This is a Validated Antibody Database (VAD) review about human ARRB2, based on 17 published articles (read how Labome selects the articles), using ARRB2 antibody in all methods. It is aimed to help Labome visitors find the most suited ARRB2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
ARRB2 synonym: ARB2; ARR2; BARR2

Knockout validation
Santa Cruz Biotechnology
mouse monoclonal
  • western blot knockout validation; mouse; 1:500; loading ...; fig s2a
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 1d
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, 514791) was used in western blot knockout validation on mouse samples at 1:500 (fig s2a) and in immunohistochemistry - frozen section on mouse samples at 1:50 (fig 1d). Cell Death Differ (2021) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C16D9)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig s2a
Cell Signaling Technology ARRB2 antibody (Cell Signaling, 3857) was used in western blot knockout validation on mouse samples at 1:1000 (fig s2a). Cell Death Differ (2021) ncbi
Santa Cruz Biotechnology
mouse monoclonal (H-9)
  • western blot; human; loading ...; fig 3a
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, sc13140) was used in western blot on human samples (fig 3a). Cancer Genomics Proteomics (2021) ncbi
mouse monoclonal
  • western blot knockout validation; mouse; 1:500; loading ...; fig s2a
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 1d
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, 514791) was used in western blot knockout validation on mouse samples at 1:500 (fig s2a) and in immunohistochemistry - frozen section on mouse samples at 1:50 (fig 1d). Cell Death Differ (2021) ncbi
mouse monoclonal (B-4)
  • western blot; human; loading ...; fig 1c
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, sc-365445) was used in western blot on human samples (fig 1c). Stem Cell Reports (2020) ncbi
mouse monoclonal
  • immunoprecipitation; mouse; loading ...; fig s6b
Santa Cruz Biotechnology ARRB2 antibody (Santa, sc-514791) was used in immunoprecipitation on mouse samples (fig s6b). Nat Commun (2020) ncbi
mouse monoclonal (H-9)
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1b
  • western blot; mouse; loading ...; fig 1a, 5a
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, sc-13140) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 1b) and in western blot on mouse samples (fig 1a, 5a). J Cell Mol Med (2019) ncbi
mouse monoclonal
  • immunoprecipitation; mouse; loading ...; fig 1a
  • immunocytochemistry; mouse; loading ...; fig 3a
  • western blot; mouse; loading ...; fig 1a
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, A-1) was used in immunoprecipitation on mouse samples (fig 1a), in immunocytochemistry on mouse samples (fig 3a) and in western blot on mouse samples (fig 1a). Mol Pharmacol (2017) ncbi
mouse monoclonal (A-1)
  • immunoprecipitation; mouse; loading ...; fig 1a
  • immunocytochemistry; mouse; loading ...; fig 3a
  • western blot; mouse; loading ...; fig 1a
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, A-1) was used in immunoprecipitation on mouse samples (fig 1a), in immunocytochemistry on mouse samples (fig 3a) and in western blot on mouse samples (fig 1a). Mol Pharmacol (2017) ncbi
mouse monoclonal (B-4)
  • western blot; rat; 1:500; fig 9
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, sc-365445) was used in western blot on rat samples at 1:500 (fig 9). J Cell Mol Med (2016) ncbi
mouse monoclonal (H-9)
  • immunoprecipitation; rat; 1:500; loading ...; fig 6b
  • western blot; rat; 1:500; loading ...; fig 6e
In order to propose that claudin-4 is required for mAChR-modulated paracellular permeability of epithelial cells and investigate the mechanism, Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, sc-13140) was used in immunoprecipitation on rat samples at 1:500 (fig 6b) and in western blot on rat samples at 1:500 (fig 6e). J Cell Sci (2015) ncbi
mouse monoclonal (H-9)
  • western blot; rat; 1:500; fig 3
Santa Cruz Biotechnology ARRB2 antibody (Santa Cruz, sc-13140) was used in western blot on rat samples at 1:500 (fig 3). Exp Ther Med (2015) ncbi
Invitrogen
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 1f
In order to propose that mu opioid receptor sequences are important determinants of functional selectivity in the opioid system, Invitrogen ARRB2 antibody (Pierce, PA1-730) was used in western blot on human samples at 1:1000 (fig 1f). Mol Pharmacol (2017) ncbi
domestic rabbit polyclonal
  • immunocytochemistry; mouse; fig s1f
In order to analyze beta-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium determined by Smoothened, Invitrogen ARRB2 antibody (Thermo Fisher Scientific, PA1-730) was used in immunocytochemistry on mouse samples (fig s1f). J Cell Biol (2016) ncbi
Abcam
mouse monoclonal
  • immunoprecipitation; human; 1:1000; loading ...; fig 1b
Abcam ARRB2 antibody (Abcam, ab54790) was used in immunoprecipitation on human samples at 1:1000 (fig 1b). Development (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (C16D9)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig s2a
Cell Signaling Technology ARRB2 antibody (Cell Signaling, 3857) was used in western blot knockout validation on mouse samples at 1:1000 (fig s2a). Cell Death Differ (2021) ncbi
domestic rabbit monoclonal (C16D9)
  • western blot; mouse; 1:1000; loading ...; fig s6a
Cell Signaling Technology ARRB2 antibody (Cell Signaling, 3857) was used in western blot on mouse samples at 1:1000 (fig s6a). Nat Commun (2020) ncbi
domestic rabbit monoclonal (C16D9)
  • western blot; mouse; loading ...; fig 4d
Cell Signaling Technology ARRB2 antibody (Cell Signaling, 3857) was used in western blot on mouse samples (fig 4d). J Exp Med (2019) ncbi
domestic rabbit monoclonal (C16D9)
  • western blot; mouse; 1:1000; loading ...; fig st2
In order to report that inactivation of the beta-arrestin-2 gene, barr2, in beta-cells greatly impairs insulin release and glucose tolerance in a calorie-rich diet, Cell Signaling Technology ARRB2 antibody (Cell Signaling, 3857) was used in western blot on mouse samples at 1:1000 (fig st2). Nat Commun (2017) ncbi
domestic rabbit monoclonal (C16D9)
  • western blot; human; loading ...; fig 1a2
Cell Signaling Technology ARRB2 antibody (Cell Signaling, 3857) was used in western blot on human samples (fig 1a2). J Biol Chem (2016) ncbi
domestic rabbit monoclonal (C16D9)
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
Cell Signaling Technology ARRB2 antibody (Cell Signaling, 3857) was used in immunoprecipitation on human samples , in immunocytochemistry on human samples and in western blot on human samples . J Biol Chem (2014) ncbi
MilliporeSigma
mouse monoclonal (3G1)
  • immunocytochemistry; human; 1:200
  • western blot; human; 1:1000
  • immunohistochemistry; mouse; 1:100
In order to study light- and phosphorylation- dependent reduction in melanopsin signaling mediated by both beta-arrestin 1 and beta-arrestin 2, MilliporeSigma ARRB2 antibody (Sigma-Aldrich, WH0000409M1) was used in immunocytochemistry on human samples at 1:200, in western blot on human samples at 1:1000 and in immunohistochemistry on mouse samples at 1:100. PLoS ONE (2014) ncbi
Articles Reviewed
  1. Cao C, Zhang Y, Cheng J, Wu F, Niu X, Hu X, et al. β-Arrestin2 Inhibits the Apoptosis and Facilitates the Proliferation of Fibroblast-like Synoviocytes in Diffuse-type Tenosynovial Giant Cell Tumor. Cancer Genomics Proteomics. 2021;18:461-470 pubmed publisher
  2. Fang Y, Jiang Q, Li S, Zhu H, Xu R, Song N, et al. Opposing functions of β-arrestin 1 and 2 in Parkinson's disease via microglia inflammation and Nprl3. Cell Death Differ. 2021;28:1822-1836 pubmed publisher
  3. Liao W, Hsu C, Chan T, Yen C, Chen W, Pan H, et al. Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Stem Cell Reports. 2020;14:462-477 pubmed publisher
  4. Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, et al. Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. Nat Commun. 2020;11:941 pubmed publisher
  5. Nakai A, Fujimoto J, Miyata H, Stumm R, Narazaki M, Schulz S, et al. The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. J Exp Med. 2019;: pubmed publisher
  6. Chen L, Kong L, Wei X, Wang Y, Wang B, Zhang X, et al. β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury. J Cell Mol Med. 2019;23:3325-3335 pubmed publisher
  7. Rauschenberger V, Bernkopf D, Krenn S, Jalal K, Heller J, Behrens J, et al. The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning. Development. 2017;144:2234-2247 pubmed publisher
  8. Weinberg Z, Zajac A, Phan T, Shiwarski D, Puthenveedu M. Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor. Mol Pharmacol. 2017;91:416-427 pubmed publisher
  9. Zhu L, Almaca J, Dadi P, Hong H, Sakamoto W, Rossi M, et al. β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun. 2017;8:14295 pubmed publisher
  10. Blume L, Patten T, Eldeeb K, Leone Kabler S, Ilyasov A, Keegan B, et al. Cannabinoid Receptor Interacting Protein 1a Competition with ?-Arrestin for CB1 Receptor Binding Sites. Mol Pharmacol. 2017;91:75-86 pubmed publisher
  11. Alvarez Curto E, Inoue A, Jenkins L, Raihan S, Prihandoko R, Tobin A, et al. Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling. J Biol Chem. 2016;291:27147-27159 pubmed publisher
  12. Ni W, Tang L, Zhou H, Ding H, Qiu Y. Renoprotective effect of berberine via regulating the PGE2 -EP1-G?q-Ca(2+) signalling pathway in glomerular mesangial cells of diabetic rats. J Cell Mol Med. 2016;20:1491-502 pubmed publisher
  13. Pal K, Hwang S, Somatilaka B, Badgandi H, Jackson P, DeFea K, et al. Smoothened determines ?-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. J Cell Biol. 2016;212:861-75 pubmed publisher
  14. Cong X, Zhang Y, Li J, Mei M, Ding C, Xiang R, et al. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells. J Cell Sci. 2015;128:2271-86 pubmed publisher
  15. Wu J, Liu B, Tong W, Zhang A, Li F, Lin J, et al. Opioid receptors and associated regulator of G protein signaling are involved in the cathartic colon of rats. Exp Ther Med. 2015;9:1229-1234 pubmed
  16. Cameron E, Robinson P. β-Arrestin-dependent deactivation of mouse melanopsin. PLoS ONE. 2014;9:e113138 pubmed publisher
  17. Kriz V, Pospichalova V, Masek J, Kilander M, Slavík J, Tanneberger K, et al. ?-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein. J Biol Chem. 2014;289:1128-41 pubmed publisher