This is a Validated Antibody Database (VAD) review about human CCDC22, based on 4 published articles (read how Labome selects the articles), using CCDC22 antibody in all methods. It is aimed to help Labome visitors find the most suited CCDC22 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CCDC22 synonym: CXorf37; JM1; RTSC2; coiled-coil domain-containing protein 22

Proteintech Group
rabbit polyclonal
  • western blot; mouse; 1:2000; fig 2
  • western blot; dog; 1:2000; fig 1
  • western blot; human; 1:2000; fig 3
In order to analyze how WASH- and CCC-mediated endosomal sorting of LDLr is needed for regular clearance of circulating LDL, Proteintech Group CCDC22 antibody (Proteintech, 16636-1-AP) was used in western blot on mouse samples at 1:2000 (fig 2), in western blot on dog samples at 1:2000 (fig 1) and in western blot on human samples at 1:2000 (fig 3). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 6
Proteintech Group CCDC22 antibody (Proteintech, 16636-1-AP) was used in western blot on human samples (fig 6). Mol Biosyst (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig s6
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 2
In order to elucidate the role of COMMD1 in copper homeostasis, Proteintech Group CCDC22 antibody (ProteinTech, 16636-1-AP) was used in western blot on mouse samples (fig s6), in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 2). Mol Biol Cell (2015) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; human; 1:500
In order to identify a hypomorphic variant of CCDC22 in patients with RSS/3C syndrome in an Austrian family, Sigma-Aldrich CCDC22 antibody (Sigma-Aldrich, HPA000888) was used in western blot on human samples at 1:500. Eur J Hum Genet (2015) ncbi
Articles Reviewed
  1. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
  2. Qi D, Wang Q, Li H, Zhang T, Lan R, Kwong D, et al. SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells. Mol Biosyst. 2015;11:3059-67 pubmed publisher
  3. Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher
  4. Kolanczyk M, Krawitz P, Hecht J, Hupalowska A, Miaczynska M, Marschner K, et al. Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome. Eur J Hum Genet. 2015;23:633-8 pubmed publisher