This is a Validated Antibody Database (VAD) review about human ADAM10, based on 20 published articles (read how Labome selects the articles), using ADAM10 antibody in all methods. It is aimed to help Labome visitors find the most suited ADAM10 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
ADAM10 synonym: AD10; AD18; CD156c; CDw156; HsT18717; MADM; RAK; kuz

Knockout validation
Abcam
domestic rabbit monoclonal (EPR5622)
  • western blot knockout validation; mouse; fig 2
Abcam ADAM10 antibody (Abcam/Epitomics, EPR5622) was used in western blot knockout validation on mouse samples (fig 2). elife (2016) ncbi
Abcam
domestic rabbit monoclonal (EPR5622)
  • western blot; rat; 1:1000; loading ...; fig 1d
Abcam ADAM10 antibody (Abcam, ab124695) was used in western blot on rat samples at 1:1000 (fig 1d). Open Life Sci (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 2a
Abcam ADAM10 antibody (Abcam, ab1997) was used in western blot on human samples at 1:1000 (fig 2a). J Biol Chem (2021) ncbi
domestic rabbit monoclonal (EPR5622)
  • western blot; mouse; 1:2000; loading ...; fig 4e
Abcam ADAM10 antibody (Abcam, ab124695) was used in western blot on mouse samples at 1:2000 (fig 4e). Front Cell Dev Biol (2021) ncbi
domestic rabbit monoclonal (EPR5622)
  • western blot; mouse; loading ...; fig 5l
Abcam ADAM10 antibody (Abcam, ab124695) was used in western blot on mouse samples (fig 5l). Redox Biol (2021) ncbi
domestic rabbit polyclonal
  • western blot; human; loading ...; fig 2c
Abcam ADAM10 antibody (Abcam, Ab1997) was used in western blot on human samples (fig 2c). Aging (Albany NY) (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 4a
Abcam ADAM10 antibody (Abcam, Ab1997) was used in western blot on human samples at 1:1000 (fig 4a). Acta Neuropathol Commun (2019) ncbi
domestic rabbit monoclonal (EPR5622)
  • western blot; mouse; loading ...; fig 4b
Abcam ADAM10 antibody (Abcam, EPR5622) was used in western blot on mouse samples (fig 4b). Front Immunol (2018) ncbi
domestic rabbit monoclonal (EPR5622)
  • western blot; mouse; fig 2a
Abcam ADAM10 antibody (Abcam, EPR5622) was used in western blot on mouse samples (fig 2a). Cell Mol Life Sci (2018) ncbi
domestic rabbit monoclonal (EPR5622)
  • western blot; mouse; 1:500; loading ...; fig 4a
Abcam ADAM10 antibody (Abcam, ab124695) was used in western blot on mouse samples at 1:500 (fig 4a). Front Pharmacol (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; fig 1h
Abcam ADAM10 antibody (Abcam, ab1997) was used in western blot on human samples at 1:1000 (fig 1h). Nat Commun (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 4b
In order to report that the receptor tyrosine kinase AXL is efficiently and sequentially cleaved by alpha- and beta-secretases in various types of cancer cell lines, Abcam ADAM10 antibody (Abcam, ab1997) was used in western blot on human samples at 1:1000 (fig 4b). FASEB J (2017) ncbi
domestic rabbit polyclonal
  • western blot; mouse; loading ...; fig 5
Abcam ADAM10 antibody (Abcam, Ab1997) was used in western blot on mouse samples (fig 5). Int J Mol Med (2017) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:500; loading ...; fig s2
In order to elucidate the relationship between protease prolyl endopeptidase and neural cell adhesion molecule, Abcam ADAM10 antibody (Abcam, ab1997) was used in western blot on human samples at 1:500 (fig s2). J Cell Sci (2016) ncbi
domestic rabbit polyclonal
  • western blot; human; fig 1
Abcam ADAM10 antibody (ABCAM, ab1997) was used in western blot on human samples (fig 1). Toxins (Basel) (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 1
Abcam ADAM10 antibody (Abcam, ab1997) was used in western blot on mouse samples (fig 1). Sci Rep (2016) ncbi
domestic rabbit monoclonal (EPR5622)
  • western blot knockout validation; mouse; fig 2
Abcam ADAM10 antibody (Abcam/Epitomics, EPR5622) was used in western blot knockout validation on mouse samples (fig 2). elife (2016) ncbi
domestic rabbit polyclonal
In order to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase, Abcam ADAM10 antibody (Abcam, ab1997) was used . J Cell Biol (2015) ncbi
domestic rabbit monoclonal (EPR5622)
  • immunoprecipitation; hamsters; fig 2
  • western blot; hamsters; fig 2
In order to identify and characterize a multiprotease complex containing both alpha- and gamma-secretase, Abcam ADAM10 antibody (Abcam, ab124695) was used in immunoprecipitation on hamsters samples (fig 2) and in western blot on hamsters samples (fig 2). J Cell Biol (2015) ncbi
Santa Cruz Biotechnology
mouse monoclonal (A-3)
  • proximity ligation assay; pigs ; 1:100; fig 5
  • immunocytochemistry; pigs ; 1:100; fig 1
In order to characterize cell junction assembly in early porcine embryo development by ADAM10, Santa Cruz Biotechnology ADAM10 antibody (Santa Cruz, sc-48400) was used in proximity ligation assay on pigs samples at 1:100 (fig 5) and in immunocytochemistry on pigs samples at 1:100 (fig 1). PLoS ONE (2016) ncbi
mouse monoclonal (A-3)
  • western blot; human; 1:500; loading ...; fig st3
In order to study the DNA damage response in senescent epithelial cells, Santa Cruz Biotechnology ADAM10 antibody (Santa Cruz, sc-48400) was used in western blot on human samples at 1:500 (fig st3). Nat Commun (2016) ncbi
mouse monoclonal (B-3)
  • immunocytochemistry; mouse; 1:500
Santa Cruz Biotechnology ADAM10 antibody (Santa, sc-28358) was used in immunocytochemistry on mouse samples at 1:500. Proc Natl Acad Sci U S A (2015) ncbi
Articles Reviewed
  1. Li X, Pan F, He B, Fang C. Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage. Open Life Sci. 2021;16:856-866 pubmed publisher
  2. Ma X, Takahashi Y, Wu W, Liang W, Chen J, Chakraborty D, et al. ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. J Biol Chem. 2021;297:101185 pubmed publisher
  3. Hu Y, Li C, Wang X, Chen W, Qian Y, Dai X. TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage. Front Cell Dev Biol. 2021;9:693342 pubmed publisher
  4. Liu Y, Cong P, Zhang T, Wang R, Wang X, Liu J, et al. Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition. Redox Biol. 2021;43:102002 pubmed publisher
  5. Hu T, Zhou Y, Lu J, Xia P, Chen Y, Cao X, et al. A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer's-like pathology. Aging (Albany NY). 2020;12:481-501 pubmed publisher
  6. Gerber H, Mosser S, Boury Jamot B, Stumpe M, Piersigilli A, Goepfert C, et al. The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta Neuropathol Commun. 2019;7:13 pubmed publisher
  7. Hwang I, Boularan C, Harrison K, Kehrl J. Gαi Signaling Promotes Marginal Zone B Cell Development by Enabling Transitional B Cell ADAM10 Expression. Front Immunol. 2018;9:687 pubmed publisher
  8. Seipold L, Altmeppen H, Koudelka T, Tholey A, Kaspárek P, Sedlacek R, et al. In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Cell Mol Life Sci. 2018;75:3251-3267 pubmed publisher
  9. Yan L, Deng Y, Gao J, Liu Y, Li F, Shi J, et al. Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production. Front Pharmacol. 2017;8:106 pubmed publisher
  10. Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
  11. Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, et al. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells. FASEB J. 2017;31:1382-1397 pubmed publisher
  12. Park T, Ryu Y, Park H, Kim J, Go J, Noh J, et al. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med. 2017;39:21-30 pubmed publisher
  13. Jaako K, Waniek A, Parik K, Klimaviciusa L, Aonurm Helm A, Noortoots A, et al. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. J Cell Sci. 2016;129:3792-3802 pubmed
  14. Ezekwe E, Weng C, Duncan J. ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus ?-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes. Toxins (Basel). 2016;8:95 pubmed publisher
  15. Kwon J, Jeong S, Choi I, Kim N. ADAM10 Is Involved in Cell Junction Assembly in Early Porcine Embryo Development. PLoS ONE. 2016;11:e0152921 pubmed publisher
  16. Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, et al. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Sci Rep. 2016;6:21534 pubmed publisher
  17. Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
  18. Kuhn P, Colombo A, Schusser B, Dreymueller D, Wetzel S, Schepers U, et al. Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function. elife. 2016;5: pubmed publisher
  19. Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
  20. Corbett G, Gonzalez F, Pahan K. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015;112:8445-50 pubmed publisher