This is a Validated Antibody Database (VAD) review about human APH1A, based on 4 published articles (read how Labome selects the articles), using APH1A antibody in all methods. It is aimed to help Labome visitors find the most suited APH1A antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
APH1A synonym: 6530402N02Rik; APH-1; APH-1A; CGI-78

Invitrogen
domestic rabbit polyclonal
In order to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase, Invitrogen APH1A antibody (Thermo Fisher, O2C2) was used . J Cell Biol (2015) ncbi
domestic rabbit polyclonal
In order to investigate presenilin assembly and catalytic activity, Invitrogen APH1A antibody (Thermo Scientific, PA1-2010) was used . J Biol Chem (2015) ncbi
BioLegend
domestic rabbit polyclonal (Poly18231)
  • western blot; mouse; loading ...; fig 2a
BioLegend APH1A antibody (BioLegend, PRB-550P) was used in western blot on mouse samples (fig 2a). J Cell Biol (2019) ncbi
domestic rabbit polyclonal (Poly18231)
  • western blot; rat; fig 8a
In order to study the activity-driven interaction between presenilin 1 and synaptotagmin 1 and links to calcium, amyloid beta, and synapse, BioLegend APH1A antibody (Covance, PRB-550P) was used in western blot on rat samples (fig 8a). BMC Biol (2016) ncbi
Articles Reviewed
  1. Liu L, Ding L, Rovere M, Wolfe M, Selkoe D. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. J Cell Biol. 2019;218:644-663 pubmed publisher
  2. Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher
  3. Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  4. Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero A, Dewachter I, et al. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem. 2015;290:7169-84 pubmed publisher