This is a Validated Antibody Database (VAD) review about human Crk, based on 23 published articles (read how Labome selects the articles), using Crk antibody in all methods. It is aimed to help Labome visitors find the most suited Crk antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Crk synonym: CRKII; p38

Abcam
mouse monoclonal (M139)
  • western blot; mouse; 1:1000; loading ...; fig 6e
Abcam Crk antibody (Abcam, ab45381) was used in western blot on mouse samples at 1:1000 (fig 6e). Cell Death Dis (2020) ncbi
domestic rabbit monoclonal (EPR4984(2))
  • western blot; human; loading ...; fig s1g
Abcam Crk antibody (Abcam, ab133581) was used in western blot on human samples (fig s1g). Cell (2019) ncbi
mouse monoclonal (M139)
  • western blot; rat; 1:1000; fig 3a
Abcam Crk antibody (Abcam, ab45381) was used in western blot on rat samples at 1:1000 (fig 3a). J Neuroinflammation (2017) ncbi
mouse monoclonal (M139)
  • immunohistochemistry; rat; 1:1000; loading ...; fig 6f
Abcam Crk antibody (Abcam, ab45381) was used in immunohistochemistry on rat samples at 1:1000 (fig 6f). Sci Rep (2016) ncbi
mouse monoclonal (M139)
  • immunocytochemistry; human; loading ...; fig 4m-p
Abcam Crk antibody (Abcam, ab45381) was used in immunocytochemistry on human samples (fig 4m-p). Oncotarget (2016) ncbi
mouse monoclonal (M139)
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 5b
  • western blot; mouse; 1:1000; fig 5c
In order to propose that FGF2/FGFR2 activates the PKC/p38 pathway in trophectoderm cells during expanded blastocyst formation, Abcam Crk antibody (Abcam, Ab45381) was used in immunohistochemistry - paraffin section on mouse samples at 1:300 (fig 5b) and in western blot on mouse samples at 1:1000 (fig 5c). Cell Cycle (2015) ncbi
Bioworld
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 5
Bioworld Crk antibody (Bioworld Technology, BS4766) was used in western blot on human samples at 1:1000 (fig 5). Oncol Lett (2016) ncbi
BD Biosciences
mouse monoclonal (22/Crk)
  • immunoprecipitation; mouse; 1:50; loading ...; fig 6l
  • western blot; mouse; 1:1000; loading ...; fig 5a
BD Biosciences Crk antibody (BD, 610035) was used in immunoprecipitation on mouse samples at 1:50 (fig 6l) and in western blot on mouse samples at 1:1000 (fig 5a). Nat Commun (2022) ncbi
mouse monoclonal (22/Crk)
  • western blot; mouse; loading ...; fig 2b
BD Biosciences Crk antibody (BD Bioscience, 610035) was used in western blot on mouse samples (fig 2b). Nature (2021) ncbi
mouse monoclonal (27/p38?/SAPK2a)
  • western blot; mouse; 1:1000; loading ...; fig ev1c
BD Biosciences Crk antibody (BD Biosciences, 612168) was used in western blot on mouse samples at 1:1000 (fig ev1c). EMBO Mol Med (2020) ncbi
mouse monoclonal (22/Crk)
  • immunoprecipitation; mouse; loading ...; fig 2b
BD Biosciences Crk antibody (BD Biosciences, 610035) was used in immunoprecipitation on mouse samples (fig 2b). elife (2019) ncbi
mouse monoclonal (27/p38?/SAPK2a)
  • western blot; mouse; 1:250; loading ...; fig s3
BD Biosciences Crk antibody (BDTransduction Laboratories, 612169) was used in western blot on mouse samples at 1:250 (fig s3). Nat Commun (2018) ncbi
mouse monoclonal (27/p38?/SAPK2a)
  • western blot; mouse; loading ...; fig e2c
BD Biosciences Crk antibody (BD Biosciences, 612169) was used in western blot on mouse samples (fig e2c). Nature (2016) ncbi
mouse monoclonal (27/p38?/SAPK2a)
  • western blot; human; loading ...; fig 2a
In order to show that 2-hydroxyoleic acid treatment alters cell signaling and intracellular transport, BD Biosciences Crk antibody (Transduction Laboratories, 612168) was used in western blot on human samples (fig 2a). Oncotarget (2016) ncbi
mouse monoclonal (22/Crk)
  • immunocytochemistry; human; loading ...; fig 5h
  • western blot; human; loading ...; fig 5a
BD Biosciences Crk antibody (BD Bioscience, 610035) was used in immunocytochemistry on human samples (fig 5h) and in western blot on human samples (fig 5a). PLoS Pathog (2016) ncbi
mouse monoclonal (27/p38?/SAPK2a)
  • western blot; dogs; loading ...; fig 2b
In order to elucidate the mechanism by which hypotonic stress reduces claudin-1 and -2 expression in renal tubular epithelial and canine kidney cells, BD Biosciences Crk antibody (BD Biosciences, 612168) was used in western blot on dogs samples (fig 2b). J Biol Chem (2016) ncbi
mouse monoclonal (22/Crk)
  • immunocytochemistry; human; loading ...; fig 2c
  • western blot; human; loading ...; fig 2c
BD Biosciences Crk antibody (BD Biosciences, 22) was used in immunocytochemistry on human samples (fig 2c) and in western blot on human samples (fig 2c). Oncogene (2017) ncbi
mouse monoclonal (27/p38?/SAPK2a)
  • western blot; human; fig 2
BD Biosciences Crk antibody (BD Biosciences, 612168) was used in western blot on human samples (fig 2). Int J Oncol (2016) ncbi
mouse monoclonal (22/Crk)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, BD Biosciences Crk antibody (BD, 22) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (22/Crk)
  • immunoprecipitation; mouse; 1:500; fig s6
  • western blot; mouse; 1:500; fig s6
BD Biosciences Crk antibody (BD Biosciences, 610035) was used in immunoprecipitation on mouse samples at 1:500 (fig s6) and in western blot on mouse samples at 1:500 (fig s6). Development (2015) ncbi
mouse monoclonal (22/Crk)
  • western blot; human; fig 7
BD Biosciences Crk antibody (BD Transduction laboratories, 610035) was used in western blot on human samples (fig 7). EMBO J (2015) ncbi
mouse monoclonal (22/Crk)
  • western blot; mouse
BD Biosciences Crk antibody (BD, 610035) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
mouse monoclonal (27/p38?/SAPK2a)
  • western blot; rat; 1:2500
BD Biosciences Crk antibody (BD Biosciences, 612168) was used in western blot on rat samples at 1:2500. Biochim Biophys Acta (2014) ncbi
Articles Reviewed
  1. Mohamed M, Gupta K, Goldufsky J, Roy R, Callaghan L, Wetzel D, et al. CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT. Nat Commun. 2022;13:1295 pubmed publisher
  2. Oury J, Zhang W, Leloup N, Koide A, Corrado A, Ketavarapu G, et al. Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia. Nature. 2021;595:404-408 pubmed publisher
  3. Jing J, Ding N, Wang D, Ge X, Ma J, Ma R, et al. Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells. Cell Death Dis. 2020;11:626 pubmed publisher
  4. Buhl E, Djudjaj S, Klinkhammer B, Ermert K, Puelles V, Lindenmeyer M, et al. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 2020;12:e11021 pubmed publisher
  5. Lundby A, Franciosa G, Emdal K, Refsgaard J, Gnosa S, Bekker Jensen D, et al. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Cell. 2019;179:543-560.e26 pubmed publisher
  6. Javier Torrent M, Marco S, Rocandio D, Pons Vizcarra M, Janes P, Lackmann M, et al. Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA. elife. 2019;8: pubmed publisher
  7. Hyrenius Wittsten A, Pilheden M, Sturesson H, Hansson J, Walsh M, Song G, et al. De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. Nat Commun. 2018;9:1770 pubmed publisher
  8. Niu J, Huang D, Zhou R, Yue M, Xu T, Yang J, et al. Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12 and P2Y13 receptors in neuropathic pain rats. J Neuroinflammation. 2017;14:185 pubmed publisher
  9. Qi J, Chen C, Meng Q, Wu Y, Wu H, Zhao T. Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia. Sci Rep. 2016;6:39442 pubmed publisher
  10. Harper K, Sosa M, Entenberg D, Hosseini H, Cheung J, Nobre R, et al. Mechanism of early dissemination and metastasis in Her2+ mammary cancer. Nature. 2016;540:588-592 pubmed publisher
  11. Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed publisher
  12. Kumar B, Dutta D, Iqbal J, Ansari M, Roy A, Chikoti L, et al. ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus. PLoS Pathog. 2016;12:e1005960 pubmed publisher
  13. Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells. J Biol Chem. 2016;291:24787-24799 pubmed
  14. Frank S, Köllmann C, van Lidth de Jeude J, Thiagarajah J, Engelholm L, Frödin M, et al. The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene. 2017;36:1816-1828 pubmed publisher
  15. Kariya Y, Tatsuta T, Sugawara S, Kariya Y, Nitta K, Hosono M. RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells. Int J Oncol. 2016;49:1334-42 pubmed publisher
  16. Yang C, Cui X, Dai X, Liao W. Downregulation of Foxc2 enhances apoptosis induced by 5-fluorouracil through activation of MAPK and AKT pathways in colorectal cancer. Oncol Lett. 2016;11:1549-1554 pubmed
  17. Wang Y, Cui R, Zhang X, Qiao Y, Liu X, Chang Y, et al. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma. Oncotarget. 2016;7:11284-98 pubmed publisher
  18. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  19. Yang J, Zhang D, Yu Y, Zhang R, Hu X, Huang H, et al. Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway. Cell Cycle. 2015;14:3318-30 pubmed publisher
  20. Sathyamurthy A, Yin D, Barik A, Shen C, Bean J, Figueiredo D, et al. ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination. Development. 2015;142:522-32 pubmed publisher
  21. Gill M, Turner R, Stevenson P, Way M. KSHV-TK is a tyrosine kinase that disrupts focal adhesions and induces Rho-mediated cell contraction. EMBO J. 2015;34:448-65 pubmed publisher
  22. Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, et al. Differential function of Themis CABIT domains during T cell development. PLoS ONE. 2014;9:e89115 pubmed publisher
  23. Borkham Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-? signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher