This is a Validated Antibody Database (VAD) review about human DCC, based on 10 published articles (read how Labome selects the articles), using DCC antibody in all methods. It is aimed to help Labome visitors find the most suited DCC antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
DCC synonym: CRC18; CRCR1; HGPPS2; IGDCC1; MRMV1; NTN1R1

BD Biosciences
mouse monoclonal (G97-449)
  • proximity ligation assay; Xenopus laevis; 1:100; loading ...; fig 3c
  • immunoprecipitation; Xenopus laevis; ; loading ...; fig 1c
  • immunocytochemistry; Xenopus laevis; 1:100; loading ...; fig 3a
  • western blot; Xenopus laevis; 1:1000; loading ...; fig 1c
  • immunoprecipitation; human; ; loading ...; fig 1s1a
  • western blot; human; 1:1000; loading ...; fig 1s1a
BD Biosciences DCC antibody (BD Biosciences, 554223) was used in proximity ligation assay on Xenopus laevis samples at 1:100 (fig 3c), in immunoprecipitation on Xenopus laevis samples at (fig 1c), in immunocytochemistry on Xenopus laevis samples at 1:100 (fig 3a), in western blot on Xenopus laevis samples at 1:1000 (fig 1c), in immunoprecipitation on human samples at (fig 1s1a) and in western blot on human samples at 1:1000 (fig 1s1a). elife (2019) ncbi
mouse monoclonal (G97-449)
  • immunohistochemistry; brown rat; 1:500; loading ...; fig 1a
  • western blot; brown rat; 1:5000; loading ...; fig 1a
In order to discuss factors that promote cancer pathogenesis, BD Biosciences DCC antibody (BD Pharmingen, 554223) was used in immunohistochemistry on brown rat samples at 1:500 (fig 1a) and in western blot on brown rat samples at 1:5000 (fig 1a). BMC Cancer (2016) ncbi
mouse monoclonal (G92-13)
  • western blot; mouse; fig 7-s2
BD Biosciences DCC antibody (BD Biosciences, 554222) was used in western blot on mouse samples (fig 7-s2). elife (2016) ncbi
mouse monoclonal (G97-449)
  • proximity ligation assay; Xenopus laevis; 1:100; fig 5
  • immunocytochemistry; Xenopus laevis; fig 5
BD Biosciences DCC antibody (BD Biosciences, 554223) was used in proximity ligation assay on Xenopus laevis samples at 1:100 (fig 5) and in immunocytochemistry on Xenopus laevis samples (fig 5). Open Biol (2016) ncbi
mouse monoclonal (G97-449)
  • immunocytochemistry; human; 1:250; fig ev3
  • western blot; human; 1:2000; fig ev3
BD Biosciences DCC antibody (BD Pharmigen, 554223) was used in immunocytochemistry on human samples at 1:250 (fig ev3) and in western blot on human samples at 1:2000 (fig ev3). EMBO Mol Med (2015) ncbi
mouse monoclonal (G97-449)
  • immunohistochemistry - paraffin section; mouse
BD Biosciences DCC antibody (BD Biosciences, 554223) was used in immunohistochemistry - paraffin section on mouse samples . J Neurosci (2014) ncbi
mouse monoclonal (G97-449)
  • immunohistochemistry; mouse
BD Biosciences DCC antibody (BD Biosciences, 554223) was used in immunohistochemistry on mouse samples . Ann Neurol (2014) ncbi
mouse monoclonal (G97-449)
  • immunohistochemistry - paraffin section; brown rat; 1:400
BD Biosciences DCC antibody (BD pharmingen, G97-449) was used in immunohistochemistry - paraffin section on brown rat samples at 1:400. J Comp Neurol (2012) ncbi
EMD Millipore
mouse monoclonal
  • western blot; human
EMD Millipore DCC antibody (Calbiochem, OP45) was used in western blot on human samples . Oncotarget (2016) ncbi
mouse monoclonal
  • blocking or activating experiments; Aplysia; fig 8
EMD Millipore DCC antibody (Millipore, OP45) was used in blocking or activating experiments on Aplysia samples (fig 8). elife (2015) ncbi
Articles Reviewed
  1. Koppers M, Cagnetta R, Shigeoka T, Wunderlich L, Vallejo Ramirez P, Qiaojin Lin J, et al. Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons. elife. 2019;8: pubmed publisher
  2. Forrest C, McNair K, Vincenten M, Darlington L, Stone T. Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer. BMC Cancer. 2016;16:772 pubmed
  3. Dragich J, Kuwajima T, Hirose Ikeda M, Yoon M, Eenjes E, Bosco J, et al. Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. elife. 2016;5: pubmed publisher
  4. Konopacki F, Wong H, Dwivedy A, Bellon A, Blower M, Holt C. ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis. Open Biol. 2016;6:150218 pubmed publisher
  5. An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed publisher
  6. Fernández Santiago R, Carballo Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez Danés A, et al. Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients. EMBO Mol Med. 2015;7:1529-46 pubmed publisher
  7. Kim S, Martin K. Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome. elife. 2015;4: pubmed publisher
  8. Bull S, Bin J, Beaumont E, Boutet A, Krimpenfort P, Sadikot A, et al. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. J Neurosci. 2014;34:9768-78 pubmed publisher
  9. Tepavcevic V, Kerninon C, Aigrot M, Meppiel E, Mozafari S, Arnould Laurent R, et al. Early netrin-1 expression impairs central nervous system remyelination. Ann Neurol. 2014;76:252-68 pubmed publisher
  10. Huang C, Chu D, Hwang W, Tsaur M. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. J Comp Neurol. 2012;520:3650-72 pubmed publisher