This is a Validated Antibody Database (VAD) review about human AXL, based on 23 published articles (read how Labome selects the articles), using AXL antibody in all methods. It is aimed to help Labome visitors find the most suited AXL antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
AXL synonym: ARK; JTK11; Tyro7; UFO

Santa Cruz Biotechnology
mouse monoclonal (H-3)
  • western blot; human; loading ...; fig 3a
Santa Cruz Biotechnology AXL antibody (SantaCruz, sc-166269) was used in western blot on human samples (fig 3a). J Cell Mol Med (2018) ncbi
mouse monoclonal (B-2)
  • western blot; human; 1:200; loading ...; fig 6f
In order to report that the receptor tyrosine kinase AXL is efficiently and sequentially cleaved by alpha- and beta-secretases in various types of cancer cell lines, Santa Cruz Biotechnology AXL antibody (Santa Cruz, sc-166268) was used in western blot on human samples at 1:200 (fig 6f). FASEB J (2017) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 2c
Invitrogen AXL antibody (Invitrogen, PA5-106118) was used in western blot on mouse samples (fig 2c). Cell Death Dis (2021) ncbi
R&D Systems
domestic goat polyclonal
  • immunohistochemistry; human; 1:50; loading ...; fig 1a
R&D Systems AXL antibody (R&D, AF854) was used in immunohistochemistry on human samples at 1:50 (fig 1a). Nat Immunol (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D12B2)
  • western blot; human; loading ...; fig 4e
Cell Signaling Technology AXL antibody (Cell Signaling, 5724S) was used in western blot on human samples (fig 4e). Cell Rep (2019) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; loading ...; fig 2g
Cell Signaling Technology AXL antibody (Cell Signaling, 8661S) was used in western blot on human samples (fig 2g). Cell Rep (2019) ncbi
domestic rabbit monoclonal (C89E7)
  • immunocytochemistry; human; loading ...; fig 4a
  • western blot; human; loading ...; fig 4c, 4d
Cell Signaling Technology AXL antibody (CST, 8661) was used in immunocytochemistry on human samples (fig 4a) and in western blot on human samples (fig 4c, 4d). Biosci Rep (2019) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; loading ...; fig s1c
Cell Signaling Technology AXL antibody (Cell Signaling, 8661) was used in western blot on human samples (fig s1c). Breast Cancer Res (2019) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; loading ...; fig 4b
Cell Signaling Technology AXL antibody (Cell Signaling, 8661) was used in western blot on human samples (fig 4b). Br J Cancer (2019) ncbi
domestic rabbit monoclonal (C89E7)
  • immunohistochemistry; black ferret; 1:100; loading ...; fig 11
Cell Signaling Technology AXL antibody (Cell signaling technology, C89E7) was used in immunohistochemistry on black ferret samples at 1:100 (fig 11). J Comp Neurol (2019) ncbi
domestic rabbit monoclonal (C2B12)
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology AXL antibody (Cell Signaling Technology, 4939) was used in western blot on human samples (fig 1a). Mol Cancer Res (2019) ncbi
domestic rabbit monoclonal (C89E7)
  • other; human; loading ...; fig 4c
Cell Signaling Technology AXL antibody (Cell Signaling, 8661) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; 1:1000; loading ...; fig 1f
Cell Signaling Technology AXL antibody (Cell Signaling Technology., C89E7) was used in western blot on human samples at 1:1000 (fig 1f). Nat Microbiol (2018) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; 1:1000; loading ...; fig 7d
Cell Signaling Technology AXL antibody (Cell Signaling, 8661) was used in western blot on human samples at 1:1000 (fig 7d). J Clin Invest (2017) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology AXL antibody (Cell Signaling, 8661) was used in western blot on human samples (fig 1a). Mol Oncol (2017) ncbi
domestic rabbit monoclonal (D12B2)
  • western blot; mouse; 1:1000; loading ...; fig 4e
In order to explore the role of Axl in promoting a suppressive myeloid microenvironment in response to ionizing radiation therapy in combination with checkpoint immunotherapy, Cell Signaling Technology AXL antibody (Cell Signaling, 5724) was used in western blot on mouse samples at 1:1000 (fig 4e). Nat Commun (2016) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; loading ...; fig s5b
Cell Signaling Technology AXL antibody (Cell Signaling Technologies, 8661) was used in western blot on human samples (fig s5b). Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit monoclonal (D12B2)
  • western blot; mouse; loading ...; fig 4d
In order to engineer and characterize a second-generation, high-affinity AXL decoy receptor, Cell Signaling Technology AXL antibody (CST, 5724) was used in western blot on mouse samples (fig 4d). J Clin Invest (2017) ncbi
domestic rabbit monoclonal (D12B2)
  • western blot; human; fig 2a, 2b, 2c
Cell Signaling Technology AXL antibody (Cell Signaling, 5724) was used in western blot on human samples (fig 2a, 2b, 2c). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D12B2)
  • western blot; human; loading ...; fig 4c
Cell Signaling Technology AXL antibody (cell signalling, 5724) was used in western blot on human samples (fig 4c). Oncotarget (2016) ncbi
domestic rabbit monoclonal (C89E7)
  • western blot; human; 1:1000; fig 2
In order to study the interaction with YAP1 in aggressive cancer types by ZEB1 turning into a transcriptional activator, Cell Signaling Technology AXL antibody (Cell Signaling Technology, 8661) was used in western blot on human samples at 1:1000 (fig 2). Nat Commun (2016) ncbi
domestic rabbit monoclonal (D12B2)
  • western blot; human; fig 3
Cell Signaling Technology AXL antibody (Cell Signaling, 5724) was used in western blot on human samples (fig 3). Int J Cancer (2016) ncbi
domestic rabbit monoclonal (C44G1)
  • western blot; human; fig 3
Cell Signaling Technology AXL antibody (Cell Signaling, 4566) was used in western blot on human samples (fig 3). Int J Cancer (2016) ncbi
domestic rabbit monoclonal (D12B2)
  • western blot; human; fig 6
Cell Signaling Technology AXL antibody (Cell Signaling Technology, 5724) was used in western blot on human samples (fig 6). Oncogene (2016) ncbi
domestic rabbit monoclonal (C44G1)
  • other; human; fig 2
  • immunoprecipitation; human; fig 1
Cell Signaling Technology AXL antibody (Cell Signaling Technology, 4566) was used in other on human samples (fig 2) and in immunoprecipitation on human samples (fig 1). Oncogene (2016) ncbi
domestic rabbit monoclonal (C44G1)
  • western blot; human; fig 5
Cell Signaling Technology AXL antibody (Cell Signaling Technology, C44G1) was used in western blot on human samples (fig 5). Cell (2014) ncbi
Articles Reviewed
  1. Al Zaeed N, Budai Z, Szondy Z, Sarang Z. TAM kinase signaling is indispensable for proper skeletal muscle regeneration in mice. Cell Death Dis. 2021;12:611 pubmed publisher
  2. Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher
  3. Hoj J, Mayro B, Pendergast A. A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. Cell Rep. 2019;29:3421-3434.e8 pubmed publisher
  4. Kong L, Wu Z, Zhao Y, Lu X, Shi H, Liu S, et al. Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression. Biosci Rep. 2019;: pubmed publisher
  5. Greer Y, Gilbert S, Gril B, Narwal R, Peacock Brooks D, Tice D, et al. MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer. Breast Cancer Res. 2019;21:27 pubmed publisher
  6. Dufour F, Silina L, Neyret Kahn H, Moreno Vega A, Krucker C, Karboul N, et al. TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer. Br J Cancer. 2019;120:555-564 pubmed publisher
  7. Hutchinson E, Chatterjee M, Reyes L, Djankpa F, Valiant W, Dardzinski B, et al. The effect of Zika virus infection in the ferret. J Comp Neurol. 2019;527:1706-1719 pubmed publisher
  8. Axelrod H, Valkenburg K, Amend S, Hicks J, Parsana P, Torga G, et al. AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer. Mol Cancer Res. 2019;17:356-369 pubmed publisher
  9. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  10. Chen J, Yang Y, Yang Y, Zou P, Chen J, He Y, et al. AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling. Nat Microbiol. 2018;3:302-309 pubmed publisher
  11. Vl kov K, Vachtenheim J, R da J, Hor k P, Ondru ov L. Inducibly decreased MITF levels do not affect proliferation and phenotype switching but reduce differentiation of melanoma cells. J Cell Mol Med. 2018;22:2240-2251 pubmed publisher
  12. Caino M, Seo J, Wang Y, Rivadeneira D, Gabrilovich D, Kim E, et al. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017;127:3755-3769 pubmed publisher
  13. Baumann C, Ullrich A, Torka R. GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance. Mol Oncol. 2017;11:1430-1447 pubmed publisher
  14. Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, et al. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells. FASEB J. 2017;31:1382-1397 pubmed publisher
  15. Aguilera T, Rafat M, Castellini L, Shehade H, Kariolis M, Hui A, et al. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016;7:13898 pubmed publisher
  16. Retallack H, Di Lullo E, Arias C, Knopp K, Laurie M, Sandoval Espinosa C, et al. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc Natl Acad Sci U S A. 2016;113:14408-14413 pubmed
  17. Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed publisher
  18. Park J, Lee C, Kim H, Kim D, Son J, Ko E, et al. Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling. Oncotarget. 2016;7:83308-83318 pubmed publisher
  19. Hsieh M, Yang P, Wong L, Lee J. The AXL receptor tyrosine kinase is associated with adverse prognosis and distant metastasis in esophageal squamous cell carcinoma. Oncotarget. 2016;7:36956-36970 pubmed publisher
  20. Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun. 2016;7:10498 pubmed publisher
  21. van der Mijn J, Broxterman H, Knol J, Piersma S, de Haas R, Dekker H, et al. Sunitinib activates Axl signaling in renal cell cancer. Int J Cancer. 2016;138:3002-10 pubmed publisher
  22. Debruyne D, Bhatnagar N, Sharma B, Luther W, Moore N, Cheung N, et al. ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT. Oncogene. 2016;35:3681-91 pubmed publisher
  23. Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher