This is a Validated Antibody Database (VAD) review about human ADAM17, based on 14 published articles (read how Labome selects the articles), using ADAM17 antibody in all methods. It is aimed to help Labome visitors find the most suited ADAM17 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
ADAM17 synonym: ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE

Knockout validation
Abcam
domestic rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; loading ...; fig 2
Abcam ADAM17 antibody (Abcam, ab39163) was used in immunohistochemistry knockout validation on mouse samples (fig 2). Hypertension (2016) ncbi
Abcam
mouse monoclonal
  • immunohistochemistry - frozen section; human; loading ...; fig s2c
Abcam ADAM17 antibody (Abcam, ab57484) was used in immunohistochemistry - frozen section on human samples (fig s2c). J Exp Med (2020) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1a
Abcam ADAM17 antibody (Abcam, ab39162) was used in immunohistochemistry - paraffin section on human samples at 1:1000 (fig 1a). Mol Cancer (2019) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 1h
Abcam ADAM17 antibody (Abcam, ab39162) was used in western blot on human samples at 1:1000 (fig 1h). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5c
In order to investigate the role of FURIN in LysM positive myeloid cells in vivo, Abcam ADAM17 antibody (Abcam, ab39162) was used in western blot on mouse samples (fig 5c). Oncotarget (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; loading ...; fig 2
Abcam ADAM17 antibody (Abcam, ab39163) was used in immunohistochemistry knockout validation on mouse samples (fig 2). Hypertension (2016) ncbi
mouse monoclonal
  • western blot; human; fig 4
Abcam ADAM17 antibody (Abcam, ab57484) was used in western blot on human samples (fig 4). Invest Ophthalmol Vis Sci (2016) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
  • western blot; human; 1:500; loading ...; fig 2c, 2f
Invitrogen ADAM17 antibody (Invitrogen, PA5-17079) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 1a) and in western blot on human samples at 1:500 (fig 2c, 2f). Int J Mol Sci (2022) ncbi
domestic rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6c
Invitrogen ADAM17 antibody (Thermo Fisher, PA5-11572) was used in western blot on mouse samples at 1:1000 (fig 6c). Aging Dis (2022) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • western blot; human; 1:2000; loading ...; fig s3a
Cell Signaling Technology ADAM17 antibody (Cell Signaling, 3976s) was used in western blot on human samples at 1:2000 (fig s3a). Front Cell Dev Biol (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2f, s2d, s2f
Cell Signaling Technology ADAM17 antibody (Cell Signaling, 3976) was used in western blot on human samples (fig 2f, s2d, s2f). Mol Cancer (2019) ncbi
domestic rabbit monoclonal (D22H4)
  • western blot; human; loading ...; fig 3e, 5b
Cell Signaling Technology ADAM17 antibody (Cell Signaling Technology, 6978) was used in western blot on human samples (fig 3e, 5b). Cancer Res (2017) ncbi
domestic rabbit monoclonal (D22H4)
  • western blot; human; 1:1000; loading ...; fig 4b
In order to report that the receptor tyrosine kinase AXL is efficiently and sequentially cleaved by alpha- and beta-secretases in various types of cancer cell lines, Cell Signaling Technology ADAM17 antibody (Cell Signaling, 6978S) was used in western blot on human samples at 1:1000 (fig 4b). FASEB J (2017) ncbi
domestic rabbit monoclonal (D22H4)
  • western blot; human; 1:3000; loading ...; fig 3
In order to assess the contribution of amphiregulin, epidermal growth factor, heparin-binding epidermal growth factor, and transforming growth factor alpha in the responsiveness of gastric cancer cell lines to cetuximab and trastuzumab, Cell Signaling Technology ADAM17 antibody (Cell Signaling, 6978) was used in western blot on human samples at 1:3000 (fig 3). J Cancer Res Clin Oncol (2017) ncbi
domestic rabbit monoclonal (D22H4)
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...
Cell Signaling Technology ADAM17 antibody (Cell Signaling, D22H4) was used in immunohistochemistry - frozen section on mouse samples at 1:1000. Proc Natl Acad Sci U S A (2016) ncbi
domestic rabbit monoclonal (D22H4)
  • western blot; human; loading ...; fig 6a
Cell Signaling Technology ADAM17 antibody (Cell Signaling Technology Inc., 6978) was used in western blot on human samples (fig 6a). Mol Carcinog (2015) ncbi
Articles Reviewed
  1. Van Meenen D, Doege A, Alefeld E, Haase A, Beier M, Kiefer T, et al. ADAM10 and ADAM17-Novel Players in Retinoblastoma Carcinogenesis. Int J Mol Sci. 2022;23: pubmed publisher
  2. Xu B, He Y, Liu L, Ye G, Chen L, Wang Q, et al. The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice. Aging Dis. 2022;13:1293-1310 pubmed publisher
  3. Pang K, Ghim M, Liu C, Tay H, Fhu C, Chia R, et al. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Front Cell Dev Biol. 2021;9:706143 pubmed publisher
  4. Kaaij M, van Tok M, Blijdorp I, Ambarus C, Stock M, Pots D, et al. Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis. J Exp Med. 2020;217: pubmed publisher
  5. Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, et al. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019;18:156 pubmed publisher
  6. Jin L, Vu T, Yuan G, Datta P. STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. Cancer Res. 2017;77:5464-5478 pubmed publisher
  7. Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
  8. Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, et al. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells. FASEB J. 2017;31:1382-1397 pubmed publisher
  9. Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, et al. Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines. J Cancer Res Clin Oncol. 2017;143:573-600 pubmed publisher
  10. Kuzmanov U, Guo H, Buchsbaum D, Cosme J, Abbasi C, Isserlin R, et al. Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2016;113:12592-12597 pubmed
  11. Cordova Z, Grönholm A, Kytölä V, Taverniti V, Hämäläinen S, Aittomäki S, et al. Myeloid cell expressed proprotein convertase FURIN attenuates inflammation. Oncotarget. 2016;7:54392-54404 pubmed publisher
  12. Takayanagi T, Forrester S, Kawai T, Obama T, Tsuji T, Elliott K, et al. Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Hypertension. 2016;68:949-955 pubmed publisher
  13. DeSantis Rodrigues A, Chang Y, Hahn R, Po I, Zhou P, Lacey C, et al. ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest Ophthalmol Vis Sci. 2016;57:1687-98 pubmed publisher
  14. Kaushik G, Venugopal A, Ramamoorthy P, Standing D, Subramaniam D, Umar S, et al. Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog. 2015;54:1710-21 pubmed publisher