shin S, Ju E, Park I, Pak J, et al. Ibulocydine sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis via calpain-mediated Bax cleavage. Int J Biochem Cell Biol. 2017;83:47-55 pubmed publisher
  13. Roybal K, Williams J, Morsut L, Rupp L, Kolinko I, Choe J, et al. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016;167:419-432.e16 pubmed publisher
  14. Wang Z, Yu B, Wang B, Yan J, Feng X, Wang Z, et al. A novel capsid-modified oncolytic recombinant adenovirus type 5 for tumor-targeting gene therapy by intravenous route. Oncotarget. 2016;7:47287-47301 pubmed publisher
  15. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  16. Liesche C, Venkatraman L, Aschenbrenner S, Grosse S, Grimm D, Eils R, et al. Death receptor-based enrichment of Cas9-expressing cells. BMC Biotechnol. 2016;16:17 pubmed publisher
  17. Braun F, Mathur R, Sehgal L, Wilkie Grantham R, Chandra J, Berkova Z, et al. Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLoS ONE. 2015;10:e0117994 pubmed publisher
  18. Gomez Bougie P, Halliez M, Maïga S, Godon C, Kervoëlen C, Pellat Deceunynck C, et al. Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups. Cancer Biol Ther. 2015;16:60-5 pubmed publisher
  19. Su Y, Cheng T, Chen C, Chang W, Tsai N, Kung C, et al. Investigation of the caspase-dependent mitochondrial apoptotic pathway in mononuclear cells of patients with systemic Lupus erythematosus. J Transl Med. 2014;12:303 pubmed publisher
  20. Chandrasekaran S, Marshall J, Messing J, Hsu J, King M. TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. PLoS ONE. 2014;9:e111487 pubmed publisher
  21. Sullivan E, Jeha S, Kang G, Cheng C, Rooney B, Holladay M, et al. NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease. Clin Cancer Res. 2014;20:5986-94 pubmed publisher
  22. McGough I, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom K, et al. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. J Cell Sci. 2014;127:4940-53 pubmed publisher
  23. Pavet V, Shlyakhtina Y, He T, Ceschin D, Kohonen P, Perala M, et al. Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells. Cell Death Dis. 2014;5:e1043 pubmed publisher
  24. Linderoth E, Pilia G, Mahajan N, Ferby I. Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death. J Biol Chem. 2013;288:32922-31 pubmed publisher
  25. Cazanave S, Mott J, Bronk S, Werneburg N, Fingas C, Meng X, et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem. 2011;286:39336-48 pubmed publisher