This is a Validated Antibody Database (VAD) review about human CGAS, based on 25 published articles (read how Labome selects the articles), using CGAS antibody in all methods. It is aimed to help Labome visitors find the most suited CGAS antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CGAS synonym: C6orf150; MB21D1; h-cGAS

Knockout validation
Cell Signaling Technology
domestic rabbit monoclonal (D1D3G)
  • western blot knockout validation; human; loading ...; fig 2a
Cell Signaling Technology CGAS antibody (Cell Signaling, D1D3G) was used in western blot knockout validation on human samples (fig 2a). Science (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1D3G)
  • western blot knockout validation; human; loading ...; fig 1b
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102) was used in western blot knockout validation on human samples (fig 1b). Nat Commun (2020) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1D3G)
  • immunocytochemistry knockout validation; human; loading ...; fig 1d
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102S) was used in immunocytochemistry knockout validation on human samples (fig 1d) and in western blot on human samples (fig 1a). Cell (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1D3G)
  • western blot knockout validation; human; fig 3a
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in western blot knockout validation on human samples (fig 3a). MBio (2019) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 4a
MilliporeSigma CGAS antibody (Sigma-Aldrich, HPA031700) was used in western blot knockout validation on human samples (fig 4a). Nat Commun (2017) ncbi
Invitrogen
mouse monoclonal (HGAYN)
Invitrogen CGAS antibody (Thermo Fisher, 14-5158-82) was used . Nat Commun (2020) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D1D3G)
  • western blot; human; 1:1000; loading ...
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in western blot on human samples at 1:1000. Nat Commun (2022) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; fig 6j
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102T) was used in western blot on human samples (fig 6j). J Immunother Cancer (2022) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; 1:1000; loading ...; fig 3b
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102S) was used in western blot on human samples at 1:1000 (fig 3b). Theranostics (2022) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; 1:1000; loading ...; fig 2b
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in western blot on human samples at 1:1000 (fig 2b). Cell Rep (2022) ncbi
domestic rabbit monoclonal (D1D3G)
  • immunocytochemistry; human; 1:200; loading ...; fig 2e
Cell Signaling Technology CGAS antibody (Cell Signalling, 15102) was used in immunocytochemistry on human samples at 1:200 (fig 2e). EMBO Mol Med (2022) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; 1:1000; loading ...; fig 3a
Cell Signaling Technology CGAS antibody (Cell Signaling, D1D3G) was used in western blot on human samples at 1:1000 (fig 3a). Cancers (Basel) (2021) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot knockout validation; human; loading ...; fig 2a
Cell Signaling Technology CGAS antibody (Cell Signaling, D1D3G) was used in western blot knockout validation on human samples (fig 2a). Science (2021) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; loading ...; fig s7b
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in western blot on human samples (fig s7b). Gastroenterology (2021) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; 1:2000; loading ...; fig s2b
Cell Signaling Technology CGAS antibody (CST, 15102) was used in western blot on human samples at 1:2000 (fig s2b). Nat Commun (2020) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot knockout validation; human; loading ...; fig 1b
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102) was used in western blot knockout validation on human samples (fig 1b). Nat Commun (2020) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102S) was used in western blot on human samples (fig 3b). elife (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; 1:1000; loading ...; fig 4c
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in western blot on human samples at 1:1000 (fig 4c). Nat Commun (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • immunocytochemistry; human; 1:200; loading ...; fig 2f
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in immunocytochemistry on human samples at 1:200 (fig 2f). Nat Commun (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102) was used in western blot on human samples (fig 2a). Cell (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • immunocytochemistry knockout validation; human; loading ...; fig 1d
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102S) was used in immunocytochemistry knockout validation on human samples (fig 1d) and in western blot on human samples (fig 1a). Cell (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • immunocytochemistry; human; 1:200; loading ...; fig 3a
  • western blot; human; loading ...; fig 1c
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102) was used in immunocytochemistry on human samples at 1:200 (fig 3a) and in western blot on human samples (fig 1c). Cell Rep (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • immunoprecipitation; human; loading ...; fig s3a
  • immunocytochemistry; human; loading ...; fig 3d
  • western blot; human; loading ...; fig 2f
Cell Signaling Technology CGAS antibody (Cell Signaling Technology, 15102) was used in immunoprecipitation on human samples (fig s3a), in immunocytochemistry on human samples (fig 3d) and in western blot on human samples (fig 2f). Cell (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot knockout validation; human; fig 3a
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in western blot knockout validation on human samples (fig 3a). MBio (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • immunocytochemistry; human; loading ...; fig 4c
  • western blot; human; loading ...; fig 4e
Cell Signaling Technology CGAS antibody (Cell Signalling, D1D3G) was used in immunocytochemistry on human samples (fig 4c) and in western blot on human samples (fig 4e). Nature (2019) ncbi
domestic rabbit monoclonal (D1D3G)
  • western blot; human; loading ...; fig 5b
Cell Signaling Technology CGAS antibody (Cell Signaling, 15102) was used in western blot on human samples (fig 5b). Nucleic Acids Res (2017) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig s2d
MilliporeSigma CGAS antibody (Sigma, HPA031700) was used in western blot on human samples at 1:500 (fig s2d). Proc Natl Acad Sci U S A (2022) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 1b
MilliporeSigma CGAS antibody (Sigma-Aldrich, HPA031700) was used in western blot on human samples (fig 1b). J Exp Med (2017) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 4a
MilliporeSigma CGAS antibody (Sigma-Aldrich, HPA031700) was used in western blot knockout validation on human samples (fig 4a). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig s2d
In order to find interferon-gamma inducible factor 16 functions in the cyclic GMP-AMP synthase-stimulator of interferon genes pathway, MilliporeSigma CGAS antibody (Sigma, HPA031700) was used in western blot on human samples (fig s2d). Nat Commun (2017) ncbi
Articles Reviewed
  1. Zimmerli D, Brambillasca C, Talens F, Bhin J, Linstra R, Romanens L, et al. MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling. Nat Commun. 2022;13:6579 pubmed publisher
  2. Ni H, Zhang H, Li L, Huang H, Guo H, Zhang L, et al. T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer. J Immunother Cancer. 2022;10: pubmed publisher
  3. Ma Z, Zhang W, Dong B, Xin Z, Ji Y, Su R, et al. Docetaxel remodels prostate cancer immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. Theranostics. 2022;12:4965-4979 pubmed publisher
  4. Taniguchi H, Caeser R, Chavan S, Zhan Y, Chow A, Manoj P, et al. WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC. Cell Rep. 2022;39:110814 pubmed publisher
  5. Wolpaw A, Grossmann L, Dessau J, Dong M, Aaron B, Brafford P, et al. Epigenetic state determines inflammatory sensing in neuroblastoma. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
  6. Groelly F, Porru M, Zimmer J, Benainous H, De Visser Y, Kosova A, et al. Anti-tumoural activity of the G-quadruplex ligand pyridostatin against BRCA1/2-deficient tumours. EMBO Mol Med. 2022;14:e14501 pubmed publisher
  7. Schwertner B, Lindner G, Toledo Stauner C, Klapproth E, Magnus C, Rohrhofer A, et al. Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo. Cancers (Basel). 2021;13: pubmed publisher
  8. Li T, Huang T, Du M, Chen X, Du F, Ren J, et al. Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. Science. 2021;371: pubmed publisher
  9. Luo Z, Ji Y, Gao H, Gomes Dos Reis F, Bandyopadhyay G, Jin Z, et al. CRIg+ Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance. Gastroenterology. 2021;160:863-874 pubmed publisher
  10. Omer A, Barrera M, Moran J, Lian X, Di Marco S, Beausejour C, et al. G3BP1 controls the senescence-associated secretome and its impact on cancer progression. Nat Commun. 2020;11:4979 pubmed publisher
  11. Deng M, Tam J, Wang L, Liang K, Li S, Zhang L, et al. TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nat Commun. 2020;11:2193 pubmed publisher
  12. Lohard S, Bourgeois N, Maillet L, Gautier F, Fétiveau A, Lasla H, et al. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nat Commun. 2020;11:259 pubmed publisher
  13. Volkman H, Cambier S, Gray E, Stetson D. Tight nuclear tethering of cGAS is essential for preventing autoreactivity. elife. 2019;8: pubmed publisher
  14. Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun. 2019;10:4624 pubmed publisher
  15. Reisländer T, Lombardi E, Groelly F, Miar A, Porru M, Di Vito S, et al. BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors. Nat Commun. 2019;10:3143 pubmed publisher
  16. Zierhut C, Yamaguchi N, Paredes M, Luo J, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178:302-315.e23 pubmed publisher
  17. Barnett K, Coronas Serna J, Zhou W, Ernandes M, Cao A, Kranzusch P, et al. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019;: pubmed publisher
  18. Gentili M, Lahaye X, Nadalin F, Nader G, Puig Lombardi E, Hervé S, et al. The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus. Cell Rep. 2019;26:2377-2393.e13 pubmed publisher
  19. Dai J, Huang Y, He X, Zhao M, Wang X, Liu Z, et al. Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. Cell. 2019;: pubmed publisher
  20. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, et al. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome. MBio. 2019;10: pubmed publisher
  21. Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher
  22. Cerboni S, Jeremiah N, Gentili M, Gehrmann U, Conrad C, Stolzenberg M, et al. Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes. J Exp Med. 2017;214:1769-1785 pubmed publisher
  23. Almine J, O Hare C, Dunphy G, Haga I, Naik R, Atrih A, et al. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nat Commun. 2017;8:14392 pubmed publisher
  24. Jønsson K, Laustsen A, Krapp C, Skipper K, Thavachelvam K, Hotter D, et al. IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat Commun. 2017;8:14391 pubmed publisher
  25. Suspène R, Mussil B, Laude H, Caval V, Berry N, Bouzidi M, et al. Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage. Nucleic Acids Res. 2017;45:3231-3241 pubmed publisher