This is a Validated Antibody Database (VAD) review about human Caspase-6, based on 16 published articles (read how Labome selects the articles), using Caspase-6 antibody in all methods. It is aimed to help Labome visitors find the most suited Caspase-6 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Caspase-6 synonym: MCH2

Knockout validation
Abcam
domestic rabbit monoclonal (EPR18043)
  • western blot knockout validation; human; loading ...; fig 4g
Abcam Caspase-6 antibody (Abcam, ab185645) was used in western blot knockout validation on human samples (fig 4g). MBio (2021) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology Caspase-6 antibody (Cell Signaling, 9762S) was used in western blot knockout validation on human samples (fig 5a). Sci Adv (2019) ncbi
Abcam
domestic rabbit monoclonal (EPR18043)
  • western blot knockout validation; human; loading ...; fig 4g
Abcam Caspase-6 antibody (Abcam, ab185645) was used in western blot knockout validation on human samples (fig 4g). MBio (2021) ncbi
domestic rabbit monoclonal (EPR18043)
  • immunocytochemistry; human; 1:100; loading ...; fig 7f
Abcam Caspase-6 antibody (Abcam, ab185645) was used in immunocytochemistry on human samples at 1:100 (fig 7f). elife (2019) ncbi
domestic rabbit monoclonal (EPR18043)
  • western blot; mouse; loading ...; fig 4e
Abcam Caspase-6 antibody (Abcam, ab185645) was used in western blot on mouse samples (fig 4e). Cell Death Dis (2018) ncbi
Santa Cruz Biotechnology
mouse monoclonal (14.1.190)
  • western blot; human; 1:1000; loading ...; fig 2d
Santa Cruz Biotechnology Caspase-6 antibody (SAnta Cruz, sc-81653) was used in western blot on human samples at 1:1000 (fig 2d). Sci Rep (2021) ncbi
mouse monoclonal (14.1.190)
  • western blot; human; loading ...; fig 5a
Santa Cruz Biotechnology Caspase-6 antibody (Santa Cruz, SC81653) was used in western blot on human samples (fig 5a). Sci Rep (2018) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s9c
  • western blot; mouse; loading ...; fig s9d
Invitrogen Caspase-6 antibody (Life Technologies, PA5-12557) was used in western blot on human samples (fig s9c) and in western blot on mouse samples (fig s9d). Science (2020) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4b
Cell Signaling Technology Caspase-6 antibody (CST, 9762T) was used in western blot on mouse samples at 1:1000 (fig 4b). Front Physiol (2022) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...; fig s7a
Cell Signaling Technology Caspase-6 antibody (Cell signal, 9761) was used in immunohistochemistry - frozen section on mouse samples at 1:400 (fig s7a). J Biol Chem (2021) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6b
Cell Signaling Technology Caspase-6 antibody (CST, 9762T) was used in western blot on mouse samples at 1:1000 (fig 6b). Oxid Med Cell Longev (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...
Cell Signaling Technology Caspase-6 antibody (CST, 9762) was used in western blot on human samples . Cell Death Dis (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 9a
Cell Signaling Technology Caspase-6 antibody (Cell Signaling, 9762) was used in western blot on human samples at 1:1000 (fig 9a). elife (2019) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology Caspase-6 antibody (Cell Signaling, 9762S) was used in western blot knockout validation on human samples (fig 5a). Sci Adv (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 7g
Cell Signaling Technology Caspase-6 antibody (Cell Signaling, 9761) was used in western blot on human samples (fig 7g). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 6a
Cell Signaling Technology Caspase-6 antibody (Cell Signaling, 9761) was used in western blot on human samples (fig 6a). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 5
In order to research differentiation of functional glutamatergic neurons from placenta-derived multipotent cells by knocking down of heat-shock protein 27, Cell Signaling Technology Caspase-6 antibody (Cell Signaling, 9762) was used in western blot on human samples at 1:1000 (fig 5). Sci Rep (2016) ncbi
BD Biosciences
mouse monoclonal (B93-4)
  • western blot; human; 1:250; loading ...; fig 2h
BD Biosciences Caspase-6 antibody (BD, B93-4) was used in western blot on human samples at 1:250 (fig 2h). Sci Rep (2021) ncbi
MBL International
monoclonal
  • western blot; human; 1:2000
MBL International Caspase-6 antibody (MBL, M070-3) was used in western blot on human samples at 1:2000. J Biol Chem (2014) ncbi
monoclonal
  • western blot; human; fig 5
MBL International Caspase-6 antibody (MBL, M070-3) was used in western blot on human samples (fig 5). Cell Death Differ (2009) ncbi
Articles Reviewed
  1. Liu Y, Xu Y, Yao Y, Cao Y, Chen G, Cai Y, et al. I-κB kinase-ε deficiency improves doxorubicin-induced dilated cardiomyopathy by inhibiting the NF-κB pathway. Front Physiol. 2022;13:934899 pubmed publisher
  2. Zhang N, Kisiswa L, Ramanujan A, Li Z, Sim E, Tian X, et al. Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains. J Biol Chem. 2021;297:100916 pubmed publisher
  3. Zhou L, Nho K, Haddad M, Cherepacha N, Tubeleviciute Aydin A, Tsai A, et al. Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration. Sci Rep. 2021;11:12695 pubmed publisher
  4. Wu W, Qu Y, Yu S, Wang S, Yin Y, Liu Q, et al. Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity. MBio. 2021;12:e0100521 pubmed publisher
  5. Cao Y, Li L, Liu Y, Chen G, Tao Z, Wang R, et al. I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice. Oxid Med Cell Longev. 2021;2021:6429197 pubmed publisher
  6. Shen X, Wang H, Weng C, Jiang H, Chen J. Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis. 2021;12:186 pubmed publisher
  7. Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, et al. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020;367:652-660 pubmed publisher
  8. Battaglia R, Beltran A, Delic S, Dumitru R, Robinson J, Kabiraj P, et al. Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. elife. 2019;8: pubmed publisher
  9. McComb S, Chan P, Guinot A, Hartmannsdottir H, Jenni S, Dobay M, et al. Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7. Sci Adv. 2019;5:eaau9433 pubmed publisher
  10. Lin X, Cui M, Xu D, Hong D, Xia Y, Xu C, et al. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death Dis. 2018;9:768 pubmed publisher
  11. Tubeleviciute Aydin A, Zhou L, Sharma G, Soni I, Savinov S, Hardy J, et al. Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity. Sci Rep. 2018;8:4428 pubmed publisher
  12. McKenzie C, D Avino P. Investigating cytokinesis failure as a strategy in cancer therapy. Oncotarget. 2016;7:87323-87341 pubmed publisher
  13. Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed publisher
  14. Cheng Y, Huang C, Lee Y, Tien L, Ku W, Chien R, et al. Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells. Sci Rep. 2016;6:30314 pubmed publisher
  15. Sánchez Osuna M, García Belinchón M, Iglesias Guimarais V, Gil Guiñón E, Casanelles E, Yuste V. Caspase-activated DNase is necessary and sufficient for oligonucleosomal DNA breakdown, but not for chromatin disassembly during caspase-dependent apoptosis of LN-18 glioblastoma cells. J Biol Chem. 2014;289:18752-69 pubmed publisher
  16. Inoue S, Browne G, Melino G, Cohen G. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ. 2009;16:1053-61 pubmed publisher