This is a Validated Antibody Database (VAD) review about human CLIC4, based on 3 published articles (read how Labome selects the articles), using CLIC4 antibody in all methods. It is aimed to help Labome visitors find the most suited CLIC4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CLIC4 synonym: CLIC4L; MTCLIC; huH1; p64H1; chloride intracellular channel protein 4; chloride intracellular channel 4 like; intracellular chloride ion channel protein p64H1

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (45.42)
  • western blot knockout validation; mouse; loading ...; fig s3b
Santa Cruz Biotechnology CLIC4 antibody (Santa Cruz Biotechnology, SC-135739) was used in western blot knockout validation on mouse samples (fig s3b). Nat Commun (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (45.42)
  • western blot knockout validation; mouse; loading ...; fig s3b
Santa Cruz Biotechnology CLIC4 antibody (Santa Cruz Biotechnology, SC-135739) was used in western blot knockout validation on mouse samples (fig s3b). Nat Commun (2017) ncbi
mouse monoclonal (45.42)
  • immunocytochemistry; mouse; 1:100; loading ...; fig 3p
  • western blot; mouse; loading ...; fig 4g
Santa Cruz Biotechnology CLIC4 antibody (Santa Cruz, sc-135739) was used in immunocytochemistry on mouse samples at 1:100 (fig 3p) and in western blot on mouse samples (fig 4g). J Biol Chem (2017) ncbi
mouse monoclonal (45.42)
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • western blot; human; fig 3
Santa Cruz Biotechnology CLIC4 antibody (Santa Cruz Biotechnology, sc-135739) was used in immunohistochemistry - paraffin section on human samples at 1:50 (fig 1) and in western blot on human samples (fig 3). Cell Biosci (2016) ncbi
Articles Reviewed
  1. Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8:202 pubmed publisher
  2. Domingo Fernández R, Coll R, Kearney J, Breit S, O Neill L. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087 pubmed publisher
  3. Xue H, Lu J, Yuan R, Liu J, Liu Y, Wu K, et al. Knockdown of CLIC4 enhances ATP-induced HN4 cell apoptosis through mitochondrial and endoplasmic reticulum pathways. Cell Biosci. 2016;6:5 pubmed publisher