This is a Validated Antibody Database (VAD) review about human CD147, based on 34 published articles (read how Labome selects the articles), using CD147 antibody in all methods. It is aimed to help Labome visitors find the most suited CD147 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CD147 synonym: 5F7; CD147; EMMPRIN; EMPRIN; OK; SLC7A11; TCSF

Santa Cruz Biotechnology
mouse monoclonal (8D6)
  • western blot; human; fig 2a
Santa Cruz Biotechnology CD147 antibody (Santa Cruz Biotechnology Inc, sc-21746) was used in western blot on human samples (fig 2a). Blood Cancer J (2019) ncbi
mouse monoclonal (F-5)
  • western blot; human; 1:300; loading ...; fig 2C
Santa Cruz Biotechnology CD147 antibody (Santa Cruz, sc-374101) was used in western blot on human samples at 1:300 (fig 2C). Oncol Lett (2017) ncbi
mouse monoclonal (8D6)
  • flow cytometry; human; fig 2
  • immunoprecipitation; human; fig 2
  • immunocytochemistry; human; fig 2
  • western blot; human; 1:200; fig 5
In order to study disruption of the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity due to immunomodulatory drugs, Santa Cruz Biotechnology CD147 antibody (Santa Cruz Biotechnology, sc-21746) was used in flow cytometry on human samples (fig 2), in immunoprecipitation on human samples (fig 2), in immunocytochemistry on human samples (fig 2) and in western blot on human samples at 1:200 (fig 5). Nat Med (2016) ncbi
mouse monoclonal (HIM6)
  • western blot; human; fig 1
Santa Cruz Biotechnology CD147 antibody (santa Cruz, sc-53693) was used in western blot on human samples (fig 1). J Extracell Vesicles (2016) ncbi
mouse monoclonal (1.BB.218)
  • immunohistochemistry - paraffin section; human; 1:400; fig 1
Santa Cruz Biotechnology CD147 antibody (santa Cruz, sc-71038) was used in immunohistochemistry - paraffin section on human samples at 1:400 (fig 1). Oncotarget (2015) ncbi
mouse monoclonal (1.BB.218)
  • immunohistochemistry - paraffin section; human; 1:400; fig 1c
Santa Cruz Biotechnology CD147 antibody (Santa Cruz Biotechnology, sc-71038) was used in immunohistochemistry - paraffin section on human samples at 1:400 (fig 1c). BMC Cancer (2015) ncbi
mouse monoclonal (F-5)
  • western blot; human; loading ...; fig 5a
In order to discover that CD147-CD98 is a major carrier of poly-N-acetyl-lactosamine on human pre-B cell line, Santa Cruz Biotechnology CD147 antibody (Santa Cruz, sc-374101) was used in western blot on human samples (fig 5a). J Immunol (2015) ncbi
mouse monoclonal (8D6)
  • immunoprecipitation; human; loading ...; fig 6a
In order to discover that CD147-CD98 is a major carrier of poly-N-acetyl-lactosamine on human pre-B cell line, Santa Cruz Biotechnology CD147 antibody (Santa Cruz, sc-21746) was used in immunoprecipitation on human samples (fig 6a). J Immunol (2015) ncbi
mouse monoclonal (1.BB.218)
  • immunocytochemistry; human; 1:200; fig 1
  • immunohistochemistry; human; 1:400; fig 5
  • western blot; human; 1:500; fig 1
Santa Cruz Biotechnology CD147 antibody (santa Cruz, sc-71038) was used in immunocytochemistry on human samples at 1:200 (fig 1), in immunohistochemistry on human samples at 1:400 (fig 5) and in western blot on human samples at 1:500 (fig 1). Oncotarget (2015) ncbi
mouse monoclonal (8D6)
  • immunohistochemistry; human; 1:100; fig 2
Santa Cruz Biotechnology CD147 antibody (Santa Cruz, sc-21746) was used in immunohistochemistry on human samples at 1:100 (fig 2). J Urol (2015) ncbi
mouse monoclonal (1.BB.218)
  • immunocytochemistry; human
Santa Cruz Biotechnology CD147 antibody (Santa Cruz, sc-71038) was used in immunocytochemistry on human samples . J Cell Mol Med (2015) ncbi
mouse monoclonal (1.BB.218)
  • immunohistochemistry - paraffin section; human; 1:400; fig 1
Santa Cruz Biotechnology CD147 antibody (Santa Cruz Biotechnology, sc-71038) was used in immunohistochemistry - paraffin section on human samples at 1:400 (fig 1). BMC Cancer (2014) ncbi
mouse monoclonal (1.BB.218)
  • western blot; human; 1:200; loading ...; fig 4a
Santa Cruz Biotechnology CD147 antibody (Santa Cruz, sc-71038) was used in western blot on human samples at 1:200 (fig 4a). Mol Carcinog (2015) ncbi
mouse monoclonal (F-5)
  • western blot; human
Santa Cruz Biotechnology CD147 antibody (Santa Cruz, sc-374101) was used in western blot on human samples . J Biomed Mater Res A (2015) ncbi
BioLegend
mouse monoclonal (HIM6)
  • immunohistochemistry; mouse; loading ...; fig s17b
BioLegend CD147 antibody (BioLegend, HIM6) was used in immunohistochemistry on mouse samples (fig s17b). Nat Commun (2020) ncbi
mouse monoclonal (HIM6)
  • immunocytochemistry; human; 1:50; loading ...; fig 1c
BioLegend CD147 antibody (BioLegend, HIM6) was used in immunocytochemistry on human samples at 1:50 (fig 1c). MBio (2018) ncbi
mouse monoclonal (HIM6)
  • flow cytometry; human; fig 5
In order to determine the differential regulation of the inflammatory phenotype of brain microvascular endothelial cells by pro-inflammatory TNFalpha and IL-1beta, BioLegend CD147 antibody (Biolegend, 306209) was used in flow cytometry on human samples (fig 5). J Neuroinflammation (2015) ncbi
mouse monoclonal (HIM6)
  • immunocytochemistry; human; 1:200; fig 6c
In order to analyze proliferation and homing of multiple myeloma cells promoted by the cyclophilin A-CD147 complex, BioLegend CD147 antibody (Biolegend, HIM6) was used in immunocytochemistry on human samples at 1:200 (fig 6c). Nat Med (2015) ncbi
mouse monoclonal (HIM6)
  • immunocytochemistry; human
BioLegend CD147 antibody (BioLegend, HIM6) was used in immunocytochemistry on human samples . J Biol Chem (2015) ncbi
mouse monoclonal (HIM6)
  • flow cytometry; human; fig s4
BioLegend CD147 antibody (BioLegend, 306207) was used in flow cytometry on human samples (fig s4). J Mol Cell Biol (2015) ncbi
mouse monoclonal (HIM6)
  • immunocytochemistry; human; 1:1000; loading ...; fig 2A
BioLegend CD147 antibody (BioLegend, H1M6) was used in immunocytochemistry on human samples at 1:1000 (fig 2A). Mol Hum Reprod (2015) ncbi
Invitrogen
mouse monoclonal (MEM-M6/6)
  • blocking or activating experiments; human; loading ...; fig 6d
Invitrogen CD147 antibody (Invitrogen, MEM6/6) was used in blocking or activating experiments on human samples (fig 6d). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (8D12)
  • flow cytometry; human; fig 6a
In order to investigate the protective effect of single domain camelid antibodies against botulinum neurotoxin, Invitrogen CD147 antibody (Affymetrix, 12-1472-42) was used in flow cytometry on human samples (fig 6a). Nat Commun (2017) ncbi
mouse monoclonal (8D12)
  • immunocytochemistry; human; loading ...; fig 3a
In order to explore targeting NKA as a means to treat cancer, Invitrogen CD147 antibody (eBiosciences, 8D12) was used in immunocytochemistry on human samples (fig 3a). Mol Ther (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:2000; fig 1
In order to analyze the induction of the phosphorylation of EGFR and downregulation of cdc25C and MEK phosphorylation by CD147-targeted siRNA in A375 malignant melanoma cells, Invitrogen CD147 antibody (Invitrogen, 34-5600) was used in western blot on human samples at 1:2000 (fig 1). Oncol Lett (2016) ncbi
mouse monoclonal (8D12)
  • flow cytometry; human; 1:100; fig s10a
In order to analyze proliferation and homing of multiple myeloma cells promoted by the cyclophilin A-CD147 complex, Invitrogen CD147 antibody (eBioscience, 8D12) was used in flow cytometry on human samples at 1:100 (fig s10a). Nat Med (2015) ncbi
mouse monoclonal (8D12)
  • flow cytometry; human; loading ...; fig s4b
In order to describe methods to efficiently 'knock-in' multi-kilobase genes in human induced pluripotent stem cells, Invitrogen CD147 antibody (eBioscience, 8D12) was used in flow cytometry on human samples (fig s4b). Nucleic Acids Res (2015) ncbi
Abcam
domestic rabbit polyclonal
  • western blot; human; loading ...; fig e3c
Abcam CD147 antibody (Abcam, ab64616) was used in western blot on human samples (fig e3c). Nature (2020) ncbi
mouse monoclonal (MEM-M6/1)
  • immunohistochemistry - paraffin section; human; loading ...; fig 3
In order to explore the synovial protein targets of peptidylarginine deiminases, Abcam CD147 antibody (Abcam, ab666) was used in immunohistochemistry - paraffin section on human samples (fig 3). Eur J Rheumatol (2016) ncbi
mouse monoclonal (MEM-M6/1)
  • immunohistochemistry - frozen section; human; fig 2
  • immunohistochemistry - paraffin section; human; fig 5
In order to test if hepatocytes produce MMPs, regulated by CD147, that remodel fibrotic extracellular matrix independent of HSC, Abcam CD147 antibody (Abcam, MEM-M6/1) was used in immunohistochemistry - frozen section on human samples (fig 2) and in immunohistochemistry - paraffin section on human samples (fig 5). PLoS ONE (2014) ncbi
LifeSpan Biosciences
mouse monoclonal
  • immunohistochemistry; human; 1:500; fig 2
LifeSpan Biosciences CD147 antibody (LS Biosciences, LS-B3163) was used in immunohistochemistry on human samples at 1:500 (fig 2). Leukemia (2016) ncbi
mouse monoclonal (MEM-M6/1)
  • immunohistochemistry; human; 1:300; fig 5f
In order to analyze proliferation and homing of multiple myeloma cells promoted by the cyclophilin A-CD147 complex, LifeSpan Biosciences CD147 antibody (LifeSpan BioSciences, MEM-M6-1) was used in immunohistochemistry on human samples at 1:300 (fig 5f). Nat Med (2015) ncbi
R&D Systems
mouse monoclonal (TRA-1-85)
  • flow cytometry; human
In order to generate and assess primary pancreatic adenocarcinoma cell lines for colony forming capacity, tumourigenicity, expression of known cancer cell surface markers and cancer stem-like characteristics, R&D Systems CD147 antibody (R&D, clone TRA-1-85) was used in flow cytometry on human samples . PLoS ONE (2014) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (E1S1V)
  • western blot; human; 1:1000; fig 5c
In order to analyze proliferation and homing of multiple myeloma cells promoted by the cyclophilin A-CD147 complex, Cell Signaling Technology CD147 antibody (Cell Signaling Technology, 13287) was used in western blot on human samples at 1:1000 (fig 5c). Nat Med (2015) ncbi
BD Biosciences
mouse monoclonal (HIM6)
  • western blot; human; loading ...; fig 4f
BD Biosciences CD147 antibody (BD, 555961) was used in western blot on human samples (fig 4f). Oncogene (2018) ncbi
mouse monoclonal (HIM6)
  • flow cytometry; human; loading ...; fig 3e
  • immunoprecipitation; human; loading ...; fig 3a
  • immunocytochemistry; human; loading ...; fig 3c
  • western blot; human; loading ...; fig 2a
BD Biosciences CD147 antibody (BD Biosciences, 555962) was used in flow cytometry on human samples (fig 3e), in immunoprecipitation on human samples (fig 3a), in immunocytochemistry on human samples (fig 3c) and in western blot on human samples (fig 2a). Exp Cell Res (2017) ncbi
mouse monoclonal (HIM6)
  • flow cytometry; human; fig s9
In order to study disruption of the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity due to immunomodulatory drugs, BD Biosciences CD147 antibody (BD Pharmingen, HIM6) was used in flow cytometry on human samples (fig s9). Nat Med (2016) ncbi
mouse monoclonal (HIM6)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences CD147 antibody (BD, 555962) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (HIM6)
  • proximity ligation assay; human; 1:250; fig 8
  • western blot; human; fig 5
BD Biosciences CD147 antibody (BD-Pharmingen, 555961) was used in proximity ligation assay on human samples at 1:250 (fig 8) and in western blot on human samples (fig 5). Oncotarget (2015) ncbi
Articles Reviewed
  1. Tseng H, Xiong W, Badeti S, Yang Y, Ma M, Liu T, et al. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11:4810 pubmed publisher
  2. Tasdogan A, Faubert B, Ramesh V, Ubellacker J, Shen B, Solmonson A, et al. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature. 2020;577:115-120 pubmed publisher
  3. Zhu Y, Shi C, Bruins L, Wang X, Riggs D, Porter B, et al. Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4. Blood Cancer J. 2019;9:19 pubmed publisher
  4. Zeltzer S, Zeltzer C, Igarashi S, Wilson J, Donaldson J, Goodrum F. Virus Control of Trafficking from Sorting Endosomes. MBio. 2018;9: pubmed publisher
  5. Dai L, Del Valle L, Miley W, Whitby D, Ochoa A, Flemington E, et al. Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene. 2018;37:4534-4545 pubmed publisher
  6. Kanjee U, Grüring C, Chaand M, Lin K, Egan E, Manzo J, et al. CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. Proc Natl Acad Sci U S A. 2017;114:E9356-E9365 pubmed publisher
  7. Huang N, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, et al. Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Nat Commun. 2017;8:423 pubmed publisher
  8. Zhou Y, Wu B, Li J, Nan G, Jiang J, Chen Z. Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion. Exp Cell Res. 2017;357:9-16 pubmed publisher
  9. Yang S, Qi F, Tang C, Wang H, Qin H, Li X, et al. CD147 promotes the proliferation, invasiveness, migration and angiogenesis of human lung carcinoma cells. Oncol Lett. 2017;13:898-904 pubmed publisher
  10. Badillo Soto M, Rodríguez Rodríguez M, Pérez Pérez M, Daza Benítez L, Bollain Y Goytia J, Carrillo Jiménez M, et al. Potential protein targets of the peptidylarginine deiminase 2 and peptidylarginine deiminase 4 enzymes in rheumatoid synovial tissue and its possible meaning. Eur J Rheumatol. 2016;3:44-49 pubmed
  11. Marshall D, Harried S, Murphy J, Hall C, Shekhani M, Pain C, et al. Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins. Mol Ther. 2016;24:1760-1770 pubmed publisher
  12. Eichner R, Heider M, Fernández Sáiz V, van Bebber F, Garz A, Lemeer S, et al. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Nat Med. 2016;22:735-43 pubmed publisher
  13. Hatanaka M, Higashi Y, Kawai K, Su J, Zeng W, Chen X, et al. CD147-targeted siRNA in A375 malignant melanoma cells induces the phosphorylation of EGFR and downregulates cdc25C and MEK phosphorylation. Oncol Lett. 2016;11:2424-2428 pubmed
  14. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  15. Ronquist K, Sanchez C, Dubois L, Chioureas D, Fonseca P, Larsson A, et al. Energy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells. J Extracell Vesicles. 2016;5:29877 pubmed publisher
  16. Pinheiro C, Granja S, Longatto Filho A, Faria A, Fragoso M, Lovisolo S, et al. Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors. Oncotarget. 2015;6:44403-21 pubmed publisher
  17. Pinheiro C, Garcia E, Morais Santos F, Moreira M, Almeida F, Jubé L, et al. Reprogramming energy metabolism and inducing angiogenesis: co-expression of monocarboxylate transporters with VEGF family members in cervical adenocarcinomas. BMC Cancer. 2015;15:835 pubmed publisher
  18. Bhat N, Adams C, Chen Y, Bieber M, Teng N. Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34-Encoded Natural IgM Antibodies. J Immunol. 2015;195:5178-88 pubmed publisher
  19. Morais Santos F, Granja S, Miranda Gonçalves V, Moreira A, Queirós S, Vilaça J, et al. Targeting lactate transport suppresses in vivo breast tumour growth. Oncotarget. 2015;6:19177-89 pubmed
  20. Panchabhai S, Kelemen K, Ahmann G, Sebastian S, Mantei J, Fonseca R. Tumor-associated macrophages and extracellular matrix metalloproteinase inducer in prognosis of multiple myeloma. Leukemia. 2016;30:951-4 pubmed publisher
  21. O Carroll S, Kho D, Wiltshire R, Nelson V, Rotimi O, Johnson R, et al. Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. J Neuroinflammation. 2015;12:131 pubmed publisher
  22. Hemdan T, Malmström P, Jahnson S, Segersten U. Emmprin Expression Predicts Response and Survival following Cisplatin Containing Chemotherapy for Bladder Cancer: A Validation Study. J Urol. 2015;194:1575-81 pubmed publisher
  23. Zhu D, Wang Z, Zhao J, Calimeri T, Meng J, Hideshima T, et al. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med. 2015;21:572-80 pubmed publisher
  24. Naito T, Takatsu H, Miyano R, Takada N, Nakayama K, Shin H. Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics. J Biol Chem. 2015;290:15004-17 pubmed publisher
  25. Khayati F, Pérez Cano L, Maouche K, Sadoux A, Boutalbi Z, Podgorniak M, et al. EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF. Oncotarget. 2015;6:9766-80 pubmed
  26. Valença I, Pértega Gomes N, Vizcaino J, Henrique R, Lopes C, Baltazar F, et al. Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. J Cell Mol Med. 2015;19:723-33 pubmed publisher
  27. Menck K, Scharf C, Bleckmann A, Dyck L, Rost U, Wenzel D, et al. Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN. J Mol Cell Biol. 2015;7:143-53 pubmed publisher
  28. Byrne S, Ortiz L, Mali P, Aach J, Church G. Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells. Nucleic Acids Res. 2015;43:e21 pubmed publisher
  29. Pinheiro C, Garcia E, Morais Santos F, Scapulatempo Neto C, Mafra A, Steenbergen R, et al. Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix. BMC Cancer. 2014;14:751 pubmed publisher
  30. Afonso J, Santos L, Miranda Gonçalves V, Morais A, Amaro T, Longatto Filho A, et al. CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance. Mol Carcinog. 2015;54:1451-66 pubmed publisher
  31. Singh H, Aplin J. Endometrial apical glycoproteomic analysis reveals roles for cadherin 6, desmoglein-2 and plexin b2 in epithelial integrity. Mol Hum Reprod. 2015;21:81-94 pubmed publisher
  32. Wennerström A, Lothe I, Sandhu V, Kure E, Myklebost O, Munthe E. Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines. PLoS ONE. 2014;9:e103873 pubmed publisher
  33. Calabro S, Maczurek A, Morgan A, Tu T, Wen V, Yee C, et al. Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis. PLoS ONE. 2014;9:e90571 pubmed publisher
  34. McNally A, Anderson J. Phenotypic expression in human monocyte-derived interleukin-4-induced foreign body giant cells and macrophages in vitro: dependence on material surface properties. J Biomed Mater Res A. 2015;103:1380-90 pubmed publisher