This is a Validated Antibody Database (VAD) review about human BCL11A, based on 11 published articles (read how Labome selects the articles), using BCL11A antibody in all methods. It is aimed to help Labome visitors find the most suited BCL11A antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
BCL11A synonym: BCL11A-L; BCL11A-S; BCL11A-XL; BCL11a-M; CTIP1; DILOS; EVI9; HBFQTL5; ZNF856; B-cell lymphoma/leukemia 11A; B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1; C2H2-type zinc finger protein; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; ecotropic viral integration site 9 protein homolog; zinc finger protein 856

Abcam
mouse monoclonal (18B12DE6)
  • western blot; mouse; 1:1000; loading ...; fig s17b
Abcam BCL11A antibody (Abcam, 19489) was used in western blot on mouse samples at 1:1000 (fig s17b). Science (2018) ncbi
mouse monoclonal (14B5)
  • western blot; mouse; fig s2c
Abcam BCL11A antibody (Abcam, ab19487) was used in western blot on mouse samples (fig s2c). Cell (2018) ncbi
mouse monoclonal (18B12DE6)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 8a
Abcam BCL11A antibody (Abcam, ab19489) was used in immunohistochemistry on mouse samples at 1:500 (fig 8a). Development (2017) ncbi
mouse monoclonal (14B5)
  • western blot; human; loading ...; fig s3h
Abcam BCL11A antibody (Abcam, ab19487) was used in western blot on human samples (fig s3h). Cell (2017) ncbi
mouse monoclonal (18B12DE6)
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig s1e
  • immunocytochemistry; human; 1:250; loading ...; fig 2a
In order to report that mutations in BCL11A contribute to intellectual disability, Abcam BCL11A antibody (Abcam, ab19489) was used in immunohistochemistry - frozen section on mouse samples at 1:250 (fig s1e) and in immunocytochemistry on human samples at 1:250 (fig 2a). Am J Hum Genet (2016) ncbi
mouse monoclonal (14B5)
  • western blot; human; loading ...; fig 2a
In order to elucidate the mechanisms by which fetal-type hemoglobin is repressed, Abcam BCL11A antibody (Abcam, ab19487) was used in western blot on human samples (fig 2a). Science (2016) ncbi
mouse monoclonal (14B5)
  • immunohistochemistry; mouse; 1:50; loading ...; fig S6d
  • western blot; mouse; 1:1000; loading ...; fig 4a; S4a
  • immunohistochemistry; human; 1:50; loading ...; fig 2a
  • western blot; human; 1:1000; loading ...; fig 4a; S5c
In order to investigate the impact of BCL11A expression on breast cancer development, Abcam BCL11A antibody (Abcam, 14B5) was used in immunohistochemistry on mouse samples at 1:50 (fig S6d), in western blot on mouse samples at 1:1000 (fig 4a; S4a), in immunohistochemistry on human samples at 1:50 (fig 2a) and in western blot on human samples at 1:1000 (fig 4a; S5c). Nat Commun (2015) ncbi
mouse monoclonal (14B5)
  • immunohistochemistry - paraffin section; human; 1:200
  • immunocytochemistry; human; 1:100
  • western blot; human; 1:1,000
Abcam BCL11A antibody (Abcam, ab19487) was used in immunohistochemistry - paraffin section on human samples at 1:200, in immunocytochemistry on human samples at 1:100 and in western blot on human samples at 1:1,000. Mol Cancer (2013) ncbi
mouse monoclonal (14B5)
  • western blot; human
Abcam BCL11A antibody (Abcam, ab19487) was used in western blot on human samples . Blood (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal
  • immunoprecipitation; human; loading ...; fig 2d
  • western blot; human; loading ...; fig 2d
Santa Cruz Biotechnology BCL11A antibody (SantaCruz, sc-514842) was used in immunoprecipitation on human samples (fig 2d) and in western blot on human samples (fig 2d). J Biol Chem (2018) ncbi
Bethyl
rabbit polyclonal
  • western blot; human; 1:1000; fig 1c
Bethyl BCL11A antibody (Bethyl, A300-382A) was used in western blot on human samples at 1:1000 (fig 1c). Exp Hematol (2015) ncbi
Articles Reviewed
  1. Grevet J, Lan X, Hamagami N, Edwards C, Sankaranarayanan L, Ji X, et al. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science. 2018;361:285-290 pubmed publisher
  2. Liu N, Hargreaves V, Zhu Q, Kurland J, Hong J, Kim W, et al. Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell. 2018;173:430-442.e17 pubmed publisher
  3. Alpsoy A, Dykhuizen E. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem. 2018;293:3892-3903 pubmed publisher
  4. Rashid M, Belmont J, Carpenter D, Turner C, Olson E. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017;144:4002-4014 pubmed publisher
  5. Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, et al. In Situ Capture of Chromatin Interactions by Biotinylated dCas9. Cell. 2017;170:1028-1043.e19 pubmed publisher
  6. Dias C, Estruch S, Graham S, McRae J, Sawiak S, Hurst J, et al. BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription. Am J Hum Genet. 2016;99:253-74 pubmed publisher
  7. Masuda T, Wang X, Maeda M, Canver M, Sher F, Funnell A, et al. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science. 2016;351:285-9 pubmed publisher
  8. Finotti A, Gasparello J, Breveglieri G, Cosenza L, Montagner G, Bresciani A, et al. Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin. Exp Hematol. 2015;43:1062-1071.e3 pubmed publisher
  9. Khaled W, Choon Lee S, Stingl J, Chen X, Raza Ali H, Rueda O, et al. BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells. Nat Commun. 2015;6:5987 pubmed publisher
  10. Jiang B, Zhang X, Su J, Meng W, Yang X, Yang J, et al. BCL11A overexpression predicts survival and relapse in non-small cell lung cancer and is modulated by microRNA-30a and gene amplification. Mol Cancer. 2013;12:61 pubmed publisher
  11. Macari E, Schaeffer E, West R, Lowrey C. Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells. Blood. 2013;121:830-9 pubmed publisher