This is a Validated Antibody Database (VAD) review about human ACE2, based on 21 published articles (read how Labome selects the articles), using ACE2 antibody in all methods. It is aimed to help Labome visitors find the most suited ACE2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
ACE2 synonym: ACEH

Knockout validation
Invitrogen
domestic rabbit recombinant (SN0754)
  • western blot knockout validation; human; 0.5 ug/ml; loading ...; fig s3a, s3c
Invitrogen ACE2 antibody (Invitrogen, MA5-32307) was used in western blot knockout validation on human samples at 0.5 ug/ml (fig s3a, s3c). Cell (2021) ncbi
Abcam
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1
Abcam ACE2 antibody (Abcam, ab15348) was used in immunohistochemistry - paraffin section on human samples at 1:500 (fig 1). Biomedicines (2022) ncbi
domestic rabbit monoclonal (EPR4435(2))
  • immunohistochemistry - paraffin section; human; loading ...; fig 2a, 2c, 2e, 2g
  • western blot; human; loading ...; fig 5a, 5b, 5c, 5d
Abcam ACE2 antibody (Abcam, ab108252) was used in immunohistochemistry - paraffin section on human samples (fig 2a, 2c, 2e, 2g) and in western blot on human samples (fig 5a, 5b, 5c, 5d). Front Cell Dev Biol (2021) ncbi
domestic rabbit monoclonal (EPR4435(2))
  • immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 5a
  • western blot; rat; 1:1000; loading ...; fig 5d
Abcam ACE2 antibody (Abcam, ab108252) was used in immunohistochemistry - paraffin section on rat samples at 1:100 (fig 5a) and in western blot on rat samples at 1:1000 (fig 5d). Exp Ther Med (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; loading ...; fig 1a
Abcam ACE2 antibody (Abcam, ab15348) was used in immunohistochemistry on human samples (fig 1a). Cell Stem Cell (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 2c
Abcam ACE2 antibody (Abcam, ab15348) was used in immunohistochemistry on mouse samples (fig 2c). Environ Res (2021) ncbi
mouse monoclonal (MM0073-11A31)
  • immunohistochemistry; mouse; loading ...; fig 3a
Abcam ACE2 antibody (Abcam, ab89111) was used in immunohistochemistry on mouse samples (fig 3a). Zool Res (2020) ncbi
domestic rabbit monoclonal
  • immunohistochemistry; mouse; loading ...; fig 2c
  • western blot; human; loading ...; fig 1b
Abcam ACE2 antibody (Abcam, ab108209) was used in immunohistochemistry on mouse samples (fig 2c) and in western blot on human samples (fig 1b). Zool Res (2020) ncbi
domestic rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3b
Abcam ACE2 antibody (Abcam, ab15348) was used in western blot on human samples at 1:1000 (fig 3b). Sci Rep (2016) ncbi
domestic rabbit monoclonal (EPR4435(2))
  • western blot; rat; 1:200
Abcam ACE2 antibody (Abcam, ab108252) was used in western blot on rat samples at 1:200. J Huazhong Univ Sci Technolog Med Sci (2015) ncbi
domestic rabbit monoclonal (EPR4435(2))
  • western blot; mouse; 1:500
Abcam ACE2 antibody (Abcam, ab108252) was used in western blot on mouse samples at 1:500. PLoS ONE (2013) ncbi
Invitrogen
domestic rabbit recombinant (SN0754)
  • western blot; human; 1:500; loading ...; fig 5a, 9a
Invitrogen ACE2 antibody (Invitrogen, MA5-32307) was used in western blot on human samples at 1:500 (fig 5a, 9a). BBA Adv (2022) ncbi
domestic rabbit recombinant (SN0754)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3e
Invitrogen ACE2 antibody (Thermofisher scientific, SN0754) was used in immunohistochemistry - paraffin section on mouse samples (fig 3e). Biochem Pharmacol (2021) ncbi
domestic rabbit recombinant (SN0754)
  • immunohistochemistry - frozen section; human; 1:200; fig 4a
Invitrogen ACE2 antibody (Thermo Fisher, MA5-32307) was used in immunohistochemistry - frozen section on human samples at 1:200 (fig 4a). bioRxiv (2021) ncbi
domestic rabbit recombinant (SN0754)
  • western blot knockout validation; human; 0.5 ug/ml; loading ...; fig s3a, s3c
Invitrogen ACE2 antibody (Invitrogen, MA5-32307) was used in western blot knockout validation on human samples at 0.5 ug/ml (fig s3a, s3c). Cell (2021) ncbi
R&D Systems
domestic goat polyclonal
  • blocking or activating experiments; human; loading ...; fig 3e
R&D Systems ACE2 antibody (R&D Systems, AF933) was used in blocking or activating experiments on human samples (fig 3e). Signal Transduct Target Ther (2022) ncbi
domestic goat polyclonal
  • immunohistochemistry; human; 1:100; loading ...; fig 3b
R&D Systems ACE2 antibody (R&D Systems, AF933) was used in immunohistochemistry on human samples at 1:100 (fig 3b). Nat Commun (2021) ncbi
mouse monoclonal (535919)
  • flow cytometry; human; 1:100; loading ...; fig s6e
R&D Systems ACE2 antibody (R&D Systems, FAB9332S) was used in flow cytometry on human samples at 1:100 (fig s6e). Immunity (2021) ncbi
domestic goat polyclonal
  • immunohistochemistry; human; 1:100; loading ...; fig 2a
R&D Systems ACE2 antibody (R&D, AF933) was used in immunohistochemistry on human samples at 1:100 (fig 2a). Part Fibre Toxicol (2021) ncbi
domestic goat polyclonal
  • immunohistochemistry - frozen section; human; 1:200; fig 4a
R&D Systems ACE2 antibody (R&D, AF933) was used in immunohistochemistry - frozen section on human samples at 1:200 (fig 4a). bioRxiv (2021) ncbi
domestic goat polyclonal
  • flow cytometry; human; loading ...; fig s2
R&D Systems ACE2 antibody (R&D Systems, AF933) was used in flow cytometry on human samples (fig s2). Nat Commun (2021) ncbi
domestic goat polyclonal
  • flow cytometry; human; loading ...; fig 6a, 6f
  • immunocytochemistry; human; loading ...; fig 6h
R&D Systems ACE2 antibody (R&D Systems, AF933) was used in flow cytometry on human samples (fig 6a, 6f) and in immunocytochemistry on human samples (fig 6h). Cell (2021) ncbi
Santa Cruz Biotechnology
mouse monoclonal (AC18Z)
  • western blot; human; 1:1000; loading ...; fig 10b
Santa Cruz Biotechnology ACE2 antibody (Santa Cruz, C-18) was used in western blot on human samples at 1:1000 (fig 10b). J Biol Chem (2015) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig s8a
MilliporeSigma ACE2 antibody (Sigma, HPA000288) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig s8a). Theranostics (2021) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 12
MilliporeSigma ACE2 antibody (Sigma, HPA000288) was used in immunohistochemistry - paraffin section on mouse samples at 1:500 (fig 12). Front Pharmacol (2020) ncbi
Articles Reviewed
  1. Goebel H, Koeditz B, Huerta M, Kameri E, Nestler T, Kamphausen T, et al. COVID-19 Infection Induce miR-371a-3p Upregulation Resulting in Influence on Male Fertility. Biomedicines. 2022;10: pubmed publisher
  2. Shen X, Geng R, Li Q, Chen Y, Li S, Wang Q, et al. ACE2-independent infection of T lymphocytes by SARS-CoV-2. Signal Transduct Target Ther. 2022;7:83 pubmed publisher
  3. Manna V, Choi H, Rotoli S, CARADONNA S. The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia. BBA Adv. 2022;2:100044 pubmed publisher
  4. Beumer J, Geurts M, Lamers M, Puschhof J, Zhang J, van der Vaart J, et al. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses. Nat Commun. 2021;12:5498 pubmed publisher
  5. Qin Z, Liu F, Blair R, Wang C, Yang H, Mudd J, et al. Endothelial cell infection and dysfunction, immune activation in severe COVID-19. Theranostics. 2021;11:8076-8091 pubmed publisher
  6. An X, Lin W, Liu H, Zhong W, Zhang X, Zhu Y, et al. SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal Tract. Front Cell Dev Biol. 2021;9:659809 pubmed publisher
  7. Zhang F, Wang Y, Liu P, Di P, Li M, Wang C. Puerarin exhibits antiinflammatory properties in gunpowder smog-induced acute lung injury in rats via regulation of the renin-angiotensin system and the NFκB signaling pathway. Exp Ther Med. 2021;22:809 pubmed publisher
  8. Lu Q, Liu J, Zhao S, Gomez Castro M, Laurent Rolle M, Dong J, et al. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity. 2021;54:1304-1319.e9 pubmed publisher
  9. Eriksen A, Møller R, Makovoz B, Uhl S, tenOever B, Blenkinsop T. SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium. Cell Stem Cell. 2021;28:1205-1220.e7 pubmed publisher
  10. Biagioli M, Marchianò S, Roselli R, Di Giorgio C, Bellini R, Bordoni M, et al. Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction. Biochem Pharmacol. 2021;188:114564 pubmed publisher
  11. Alawi L, Dhakal S, Emberesh S, Sawant H, Hosawi A, Thanekar U, et al. Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension. Front Pharmacol. 2020;11:602985 pubmed publisher
  12. Li H, Liu C, Hsu T, Lin J, Hsu J, Li A, et al. Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19. Part Fibre Toxicol. 2021;18:11 pubmed publisher
  13. Andrews M, Mukhtar T, Eze U, Simoneau C, Perez Y, Mostajo Radji M, et al. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021;: pubmed publisher
  14. Sagawa T, Tsujikawa T, Honda A, Miyasaka N, Tanaka M, Kida T, et al. Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung. Environ Res. 2021;195:110722 pubmed publisher
  15. Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, et al. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021;12:134 pubmed publisher
  16. Daniloski Z, Jordan T, Wessels H, Hoagland D, Kasela S, Legut M, et al. Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Cell. 2021;184:92-105.e16 pubmed publisher
  17. Liang Y, Li H, Li J, Yang Z, Li J, Zheng H, et al. Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model. Zool Res. 2020;41:621-631 pubmed publisher
  18. Leoncikas V, Wu H, Ward L, Kierzek A, Plant N. Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production. Sci Rep. 2016;6:19771 pubmed publisher
  19. Wu L, Zhou P, Xie J, Zhu R, Zhou S, Wang G, et al. Effects of Yinchenhao decoction on self-regulation of renin-angiotensin system by targeting angiotensin converting enzyme 2 in bile duct-ligated rat liver. J Huazhong Univ Sci Technolog Med Sci. 2015;35:519-524 pubmed publisher
  20. Le Q, Blanchet M, Seidah N, Labonté P. Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9. J Biol Chem. 2015;290:23385-400 pubmed publisher
  21. Frantz E, Crespo Mascarenhas C, Barreto Vianna A, Aguila M, Mandarim de Lacerda C. Renin-angiotensin system blockers protect pancreatic islets against diet-induced obesity and insulin resistance in mice. PLoS ONE. 2013;8:e67192 pubmed publisher