This is a Validated Antibody Database (VAD) review about human CD98, based on 17 published articles (read how Labome selects the articles), using CD98 antibody in all methods. It is aimed to help Labome visitors find the most suited CD98 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CD98 synonym: 4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1; NACAE

Knockout validation
TRANS GENIC
mouse monoclonal (WK4)
  • immunocytochemistry knockout validation; human; 1:1000; fig 1
  • flow cytometry; human; 1:100; fig 1
In order to demonstrate the key role of essential amino acid transport in the control of mTORC1 and tumor growth caused by genetic disruption of the multifunctional CD98/LAT1 complex, TRANS GENIC CD98 antibody (TransGenic, KS129) was used in immunocytochemistry knockout validation on human samples at 1:1000 (fig 1) and in flow cytometry on human samples at 1:100 (fig 1). Cancer Res (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (E-5)
  • western blot; human; 1:500; fig 1e
Santa Cruz Biotechnology CD98 antibody (Santa Cruz, sc-376815) was used in western blot on human samples at 1:500 (fig 1e). Nat Microbiol (2021) ncbi
mouse monoclonal (E-5)
  • immunohistochemistry; human; fig 6e
  • western blot; human; loading ...; fig s7a
Santa Cruz Biotechnology CD98 antibody (Santa Cruz, sc-376815) was used in immunohistochemistry on human samples (fig 6e) and in western blot on human samples (fig s7a). Mol Cell (2021) ncbi
mouse monoclonal (E-5)
  • western blot; rat; 1:1000; fig 3
Santa Cruz Biotechnology CD98 antibody (Santa Cruz, sc-376815) was used in western blot on rat samples at 1:1000 (fig 3). Exp Ther Med (2017) ncbi
mouse monoclonal (4F2)
  • immunoprecipitation; human; loading ...; fig 5b
Santa Cruz Biotechnology CD98 antibody (SantaCruz, 4F2) was used in immunoprecipitation on human samples (fig 5b). Korean J Physiol Pharmacol (2016) ncbi
mouse monoclonal (E-5)
  • western blot; human; loading ...; fig 7b
In order to discover that CD147-CD98 is a major carrier of poly-N-acetyl-lactosamine on human pre-B cell line, Santa Cruz Biotechnology CD98 antibody (Santa Cruz, sc-376815) was used in western blot on human samples (fig 7b). J Immunol (2015) ncbi
BioLegend
mouse monoclonal (MEM-108)
  • immunocytochemistry; human; 1:50; loading ...; fig 6c
BioLegend CD98 antibody (BioLegend, MEM-108) was used in immunocytochemistry on human samples at 1:50 (fig 6c). MBio (2018) ncbi
mouse monoclonal (MEM-108)
  • flow cytometry; human; loading ...; fig 2e
In order to identify cellular changes induced by IL-2, BioLegend CD98 antibody (BioLegend, MEM-108) was used in flow cytometry on human samples (fig 2e). J Immunol (2017) ncbi
mouse monoclonal (MEM-108)
  • immunocytochemistry; human; 1:1000; loading ...; fig 1a
BioLegend CD98 antibody (BioLegend, MEM-108) was used in immunocytochemistry on human samples at 1:1000 (fig 1a). J Cell Sci (2017) ncbi
Abcam
mouse monoclonal (44D7)
  • immunocytochemistry; human; fig 1
Abcam CD98 antibody (Abcam, ab23495) was used in immunocytochemistry on human samples (fig 1). J Exp Clin Cancer Res (2015) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D6O3P)
  • western blot; rat; loading ...; fig 4a, 4c
Cell Signaling Technology CD98 antibody (Cell Signaling, 13180) was used in western blot on rat samples (fig 4a, 4c). Front Mol Biosci (2021) ncbi
domestic rabbit monoclonal (D6O3P)
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig s2
  • western blot; human; 1:1000; loading ...; fig 4a
Cell Signaling Technology CD98 antibody (Cell Signaling Technology, 13180S) was used in immunohistochemistry - paraffin section on human samples at 1:1000 (fig s2) and in western blot on human samples at 1:1000 (fig 4a). Cell Death Dis (2019) ncbi
domestic rabbit monoclonal (D6O3P)
  • western blot; human; 1:2000; loading ...; fig 2g
Cell Signaling Technology CD98 antibody (cell signaling, 13180) was used in western blot on human samples at 1:2000 (fig 2g). Nature (2019) ncbi
TRANS GENIC
mouse monoclonal (WK4)
  • immunocytochemistry knockout validation; human; 1:1000; fig 1
  • flow cytometry; human; 1:100; fig 1
In order to demonstrate the key role of essential amino acid transport in the control of mTORC1 and tumor growth caused by genetic disruption of the multifunctional CD98/LAT1 complex, TRANS GENIC CD98 antibody (TransGenic, KS129) was used in immunocytochemistry knockout validation on human samples at 1:1000 (fig 1) and in flow cytometry on human samples at 1:100 (fig 1). Cancer Res (2016) ncbi
BD Biosciences
mouse monoclonal (UM7F8)
  • flow cytometry; human; fig e1
BD Biosciences CD98 antibody (BD, 556074) was used in flow cytometry on human samples (fig e1). Nat Microbiol (2021) ncbi
mouse monoclonal (UM7F8)
  • flow cytometry; human; fig 5d
BD Biosciences CD98 antibody (BD PharMingen, 556077) was used in flow cytometry on human samples (fig 5d). Mol Cell (2021) ncbi
mouse monoclonal (UM7F8)
  • immunocytochemistry; human; fig 1d
In order to study the use of SH-BC-893 as an anti-cancer treatment, BD Biosciences CD98 antibody (BD Biosciences, 556077) was used in immunocytochemistry on human samples (fig 1d). J Clin Invest (2016) ncbi
mouse monoclonal (UM7F8)
  • other; human; 500 ug/ml; fig 1
BD Biosciences CD98 antibody (Becton Dickinson, 556074) was used in other on human samples at 500 ug/ml (fig 1). J Extracell Vesicles (2016) ncbi
mouse monoclonal (UM7F8)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences CD98 antibody (BD, 556077) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (UM7F8)
  • flow cytometry; human; fig 4
BD Biosciences CD98 antibody (BD Pharmingen TM, 556,077) was used in flow cytometry on human samples (fig 4). Cytometry A (2015) ncbi
Articles Reviewed
  1. Malleret B, El Sahili A, Tay M, Carissimo G, Ong A, Novera W, et al. Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells. Nat Microbiol. 2021;6:991-999 pubmed publisher
  2. Chang B, Guan H, Wang X, Chen Z, Zhu W, Wei X, et al. Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells. Front Mol Biosci. 2021;8:660072 pubmed publisher
  3. Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Mol Cell. 2021;: pubmed publisher
  4. Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner B, et al. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019;10:682 pubmed publisher
  5. Wang W, Green M, Choi J, Gijon M, Kennedy P, Johnson J, et al. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270-274 pubmed publisher
  6. Zeltzer S, Zeltzer C, Igarashi S, Wilson J, Donaldson J, Goodrum F. Virus Control of Trafficking from Sorting Endosomes. MBio. 2018;9: pubmed publisher
  7. Xu L, Tong R, Li X, Liang L, Huang H. Effects of CASZI on bronchopulmonary development of neonatal rats. Exp Ther Med. 2017;14:6243-6246 pubmed publisher
  8. Jensen H, Potempa M, Gotthardt D, Lanier L. Cutting Edge: IL-2-Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells. J Immunol. 2017;199:1967-1972 pubmed publisher
  9. Johnson D, Wayt J, Wilson J, Donaldson J. Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking. J Cell Sci. 2017;130:2405-2415 pubmed publisher
  10. Kim S, Roy S, Chen B, Nguyen T, McMonigle R, McCracken A, et al. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest. 2016;126:4088-4102 pubmed publisher
  11. Kim M, Cho J. Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion. Korean J Physiol Pharmacol. 2016;20:515-23 pubmed publisher
  12. Cormerais Y, Giuliano S, Lefloch R, Front B, Durivault J, Tambutte E, et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016;76:4481-92 pubmed publisher
  13. Belov L, Matic K, Hallal S, Best O, Mulligan S, Christopherson R. Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples. J Extracell Vesicles. 2016;5:25355 pubmed publisher
  14. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  15. Bhat N, Adams C, Chen Y, Bieber M, Teng N. Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34-Encoded Natural IgM Antibodies. J Immunol. 2015;195:5178-88 pubmed publisher
  16. Wu B, Wang Y, Yang X, Xu B, Feng F, Wang B, et al. Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma. J Exp Clin Cancer Res. 2015;34:110 pubmed publisher
  17. Baradez M, Lekishvili T, Marshall D. Rapid phenotypic fingerprinting of cell products by robust measurement of ubiquitous surface markers. Cytometry A. 2015;87:624-35 pubmed publisher