This is a Validated Antibody Database (VAD) review about human DEPTOR, based on 9 published articles (read how Labome selects the articles), using DEPTOR antibody in all methods. It is aimed to help Labome visitors find the most suited DEPTOR antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DEPTOR synonym: DEP.6; DEPDC6

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D9F5)
  • western blot; human; loading ...; fig 4e
  • immunohistochemistry knockout validation; mouse; loading ...; fig s1c
Cell Signaling Technology DEPTOR antibody (Cell Signaling Technology, 11816) was used in western blot on human samples (fig 4e) and in immunohistochemistry knockout validation on mouse samples (fig s1c). Oncogene (2020) ncbi
Santa Cruz Biotechnology
mouse monoclonal
  • western blot; mouse; loading ...; fig 8b
Santa Cruz Biotechnology DEPTOR antibody (Santa Cruz, sc-398169) was used in western blot on mouse samples (fig 8b). Am J Pathol (2020) ncbi
mouse monoclonal
  • western blot; human; 1:1000; loading ...; fig 2a
Santa Cruz Biotechnology DEPTOR antibody (Santa Cruz Biotechnology, sc-398169) was used in western blot on human samples at 1:1000 (fig 2a). Oncotarget (2016) ncbi
Novus Biologicals
domestic rabbit polyclonal (TL2.1)
  • western blot; human; 1:1000; fig s7
In order to elucidate the mechanisms by which mutant IDH1/2 contributes to oncogenesis, Novus Biologicals DEPTOR antibody (Novus Biologicals, NBP1-49674) was used in western blot on human samples at 1:1000 (fig s7). Nat Commun (2016) ncbi
domestic rabbit polyclonal (TL2.1)
Novus Biologicals DEPTOR antibody (Novus Biologicals, NBP1-49674) was used . J Comp Neurol (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D9F5)
  • immunocytochemistry; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 4a
Cell Signaling Technology DEPTOR antibody (Cell Signaling Technology, 11816) was used in immunocytochemistry on human samples (fig 2b) and in western blot on human samples (fig 4a). Theranostics (2021) ncbi
domestic rabbit monoclonal (D9F5)
  • western blot; human; loading ...; fig 4e
  • immunohistochemistry knockout validation; mouse; loading ...; fig s1c
Cell Signaling Technology DEPTOR antibody (Cell Signaling Technology, 11816) was used in western blot on human samples (fig 4e) and in immunohistochemistry knockout validation on mouse samples (fig s1c). Oncogene (2020) ncbi
domestic rabbit monoclonal (D9F5)
  • western blot; human; 1:1000; loading ...; fig 1s1b
Cell Signaling Technology DEPTOR antibody (Cell signaling, 11816) was used in western blot on human samples at 1:1000 (fig 1s1b). elife (2019) ncbi
domestic rabbit monoclonal (D9F5)
  • western blot; human; 1:500; fig 3
In order to elucidate the mechanisms by which mutant IDH1/2 contributes to oncogenesis, Cell Signaling Technology DEPTOR antibody (Cell signaling, D9F5) was used in western blot on human samples at 1:500 (fig 3). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D9F5)
  • western blot; mouse; fig 9a
Cell Signaling Technology DEPTOR antibody (Cell Signaling Technology, 11816) was used in western blot on mouse samples (fig 9a). J Cell Biol (2015) ncbi
domestic rabbit monoclonal (D9F5)
  • western blot; human
Cell Signaling Technology DEPTOR antibody (Cell Signaling Technologies, 11816) was used in western blot on human samples . J Biol Chem (2015) ncbi
Articles Reviewed
  1. Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, et al. DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. Theranostics. 2021;11:6355-6369 pubmed publisher
  2. Zhang X, Olsavszky V, Yin Y, Wang B, Engleitner T, Ollinger R, et al. Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration. Am J Pathol. 2020;190:358-371 pubmed publisher
  3. Chen X, Xiong X, Cui D, Yang F, Wei D, Li H, et al. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020;39:1557-1571 pubmed publisher
  4. Jewell J, Fu V, Hong A, Yu F, Meng D, Melick C, et al. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. elife. 2019;8: pubmed publisher
  5. Catena V, Bruno T, De Nicola F, Goeman F, Pallocca M, Iezzi S, et al. Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells. Oncotarget. 2016;7:70546-70558 pubmed publisher
  6. Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
  7. Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed publisher
  8. Verma R, Marchese A. The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. J Biol Chem. 2015;290:6810-24 pubmed publisher
  9. Caron A, Baraboi E, Laplante M, Richard D. DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication. J Comp Neurol. 2015;523:93-107 pubmed publisher