This is a Validated Antibody Database (VAD) review about human CLIC1, based on 4 published articles (read how Labome selects the articles), using CLIC1 antibody in all methods. It is aimed to help Labome visitors find the most suited CLIC1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CLIC1 synonym: CL1C1; NCC27; chloride intracellular channel protein 1; RNCC protein; chloride channel ABP; hRNCC; nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; regulatory nuclear chloride ion channel protein

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (356.1)
  • western blot knockout validation; human; loading ...; fig 5c
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4c
Santa Cruz Biotechnology CLIC1 antibody (Santa Cruz, sc-81873) was used in western blot knockout validation on human samples (fig 5c), in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 4a) and in western blot on mouse samples (fig 4c). PLoS ONE (2016) ncbi
Proteintech Group
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig s3b
Proteintech Group CLIC1 antibody (Proteintech, 14545-1-AP) was used in western blot knockout validation on mouse samples (fig s3b). Nat Commun (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (356.1)
  • immunocytochemistry; mouse; 1:100; loading ...; fig 3p
  • western blot; mouse; loading ...; fig 4g
Santa Cruz Biotechnology CLIC1 antibody (Santa Cruz, sc-81873) was used in immunocytochemistry on mouse samples at 1:100 (fig 3p) and in western blot on mouse samples (fig 4g). J Biol Chem (2017) ncbi
mouse monoclonal (356.1)
  • western blot knockout validation; human; loading ...; fig 5c
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4c
Santa Cruz Biotechnology CLIC1 antibody (Santa Cruz, sc-81873) was used in western blot knockout validation on human samples (fig 5c), in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 4a) and in western blot on mouse samples (fig 4c). PLoS ONE (2016) ncbi
Proteintech Group
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig s3b
Proteintech Group CLIC1 antibody (Proteintech, 14545-1-AP) was used in western blot knockout validation on mouse samples (fig s3b). Nat Commun (2017) ncbi
Abnova
mouse monoclonal (2D4)
  • western blot; human; 1:2000
Abnova CLIC1 antibody (Abnova, H00001192-M01) was used in western blot on human samples at 1:2000. Biochim Biophys Acta (2015) ncbi
Articles Reviewed
  1. Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8:202 pubmed publisher
  2. Domingo Fernández R, Coll R, Kearney J, Breit S, O Neill L. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087 pubmed publisher
  3. Xu Y, Zhu J, Hu X, Wang C, Lu D, Gong C, et al. CLIC1 Inhibition Attenuates Vascular Inflammation, Oxidative Stress, and Endothelial Injury. PLoS ONE. 2016;11:e0166790 pubmed publisher
  4. Poschmann G, Grzendowski M, Stefanski A, Bruns E, Meyer H, Stühler K. Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress. Biochim Biophys Acta. 2015;1854:624-31 pubmed publisher