This is a Validated Antibody Database (VAD) review about human CCR4, based on 28 published articles (read how Labome selects the articles), using CCR4 antibody in all methods. It is aimed to help Labome visitors find the most suited CCR4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CCR4 synonym: CC-CKR-4; CD194; CKR4; CMKBR4; ChemR13; HGCN:14099; K5-5

BioLegend
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...
BioLegend CCR4 antibody (BioLegend, 359420) was used in flow cytometry on human samples . Cell (2021) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig s1
BioLegend CCR4 antibody (BioLegend, L291H4) was used in flow cytometry on human samples (fig s1). elife (2020) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig 4e-4f
BioLegend CCR4 antibody (BioLegend, 359404) was used in flow cytometry on human samples (fig 4e-4f). elife (2020) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; mouse; loading ...; fig s2u
BioLegend CCR4 antibody (BioLegend, L291H4) was used in flow cytometry on mouse samples (fig s2u). Cell (2020) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; 1:100; loading ...; fig 2b
BioLegend CCR4 antibody (Biolegend, 359408) was used in flow cytometry on human samples at 1:100 (fig 2b). elife (2020) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig s20
BioLegend CCR4 antibody (Biolegend, 359411) was used in flow cytometry on human samples (fig s20). Science (2019) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig s3
BioLegend CCR4 antibody (BioLegend, L291H4) was used in flow cytometry on human samples (fig s3). Eur J Immunol (2019) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig s2f
BioLegend CCR4 antibody (BioLegend, 359406) was used in flow cytometry on human samples (fig s2f). Cell (2019) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig s1
In order to evaluate the effectiveness of adoptive natural killer cell therapy against the pulmonary metastasis of Ewing sarcoma, BioLegend CCR4 antibody (BioLegend, L291H4) was used in flow cytometry on human samples (fig s1). Oncoimmunology (2017) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig 2f
In order to observe that the use of chimeric antigen receptor technology is a clinically applicable refinement of regulatory T cell therapy for organ transplantation, BioLegend CCR4 antibody (BioLegend, L291H4) was used in flow cytometry on human samples (fig 2f). Am J Transplant (2017) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig 3a
BioLegend CCR4 antibody (Biolegend, L291H4) was used in flow cytometry on human samples (fig 3a). PLoS ONE (2016) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human; loading ...; fig 4a
In order to characterize innate lymphoid cell subpopulations isolated from patients with systemic sclerosis, BioLegend CCR4 antibody (biolegend, L291H4) was used in flow cytometry on human samples (fig 4a). J Immunol (2016) ncbi
mouse monoclonal (L291H4)
  • flow cytometry; human
BioLegend CCR4 antibody (Biolegend, L291H4) was used in flow cytometry on human samples . Mol Oncol (2015) ncbi
Abcam
domestic goat polyclonal
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig s1a
  • flow cytometry; human; loading ...; fig s2
In order to assess the use of anti-CCR4 antibody in a mouse model of renal cell carcinoma, Abcam CCR4 antibody (Abcam, ab1669) was used in immunohistochemistry - paraffin section on human samples at 1:300 (fig s1a) and in flow cytometry on human samples (fig s2). J Clin Invest (2017) ncbi
BD Biosciences
mouse monoclonal (1G1)
  • flow cytometry; human; loading ...; fig 2c
BD Biosciences CCR4 antibody (BD Biosciences, 561110) was used in flow cytometry on human samples (fig 2c). Blood Cancer J (2022) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; loading ...; fig 1
BD Biosciences CCR4 antibody (BD, 1G1) was used in flow cytometry on human samples (fig 1). Arthritis Res Ther (2021) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; fig 7b
BD Biosciences CCR4 antibody (BD Pharmingen, 1G1) was used in flow cytometry on human samples (fig 7b). elife (2017) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; fig 1
BD Biosciences CCR4 antibody (BD Biosciences, 551120) was used in flow cytometry on human samples (fig 1). J Cell Physiol (2017) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; fig 4
In order to investigate lactam-specific T-cell response in the skin and blood of humans, BD Biosciences CCR4 antibody (BD Biosciences, 1G1) was used in flow cytometry on human samples (fig 4). J Allergy Clin Immunol (2018) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; loading ...
In order to establish the T Cell receptor-inducible costimulator as a promising target for direct T regulatory cell-targeting therapeutic agents for gastric cancer, BD Biosciences CCR4 antibody (BD Biosciences, 1G1) was used in flow cytometry on human samples . Int J Cancer (2017) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; loading ...; fig 5d
BD Biosciences CCR4 antibody (BD Biosciences, 1G1) was used in flow cytometry on human samples (fig 5d). J Immunol (2016) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; loading ...; fig 3
In order to demonstrate that effector T-cell accumulation and TCR repertoire diversity reduction precede the development of foot ulcers in diabetic patients, BD Biosciences CCR4 antibody (Pharmingen, 1G1) was used in flow cytometry on human samples (fig 3). Cell Mol Immunol (2017) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; fig 3a
In order to analyze HIV progression traits of a selective loss of early differentiated and highly functional PD1high CD4 T cells, BD Biosciences CCR4 antibody (BD Biosciences, 1G1) was used in flow cytometry on human samples (fig 3a). PLoS ONE (2015) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; fig 1
BD Biosciences CCR4 antibody (BD Biosciences, 1G1) was used in flow cytometry on human samples (fig 1). Retrovirology (2015) ncbi
mouse monoclonal (1G1)
  • flow cytometry; mouse; 1:1000
BD Biosciences CCR4 antibody (BD Bioscience, 1G1) was used in flow cytometry on mouse samples at 1:1000. J Endod (2016) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human
BD Biosciences CCR4 antibody (BD Biosciences, 1G1) was used in flow cytometry on human samples . PLoS ONE (2014) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human
BD Biosciences CCR4 antibody (BD Biosciences, 1G1) was used in flow cytometry on human samples . J Immunol (2014) ncbi
mouse monoclonal (1G1)
  • flow cytometry; human; fig 1
In order to investigate the impact of CCR6(+)CXCR3(+)CCR4(-) cells in latent tuberculosis infection, BD Biosciences CCR4 antibody (BD Bioscience, 1G1) was used in flow cytometry on human samples (fig 1). J Immunol (2014) ncbi
Articles Reviewed
  1. Geng X, Wang C, Gao X, Chowdhury P, Weiss J, Villegas J, et al. GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms. Blood Cancer J. 2022;12:149 pubmed publisher
  2. Rosshirt N, Trauth R, Platzer H, Tripel E, Nees T, Lorenz H, et al. Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis. Arthritis Res Ther. 2021;23:37 pubmed publisher
  3. Rodda L, Netland J, Shehata L, Pruner K, Morawski P, Thouvenel C, et al. Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell. 2021;184:169-183.e17 pubmed publisher
  4. Kasatskaya S, Ladell K, Egorov E, Miners K, Davydov A, Metsger M, et al. Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs. elife. 2020;9: pubmed publisher
  5. Bhattacharya P, Ellegård R, Khalid M, Svanberg C, Govender M, Keita A, et al. Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells. elife. 2020;9: pubmed publisher
  6. Pasciuto E, Burton O, Roca C, Lagou V, Rajan W, Theys T, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020;182:625-640.e24 pubmed publisher
  7. Bennstein S, Weinhold S, Manser A, Scherenschlich N, Noll A, Raba K, et al. Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR+NKG2A- NK cells. elife. 2020;9: pubmed publisher
  8. Uhlen M, Karlsson M, Zhong W, Tebani A, Pou C, Mikes J, et al. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells. Science. 2019;366: pubmed publisher
  9. Remmerswaal E, Hombrink P, Nota B, Pircher H, ten Berge I, van Lier R, et al. Expression of IL-7Rα and KLRG1 defines functionally distinct CD8+ T-cell populations in humans. Eur J Immunol. 2019;49:694-708 pubmed publisher
  10. Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango M, Kaufmann S, et al. Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. Cell. 2019;: pubmed publisher
  11. Lepore M, Kalinichenko A, Calogero S, Kumar P, Paleja B, Schmaler M, et al. Functionally diverse human T cells recognize non-microbial antigens presented by MR1. elife. 2017;6: pubmed publisher
  12. Tong A, Hashem H, Eid S, Allen F, Kingsley D, Huang A. Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma. Oncoimmunology. 2017;6:e1303586 pubmed publisher
  13. Buskermolen J, Roffel S, Gibbs S. Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets. J Cell Physiol. 2017;232:2996-3005 pubmed publisher
  14. Sullivan A, Wang E, Farrell J, Whitaker P, Faulkner L, Peckham D, et al. ?-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells. J Allergy Clin Immunol. 2018;141:235-249.e8 pubmed publisher
  15. Berlato C, Khan M, Schioppa T, Thompson R, Maniati E, Montfort A, et al. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer. J Clin Invest. 2017;127:801-813 pubmed publisher
  16. Boardman D, Philippeos C, Fruhwirth G, Ibrahim M, Hannen R, Cooper D, et al. Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection. Am J Transplant. 2017;17:931-943 pubmed publisher
  17. Nagase H, Takeoka T, Urakawa S, Morimoto Okazawa A, Kawashima A, Iwahori K, et al. ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori. Int J Cancer. 2017;140:686-695 pubmed publisher
  18. Gadd V, Patel P, Jose S, Horsfall L, Powell E, Irvine K. Altered Peripheral Blood Monocyte Phenotype and Function in Chronic Liver Disease: Implications for Hepatic Recruitment and Systemic Inflammation. PLoS ONE. 2016;11:e0157771 pubmed publisher
  19. Loyon R, Picard E, Mauvais O, Queiroz L, Mougey V, Pallandre J, et al. IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner. J Immunol. 2016;197:85-96 pubmed publisher
  20. Moura J, Rodrigues J, Goncalves M, Amaral C, Lima M, Carvalho E. Impaired T-cell differentiation in diabetic foot ulceration. Cell Mol Immunol. 2017;14:758-769 pubmed publisher
  21. Roan F, Stoklasek T, Whalen E, Molitor J, Bluestone J, Buckner J, et al. CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 2016;196:2051-2062 pubmed publisher
  22. Paris R, Petrovas C, Ferrando Martinez S, Moysi E, Boswell K, Archer E, et al. Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression. PLoS ONE. 2015;10:e0144767 pubmed publisher
  23. Cleret Buhot A, Zhang Y, Planas D, Goulet J, Monteiro P, Gosselin A, et al. Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach. Retrovirology. 2015;12:102 pubmed publisher
  24. Francisconi C, Vieira A, Biguetti C, Glowacki A, Trombone A, Letra A, et al. Characterization of the Protective Role of Regulatory T Cells in Experimental Periapical Lesion Development and Their Chemoattraction Manipulation as a Therapeutic Tool. J Endod. 2016;42:120-6 pubmed publisher
  25. Wang Z, Wei M, Zhang H, Chen H, Germana S, Huang C, et al. Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4(+) cells in vivo. Mol Oncol. 2015;9:1458-70 pubmed publisher
  26. Kamburova E, Koenen H, van den Hoogen M, Baas M, Joosten I, Hilbrands L. Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy. PLoS ONE. 2014;9:e112658 pubmed publisher
  27. Davey M, Morgan M, Liuzzi A, Tyler C, Khan M, Szakmany T, et al. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. J Immunol. 2014;193:3704-3716 pubmed publisher
  28. Arlehamn C, Seumois G, Gerasimova A, Huang C, Fu Z, Yue X, et al. Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features. J Immunol. 2014;193:2931-40 pubmed publisher