This is a Validated Antibody Database (VAD) review about human 4 1BB, based on 23 published articles (read how Labome selects the articles), using 4 1BB antibody in all methods. It is aimed to help Labome visitors find the most suited 4 1BB antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
4 1BB synonym: 4-1BB; CD137; CDw137; ILA; tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CD137 antigen; T cell antigen ILA; T-cell antigen 4-1BB homolog; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB

BioLegend
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig s2b
BioLegend 4 1BB antibody (Biolegend, 4B4-1) was used in flow cytometry on human samples (fig s2b). Nat Med (2019) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig s1c
BioLegend 4 1BB antibody (BioLegend, VI C-7) was used in flow cytometry on human samples (fig s1c). J Immunol (2017) ncbi
mouse monoclonal (4B4-1)
  • mass cytometry; human; loading ...; fig 2a
In order to investigate the immune composition of tumor microenvironment in hepatocellular carcinoma, BioLegend 4 1BB antibody (BioLegend, 4B4-1) was used in mass cytometry on human samples (fig 2a). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 2a
BioLegend 4 1BB antibody (BioLegend, n4b4-1) was used in flow cytometry on human samples (fig 2a). elife (2017) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 1a
In order to evaluate the predictive values of the protective T-cell response for human cytomegalovirus disease, BioLegend 4 1BB antibody (BioLegend, 4B4-1) was used in flow cytometry on human samples (fig 1a). New Microbiol (2016) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; fig 6
BioLegend 4 1BB antibody (BioLegend, 4B4-1) was used in flow cytometry on human samples (fig 6). J Immunol Methods (2016) ncbi
mouse monoclonal (4B4-1)
  • immunocytochemistry; human; fig 1
BioLegend 4 1BB antibody (BioLegend, 309817) was used in immunocytochemistry on human samples (fig 1). Clin Cancer Res (2015) ncbi
mouse monoclonal (4B4-1)
  • blocking or activating experiments; human; 10 ug/ml; fig 4
BioLegend 4 1BB antibody (Biolegend, 4b4-1) was used in blocking or activating experiments on human samples at 10 ug/ml (fig 4). J Virol (2015) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human
In order to determine the presence, frequency, association to other immune parameters, and functional properties of circulating CD14(+) cells lacking HLA-DR expression in patients with untreated chronic lymphocytic leukemia, BioLegend 4 1BB antibody (Biolegend, 4B4-1) was used in flow cytometry on human samples . Blood (2014) ncbi
Invitrogen
mouse monoclonal (4B4 (4B4-1))
  • flow cytometry; human; loading ...; fig 4b
In order to define the contribution of CD103+ tumor-infiltrating lymphocytes to high-grade serous epithelial ovarian cancer, Invitrogen 4 1BB antibody (eBioscience, 4B4) was used in flow cytometry on human samples (fig 4b). Oncotarget (2016) ncbi
BD Biosciences
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 1e
BD Biosciences 4 1BB antibody (BD Biosciences, 4B4-1) was used in flow cytometry on human samples (fig 1e). Nat Med (2018) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 2
BD Biosciences 4 1BB antibody (BD, 4B4-1) was used in flow cytometry on human samples (fig 2). Biol Blood Marrow Transplant (2018) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 1c
In order to determine the role of PD-1 in regulating anti-tumor T cell reactivities, BD Biosciences 4 1BB antibody (BD Biosciences, 4B41) was used in flow cytometry on human samples (fig 1c). Science (2017) ncbi
mouse monoclonal (4B4-1)
  • mass cytometry; human; fig s8
BD Biosciences 4 1BB antibody (BD, 555955) was used in mass cytometry on human samples (fig s8). Nature (2017) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 3
In order to assess receptor for hyaluronic acid-mediated motility specific dendritic cell responses, BD Biosciences 4 1BB antibody (BD Biosciences, 555956) was used in flow cytometry on human samples (fig 3). Oncotarget (2016) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; fig st1
In order to find cell-surface markers specific to human neutrophils, BD Biosciences 4 1BB antibody (BD, 555956) was used in flow cytometry on human samples (fig st1). Exp Cell Res (2016) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 2b
In order to examine the effects of immunosuppressive agents on Polyomavirus BKV-specific T cells, BD Biosciences 4 1BB antibody (BD Biosciences, 4B4-1) was used in flow cytometry on human samples (fig 2b). Kidney Int (2015) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human
BD Biosciences 4 1BB antibody (BD, 4B4-1) was used in flow cytometry on human samples . J Immunol (2015) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; fig 2
BD Biosciences 4 1BB antibody (BD Biosciences, 4B4-1) was used in flow cytometry on human samples (fig 2). Vaccine (2015) ncbi
mouse monoclonal (4B4-1)
  • immunocytochemistry; human
In order to examine the effect of CD137 on epithelial cell function, BD Biosciences 4 1BB antibody (BD Bioscience, 552533) was used in immunocytochemistry on human samples . Physiol Rep (2014) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human
BD Biosciences 4 1BB antibody (BD Bioscience, 4B4-1) was used in flow cytometry on human samples . Med Microbiol Immunol (2014) ncbi
mouse monoclonal (C65-485)
  • flow cytometry; human; loading ...; fig 1
In order to discuss the importance of assessing immune competence in cancer patients, BD Biosciences 4 1BB antibody (BD, C65-485) was used in flow cytometry on human samples (fig 1). Cancer Immunol Immunother (2014) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human; loading ...; fig 1
In order to discuss the importance of assessing immune competence in cancer patients, BD Biosciences 4 1BB antibody (BD, 4B4-1) was used in flow cytometry on human samples (fig 1). Cancer Immunol Immunother (2014) ncbi
mouse monoclonal (4B4-1)
  • flow cytometry; human
BD Biosciences 4 1BB antibody (BD Biosciences, 4B4-1) was used in flow cytometry on human samples . Clin Cancer Res (2014) ncbi
Articles Reviewed
  1. Scheper W, Kelderman S, Fanchi L, Linnemann C, Bendle G, de Rooij M, et al. Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nat Med. 2019;25:89-94 pubmed publisher
  2. Zacharakis N, Chinnasamy H, Black M, Xu H, Lu Y, Zheng Z, et al. Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. Nat Med. 2018;24:724-730 pubmed publisher
  3. Hutten T, Norde W, Woestenenk R, Wang R, Maas F, Kester M, et al. Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018;24:666-677 pubmed publisher
  4. Salio M, Gasser O, González López C, Martens A, Veerapen N, Gileadi U, et al. Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells. J Immunol. 2017;199:2631-2638 pubmed publisher
  5. Chew V, Lai L, Pan L, Lim C, Li J, Ong R, et al. Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses. Proc Natl Acad Sci U S A. 2017;114:E5900-E5909 pubmed publisher
  6. Lepore M, Kalinichenko A, Calogero S, Kumar P, Paleja B, Schmaler M, et al. Functionally diverse human T cells recognize non-microbial antigens presented by MR1. elife. 2017;6: pubmed publisher
  7. Stevanović S, Pasetto A, Helman S, Gartner J, Prickett T, Howie B, et al. Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer. Science. 2017;356:200-205 pubmed publisher
  8. Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017;543:728-732 pubmed publisher
  9. Gabanti E, Bruno F, Scaramuzzi L, Mangione F, Zelini P, Gerna G, et al. Predictive value of human cytomegalovirus (HCMV) T-cell response in the control of HCMV infection by seropositive solid-organ transplant recipients according to different assays and stimuli. New Microbiol. 2016;39:247-258 pubmed
  10. Willemen Y, Van den Bergh J, Bonte S, Anguille S, Heirman C, Stein B, et al. The tumor-associated antigen RHAMM (HMMR/CD168) is expressed by monocyte-derived dendritic cells and presented to T cells. Oncotarget. 2016;7:73960-73970 pubmed publisher
  11. Komdeur F, Wouters M, Workel H, Tijans A, Terwindt A, Brunekreeft K, et al. CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy. Oncotarget. 2016;7:75130-75144 pubmed publisher
  12. Lakschevitz F, Hassanpour S, Rubin A, Fine N, Sun C, Glogauer M. Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry. Exp Cell Res. 2016;342:200-9 pubmed publisher
  13. Jutz S, Leitner J, Schmetterer K, Doel Perez I, Majdic O, Grabmeier Pfistershammer K, et al. Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1. J Immunol Methods. 2016;430:10-20 pubmed publisher
  14. Weist B, Wehler P, El Ahmad L, Schmueck Henneresse M, Millward J, Nienen M, et al. A revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients. Kidney Int. 2015;88:1293-1303 pubmed publisher
  15. Schmueck Henneresse M, Sharaf R, Vogt K, Weist B, Landwehr Kenzel S, Fuehrer H, et al. Peripheral blood-derived virus-specific memory stem T cells mature to functional effector memory subsets with self-renewal potency. J Immunol. 2015;194:5559-67 pubmed publisher
  16. Tomimaru Y, Mishra S, Safran H, Charpentier K, Martin W, De Groot A, et al. Aspartate-β-hydroxylase induces epitope-specific T cell responses in hepatocellular carcinoma. Vaccine. 2015;33:1256-66 pubmed publisher
  17. Chacon J, Sarnaik A, Chen J, Creasy C, Kale C, Robinson J, et al. Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy. Clin Cancer Res. 2015;21:611-21 pubmed publisher
  18. Flinsenberg T, Spel L, Jansen M, Koning D, de Haar C, Plantinga M, et al. Cognate CD4 T-cell licensing of dendritic cells heralds anti-cytomegalovirus CD8 T-cell immunity after human allogeneic umbilical cord blood transplantation. J Virol. 2015;89:1058-69 pubmed publisher
  19. Gusti V, Bennett K, Lo D. CD137 signaling enhances tight junction resistance in intestinal epithelial cells. Physiol Rep. 2014;2: pubmed publisher
  20. Weist B, Schmueck M, Fuehrer H, Sattler A, Reinke P, Babel N. The role of CD4(+) T cells in BKV-specific T cell immunity. Med Microbiol Immunol. 2014;203:395-408 pubmed publisher
  21. Jitschin R, Braun M, Büttner M, Dettmer Wilde K, Bricks J, Berger J, et al. CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs. Blood. 2014;124:750-60 pubmed publisher
  22. Chang S, Kohrt H, Maecker H. Monitoring the immune competence of cancer patients to predict outcome. Cancer Immunol Immunother. 2014;63:713-9 pubmed publisher
  23. Turcotte S, Gros A, Tran E, Lee C, Wunderlich J, Robbins P, et al. Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy. Clin Cancer Res. 2014;20:331-43 pubmed publisher