This is a Validated Antibody Database (VAD) review about human AMOTL1, based on 2 published articles (read how Labome selects the articles), using AMOTL1 antibody in all methods. It is aimed to help Labome visitors find the most suited AMOTL1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
AMOTL1 synonym: JEAP; angiomotin-like protein 1; junction-enriched and associated protein

Knockout validation
Sigma-Aldrich
rabbit polyclonal
  • immunocytochemistry knockout validation; human; fig 5
  • immunohistochemistry - paraffin section; human; fig 2
  • immunohistochemistry; human; fig 2
  • western blot; human; fig 3
In order to analyze AMOTL1 and how it is antagonized by Merlin and promotes breast cancer progression, Sigma-Aldrich AMOTL1 antibody (Sigma, HPA001196) was used in immunocytochemistry knockout validation on human samples (fig 5), in immunohistochemistry - paraffin section on human samples (fig 2), in immunohistochemistry on human samples (fig 2) and in western blot on human samples (fig 3). Neoplasia (2016) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; rat; 1:300; loading ...; fig s3o
  • immunohistochemistry; mouse; 1:50; loading ...; fig 5c
In order to find that that Fat4 modulates Hippo signaling and restricts hearth growth in mice, Sigma-Aldrich AMOTL1 antibody (Sigma, HPA001196) was used in western blot on rat samples at 1:300 (fig s3o) and in immunohistochemistry on mouse samples at 1:50 (fig 5c). Nat Commun (2017) ncbi
rabbit polyclonal
  • immunocytochemistry knockout validation; human; fig 5
  • immunohistochemistry - paraffin section; human; fig 2
  • immunohistochemistry; human; fig 2
  • western blot; human; fig 3
In order to analyze AMOTL1 and how it is antagonized by Merlin and promotes breast cancer progression, Sigma-Aldrich AMOTL1 antibody (Sigma, HPA001196) was used in immunocytochemistry knockout validation on human samples (fig 5), in immunohistochemistry - paraffin section on human samples (fig 2), in immunohistochemistry on human samples (fig 2) and in western blot on human samples (fig 3). Neoplasia (2016) ncbi
Articles Reviewed
  1. Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher
  2. Couderc C, Boin A, Fuhrmann L, Vincent Salomon A, Mandati V, Kieffer Y, et al. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. Neoplasia. 2016;18:10-24 pubmed publisher