This is a Validated Antibody Database (VAD) review about human CD244, based on 36 published articles (read how Labome selects the articles), using CD244 antibody in all methods. It is aimed to help Labome visitors find the most suited CD244 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CD244 synonym: 2B4; NAIL; NKR2B4; Nmrk; SLAMF4

BioLegend
mouse monoclonal (C1.7)
  • other; mouse
BioLegend CD244 antibody (BioLegend, C1.7) was used in other on mouse samples . Nat Commun (2020) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...
BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on human samples . elife (2020) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig s3
BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on human samples (fig s3). Eur J Immunol (2019) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig s2d
BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on human samples (fig s2d). J Infect Dis (2019) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig 1a
BioLegend CD244 antibody (Biolegend, 329502) was used in flow cytometry on human samples (fig 1a). Cell (2018) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human
BioLegend CD244 antibody (Biolegend, 329508) was used in flow cytometry on human samples . Leukemia (2019) ncbi
mouse monoclonal (C1.7)
  • mass cytometry; human; loading ...; fig 2a
In order to investigate the immune composition of tumor microenvironment in hepatocellular carcinoma, BioLegend CD244 antibody (BioLegend, CL7) was used in mass cytometry on human samples (fig 2a). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig 4h
In order to detail MAIT cell responses to various microorganisms and cytokines, BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on human samples (fig 4h). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig s8
BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on human samples (fig s8). Science (2016) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; fig 1
In order to test if CD4 positive T cells expressing immune checkpoint molecules are enriched in HIV-infected cells in patients receiving antiretroviral therapy, BioLegend CD244 antibody (Biolegend, 329515) was used in flow cytometry on human samples (fig 1). PLoS Pathog (2016) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig 1d
In order to study the effect of anti-SLAMF6 antibody and ibrutinib on chronic lymphocytic leukemia cells, BioLegend CD244 antibody (biolegend, C1.7) was used in flow cytometry on human samples (fig 1d). Oncotarget (2016) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; fig 1
BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on human samples (fig 1). J Hematol Oncol (2015) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; mouse; fig s1a
BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on mouse samples (fig s1a). J Infect Dis (2015) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; fig 2
BioLegend CD244 antibody (Biolegend, C1.7) was used in flow cytometry on human samples (fig 2). Eur J Immunol (2015) ncbi
mouse monoclonal (C1.7)
  • immunocytochemistry; human
BioLegend CD244 antibody (Biolegend, C1.7) was used in immunocytochemistry on human samples . Biochem Biophys Res Commun (2014) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human
In order to examine human differentiated effector CD4(+) T cells that are defined by low levels of IL-2 and IL-7 receptors, BioLegend CD244 antibody (BioLegend, C1.7) was used in flow cytometry on human samples . Cancer Res (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (CM2B4)
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 3b
Santa Cruz Biotechnology CD244 antibody (Santa, CM2B4) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 3b). Endocr Pathol (2020) ncbi
mouse monoclonal (CM2B4)
  • western blot; human; loading ...; fig 4d
Santa Cruz Biotechnology CD244 antibody (Santa Cruz Biotechnologies, Sc-136172) was used in western blot on human samples (fig 4d). Oncotarget (2018) ncbi
mouse monoclonal (CM2B4)
  • chromatin immunoprecipitation; human; fig 6
  • immunocytochemistry; human; 1:50; fig 9b
  • western blot; human; fig 2c
Santa Cruz Biotechnology CD244 antibody (Santa Cruz Biotechnology, sc-136172) was used in chromatin immunoprecipitation on human samples (fig 6), in immunocytochemistry on human samples at 1:50 (fig 9b) and in western blot on human samples (fig 2c). PLoS Pathog (2015) ncbi
mouse monoclonal (CM2B4)
Santa Cruz Biotechnology CD244 antibody (Santa Cruz, CM2B4) was used . Cancers (Basel) (2014) ncbi
mouse monoclonal (CM2B4)
  • immunohistochemistry - paraffin section; human; 1:100
In order to reoprt on a case of an unusual primary gastric Merkel cell carcinoma, Santa Cruz Biotechnology CD244 antibody (Santa Cruz Biotechnology, CM2B4) was used in immunohistochemistry - paraffin section on human samples at 1:100. Hum Pathol (2014) ncbi
Invitrogen
mouse monoclonal (eBioPP35 (PP35))
  • blocking or activating experiments; human; loading ...; fig 5
Invitrogen CD244 antibody (eBiosciences, eBioPP35) was used in blocking or activating experiments on human samples (fig 5). J Exp Med (2017) ncbi
mouse monoclonal (eBioC1.7 (C1.7))
  • flow cytometry; human; fig 2
In order to utilize flow cytometry to analyze intracellular Ca(2+) mobilization in human NK cell subsets, Invitrogen CD244 antibody (eBioscience, C1.7) was used in flow cytometry on human samples (fig 2). Methods Mol Biol (2016) ncbi
mouse monoclonal (eBioDM244)
  • flow cytometry; human
Invitrogen CD244 antibody (eBioscience, eBioDM244) was used in flow cytometry on human samples . Clin Cancer Res (2014) ncbi
Miltenyi Biotec
human monoclonal (REA112)
  • flow cytometry; human; loading ...; fig 3c
In order to examine the potential of IL-2 to enhance T regulatory cell therapy, Miltenyi Biotec CD244 antibody (Miltenyi Biotec, REA112) was used in flow cytometry on human samples (fig 3c). Clin Exp Immunol (2017) ncbi
Beckman Coulter
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig 3c
Beckman Coulter CD244 antibody (Beckman Coulter, C1.7.1) was used in flow cytometry on human samples (fig 3c). Immun Ageing (2017) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human; loading ...; fig 3a
In order to show T cell immunoglobulin and ITIM domain expression increases over time despite early initiation of antiretroviral treatment, Beckman Coulter CD244 antibody (Beckman Coulter, C1.7) was used in flow cytometry on human samples (fig 3a). Sci Rep (2017) ncbi
mouse monoclonal (C1.7)
  • blocking or activating experiments; human; loading ...; fig s14b
  • flow cytometry; human
In order to investigate NF-KB signaling in natural killer cells, Beckman Coulter CD244 antibody (Beckman Coulter, C1.7) was used in blocking or activating experiments on human samples (fig s14b) and in flow cytometry on human samples . Nat Commun (2016) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human
In order to determine if HIV elite controllers have exhausted T cells, Beckman Coulter CD244 antibody (Beckman Coulter, C1.7) was used in flow cytometry on human samples . J Infect Dis (2015) ncbi
mouse monoclonal (C1.7)
  • blocking or activating experiments; human
Beckman Coulter CD244 antibody (Beckman Coulter, C1.7) was used in blocking or activating experiments on human samples . EMBO J (2014) ncbi
mouse monoclonal (C1.7)
  • blocking or activating experiments; human
Beckman Coulter CD244 antibody (Immunotech, C1.7) was used in blocking or activating experiments on human samples . PLoS ONE (2014) ncbi
mouse monoclonal (C1.7)
  • flow cytometry; human
In order to study NK function in solid tumors, Beckman Coulter CD244 antibody (Immunotech, C1.7) was used in flow cytometry on human samples . Int J Cancer (2014) ncbi
BD Biosciences
mouse monoclonal (2-69)
  • flow cytometry; human; loading ...; fig 2
BD Biosciences CD244 antibody (BD, 2-69) was used in flow cytometry on human samples (fig 2). Biol Blood Marrow Transplant (2018) ncbi
mouse monoclonal (2-69)
  • flow cytometry; human; loading ...; fig 1e
BD Biosciences CD244 antibody (BD Biosciences, 2-69) was used in flow cytometry on human samples (fig 1e). J Immunol (2016) ncbi
mouse monoclonal (2-69)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences CD244 antibody (BD, 550816) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (2-69)
  • flow cytometry; human; fig 1b
BD Biosciences CD244 antibody (BD Biosciences, 2-69) was used in flow cytometry on human samples (fig 1b). Proc Natl Acad Sci U S A (2015) ncbi
Articles Reviewed
  1. Tseng H, Xiong W, Badeti S, Yang Y, Ma M, Liu T, et al. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11:4810 pubmed publisher
  2. Hood S, Cosma G, Foulds G, Johnson C, Reeder S, McArdle S, et al. Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data. elife. 2020;9: pubmed publisher
  3. La Rosa S, Bonzini M, Sciarra A, Asioli S, Maragliano R, Arrigo M, et al. Exploring the Prognostic Role of Ki67 Proliferative Index in Merkel Cell Carcinoma of the Skin: Clinico-Pathologic Analysis of 84 Cases and Review of the Literature. Endocr Pathol. 2020;31:392-400 pubmed publisher
  4. Remmerswaal E, Hombrink P, Nota B, Pircher H, ten Berge I, van Lier R, et al. Expression of IL-7Rα and KLRG1 defines functionally distinct CD8+ T-cell populations in humans. Eur J Immunol. 2019;49:694-708 pubmed publisher
  5. van Erp E, Feyaerts D, Duijst M, Mulder H, Wicht O, Luytjes W, et al. Respiratory Syncytial Virus Infects Primary Neonatal and Adult Natural Killer Cells and Affects Their Antiviral Effector Function. J Infect Dis. 2019;219:723-733 pubmed publisher
  6. Olin A, Henckel E, Chen Y, Lakshmikanth T, Pou C, Mikes J, et al. Stereotypic Immune System Development in Newborn Children. Cell. 2018;174:1277-1292.e14 pubmed publisher
  7. Rasheed K, Abdulsalam I, Fismen S, Grimstad Ø, Sveinbjørnsson B, Moens U. CCL17/TARC and CCR4 expression in Merkel cell carcinoma. Oncotarget. 2018;9:31432-31447 pubmed publisher
  8. Haubner S, Perna F, Köhnke T, Schmidt C, Berman S, Augsberger C, et al. Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML. Leukemia. 2019;33:64-74 pubmed publisher
  9. Hutten T, Norde W, Woestenenk R, Wang R, Maas F, Kester M, et al. Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018;24:666-677 pubmed publisher
  10. Chew V, Lai L, Pan L, Lim C, Li J, Ong R, et al. Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses. Proc Natl Acad Sci U S A. 2017;114:E5900-E5909 pubmed publisher
  11. Dias J, Leeansyah E, Sandberg J. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines. Proc Natl Acad Sci U S A. 2017;114:E5434-E5443 pubmed publisher
  12. Djaoud Z, Guethlein L, Horowitz A, Azzi T, Nemat Gorgani N, Olive D, et al. Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and ?? T cells. J Exp Med. 2017;214:1827-1841 pubmed publisher
  13. van der Geest K, Wang Q, Eijsvogels T, Koenen H, Joosten I, Brouwer E, et al. Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study. Immun Ageing. 2017;14:5 pubmed publisher
  14. Jeffery H, Jeffery L, Lutz P, Corrigan M, Webb G, Hirschfield G, et al. Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases. Clin Exp Immunol. 2017;188:394-411 pubmed publisher
  15. Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sonnerborg A, et al. Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep. 2017;7:40354 pubmed publisher
  16. Sen D, Kaminski J, Barnitz R, Kurachi M, Gerdemann U, Yates K, et al. The epigenetic landscape of T cell exhaustion. Science. 2016;354:1165-1169 pubmed
  17. Fromentin R, Bakeman W, Lawani M, Khoury G, Hartogensis W, DaFonseca S, et al. CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART. PLoS Pathog. 2016;12:e1005761 pubmed publisher
  18. Loyon R, Picard E, Mauvais O, Queiroz L, Mougey V, Pallandre J, et al. IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner. J Immunol. 2016;197:85-96 pubmed publisher
  19. Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed publisher
  20. Theorell J, Bryceson Y. Analysis of Intracellular Ca(2+) Mobilization in Human NK Cell Subsets by Flow Cytometry. Methods Mol Biol. 2016;1441:117-30 pubmed publisher
  21. Yigit B, Halibozek P, Chen S, O Keeffe M, Arnason J, Avigan D, et al. A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells. Oncotarget. 2016;7:26346-60 pubmed publisher
  22. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  23. Schnorfeil F, Lichtenegger F, Emmerig K, Schlueter M, Neitz J, Draenert R, et al. T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment. J Hematol Oncol. 2015;8:93 pubmed publisher
  24. Theiss J, Gunther T, Alawi M, Neumann F, Tessmer U, Fischer N, et al. A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence. PLoS Pathog. 2015;11:e1004974 pubmed publisher
  25. Wang Y, Zhong H, Xie X, Chen C, Huang D, Shen L, et al. Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection. Proc Natl Acad Sci U S A. 2015;112:E3883-92 pubmed publisher
  26. Pombo C, Wherry E, Gostick E, Price D, Betts M. Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers. J Infect Dis. 2015;212:1376-86 pubmed publisher
  27. Chijioke O, Marcenaro E, Moretta A, Capaul R, Münz C. Role of the 2B4 Receptor in CD8+ T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components. J Infect Dis. 2015;212:803-7 pubmed publisher
  28. Gütgemann S, Sandusky M, Wingert S, Claus M, Watzl C. Recruitment of activating NK-cell receptors 2B4 and NKG2D to membrane microdomains in mammalian cells is dependent on their transmembrane regions. Eur J Immunol. 2015;45:1258-69 pubmed publisher
  29. Chibueze C, Yoshimitsu M, Arima N. CD160 expression defines a uniquely exhausted subset of T lymphocytes in HTLV-1 infection. Biochem Biophys Res Commun. 2014;453:379-84 pubmed publisher
  30. Ohue Y, Kurose K, Mizote Y, Matsumoto H, Nishio Y, Isobe M, et al. Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody. Clin Cancer Res. 2014;20:5052-63 pubmed publisher
  31. Diaz J, Wang X, Tsang S, Jiao J, You J. Phosphorylation of large T antigen regulates merkel cell polyomavirus replication. Cancers (Basel). 2014;6:1464-86 pubmed publisher
  32. Celis Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, et al. Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J. 2014;33:1928-40 pubmed publisher
  33. Awad A, Yassine H, Barrier M, Vorng H, Marquillies P, Tsicopoulos A, et al. Natural killer cells induce eosinophil activation and apoptosis. PLoS ONE. 2014;9:e94492 pubmed publisher
  34. Capella C, Marando A, Longhi E, Bernasconi B, Finzi G, Parravicini C, et al. Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma. Hum Pathol. 2014;45:1310-4 pubmed publisher
  35. Prinz P, Mendler A, Brech D, Masouris I, Oberneder R, Noessner E. NK-cell dysfunction in human renal carcinoma reveals diacylglycerol kinase as key regulator and target for therapeutic intervention. Int J Cancer. 2014;135:1832-41 pubmed publisher
  36. Peguillet I, Milder M, Louis D, Vincent Salomon A, Dorval T, Piperno Neumann S, et al. High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer. Cancer Res. 2014;74:2204-16 pubmed publisher