This is a Validated Antibody Database (VAD) review about human CRBN, based on 7 published articles (read how Labome selects the articles), using CRBN antibody in all methods. It is aimed to help Labome visitors find the most suited CRBN antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CRBN synonym: MRT2; MRT2A; protein cereblon; protein x 0001

Proteintech Group
rabbit polyclonal
  • western blot; human; 1:500; loading ...
Proteintech Group CRBN antibody (ProteinTech, 11435-C1-AP) was used in western blot on human samples at 1:500. elife (2019) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:50
Proteintech Group CRBN antibody (Proteintech, 11435-1-AP) was used in immunohistochemistry - paraffin section on human samples at 1:50. Ann Hematol (2014) ncbi
Abnova
mouse polyclonal
  • western blot; human; fig 2
In order to investigate how ubiquitination of BK channels contributes to epilepsy, Abnova CRBN antibody (Abnova, H00051185-B01P) was used in western blot on human samples (fig 2). Nat Commun (2014) ncbi
Novus Biologicals
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 1c
Novus Biologicals CRBN antibody (Novus, H6-NBP1-91810) was used in western blot on human samples at 1:1000 (fig 1c). Oncol Lett (2017) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; fig 2a
Sigma-Aldrich CRBN antibody (Sigma-Aldrich, HPA045910) was used in western blot on human samples (fig 2a). Blood Cancer J (2019) ncbi
rabbit polyclonal
  • western blot; human; fig 6c
Sigma-Aldrich CRBN antibody (Sigma, HPA045910) was used in western blot on human samples (fig 6c). Proc Natl Acad Sci U S A (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig s1b
In order to explore how cereblon modulates the efficacy of immunomodulatory drugs, Sigma-Aldrich CRBN antibody (Sigma, HPA045910) was used in western blot on human samples (fig s1b). Proc Natl Acad Sci U S A (2016) ncbi
Articles Reviewed
  1. Silva M, Ferguson F, Cai Q, Donovan K, Nandi G, Patnaik D, et al. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. elife. 2019;8: pubmed publisher
  2. Zhu Y, Shi C, Bruins L, Wang X, Riggs D, Porter B, et al. Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4. Blood Cancer J. 2019;9:19 pubmed publisher
  3. Jian Y, Gao W, Geng C, Zhou H, Leng Y, Li Y, et al. Arsenic trioxide potentiates sensitivity of multiple myeloma cells to lenalidomide by upregulating cereblon expression levels. Oncol Lett. 2017;14:3243-3248 pubmed publisher
  4. Nguyen T, Li J, Lu C, Mamrosh J, Lu G, Cathers B, et al. p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A. 2017;114:3565-3571 pubmed publisher
  5. Millrine D, Tei M, Gemechu Y, Kishimoto T. Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production. Proc Natl Acad Sci U S A. 2016;113:10625-30 pubmed publisher
  6. Liu J, Ye J, Zou X, Xu Z, Feng Y, Zou X, et al. CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis. Nat Commun. 2014;5:3924 pubmed publisher
  7. Huang S, Lin C, Lin H, Yao M, Tang J, Wu S, et al. Expression of cereblon protein assessed by immunohistochemicalstaining in myeloma cells is associated with superior response of thalidomide- and lenalidomide-based treatment, but not bortezomib-based treatment, in patients with multiple myeloma. Ann Hematol. 2014;93:1371-80 pubmed publisher