This is a Validated Antibody Database (VAD) review about human CASP4, based on 18 published articles (read how Labome selects the articles), using CASP4 antibody in all methods. It is aimed to help Labome visitors find the most suited CASP4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CASP4 synonym: ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; TX

Knockout validation
Novus Biologicals
rat monoclonal (17D9)
  • western blot knockout validation; mouse; fig 6a
Novus Biologicals CASP4 antibody (Novus Biologicals, NB-120-10454) was used in western blot knockout validation on mouse samples (fig 6a). J Clin Invest (2017) ncbi
MBL International
mouse monoclonal (4B9)
  • western blot knockout validation; human; fig 1
MBL International CASP4 antibody (MBL, 4B9) was used in western blot knockout validation on human samples (fig 1). Nature (2014) ncbi
Santa Cruz Biotechnology
mouse monoclonal (4B9)
  • immunocytochemistry; human; loading ...; fig s4b
  • western blot; human; loading ...; fig 1g
Santa Cruz Biotechnology CASP4 antibody (Santa Cruz, 4B9) was used in immunocytochemistry on human samples (fig s4b) and in western blot on human samples (fig 1g). Cell Death Differ (2022) ncbi
mouse monoclonal (4B9)
  • western blot; human; loading ...; fig 7a
Santa Cruz Biotechnology CASP4 antibody (Santa Cruz, 4B9) was used in western blot on human samples (fig 7a). Nat Immunol (2019) ncbi
mouse monoclonal (4B9)
  • western blot; human; loading ...; fig 5m
Santa Cruz Biotechnology CASP4 antibody (Santa Cruz, 4B9) was used in western blot on human samples (fig 5m). Nat Commun (2018) ncbi
mouse monoclonal (4B9)
  • western blot; human; fig 2b
Santa Cruz Biotechnology CASP4 antibody (Santa, sc-56056) was used in western blot on human samples (fig 2b). J Clin Invest (2017) ncbi
mouse monoclonal (4B9)
  • western blot; human; fig 3a
Santa Cruz Biotechnology CASP4 antibody (Santa Cruz, 4B9) was used in western blot on human samples (fig 3a). Nat Chem Biol (2017) ncbi
mouse monoclonal (4B9)
  • western blot; human; loading ...; fig 3b
Santa Cruz Biotechnology CASP4 antibody (Santa Cruz Biotechnology, sc-56056) was used in western blot on human samples (fig 3b). Mucosal Immunol (2017) ncbi
mouse monoclonal (4B9)
  • western blot; human; 1:500; fig 2
In order to study oxygen-induced endoplasmic reticulum stress in the lens, Santa Cruz Biotechnology CASP4 antibody (Santa Cruz Biotechnology, sc-56056) was used in western blot on human samples at 1:500 (fig 2). Exp Ther Med (2015) ncbi
Novus Biologicals
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 3a
Novus Biologicals CASP4 antibody (Novus Biologicals, NB120-10454) was used in western blot on mouse samples (fig 3a). Cell (2021) ncbi
rat monoclonal (17D9)
  • western blot; mouse; fig s7a
Novus Biologicals CASP4 antibody (Novus Biologicals, NB120-10454) was used in western blot on mouse samples (fig s7a). J Clin Invest (2018) ncbi
rat monoclonal (17D9)
  • western blot knockout validation; mouse; fig 6a
Novus Biologicals CASP4 antibody (Novus Biologicals, NB-120-10454) was used in western blot knockout validation on mouse samples (fig 6a). J Clin Invest (2017) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig 4a
Novus Biologicals CASP4 antibody (Novus Biologicals, 17D9) was used in western blot on mouse samples (fig 4a). Immunology (2017) ncbi
rat monoclonal (17D9)
  • western blot; mouse; 1:1000; loading ...; fig 2d
Novus Biologicals CASP4 antibody (Novus Biologicals, 17D9) was used in western blot on mouse samples at 1:1000 (fig 2d). Nat Immunol (2016) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig s7d
Novus Biologicals CASP4 antibody (Novus Biologicals, 17D9) was used in western blot on mouse samples (fig s7d). Nature (2015) ncbi
rat monoclonal (17D9)
  • western blot; mouse; loading ...; fig s6b
Novus Biologicals CASP4 antibody (Novus Biologicals, NB120-10454) was used in western blot on mouse samples (fig s6b). Nature (2015) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 6a
Cell Signaling Technology CASP4 antibody (Cell Signaling, 4450) was used in western blot on human samples at 1:1000 (fig 6a). J Exp Med (2016) ncbi
MBL International
mouse monoclonal (4B9)
  • western blot; human; loading ...; fig 1c
MBL International CASP4 antibody (MBL, M029-3) was used in western blot on human samples (fig 1c). Front Cell Dev Biol (2021) ncbi
mouse monoclonal (4B9)
  • western blot; human; 1:1000
In order to assess the effect of carnosic acid on apoptosis induced by Abeta42 or Abeta43 in human neuroblastoma cells, MBL International CASP4 antibody (Medical & Biological Laboratories, #M029-3) was used in western blot on human samples at 1:1000. Neurosci Res (2015) ncbi
mouse monoclonal (4B9)
  • western blot knockout validation; human; fig 1
MBL International CASP4 antibody (MBL, 4B9) was used in western blot knockout validation on human samples (fig 1). Nature (2014) ncbi
mouse monoclonal (4B9)
  • western blot; mouse; 1:1000; fig 5
MBL International CASP4 antibody (MBL, M029-3) was used in western blot on mouse samples at 1:1000 (fig 5). Cell Death Dis (2014) ncbi
Articles Reviewed
  1. Fernández Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar F, et al. Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. Cell Death Differ. 2022;29:1267-1282 pubmed publisher
  2. Chen Q, Liu X, Wang D, Zheng J, Chen L, Xie Q, et al. Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis. Front Cell Dev Biol. 2021;9:663037 pubmed publisher
  3. Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149-168.e17 pubmed publisher
  4. Choi Y, Kim S, Choi Y, Nielsen T, Yan J, Lu A, et al. SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019;20:276-287 pubmed publisher
  5. Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  6. Chu L, Indramohan M, Ratsimandresy R, Gangopadhyay A, Morris E, Monack D, et al. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018;9:996 pubmed publisher
  7. Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed publisher
  8. Klaska I, Muckersie E, Martin Granados C, Christofi M, Forrester J. Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. Immunology. 2017;150:364-377 pubmed publisher
  9. Okondo M, Johnson D, Sridharan R, Go E, Chui A, Wang M, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017;13:46-53 pubmed publisher
  10. Napier B, Brubaker S, Sweeney T, Monette P, Rothmeier G, Gertsvolf N, et al. Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity. J Exp Med. 2016;213:2365-2382 pubmed
  11. Pallett M, Crepin V, Serafini N, Habibzay M, Kotik O, Sanchez Garrido J, et al. Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells. Mucosal Immunol. 2017;10:602-612 pubmed publisher
  12. Mortimer L, Moreau F, MacDonald J, Chadee K. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol. 2016;17:1176-86 pubmed publisher
  13. Zheng X, Xu J, Chen X, Li W, Wang T. Attenuation of oxygen fluctuation-induced endoplasmic reticulum stress in human lens epithelial cells. Exp Ther Med. 2015;10:1883-1887 pubmed
  14. Kayagaki N, Stowe I, Lee B, O Rourke K, Anderson K, Warming S, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526:666-71 pubmed publisher
  15. Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660-5 pubmed publisher
  16. Meng P, Yoshida H, Tanji K, Matsumiya T, Xing F, Hayakari R, et al. Carnosic acid attenuates apoptosis induced by amyloid-β 1-42 or 1-43 in SH-SY5Y human neuroblastoma cells. Neurosci Res. 2015;94:1-9 pubmed publisher
  17. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, et al. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514:187-92 pubmed publisher
  18. Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, et al. Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death Dis. 2014;5:e1332 pubmed publisher