This is a Validated Antibody Database (VAD) review about human CD226, based on 19 published articles (read how Labome selects the articles), using CD226 antibody in all methods. It is aimed to help Labome visitors find the most suited CD226 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CD226 synonym: DNAM-1; DNAM1; PTA1; TLiSA1

BioLegend
mouse monoclonal (11A8)
  • flow cytometry; human; loading ...; fig s2
BioLegend CD226 antibody (BioLegend, 338312) was used in flow cytometry on human samples (fig s2). BMC Cancer (2019) ncbi
mouse monoclonal (11A8)
  • flow cytometry; human; loading ...; fig 2a
BioLegend CD226 antibody (Biolegend, 11A8) was used in flow cytometry on human samples (fig 2a). Front Immunol (2019) ncbi
mouse monoclonal (11A8)
  • flow cytometry; human; loading ...; fig s5a
In order to detail MAIT cell responses to various microorganisms and cytokines, BioLegend CD226 antibody (BioLegend, 11A8) was used in flow cytometry on human samples (fig s5a). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (11A8)
  • flow cytometry; human; fig 7
In order to study the functions of WASp knock out natural killer cells, BioLegend CD226 antibody (Biolegend, 338304) was used in flow cytometry on human samples (fig 7). Sci Rep (2016) ncbi
Bio-Rad
mouse monoclonal (DX11)
  • blocking or activating experiments; human; fig 2
Bio-Rad CD226 antibody (Serotec, DX11) was used in blocking or activating experiments on human samples (fig 2). BMC Cancer (2015) ncbi
BD Biosciences
mouse monoclonal (DX11)
  • flow cytometry; human; loading ...; fig 5a
BD Biosciences CD226 antibody (BD Pharmingen, DX11) was used in flow cytometry on human samples (fig 5a). Front Immunol (2019) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; loading ...; fig 3b
In order to evaluate the effectiveness of adoptive natural killer cell therapy against the pulmonary metastasis of Ewing sarcoma, BD Biosciences CD226 antibody (BD Pharmingen, DX11) was used in flow cytometry on human samples (fig 3b). Oncoimmunology (2017) ncbi
mouse monoclonal (DX11)
  • blocking or activating experiments; human; loading ...; fig 5
BD Biosciences CD226 antibody (BD Biosciences, DX11) was used in blocking or activating experiments on human samples (fig 5). J Exp Med (2017) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; loading ...
In order to show T cell immunoglobulin and ITIM domain expression increases over time despite early initiation of antiretroviral treatment, BD Biosciences CD226 antibody (BD Bioscience, DX11) was used in flow cytometry on human samples . Sci Rep (2017) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; fig 1a
In order to assess the effects of platelet-derived ectosomes on natural killer cells, BD Biosciences CD226 antibody (BD Biosciences, DX11) was used in flow cytometry on human samples (fig 1a). J Immunol (2016) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; loading ...; fig 5c
BD Biosciences CD226 antibody (BD Pharmingen, DX11) was used in flow cytometry on human samples (fig 5c). J Biol Chem (2016) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; loading ...; fig 1e
BD Biosciences CD226 antibody (BD Biosciences, DX11) was used in flow cytometry on human samples (fig 1e). J Immunol (2016) ncbi
mouse monoclonal (DX11)
  • blocking or activating experiments; human; loading ...; fig s9a
  • flow cytometry; human
In order to investigate NF-KB signaling in natural killer cells, BD Biosciences CD226 antibody (BD Biosciences, DX11) was used in blocking or activating experiments on human samples (fig s9a) and in flow cytometry on human samples . Nat Commun (2016) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; fig 2
In order to utilize flow cytometry to analyze intracellular Ca(2+) mobilization in human NK cell subsets, BD Biosciences CD226 antibody (BD Biosciences, DX11) was used in flow cytometry on human samples (fig 2). Methods Mol Biol (2016) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences CD226 antibody (BD, 559789) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; tbl 1
BD Biosciences CD226 antibody (BD Biosciences, DX11) was used in flow cytometry on human samples (tbl 1). Cancer Immunol Immunother (2015) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human; fig s1
BD Biosciences CD226 antibody (BD Biosciences, DX11) was used in flow cytometry on human samples (fig s1). J Immunol (2015) ncbi
mouse monoclonal (DX11)
  • flow cytometry; human
BD Biosciences CD226 antibody (BD, DX11) was used in flow cytometry on human samples . Eur J Immunol (2015) ncbi
mouse monoclonal (DX11)
  • western blot; human
BD Biosciences CD226 antibody (BD, DX11) was used in western blot on human samples . Clin Cancer Res (2014) ncbi
Articles Reviewed
  1. Choi J, Lee E, Kim S, Park S, Oh S, Kang J, et al. Cytotoxic effects of ex vivo-expanded natural killer cell-enriched lymphocytes (MYJ1633) against liver cancer. BMC Cancer. 2019;19:817 pubmed publisher
  2. Ingegnere T, Mariotti F, Pelosi A, Quintarelli C, De Angelis B, Tumino N, et al. Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing. Front Immunol. 2019;10:957 pubmed publisher
  3. Lim S, Kim J, Jeon S, Shin M, Kwon J, Kim T, et al. Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients. Front Immunol. 2019;10:496 pubmed publisher
  4. Dias J, Leeansyah E, Sandberg J. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines. Proc Natl Acad Sci U S A. 2017;114:E5434-E5443 pubmed publisher
  5. Tong A, Hashem H, Eid S, Allen F, Kingsley D, Huang A. Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma. Oncoimmunology. 2017;6:e1303586 pubmed publisher
  6. Djaoud Z, Guethlein L, Horowitz A, Azzi T, Nemat Gorgani N, Olive D, et al. Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and ?? T cells. J Exp Med. 2017;214:1827-1841 pubmed publisher
  7. Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sonnerborg A, et al. Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep. 2017;7:40354 pubmed publisher
  8. Kritikou J, Dahlberg C, Baptista M, Wagner A, Banerjee P, Gwalani L, et al. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016;6:30636 pubmed publisher
  9. Sadallah S, Schmied L, Eken C, Charoudeh H, Amicarella F, Schifferli J. Platelet-Derived Ectosomes Reduce NK Cell Function. J Immunol. 2016;197:1663-71 pubmed publisher
  10. Zanetti S, Ziblat A, Torres N, Zwirner N, Bouzat C. Expression and Functional Role of ?7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells. J Biol Chem. 2016;291:16541-52 pubmed publisher
  11. Loyon R, Picard E, Mauvais O, Queiroz L, Mougey V, Pallandre J, et al. IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner. J Immunol. 2016;197:85-96 pubmed publisher
  12. Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed publisher
  13. Theorell J, Bryceson Y. Analysis of Intracellular Ca(2+) Mobilization in Human NK Cell Subsets by Flow Cytometry. Methods Mol Biol. 2016;1441:117-30 pubmed publisher
  14. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  15. Boerman G, van Ostaijen Ten Dam M, Kraal K, Santos S, Ball L, Lankester A, et al. Role of NKG2D, DNAM-1 and natural cytotoxicity receptors in cytotoxicity toward rhabdomyosarcoma cell lines mediated by resting and IL-15-activated human natural killer cells. Cancer Immunol Immunother. 2015;64:573-83 pubmed publisher
  16. Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol. 2015;194:2467-71 pubmed publisher
  17. Fionda C, Abruzzese M, Zingoni A, Soriani A, Ricci B, Molfetta R, et al. Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation. BMC Cancer. 2015;15:17 pubmed publisher
  18. Ziblat A, Domaica C, Spallanzani R, Iraolagoitia X, Rossi L, Avila D, et al. IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness. Eur J Immunol. 2015;45:192-202 pubmed publisher
  19. Sullivan E, Jeha S, Kang G, Cheng C, Rooney B, Holladay M, et al. NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease. Clin Cancer Res. 2014;20:5986-94 pubmed publisher