This is a Validated Antibody Database (VAD) review about human CACNA2D1, based on 18 published articles (read how Labome selects the articles), using CACNA2D1 antibody in all methods. It is aimed to help Labome visitors find the most suited CACNA2D1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CACNA2D1 synonym: CACNA2; CACNL2A; CCHL2A; LINC01112; lncRNA-N3; voltage-dependent calcium channel subunit alpha-2/delta-1; calcium channel, L type, alpha 2 polypeptide; calcium channel, voltage-dependent, alpha 2/delta subunit 1; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; voltage-gated calcium channel subunit alpha-2/delta-1

Abcam
mouse monoclonal (20A)
  • western blot; mouse; loading ...; fig 5a
In order to report the effects of short- and long-term high-fat diets on fast-twitch skeletal muscles, Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on mouse samples (fig 5a). Physiol Rep (2017) ncbi
mouse monoclonal (20A)
  • western blot; rat; loading ...; fig 2e
In order to assess the role of redox stress in PH-induced diaphragm weakness, Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on rat samples (fig 2e). PLoS ONE (2017) ncbi
mouse monoclonal (20A)
  • western blot; mouse; 1:1000; fig 5a
In order to examine the effects of sildenafil on skeletal muscle, Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on mouse samples at 1:1000 (fig 5a). Exp Mol Med (2016) ncbi
mouse monoclonal (20A)
  • western blot; mouse; loading ...; fig 4
In order to test if increased submaximal force induced by nitrate supplementation reduces the effort of submaximal voluntary running, Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on mouse samples (fig 4). Physiol Behav (2017) ncbi
mouse monoclonal (20A)
  • immunohistochemistry - paraffin section; human; 1:500; fig 1b
Abcam CACNA2D1 antibody (Abcam, ab2864) was used in immunohistochemistry - paraffin section on human samples at 1:500 (fig 1b). Am J Cancer Res (2016) ncbi
mouse monoclonal (20A)
  • immunohistochemistry; mouse; 1:400; fig 3
Abcam CACNA2D1 antibody (abcam, Ab2864) was used in immunohistochemistry on mouse samples at 1:400 (fig 3). Sci Rep (2016) ncbi
mouse monoclonal (20A)
  • immunohistochemistry; mouse; 1:400; fig 4
In order to utilize a system for neuromuscular junction development and maintenance to study mechanisms, Abcam CACNA2D1 antibody (Abcam, Ab2864) was used in immunohistochemistry on mouse samples at 1:400 (fig 4). Development (2016) ncbi
mouse monoclonal (20A)
  • western blot; mouse; fig 1
  • western blot; human; fig 2
In order to investigate the deficiency that affects SERCA expression and function in the skeletal muscle by Calpain 3, Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on mouse samples (fig 1) and in western blot on human samples (fig 2). Expert Rev Mol Med (2016) ncbi
mouse monoclonal (20A)
  • immunohistochemistry - frozen section; rat; 1:50; fig 5
Abcam CACNA2D1 antibody (Abcam, ab2864) was used in immunohistochemistry - frozen section on rat samples at 1:50 (fig 5). Front Pharmacol (2016) ncbi
mouse monoclonal (20A)
  • western blot; human
In order to characterize the effect of cyclosporine A treatment in a mouse model of lethal mitochondrial myopathy, Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on human samples . Hum Mol Genet (2015) ncbi
mouse monoclonal (20A)
  • western blot; human; fig 3e
In order to study mechanisms by which chronic beta2-adrenergic stimulation enhances muscle force and power output during maximal cycle ergometer exercise in young men, Abcam CACNA2D1 antibody (abcam, ab2864) was used in western blot on human samples (fig 3e). J Appl Physiol (1985) (2015) ncbi
mouse monoclonal (20A)
  • western blot; rabbit; loading ...; fig 1a
Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on rabbit samples (fig 1a). Sci Rep (2015) ncbi
mouse monoclonal (20A)
  • western blot; human; 1:1000; loading ...; fig 2a
Abcam CACNA2D1 antibody (Abcam, ab2864) was used in western blot on human samples at 1:1000 (fig 2a). Pflugers Arch (2015) ncbi
mouse monoclonal (20A)
  • immunohistochemistry - paraffin section; mouse
Abcam CACNA2D1 antibody (Abcam, ab-2864) was used in immunohistochemistry - paraffin section on mouse samples . Oncotarget (2014) ncbi
Invitrogen
mouse monoclonal (20A)
  • western blot; rat; loading ...; fig 3b
In order to ask if SK channels in the mitochondria inner membrane play an important role in regulating mitochondrial function in chronic cardiac diseases, Invitrogen CACNA2D1 antibody (Thermo Fisher, MA3-921) was used in western blot on rat samples (fig 3b). Cardiovasc Res (2017) ncbi
mouse monoclonal (20A)
  • western blot; mouse; 1:500; loading ...; fig 1b
In order to examine the effects of marijuana on CB1R activation in skeletal muscle, Invitrogen CACNA2D1 antibody (Thermo Fisher, MA3-921) was used in western blot on mouse samples at 1:500 (fig 1b). J Physiol (2016) ncbi
mouse monoclonal (20A)
  • immunocytochemistry; rabbit; fig 1
In order to analyze the dihydropyridine receptor alpha-1S subunit to reveal conformational differences induced by binding of the beta-1a subnit discovered by fluorescence resonance energy transfer-based structural analysis, Invitrogen CACNA2D1 antibody (Thermo Scientific, MA3-921) was used in immunocytochemistry on rabbit samples (fig 1). J Biol Chem (2016) ncbi
mouse monoclonal (20A)
  • immunocytochemistry; mouse
In order to determine the role of the C-terminal end of the beta1a subunit in the functional and structural communication between the DHPR and the Ca(2+) release channel (RyR1), Invitrogen CACNA2D1 antibody (Thermo Scientific, MA3-921) was used in immunocytochemistry on mouse samples . J Biol Chem (2014) ncbi
Articles Reviewed
  1. Eshima H, Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, et al. Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle. Physiol Rep. 2017;5: pubmed publisher
  2. Himori K, Abe M, Tatebayashi D, Lee J, Westerblad H, Lanner J, et al. Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension. PLoS ONE. 2017;12:e0169146 pubmed publisher
  3. Kim T, Terentyeva R, Roder K, Li W, Liu M, Greener I, et al. SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR. Cardiovasc Res. 2017;113:343-353 pubmed publisher
  4. Huang M, Lee K, Kim K, Ahn M, Cho C, Kim D, et al. The maintenance ability and Ca2+ availability of skeletal muscle are enhanced by sildenafil. Exp Mol Med. 2016;48:e278 pubmed publisher
  5. Ivarsson N, Schiffer T, Hernandez A, Lanner J, Weitzberg E, Lundberg J, et al. Dietary nitrate markedly improves voluntary running in mice. Physiol Behav. 2017;168:55-61 pubmed publisher
  6. Yu D, Holm R, Goscinski M, Trope C, Nesland J, Suo Z. Prognostic and clinicopathological significance of Cacna2d1 expression in epithelial ovarian cancers: a retrospective study. Am J Cancer Res. 2016;6:2088-2097 pubmed
  7. Oláh T, Bodnár D, Tóth A, Vincze J, Fodor J, Reischl B, et al. Cannabinoid signalling inhibits sarcoplasmic Ca2+ release and regulates excitation-contraction coupling in mammalian skeletal muscle. J Physiol. 2016;594:7381-7398 pubmed publisher
  8. Vilmont V, Cadot B, Vezin E, Le Grand F, Gomes E. Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS. Sci Rep. 2016;6:27804 pubmed publisher
  9. Vilmont V, Cadot B, Ouanounou G, Gomes E. A system for studying mechanisms of neuromuscular junction development and maintenance. Development. 2016;143:2464-77 pubmed publisher
  10. Mahalingam M, Perez C, Fessenden J. Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor ?1S Subunit Reveals Conformational Differences Induced by Binding of the ?1a Subunit. J Biol Chem. 2016;291:13762-70 pubmed publisher
  11. Toral Ojeda I, Aldanondo G, Lasa Elgarresta J, Lasa Fernández H, Fernandez Torron R, Lopez de Munain A, et al. Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle. Expert Rev Mol Med. 2016;18:e7 pubmed publisher
  12. Bragança B, Oliveira Monteiro N, Ferreirinha F, Lima P, Faria M, Fontes Sousa A, et al. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 2016;7:45 pubmed publisher
  13. Gineste C, Hernandez A, Ivarsson N, Cheng A, Naess K, Wibom R, et al. Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy. Hum Mol Genet. 2015;24:6580-7 pubmed publisher
  14. Hostrup M, Kalsen A, Onslev J, Jessen S, Haase C, Habib S, et al. Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men. J Appl Physiol (1985). 2015;119:475-86 pubmed publisher
  15. Hu H, Wang Z, Wei R, Fan G, Wang Q, Zhang K, et al. The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex. Sci Rep. 2015;5:8370 pubmed publisher
  16. Eltit J, Franzini Armstrong C, Perez C. Amino acid residues 489-503 of dihydropyridine receptor (DHPR) β1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor. J Biol Chem. 2014;289:36116-24 pubmed publisher
  17. Rougier J, Albesa M, Syam N, Halet G, Abriel H, Viard P. Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels. Pflugers Arch. 2015;467:1919-29 pubmed publisher
  18. Katuri V, Gerber S, Qiu X, McCarty G, Goldstein S, Hammers H, et al. WT1 regulates angiogenesis in Ewing Sarcoma. Oncotarget. 2014;5:2436-49 pubmed