This is a Validated Antibody Database (VAD) review about human AIM2, based on 10 published articles (read how Labome selects the articles), using AIM2 antibody in all methods. It is aimed to help Labome visitors find the most suited AIM2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
AIM2 synonym: PYHIN4

Knockout validation
Abcam
domestic rabbit polyclonal
  • western blot knockout validation; human; fig 2a
Abcam AIM2 antibody (Abcam, ab93015) was used in western blot knockout validation on human samples (fig 2a). MBio (2019) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5X7K)
  • western blot knockout validation; human; loading ...; fig 2c
Cell Signaling Technology AIM2 antibody (Cell Signaling, D5X7K) was used in western blot knockout validation on human samples (fig 2c). Science (2016) ncbi
Abcam
mouse monoclonal (3C4G11)
  • western blot; human; fig 5d
Abcam AIM2 antibody (Abcam, ab204995) was used in western blot on human samples (fig 5d). Signal Transduct Target Ther (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:200; loading ...; fig 1a
  • western blot; human; loading ...; fig 2c
Abcam AIM2 antibody (Abcam, ab93015) was used in immunohistochemistry on human samples at 1:200 (fig 1a) and in western blot on human samples (fig 2c). Sci Rep (2021) ncbi
domestic rabbit polyclonal
  • western blot knockout validation; human; fig 2a
Abcam AIM2 antibody (Abcam, ab93015) was used in western blot knockout validation on human samples (fig 2a). MBio (2019) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
Abcam AIM2 antibody (Abcam, ab93015) was used in immunohistochemistry - paraffin section on human samples (fig 1a). Oncotarget (2016) ncbi
BioLegend
mouse monoclonal (3B10)
  • flow cytometry; human; loading ...; fig 1b
BioLegend AIM2 antibody (Biolegend, 652804) was used in flow cytometry on human samples (fig 1b). Signal Transduct Target Ther (2021) ncbi
mouse monoclonal (3B10)
  • flow cytometry; human; 1:20; loading ...; fig 2a
BioLegend AIM2 antibody (Biolegend, 652803) was used in flow cytometry on human samples at 1:20 (fig 2a). PLoS ONE (2017) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2b
  • western blot; mouse; 1:1000; loading ...; fig 2c
Invitrogen AIM2 antibody (eBioscience, 14?C6008?C93) was used in immunohistochemistry - paraffin section on mouse samples at 1:1000 (fig 2b) and in western blot on mouse samples at 1:1000 (fig 2c). Cell Death Dis (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2d
In order to study inflammasome activation during primary Epstein-Barr virus infection, Invitrogen AIM2 antibody (eBioscience, 14-6008) was used in western blot on human samples (fig 2d). PLoS ONE (2017) ncbi
Cell Signaling Technology
domestic rabbit monoclonal (D5X7K)
  • western blot; human; loading ...; fig s2a
Cell Signaling Technology AIM2 antibody (Cell Signaling Technology, 12948) was used in western blot on human samples (fig s2a). Cell (2017) ncbi
domestic rabbit monoclonal (D5X7K)
  • western blot; human; 1:500; loading ...; fig s4
Cell Signaling Technology AIM2 antibody (CST, 12948) was used in western blot on human samples at 1:500 (fig s4). PLoS ONE (2017) ncbi
domestic rabbit monoclonal (D5X7K)
  • immunoprecipitation; human; loading ...; fig 3a
  • immunocytochemistry; human; loading ...; fig 3c
  • western blot; human; loading ...; fig 1d; 3a
Cell Signaling Technology AIM2 antibody (Cell Signaling, D5X7K) was used in immunoprecipitation on human samples (fig 3a), in immunocytochemistry on human samples (fig 3c) and in western blot on human samples (fig 1d; 3a). Virol J (2017) ncbi
domestic rabbit monoclonal (D5X7K)
  • western blot; human; loading ...; fig 5a
Cell Signaling Technology AIM2 antibody (Cell Signaling, 12948) was used in western blot on human samples (fig 5a). Oncotarget (2016) ncbi
domestic rabbit monoclonal (D5X7K)
  • western blot knockout validation; human; loading ...; fig 2c
Cell Signaling Technology AIM2 antibody (Cell Signaling, D5X7K) was used in western blot knockout validation on human samples (fig 2c). Science (2016) ncbi
Articles Reviewed
  1. Yang M, Long D, Hu L, Zhao Z, Li Q, Guo Y, et al. AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation. Signal Transduct Target Ther. 2021;6:341 pubmed publisher
  2. Wang D, Zou J, Dai J, Cheng Z. Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway. Sci Rep. 2021;11:8235 pubmed publisher
  3. Yuan B, Zhou X, You Z, Xu W, Fan J, Chen S, et al. Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death Dis. 2020;11:76 pubmed publisher
  4. Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, et al. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome. MBio. 2019;10: pubmed publisher
  5. Gaidt M, Ebert T, Chauhan D, Ramshorn K, Pinci F, Zuber S, et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3. Cell. 2017;171:1110-1124.e18 pubmed publisher
  6. Svensson A, Patzi Churqui M, Schlüter K, Lind L, Eriksson K. Maturation-dependent expression of AIM2 in human B-cells. PLoS ONE. 2017;12:e0183268 pubmed publisher
  7. Torii Y, Kawada J, Murata T, Yoshiyama H, Kimura H, Ito Y. Epstein-Barr virus infection-induced inflammasome activation in human monocytes. PLoS ONE. 2017;12:e0175053 pubmed publisher
  8. Huang Y, Ma D, Huang H, Lu Y, Liao Y, Liu L, et al. Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome. Virol J. 2017;14:34 pubmed publisher
  9. Ma X, Guo P, Qiu Y, Mu K, Zhu L, Zhao W, et al. Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway. Oncotarget. 2016;7:36185-36197 pubmed publisher
  10. Chuong E, Elde N, Feschotte C. Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science. 2016;351:1083-7 pubmed publisher