This is a Validated Antibody Database (VAD) review about human AKR1C3, based on 9 published articles (read how Labome selects the articles), using AKR1C3 antibody in all methods. It is aimed to help Labome visitors find the most suited AKR1C3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
AKR1C3 synonym: DD3; DDX; HA1753; HAKRB; HAKRe; HSD17B5; PGFS; hluPGFS; aldo-keto reductase family 1 member C3; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type II, brain; chlordecone reductase homolog HAKRb; dihydrodiol dehydrogenase 3; dihydrodiol dehydrogenase X; indanol dehydrogenase; prostaglandin F synthase; testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase

Abcam
rabbit polyclonal
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 1
Abcam AKR1C3 antibody (Abcam, Ab137546) was used in immunocytochemistry on human samples (fig 1) and in western blot on human samples (fig 1). Sci Rep (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
In order to test if osteoblasts regulate the intratumoral steroidogenesis of castration-resistant prostate cancer, Abcam AKR1C3 antibody (Abcam, ab84327) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 2). Mol Cell Endocrinol (2016) ncbi
goat polyclonal
  • western blot; human; fig 6
Abcam AKR1C3 antibody (Abcam, ab27491) was used in western blot on human samples (fig 6). Biomed Pharmacother (2015) ncbi
goat polyclonal
  • immunohistochemistry; human; 1:200
Abcam AKR1C3 antibody (Abcam, ab27491) was used in immunohistochemistry on human samples at 1:200. BMC Pregnancy Childbirth (2014) ncbi
rabbit polyclonal
  • western blot; cow; 1:500; fig 4
Abcam AKR1C3 antibody (Abcam, #ab84327) was used in western blot on cow samples at 1:500 (fig 4). Biol Reprod (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:1000
Abcam AKR1C3 antibody (Abcam, Ab84327) was used in western blot on human samples at 1:1000. Mol Hum Reprod (2013) ncbi
Invitrogen
rabbit polyclonal
  • immunohistochemistry - paraffin section; pig; 2 ug/ml; fig 3a
  • western blot; pig; 0.04 ug/ml; fig 1b
In order to evaluate the impact of flutamide on luteal prostaglandin F2alpha synthase and prostaglandin F2alpha receptor expression during pregnancy in pigs, Invitrogen AKR1C3 antibody (Thermo Fisher, PA5-28065) was used in immunohistochemistry - paraffin section on pig samples at 2 ug/ml (fig 3a) and in western blot on pig samples at 0.04 ug/ml (fig 1b). Domest Anim Endocrinol (2017) ncbi
R&D Systems
mouse monoclonal (871701)
  • immunohistochemistry - paraffin section; human; 1:100; fig 3b
In order to study the initiation of steroidogenesis at the end of the first trimester, R&D Systems AKR1C3 antibody (R&D Systems, MAB7678) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 3b). Endocr Connect (2017) ncbi
Abnova
mouse polyclonal
  • western blot; human
Abnova AKR1C3 antibody (Abnova, H00008644-B01) was used in western blot on human samples . PLoS ONE (2015) ncbi
Articles Reviewed
  1. Savchuk I, Morvan M, Antignac J, Gemzell Danielsson K, le Bizec B, Soder O, et al. Androgenic potential of human fetal adrenals at the end of the first trimester. Endocr Connect. 2017;6:348-359 pubmed publisher
  2. Grzesiak M, Knapczyk Stwora K, Slomczynska M. The impact of flutamide on prostaglandin F2α synthase and prostaglandin F2α receptor expression, and prostaglandin F2α concentration in the porcine corpus luteum of pregnancy. Domest Anim Endocrinol. 2017;59:81-89 pubmed publisher
  3. Gibson D, Simitsidellis I, Cousins F, Critchley H, Saunders P. Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes. Sci Rep. 2016;6:19970 pubmed publisher
  4. Hagberg Thulin M, Nilsson M, Thulin P, Céraline J, Ohlsson C, Damber J, et al. Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis. Mol Cell Endocrinol. 2016;422:182-191 pubmed publisher
  5. Zub K, Sousa M, Sarno A, Sharma A, Demirovic A, Rao S, et al. Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. PLoS ONE. 2015;10:e0119857 pubmed publisher
  6. Zhong T, Xu F, Xu J, Liu L, Chen Y. Aldo-keto reductase 1C3 (AKR1C3) is associated with the doxorubicin resistance in human breast cancer via PTEN loss. Biomed Pharmacother. 2015;69:317-25 pubmed publisher
  7. Phillips R, Fortier M, Lopez Bernal A. Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation. BMC Pregnancy Childbirth. 2014;14:241 pubmed publisher
  8. Kowalczyk Zieba I, Boruszewska D, Sinderewicz E, Skarzynski D, Woclawek Potocka I. Influence of lysophosphatidic acid on nitric oxide-induced luteolysis in steroidogenic luteal cells in cows. Biol Reprod. 2014;90:17 pubmed publisher
  9. O Shaughnessy P, Monteiro A, Bhattacharya S, Fraser M, Fowler P. Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. Mol Hum Reprod. 2013;19:177-87 pubmed publisher