This is a Validated Antibody Database (VAD) review about human BRCA2, based on 3 published articles (read how Labome selects the articles), using BRCA2 antibody in all methods. It is aimed to help Labome visitors find the most suited BRCA2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
BRCA2 synonym: BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11

R&D Systems
mouse monoclonal (234403)
  • western blot; human; 1:1000; loading ...; fig 5b
R&D Systems BRCA2 antibody (R&D Systems, 234403) was used in western blot on human samples at 1:1000 (fig 5b). Int J Mol Sci (2021) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2s4
In order to investigate DNA repair in CD44+/CD24- cells, MilliporeSigma BRCA2 antibody (Atlas Antibodies, HPA026815) was used in western blot on human samples (fig 2s4). elife (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig 3
  • immunohistochemistry - paraffin section; mouse; fig 3
In order to utilize a model of metastatic HPV+ oropharyngeal squamous cell carcinoma to displays heterogeneity in tumor metastasis, MilliporeSigma BRCA2 antibody (Sigma, HPA026815) was used in immunohistochemistry - paraffin section on human samples (fig 3) and in immunohistochemistry - paraffin section on mouse samples (fig 3). Oncotarget (2016) ncbi
Articles Reviewed
  1. Tseng W, Chen C, Chern C, Wang C, Lee W, Chi Y, et al. Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. Int J Mol Sci. 2021;22: pubmed publisher
  2. Pal D, Pertot A, Shirole N, Yao Z, Anaparthy N, Garvin T, et al. TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells. elife. 2017;6: pubmed publisher
  3. Vermeer D, Coppock J, Zeng E, Lee K, Spanos W, Onken M, et al. Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis. Oncotarget. 2016;7:24194-207 pubmed publisher