This is a Validated Antibody Database (VAD) review about human DDB2, based on 8 published articles (read how Labome selects the articles), using DDB2 antibody in all methods. It is aimed to help Labome visitors find the most suited DDB2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DDB2 synonym: DDBB; UV-DDB2; XPE; DNA damage-binding protein 2; DDB p48 subunit; UV-DDB 2; UV-damaged DNA-binding protein 2; damage-specific DNA binding protein 2, 48kDa; xeroderma pigmentosum group E protein

Abcam
mouse monoclonal (2246C4a)
  • immunohistochemistry; human; 1:100; loading ...; fig s8c
Abcam DDB2 antibody (Abcam, ab51017) was used in immunohistochemistry on human samples at 1:100 (fig s8c). Nat Commun (2018) ncbi
mouse monoclonal (2246C4a)
  • western blot; human; 1:50; fig 3
In order to study UVA response and nucleotide excision repair deficiency in melanoma, Abcam DDB2 antibody (Abcam, 2246C4) was used in western blot on human samples at 1:50 (fig 3). Exp Hematol Oncol (2015) ncbi
mouse monoclonal (2246C4a)
  • western blot; human; 1:500
Abcam DDB2 antibody (Abcam, ab51017) was used in western blot on human samples at 1:500. PLoS ONE (2013) ncbi
mouse monoclonal (2246C4a)
  • immunocytochemistry; human; 1:100
Abcam DDB2 antibody (Abcam, ab51017) was used in immunocytochemistry on human samples at 1:100. Nucleic Acids Res (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal (2246C4a)
  • western blot; human; fig 4e
Santa Cruz Biotechnology DDB2 antibody (Santa Cruz, sc-81246) was used in western blot on human samples (fig 4e). Mol Cell Biol (2016) ncbi
R&D Systems
goat polyclonal
  • western blot; human; 1:2000; fig 3
R&D Systems DDB2 antibody (R&D Systems, AF3297) was used in western blot on human samples at 1:2000 (fig 3). Cell Cycle (2015) ncbi
MyBioSource
mouse monoclonal (2246C4a)
  • immunocytochemistry; mouse; 1:400; fig 2
In order to elucidate ubiquitylation of XPC, MyBioSource DDB2 antibody (MybioSource, MBS120183) was used in immunocytochemistry on mouse samples at 1:400 (fig 2). Nat Commun (2015) ncbi
Cell Signaling Technology
rabbit monoclonal (D4C4)
  • western blot; human; 1:1000; loading ...; fig s8b
Cell Signaling Technology DDB2 antibody (Cell Signaling, 5416) was used in western blot on human samples at 1:1000 (fig s8b). Nat Commun (2018) ncbi
rabbit monoclonal (D4C4)
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology DDB2 antibody (Cell Signaling, 5416) was used in western blot on human samples (fig 4c). Mol Biol Cell (2017) ncbi
Articles Reviewed
  1. Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, et al. The protective role of DOT1L in UV-induced melanomagenesis. Nat Commun. 2018;9:259 pubmed publisher
  2. Fantini D, Huang S, Asara J, Bagchi S, Raychaudhuri P. Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Mol Biol Cell. 2017;28:192-200 pubmed publisher
  3. Murray H, Maltby V, Smith D, Bowden N. Nucleotide excision repair deficiency in melanoma in response to UVA. Exp Hematol Oncol. 2015;5:6 pubmed publisher
  4. Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, et al. UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation. Mol Cell Biol. 2016;36:394-406 pubmed publisher
  5. van Cuijk L, van Belle G, Turkyilmaz Y, Poulsen S, Janssens R, Theil A, et al. SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair. Nat Commun. 2015;6:7499 pubmed publisher
  6. Han C, Wani G, Zhao R, Qian J, Sharma N, He J, et al. Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair. Cell Cycle. 2015;14:1103-15 pubmed publisher
  7. Rossner P, Mrhalkova A, Uhlirova K, Spatova M, Rossnerova A, Libalova H, et al. Nucleotide excision repair is not induced in human embryonic lung fibroblasts treated with environmental pollutants. PLoS ONE. 2013;8:e69197 pubmed publisher
  8. Wang Q, Han C, Zhao R, Wani G, Zhu Q, Gong L, et al. p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair. Nucleic Acids Res. 2013;41:1722-33 pubmed publisher