This is a Validated Antibody Database (VAD) review about human B-Raf, based on 65 published articles (read how Labome selects the articles), using B-Raf antibody in all methods. It is aimed to help Labome visitors find the most suited B-Raf antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
B-Raf synonym: B-RAF1; B-raf; BRAF1; NS7; RAFB1; serine/threonine-protein kinase B-raf; 94 kDa B-raf protein; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf serine/threonine-protein; murine sarcoma viral (v-raf) oncogene homolog B1; proto-oncogene B-Raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal (F-7)
  • western blot; human; 1:1000; fig 9
  • western blot knockout validation; mouse; 1:1000; fig 3
In order to study prevention of allergic skin disease by epidermal RAF, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in western blot on human samples at 1:1000 (fig 9) and in western blot knockout validation on mouse samples at 1:1000 (fig 3). elife (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (F-7)
  • western blot knockout validation; mouse; 1:500; fig 4b
Santa Cruz Biotechnology B-Raf antibody (Santa, sc-5284) was used in western blot knockout validation on mouse samples at 1:500 (fig 4b). Cell Signal (2013) ncbi
Santa Cruz Biotechnology
mouse monoclonal (F-3)
  • western blot; human; 1:1000; loading ...; fig ex1m
Santa Cruz Biotechnology B-Raf antibody (Santa, sc-55522) was used in western blot on human samples at 1:1000 (fig ex1m). Nature (2018) ncbi
mouse monoclonal (F-7)
  • western blot; human; 1:1000; loading ...; fig 5c
Santa Cruz Biotechnology B-Raf antibody (SantaCruz, sc-5284) was used in western blot on human samples at 1:1000 (fig 5c). Nat Commun (2017) ncbi
mouse monoclonal (F-7)
  • western blot; human; loading ...; fig 3e
In order to show that PHB1 is highly expressed in non-small cell lung cancers patients and correlates with poor survival, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in western blot on human samples (fig 3e). Oncogene (2017) ncbi
mouse monoclonal (F-7)
  • reverse phase protein lysate microarray; human; loading ...; fig st6
In order to characterize the molecular identity of uterine carcinosarcomas., Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in reverse phase protein lysate microarray on human samples (fig st6). Cancer Cell (2017) ncbi
mouse monoclonal (F-7)
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
In order to describe the features of 228 primary cervical cancers, Santa Cruz Biotechnology B-Raf antibody (SantaCruz, sc-5284) was used in reverse phase protein lysate microarray on human samples (fig 3a). Nature (2017) ncbi
mouse monoclonal (F-7)
  • western blot; human; loading ...; fig 2c
Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in western blot on human samples (fig 2c). Oncogene (2017) ncbi
mouse monoclonal (F-7)
  • proximity ligation assay; hamsters; loading ...; fig 3d
In order to clarify the interaction of SPRED1 with Ras and Raf, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in proximity ligation assay on hamsters samples (fig 3d). Mol Cell Biol (2016) ncbi
mouse monoclonal (F-7)
  • western blot; human; 1:1000; fig 9
  • western blot knockout validation; mouse; 1:1000; fig 3
In order to study prevention of allergic skin disease by epidermal RAF, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in western blot on human samples at 1:1000 (fig 9) and in western blot knockout validation on mouse samples at 1:1000 (fig 3). elife (2016) ncbi
mouse monoclonal (F-7)
  • western blot; human; fig 6b
In order to develop a patient-derived xenograft platform and use it to identify genes that contribute the cancer resistance of melanoma patients treated with BRAF inhibitors, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, F7) was used in western blot on human samples (fig 6b). Cell Rep (2016) ncbi
mouse monoclonal
  • western blot; human; fig 6b
In order to develop a patient-derived xenograft platform and use it to identify genes that contribute the cancer resistance of melanoma patients treated with BRAF inhibitors, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, F7) was used in western blot on human samples (fig 6b). Cell Rep (2016) ncbi
mouse monoclonal (F-7)
  • western blot; human; 1:1000; fig s1
Santa Cruz Biotechnology B-Raf antibody (santa Cruz, sc-5284) was used in western blot on human samples at 1:1000 (fig s1). Sci Rep (2016) ncbi
mouse monoclonal (F-7)
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 2
In order to determine limits on FAK-dependent invasion and enhancement of the response to melanoma treatment with BRAF inhibitors due to HSP70 inhibition, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in immunoprecipitation on human samples (fig 2) and in western blot on human samples (fig 2). Cancer Res (2016) ncbi
mouse monoclonal (F-7)
  • western blot; human; 1:1000; tbl 2
Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in western blot on human samples at 1:1000 (tbl 2). elife (2016) ncbi
mouse monoclonal (F-7)
  • western blot; human; fig 1
Santa Cruz Biotechnology B-Raf antibody (santa cruz, sc-5284) was used in western blot on human samples (fig 1). Carcinogenesis (2015) ncbi
mouse monoclonal (F-7)
  • western blot; human; loading ...; fig S3A
Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in western blot on human samples (fig S3A). Autophagy (2015) ncbi
mouse monoclonal (F-7)
  • western blot; human; fig 3b
Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in western blot on human samples (fig 3b). Oncotarget (2015) ncbi
mouse monoclonal (F-7)
  • immunoprecipitation; human; 1:1000; fig 2
  • immunocytochemistry; human; 1:25; fig 5
Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, sc-5284) was used in immunoprecipitation on human samples at 1:1000 (fig 2) and in immunocytochemistry on human samples at 1:25 (fig 5). Oncogene (2016) ncbi
mouse monoclonal (F-3)
  • western blot; mouse; 1:200; fig 2
In order to investigate how BRAF/MAPK activity regulates intestinal stem cell populations and contributes to colon cancer, Santa Cruz Biotechnology B-Raf antibody (Santa Cruz, 55522) was used in western blot on mouse samples at 1:200 (fig 2). Oncogene (2015) ncbi
mouse monoclonal (F-7)
  • western blot; human
Santa Cruz Biotechnology B-Raf antibody (Santa Cruz Biotechnology, sc-5284) was used in western blot on human samples . Cancer Res (2014) ncbi
mouse monoclonal (F-7)
  • western blot knockout validation; mouse; 1:500; fig 4b
Santa Cruz Biotechnology B-Raf antibody (Santa, sc-5284) was used in western blot knockout validation on mouse samples at 1:500 (fig 4b). Cell Signal (2013) ncbi
mouse monoclonal (F-7)
  • western blot; hamsters
Santa Cruz Biotechnology B-Raf antibody (Santa Cruz Biotechnology, sc-5284) was used in western blot on hamsters samples . Mol Cell Biol (2013) ncbi
Abcam
rabbit monoclonal (EPR2207)
  • western blot; mouse; 1:1000; fig 2c
In order to identify specific genes involved in leukemogenesis through comprehensive ex vivo transposon mutagenesis, Abcam B-Raf antibody (Abcam, EPR2207) was used in western blot on mouse samples at 1:1000 (fig 2c). Cancer Res (2016) ncbi
rabbit monoclonal (RM8)
  • western blot; Human herpesvirus 1; fig 2
Abcam B-Raf antibody (Abcam, Ab200535) was used in western blot on Human herpesvirus 1 samples (fig 2). J Cell Biol (2015) ncbi
MilliporeSigma
rabbit polyclonal
  • western blot; human; loading ...; fig s3c
MilliporeSigma B-Raf antibody (Sigma, HPA001328) was used in western blot on human samples (fig s3c). Cancer Res (2018) ncbi
mouse monoclonal (3C6)
  • immunoprecipitation; human; tbl 3
MilliporeSigma B-Raf antibody (Sigma, WH0000673M1) was used in immunoprecipitation on human samples (tbl 3). elife (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 3
In order to study Val600 in the activation portion of BRAF and its peculiar yin-yang of kinase activation and unfolding, MilliporeSigma B-Raf antibody (SIGMA, HPA001328) was used in western blot on human samples (fig 3). elife (2016) ncbi
rabbit polyclonal
  • western blot; human; fig s1
MilliporeSigma B-Raf antibody (SIGMA, HPA001328) was used in western blot on human samples (fig s1). Sci Rep (2015) ncbi
Cell Signaling Technology
rabbit monoclonal (56A6)
  • other; human; loading ...; fig 4c
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
rabbit polyclonal
  • other; human; loading ...; fig 4c
Cell Signaling Technology B-Raf antibody (Cell Signaling, 2696) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
rabbit monoclonal (56A6)
  • western blot; human; 1:1000; loading ...; fig 1e
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in western blot on human samples at 1:1000 (fig 1e). Science (2018) ncbi
rabbit monoclonal (56A6)
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology B-Raf antibody (Cell Signaling, cs-9427) was used in western blot on human samples (fig 3b). Int J Oncol (2018) ncbi
rabbit monoclonal (56A6)
  • western blot; mouse; loading ...; fig 4g
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427S) was used in western blot on mouse samples (fig 4g). Cancer Cell (2018) ncbi
rabbit monoclonal (56A6)
  • western blot; human; loading ...; fig 3b
In order to show that PHB1 is highly expressed in non-small cell lung cancers patients and correlates with poor survival, Cell Signaling Technology B-Raf antibody (Cell Signalling, 9427) was used in western blot on human samples (fig 3b). Oncogene (2017) ncbi
rabbit monoclonal (56A6)
  • western blot; human; loading ...; fig 3a
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in western blot on human samples (fig 3a). J Biol Chem (2017) ncbi
rabbit monoclonal (56A6)
  • western blot; human; loading ...; fig 1b
In order to observe that chronic presence of internalized Escherichia coli leads to enhanced oncogenicity in colon cancer cells, Cell Signaling Technology B-Raf antibody (cell signalling, 9427) was used in western blot on human samples (fig 1b). Cell Death Dis (2017) ncbi
rabbit monoclonal (56A6)
  • reverse phase protein lysate microarray; human; loading ...; fig st6
In order to characterize the molecular identity of uterine carcinosarcomas., Cell Signaling Technology B-Raf antibody (CST, 9427) was used in reverse phase protein lysate microarray on human samples (fig st6). Cancer Cell (2017) ncbi
rabbit monoclonal (56A6)
  • western blot; human; loading ...; fig 4d
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9427) was used in western blot on human samples (fig 4d). Cell (2017) ncbi
rabbit monoclonal (56A6)
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
In order to describe the features of 228 primary cervical cancers, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in reverse phase protein lysate microarray on human samples (fig 3a). Nature (2017) ncbi
rabbit monoclonal (56A6)
  • western blot; mouse; loading ...; fig 2a
Cell Signaling Technology B-Raf antibody (cell signalling, 9427) was used in western blot on mouse samples (fig 2a). Proc Natl Acad Sci U S A (2017) ncbi
rabbit polyclonal
  • western blot; human; fig 1c
In order to assess the effects of LY3009120, a panRAF and RAF dimer inhibitor, in human models of colorectal cancer, Cell Signaling Technology B-Raf antibody (Cell Signaling, 2696) was used in western blot on human samples (fig 1c). Oncotarget (2017) ncbi
rabbit monoclonal (56A6)
  • western blot; human; fig 1c
In order to assess the effects of LY3009120, a panRAF and RAF dimer inhibitor, in human models of colorectal cancer, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in western blot on human samples (fig 1c). Oncotarget (2017) ncbi
rabbit polyclonal
  • western blot; dog; loading ...; tbl 1
In order to report the changes associated with gonadotropin-releasing hormone agonist treatment, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9421S) was used in western blot on dog samples (tbl 1). Mol Reprod Dev (2016) ncbi
rabbit monoclonal (56A6)
  • western blot; human; loading ...; fig 5c
In order to investigate how 6-C-(E-phenylethenyl)naringenin inhibits cancer cell growth, Cell Signaling Technology B-Raf antibody (Cell signaling, 9427) was used in western blot on human samples (fig 5c). Eur J Cancer (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:100; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology B-Raf antibody (Cell Signaling, 2696) was used in western blot on human samples at 1:100 (fig st1). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9421) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
rabbit monoclonal (56A6)
  • western blot; human; 1:1000
Cell Signaling Technology B-Raf antibody (CST, 9427) was used in western blot on human samples at 1:1000. Cell Death Dis (2016) ncbi
rabbit monoclonal (56A6)
  • western blot; human; fig 3
Cell Signaling Technology B-Raf antibody (Cell signaling, 9427) was used in western blot on human samples (fig 3). FASEB J (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 4
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9421) was used in western blot on human samples (fig 4). BMC Complement Altern Med (2016) ncbi
rabbit monoclonal (56A6)
  • western blot; human; 1:500; fig 8
In order to research induction of epithelial-to-mesenchymal transition by Polo-like kinase 1 and promotion of epithelial cell motility by activating CRAF/ERK signaling, Cell Signaling Technology B-Raf antibody (Cell signaling, 9427) was used in western blot on human samples at 1:500 (fig 8). elife (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 5
Cell Signaling Technology B-Raf antibody (Cell Signaling Tech, 9421S) was used in western blot on human samples at 1:1000 (fig 5). Oncol Lett (2016) ncbi
rabbit monoclonal (55C6)
  • immunohistochemistry - paraffin section; human; 1:100; fig 4
  • western blot; human; 1:1000
In order to elucidate a screening that identifies kinases involved in prostate cancer visceral and bone metastasis, Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 55C6) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 4) and in western blot on human samples at 1:1000. Proc Natl Acad Sci U S A (2016) ncbi
rabbit monoclonal (56A6)
  • western blot; human; 1:1000; loading ...; fig 3a
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in western blot on human samples at 1:1000 (fig 3a). Am J Physiol Lung Cell Mol Physiol (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig 3c
Cell Signaling Technology B-Raf antibody (Cell Signaling, 2696) was used in western blot on human samples at 1:500 (fig 3c). Am J Physiol Lung Cell Mol Physiol (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 5
  • western blot; mouse; fig 5
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9421) was used in western blot on human samples (fig 5) and in western blot on mouse samples (fig 5). Oncogene (2016) ncbi
rabbit monoclonal (56A6)
  • western blot; mouse; fig 5
  • western blot; human; fig 5
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9427) was used in western blot on mouse samples (fig 5) and in western blot on human samples (fig 5). Oncogene (2016) ncbi
rabbit polyclonal
  • western blot; human
In order to study the molecular signaling responsible for retinoic acid-induced differentiation, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9421) was used in western blot on human samples . PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; human
In order to study the molecular signaling responsible for retinoic acid-induced differentiation, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9431) was used in western blot on human samples . PLoS ONE (2015) ncbi
rabbit polyclonal
  • other; mouse; 1:500; fig s1
In order to identify host signaling dynamics upon Burkholderia spp. infection by a reverse-phase protein microarray-based screen, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9421) was used in other on mouse samples at 1:500 (fig s1). Front Microbiol (2015) ncbi
rabbit monoclonal (56A6)
  • western blot; hamsters; loading ...; fig 2f
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427S) was used in western blot on hamsters samples (fig 2f). elife (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 3b
Cell Signaling Technology B-Raf antibody (Cell Signaling, 2696) was used in western blot on human samples (fig 3b). Oncotarget (2015) ncbi
rabbit monoclonal (55C6)
  • western blot; human; fig 2e
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9433) was used in western blot on human samples (fig 2e). Oncogene (2016) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology B-Raf antibody (CST, 9421) was used in western blot on human samples . Cell Signal (2015) ncbi
rabbit monoclonal (55C6)
  • western blot; human; 1:1000; fig 5a
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9433) was used in western blot on human samples at 1:1000 (fig 5a). Cancer Cell Int (2015) ncbi
rabbit monoclonal (56A6)
  • western blot; mouse; fig 4
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9427) was used in western blot on mouse samples (fig 4). Mol Biol Cell (2015) ncbi
rabbit monoclonal (56A6)
  • western blot; human; fig S3
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9427) was used in western blot on human samples (fig S3). PLoS ONE (2015) ncbi
rabbit monoclonal (55C6)
  • western blot; human; 1:1000
In order to test if NBDHEX and MC3181 have antitumor activity against melanoma cells resistant to vemurafenib, Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9433) was used in western blot on human samples at 1:1000. Biochem Pharmacol (2015) ncbi
rabbit monoclonal (56A6)
  • western blot; human
Cell Signaling Technology B-Raf antibody (Cell Signaling Technology, 9427) was used in western blot on human samples . Int J Oncol (2015) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology B-Raf antibody (Cell Signaling, # 2696) was used in western blot on human samples . Oncotarget (2015) ncbi
rabbit monoclonal (56A6)
  • western blot; hamsters
Cell Signaling Technology B-Raf antibody (Cell Signaling technology, 9427) was used in western blot on hamsters samples . Med Microbiol Immunol (2014) ncbi
rabbit monoclonal (56A6)
  • western blot; human
Cell Signaling Technology B-Raf antibody (Cell Signalling, 9427) was used in western blot on human samples . Cell Microbiol (2014) ncbi
rabbit monoclonal (56A6)
  • western blot; human
In order to study the ERbB signaling network with a view to understanding the basis for context-specific signaling plasticity, Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in western blot on human samples . Sci Signal (2013) ncbi
rabbit monoclonal (56A6)
  • western blot; human; 1:1000
Cell Signaling Technology B-Raf antibody (Cell Signaling, #9427P) was used in western blot on human samples at 1:1000. J Mol Histol (2014) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9421) was used in western blot on human samples . J Biol Chem (2013) ncbi
rabbit polyclonal
  • western blot; human; fig 6
In order to study the GNAS locus as a driver in 20q amplified breast cancer found in an siRNA screen, Cell Signaling Technology B-Raf antibody (Cell Signalling Technology, 9421) was used in western blot on human samples (fig 6). Oncogene (2014) ncbi
rabbit monoclonal (56A6)
  • western blot; human
Cell Signaling Technology B-Raf antibody (Cell Signaling, 9427) was used in western blot on human samples . Cancer Cell Int (2013) ncbi
BD Biosciences
mouse monoclonal (13/B-RAF)
  • immunoprecipitation; mouse; loading ...; fig 4s1b, 4s1d
BD Biosciences B-Raf antibody (BD, 612375) was used in immunoprecipitation on mouse samples (fig 4s1b, 4s1d). elife (2016) ncbi
mouse monoclonal (13/B-RAF)
  • western blot; human; 1:5000; loading ...; fig 1a
In order to demonstrate the bipartite role of Hsp90 in chaperoning CRAF kinase, BD Biosciences B-Raf antibody (BD Biosciences, 612375) was used in western blot on human samples at 1:5000 (fig 1a). J Biol Chem (2016) ncbi
EMD Millipore
rabbit polyclonal
  • western blot; human; 1:200; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, EMD Millipore B-Raf antibody (Upstate, 07-583) was used in western blot on human samples at 1:200 (fig st1). Nat Commun (2016) ncbi
Articles Reviewed
  1. Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, de Tullio P, et al. Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature. 2018;558:605-609 pubmed publisher
  2. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  3. Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández Mateos J, Khan K, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science. 2018;359:920-926 pubmed publisher
  4. Qi Z, Xu H, Zhang S, Xu J, Li S, Gao H, et al. RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. Int J Oncol. 2018;52:1105-1116 pubmed publisher
  5. Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. 2018;33:44-59.e8 pubmed publisher
  6. Yu R, Longo J, van Leeuwen J, Mullen P, Ba Alawi W, Haibe Kains B, et al. Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins. Cancer Res. 2018;78:1347-1357 pubmed publisher
  7. Schwartz J, Ma J, Lamprecht T, Walsh M, Wang S, Bryant V, et al. The genomic landscape of pediatric myelodysplastic syndromes. Nat Commun. 2017;8:1557 pubmed publisher
  8. Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, et al. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017;36:4778-4789 pubmed publisher
  9. Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
  10. Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  11. Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  12. Wang T, Yu H, Hughes N, Liu B, Kendirli A, Klein K, et al. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017;168:890-903.e15 pubmed publisher
  13. . Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  14. Riverso M, Montagnani V, Stecca B. KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth. Oncogene. 2017;36:3322-3333 pubmed publisher
  15. Kidger A, Rushworth L, Stellzig J, Davidson J, Bryant C, Bayley C, et al. Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling. Proc Natl Acad Sci U S A. 2017;114:E317-E326 pubmed publisher
  16. Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan X, et al. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. Oncotarget. 2017;8:9251-9266 pubmed publisher
  17. Shin J, Watanabe S, Hoelper S, Kruger M, Kostin S, Pöling J, et al. BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. elife. 2016;5: pubmed publisher
  18. Bulldan A, Shihan M, Goericke Pesch S, Scheiner Bobis G. Signaling events associated with gonadotropin releasing hormone-agonist-induced hormonal castration and its reversal in canines. Mol Reprod Dev. 2016;83:1092-1101 pubmed publisher
  19. Zhao Y, Fan D, Ru B, Cheng K, Hu S, Zhang J, et al. 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells. Eur J Cancer. 2016;68:38-50 pubmed publisher
  20. Mitra S, Ghosh B, Gayen N, Roy J, Mandal A. Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation. J Biol Chem. 2016;291:24579-24593 pubmed
  21. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  22. Siljamäki E, Abankwa D. SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling. Mol Cell Biol. 2016;36:2612-25 pubmed publisher
  23. Anta B, Pérez Rodríguez A, Castro J, García Domínguez C, Ibiza S, Martínez N, et al. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes. Cell Death Dis. 2016;7:e2311 pubmed publisher
  24. Raguz J, Jerić I, Niault T, Nowacka J, Kuzet S, Rupp C, et al. Epidermal RAF prevents allergic skin disease. elife. 2016;5: pubmed publisher
  25. Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  26. Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed publisher
  27. Choi H, Kim M, Choi Y, Shin Y, Cho S, Ko S. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med. 2016;16:122 pubmed publisher
  28. Chatelle C, Hövermann D, Muller A, Wagner H, Weber W, Radziwill G. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep. 2016;6:23713 pubmed publisher
  29. Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher
  30. Budina Kolomets A, Webster M, Leu J, Jennis M, Krepler C, Guerrini A, et al. HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016;76:2720-30 pubmed publisher
  31. Bhargava A, Pelech S, Woodard B, Kerwin J, Maherali N. Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. elife. 2016;5: pubmed publisher
  32. Zhang Z, Zhang H, Peng T, Li D, Xu J. Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma. Oncol Lett. 2016;11:610-618 pubmed
  33. Kiel C, Benisty H, Lloréns Rico V, Serrano L. The yin-yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF. elife. 2016;5:e12814 pubmed publisher
  34. Guo Y, Updegraff B, Park S, Durakoglugil D, Cruz V, Maddux S, et al. Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis. Cancer Res. 2016;76:773-86 pubmed publisher
  35. Faltermeier C, Drake J, Clark P, Smith B, Zong Y, Volpe C, et al. Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. Proc Natl Acad Sci U S A. 2016;113:E172-81 pubmed publisher
  36. Beltrán Sastre V, Benisty H, Burnier J, Berger I, Serrano L, Kiel C. Tuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering. Sci Rep. 2015;5:17432 pubmed publisher
  37. Awad K, Elinoff J, Wang S, Gairhe S, Ferreyra G, Cai R, et al. Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L187-201 pubmed publisher
  38. Jovasevic V, Naghavi M, Walsh D. Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells. J Cell Biol. 2015;211:323-37 pubmed publisher
  39. Park Y, Kim S, Kwon T, Kim J, Song I, Shin H, et al. Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. Oncogene. 2016;35:3503-13 pubmed publisher
  40. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper D. Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Carcinogenesis. 2015;36:1263-74 pubmed publisher
  41. Bunaciu R, Jensen H, Macdonald R, Latocha D, Varner J, Yen A. 6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. PLoS ONE. 2015;10:e0135668 pubmed publisher
  42. Chiang C, Uzoma I, Lane D, Memišević V, Alem F, Yao K, et al. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection. Front Microbiol. 2015;6:683 pubmed publisher
  43. Šolman M, Ligabue A, Blaževitš O, Jaiswal A, Zhou Y, Liang H, et al. Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation. elife. 2015;4:e08905 pubmed publisher
  44. Wiersma V, de Bruyn M, Wei Y, van Ginkel R, Hirashima M, Niki T, et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy. 2015;11:1373-88 pubmed publisher
  45. Condelli V, Maddalena F, Sisinni L, Lettini G, Matassa D, Piscazzi A, et al. Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma. Oncotarget. 2015;6:22298-309 pubmed
  46. Fedorenko I, Abel E, Koomen J, Fang B, Wood E, Chen Y, et al. Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells. Oncogene. 2016;35:1225-35 pubmed publisher
  47. Ho J, Nadeem A, Rydström A, Puthia M, Svanborg C. Targeting of nucleotide-binding proteins by HAMLET--a conserved tumor cell death mechanism. Oncogene. 2016;35:897-907 pubmed publisher
  48. Tang X, Chen X, Xu Y, Qiao Y, Zhang X, Wang Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015;27:1694-702 pubmed publisher
  49. Wang Z, Ma B, Ji X, Deng Y, Zhang T, Zhang X, et al. MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF. Cancer Cell Int. 2015;15:40 pubmed publisher
  50. Boswell B, Musil L. Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells. Mol Biol Cell. 2015;26:2561-72 pubmed publisher
  51. Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, et al. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology. PLoS ONE. 2015;10:e0125697 pubmed publisher
  52. Graziani G, Artuso S, De Luca A, Muzi A, Rotili D, Scimeca M, et al. A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib. Biochem Pharmacol. 2015;95:16-27 pubmed publisher
  53. Wang Y, Han A, Chen E, Singh R, Chichester C, Moore R, et al. The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells. Int J Oncol. 2015;46:1924-34 pubmed publisher
  54. Petti C, Picco G, Martelli M, Trisolini E, Bucci E, Perera T, et al. Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells. Oncotarget. 2015;6:221-33 pubmed
  55. Riemer P, Sreekumar A, Reinke S, Rad R, Schäfer R, Sers C, et al. Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity. Oncogene. 2015;34:3164-75 pubmed publisher
  56. Kugel C, Hartsough E, Davies M, Setiady Y, Aplin A. Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor. Cancer Res. 2014;74:4122-32 pubmed publisher
  57. Meng G, Tian C, Wang H, Xu Y, Zhang B, Shi Q, et al. Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss. Med Microbiol Immunol. 2014;203:291-302 pubmed publisher
  58. Eucker T, Samuelson D, Hunzicker Dunn M, Konkel M. The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens. Cell Microbiol. 2014;16:1441-55 pubmed publisher
  59. Kiel C, Verschueren E, Yang J, Serrano L. Integration of protein abundance and structure data reveals competition in the ErbB signaling network. Sci Signal. 2013;6:ra109 pubmed publisher
  60. Wang Z, Ren Z, Hu Z, Hu X, Zhang H, Wu H, et al. Angiotensin-II induces phosphorylation of ERK1/2 and promotes aortic adventitial fibroblasts differentiating into myofibroblasts during aortic dissection formation. J Mol Histol. 2014;45:401-12 pubmed publisher
  61. Li Y, Takahashi M, Stork P. Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation. J Biol Chem. 2013;288:27646-57 pubmed publisher
  62. Garcia Murillas I, Sharpe R, Pearson A, Campbell J, Natrajan R, Ashworth A, et al. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene. 2014;33:2478-86 pubmed publisher
  63. Zeng L, Ehrenreiter K, Menon J, Menard R, Kern F, Nakazawa Y, et al. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013;25:1156-65 pubmed publisher
  64. Lin S, Hoffmann K, Xiao Z, Jin N, Galli U, Mohr E, et al. MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma. Cancer Cell Int. 2013;13:3 pubmed publisher
  65. van der Hoeven D, Cho K, Ma X, Chigurupati S, Parton R, Hancock J. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol. 2013;33:237-51 pubmed publisher