This is a Validated Antibody Database (VAD) review about human DISC1, based on 6 published articles (read how Labome selects the articles), using DISC1 antibody in all methods. It is aimed to help Labome visitors find the most suited DISC1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DISC1 synonym: C1orf136; SCZD9; disrupted in schizophrenia 1 protein

Invitrogen
rabbit polyclonal
  • western blot; mouse; fig 7
In order to analyze selective partitioning into complexes and supercomplexes during synapse maturation by NMDA receptors, Invitrogen DISC1 antibody (Invitrogen, 40-6800) was used in western blot on mouse samples (fig 7). Nat Commun (2016) ncbi
rabbit monoclonal (4HCLC)
  • RNA immunoprecipitation; human
In order to develop reagents to study RNA binding proteins, Invitrogen DISC1 antibody (Invitrogen, 710203) was used in RNA immunoprecipitation on human samples . Mol Cell (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - free floating section; mouse; 1:500
  • western blot; mouse; 1:1500
In order to identify rare, highly penetrant risk mutations that contribute to schizophrenia, Invitrogen DISC1 antibody (Invitrogen, 40-6900) was used in immunohistochemistry - free floating section on mouse samples at 1:500 and in western blot on mouse samples at 1:1500. Hum Mol Genet (2014) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse; fig 4
In order to investigate how genetic variations in DISC1 influence interactions with PDE4 and GSK-3, Invitrogen DISC1 antibody (Invitrogen, 40-6800) was used in immunoprecipitation on mouse samples (fig 4). Neuropharmacology (2012) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse; fig 4
In order to report that GSK-3 inactivation reverses prepulse inhibition, latent inhibition deficits, and the normalizing the hyperactivity of Disc1-L100P mutants, Invitrogen DISC1 antibody (Invitrogen, 40-6800) was used in immunoprecipitation on mouse samples (fig 4). Synapse (2011) ncbi
Abcam
rabbit monoclonal (EPR14684)
  • western blot; mouse; 1:1000; fig s2a
In order to assess the use of the electroactive conductive polymer polypyrrole to counter impaired neurite outgrowth of primary pre-frontal cortical neurons, Abcam DISC1 antibody (Abcam, ab192258) was used in western blot on mouse samples at 1:1000 (fig s2a). Sci Rep (2017) ncbi
Articles Reviewed
  1. Zhang Q, Esrafilzadeh D, Crook J, Kapsa R, Stewart E, Tomaskovic Crook E, et al. Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice. Sci Rep. 2017;7:42525 pubmed publisher
  2. Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed publisher
  3. Sundararaman B, Zhan L, Blue S, Stanton R, Elkins K, Olson S, et al. Resources for the Comprehensive Discovery of Functional RNA Elements. Mol Cell. 2016;61:903-13 pubmed publisher
  4. Morris D, Pearson R, Cormican P, Kenny E, O Dushlaine C, Perreault L, et al. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014;23:3316-26 pubmed publisher
  5. Lipina T, Wang M, Liu F, Roder J. Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. Neuropharmacology. 2012;62:1252-62 pubmed publisher
  6. Lipina T, Kaidanovich Beilin O, Patel S, Wang M, Clapcote S, Liu F, et al. Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse. 2011;65:234-48 pubmed publisher