This is a Validated Antibody Database (VAD) review about guinea pig Ryr1, based on 30 published articles (read how Labome selects the articles), using Ryr1 antibody in all methods. It is aimed to help Labome visitors find the most suited Ryr1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Invitrogen
mouse monoclonal (C3-33)
  • western blot; rat; 1:2000; loading ...; fig 7a
Invitrogen Ryr1 antibody (Invitrogen, MA3-916) was used in western blot on rat samples at 1:2000 (fig 7a). elife (2020) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; loading ...; fig 1b
Invitrogen Ryr1 antibody (Thermo Fisher, MA3-916) was used in western blot on mouse samples (fig 1b). Science (2018) ncbi
mouse monoclonal (C3-33)
  • western blot; domestic rabbit; 1:1000; loading ...; fig 5
In order to report the effects of heart failure on the electrical activity of sinoatrial nodes with and without pharmacological interventions, Invitrogen Ryr1 antibody (Thermo Fisher, MA3-916) was used in western blot on domestic rabbit samples at 1:1000 (fig 5). Exp Ther Med (2017) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; 1:1000; loading ...; fig 3e
In order to test the ability of the Notch inhibitor DAPT to convert murine fibroblasts into cardiomyocytes, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in western blot on mouse samples at 1:1000 (fig 3e). Stem Cell Reports (2017) ncbi
mouse monoclonal (C3-33)
  • immunoprecipitation; rat; loading ...
  • western blot; rat; 1:5000; loading ...; fig 6a
In order to ask if SK channels in the mitochondria inner membrane play an important role in regulating mitochondrial function in chronic cardiac diseases, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in immunoprecipitation on rat samples and in western blot on rat samples at 1:5000 (fig 6a). Cardiovasc Res (2017) ncbi
mouse monoclonal (C3-33)
  • immunohistochemistry - frozen section; domestic sheep; 1:100; loading ...; fig 3a
In order to describe transverse-tubule development in the large mammalian fetal heart, Invitrogen Ryr1 antibody (Thermo, MA3- 916) was used in immunohistochemistry - frozen section on domestic sheep samples at 1:100 (fig 3a). J Muscle Res Cell Motil (2016) ncbi
mouse monoclonal (C3-33)
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 7a
In order to suggest that ectopic beats originating in the myocardial sleeves of the pulmonary veins occur only under pathological conditions, Invitrogen Ryr1 antibody (Thermo Fisher Scientific, MA3-916) was used in immunohistochemistry - frozen section on rat samples at 1:100 (fig 7a). Exp Ther Med (2016) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; 1:5000; loading ...; fig 2g
In order to explore the role of junctophilin-2 in the ventricular muscle cells of the heart, Invitrogen Ryr1 antibody (Thermo, MA3916) was used in western blot on mouse samples at 1:5000 (fig 2g). J Cell Sci (2016) ncbi
mouse monoclonal (C3-33)
  • immunocytochemistry; mouse; loading ...
  • western blot; mouse; loading ...; fig 1d
  • immunoprecipitation; human; loading ...; fig 1e
  • western blot; human; loading ...; fig 1e
In order to investigate the function of striated muscle preferentially expressed gene, Invitrogen Ryr1 antibody (Thermo Fisher, MA3-916) was used in immunocytochemistry on mouse samples , in western blot on mouse samples (fig 1d), in immunoprecipitation on human samples (fig 1e) and in western blot on human samples (fig 1e). Circ Res (2017) ncbi
mouse monoclonal (C3-33)
  • immunohistochemistry; rat; 1:50; loading ...; fig 3b
  • immunohistochemistry; mouse; 1:50; loading ...; fig 3c
In order to test if mitochondrial calcium uniporter concentrated at the mitochondria-sarcoplasmic reticulum interface promotes calcium transfer, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in immunohistochemistry on rat samples at 1:50 (fig 3b) and in immunohistochemistry on mouse samples at 1:50 (fig 3c). J Biol Chem (2016) ncbi
mouse monoclonal (C3-33)
  • western blot; domestic rabbit; 1:2000; fig 6a
In order to investigate the regulation of Ca(2+)/calmodulin-dependent protein kinase II in sinoatrial node cells, Invitrogen Ryr1 antibody (Thermo Scientific, C3-33) was used in western blot on domestic rabbit samples at 1:2000 (fig 6a). Am J Physiol Heart Circ Physiol (2016) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; fig 5
In order to determine the reduction of store overload-induced calcium release and protection against ventricular arrhythmia due to inhibition of Rac1, Invitrogen Ryr1 antibody (Affinity Bioreagents, MA3-916) was used in western blot on mouse samples (fig 5). J Cell Mol Med (2016) ncbi
mouse monoclonal (C3-33)
  • western blot; rat; 1:1000; fig s1
In order to investigate left ventricular cardiomyocytes from post-infaction rats with and without heart failure after beta-adrenoceptor stimulation to revela Ca2+ waves and sarcoplasmic reticulum Ca2+ depletion, Invitrogen Ryr1 antibody (Thermo Fisher Scientific, MA3-916) was used in western blot on rat samples at 1:1000 (fig s1). PLoS ONE (2016) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; loading ...; fig 7e
In order to study the role of angiotensin receptor-associated protein Atrap on cardiac Ca2+-ATPase SERCA2a, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in western blot on mouse samples (fig 7e). Cardiovasc Res (2016) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; 1:1000; loading ...; fig s8a
In order to elucidate how DWORF activates the SERCA pump, Invitrogen Ryr1 antibody (Pierce, C3-33) was used in western blot on mouse samples at 1:1000 (fig s8a). Science (2016) ncbi
mouse monoclonal (C3-33)
  • immunocytochemistry; rat; fig 3
  • western blot; rat; fig 2
In order to study the effects of ascending aortic banding on calcium handling in rat isolated atrial myocytes, Invitrogen Ryr1 antibody (Thermo Scientific, MA3916) was used in immunocytochemistry on rat samples (fig 3) and in western blot on rat samples (fig 2). PLoS ONE (2015) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; fig 3
In order to maintain cardiac function through a heterozygous deletion of sarcolipin, Invitrogen Ryr1 antibody (Affinity BioReagents, MA3-916) was used in western blot on mouse samples (fig 3). Am J Physiol Heart Circ Physiol (2016) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; 1:2000; fig 1
In order to research bone metastases in mice by excess TGF-beta mediating muscle weakness, Invitrogen Ryr1 antibody (Affinity Bioreagents, MA3-916) was used in western blot on mouse samples at 1:2000 (fig 1). Nat Med (2015) ncbi
mouse monoclonal (C3-33)
  • immunohistochemistry; rat; fig 1
In order to characterize Ca2+ release patterns in cardiomyocytes and examine the effects of heterogeneous organization of RyR clusters, mitochondria, and myofibrils, Invitrogen Ryr1 antibody (Affinity Bioreagents, C3-33) was used in immunohistochemistry on rat samples (fig 1). PLoS Comput Biol (2015) ncbi
mouse monoclonal (C3-33)
  • immunohistochemistry - frozen section; dogs; 1:100; fig 1
In order to study dyssynchronous heart failure after cardiac resynchronization therapy, Invitrogen Ryr1 antibody (ThermoFisher Scientific, MA3-916) was used in immunohistochemistry - frozen section on dogs samples at 1:100 (fig 1). Circ Heart Fail (2015) ncbi
mouse monoclonal (C3-33)
  • immunocytochemistry; rat; 1:200; fig 1
In order to study t-tubule function during cardiac failure, Invitrogen Ryr1 antibody (Thermo Fisher Scientific,, MA3-916) was used in immunocytochemistry on rat samples at 1:200 (fig 1). J Mol Cell Cardiol (2015) ncbi
mouse monoclonal (C3-33)
  • immunohistochemistry - frozen section; human; 1:100
In order to describe a method of multi-scale imaging of human cardiac tissue, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in immunohistochemistry - frozen section on human samples at 1:100. Methods (2015) ncbi
mouse monoclonal (C3-33)
  • immunocytochemistry; mouse; 1:200; tbl 1
In order to examine the interaction between store-operated calcium entry and store content and its role in cardiac pacemaking, Invitrogen Ryr1 antibody (ABR, MA3-916) was used in immunocytochemistry on mouse samples at 1:200 (tbl 1). Front Physiol (2015) ncbi
mouse monoclonal (C3-33)
  • immunohistochemistry; rat; 1:100
In order to quantify the spatial distribution ryanodine receptors throughout the myoplasm, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in immunohistochemistry on rat samples at 1:100. J Mol Cell Cardiol (2015) ncbi
mouse monoclonal (C3-33)
  • western blot; human; 1:5000
  • immunoprecipitation; mouse
  • western blot; mouse; 1:5000
In order to study the loss of thd miR-106b-25 cluster in the pathogenesis of atrial fibrillation, Invitrogen Ryr1 antibody (Thermo Fisher Scientific, MA3-916) was used in western blot on human samples at 1:5000, in immunoprecipitation on mouse samples and in western blot on mouse samples at 1:5000. Circ Arrhythm Electrophysiol (2014) ncbi
mouse monoclonal (C3-33)
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
  • immunocytochemistry; domestic rabbit
  • immunohistochemistry; domestic rabbit
In order to study the contribution of nuclear Ca(2+) handling on the development and progression of heart failure, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in immunocytochemistry on mouse samples , in immunohistochemistry on mouse samples , in immunocytochemistry on domestic rabbit samples and in immunohistochemistry on domestic rabbit samples . Circulation (2014) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse; 1:1000
In order to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease, Invitrogen Ryr1 antibody (Affinity Bioreagents, MA3-916) was used in western blot on mouse samples at 1:1000. J Neurosci (2014) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse
  • western blot; rat
In order to study the mechanisms underlying the effects of zinc on cardiomyocyte contraction-relaxation, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in western blot on mouse samples and in western blot on rat samples . Am J Physiol Heart Circ Physiol (2013) ncbi
mouse monoclonal (C3-33)
  • western blot; rat
In order to study the effect of Zn(2+) on cardiomyocyte relaxation in a hyperglycemic diabetic rat model expressing only beta-myosin heavy chain in the heart, Invitrogen Ryr1 antibody (Thermo Scientific, MA3-916) was used in western blot on rat samples . Cardiovasc Diabetol (2012) ncbi
mouse monoclonal (C3-33)
  • western blot; mouse
In order to demonstrate that ablation of splicing factor SC35 in the heart causes dilated cardiomyopathy, Invitrogen Ryr1 antibody (Affinity BioReagents, MA3-916) was used in western blot on mouse samples . EMBO J (2004) ncbi
Articles Reviewed
  1. Asghari P, Scriven D, Ng M, Panwar P, Chou K, Van Petegem F, et al. Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification. elife. 2020;9: pubmed publisher
  2. Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362: pubmed publisher
  3. Chang S, Chuang H, Chen Y, Kao Y, Lin Y, Yeh Y, et al. Heart failure modulates electropharmacological characteristics of sinoatrial nodes. Exp Ther Med. 2017;13:771-779 pubmed publisher
  4. Abad M, Hashimoto H, Zhou H, Morales M, Chen B, Bassel Duby R, et al. Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity. Stem Cell Reports. 2017;8:548-560 pubmed publisher
  5. Kim T, Terentyeva R, Roder K, Li W, Liu M, Greener I, et al. SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR. Cardiovasc Res. 2017;113:343-353 pubmed publisher
  6. Munro M, Soeller C. Early transverse tubule development begins in utero in the sheep heart. J Muscle Res Cell Motil. 2016;37:195-202 pubmed publisher
  7. Xiao Y, Cai X, Atkinson A, Logantha S, Boyett M, Dobrzynski H. Expression of connexin 43, ion channels and Ca2+-handling proteins in rat pulmonary vein cardiomyocytes. Exp Ther Med. 2016;12:3233-3241 pubmed
  8. Munro M, Jayasinghe I, Wang Q, Quick A, Wang W, Baddeley D, et al. Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci. 2016;129:4388-4398 pubmed
  9. Quick A, Wang Q, Philippen L, Barreto Torres G, Chiang D, Beavers D, et al. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017;120:110-119 pubmed publisher
  10. de la Fuente S, Fernandez Sanz C, Vail C, Agra E, Holmström K, Sun J, et al. Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle. J Biol Chem. 2016;291:23343-23362 pubmed
  11. Li Y, Sirenko S, Riordon D, Yang D, Spurgeon H, Lakatta E, et al. CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases. Am J Physiol Heart Circ Physiol. 2016;311:H532-44 pubmed publisher
  12. Zhang L, Lu X, Gui L, Wu Y, Sims S, Wang G, et al. Inhibition of Rac1 reduces store overload-induced calcium release and protects against ventricular arrhythmia. J Cell Mol Med. 2016;20:1513-22 pubmed publisher
  13. Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed publisher
  14. Mederle K, Gess B, Pluteanu F, Plackic J, Tiefenbach K, Grill A, et al. The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a. Cardiovasc Res. 2016;110:359-70 pubmed publisher
  15. Nelson B, Makarewich C, Anderson D, Winders B, Troupes C, Wu F, et al. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science. 2016;351:271-5 pubmed publisher
  16. Zhang H, Cannell M, Kim S, Watson J, Norman R, Calaghan S, et al. Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload. PLoS ONE. 2015;10:e0144309 pubmed publisher
  17. Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, et al. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 2016;310:H92-103 pubmed publisher
  18. Waning D, Mohammad K, Reiken S, Xie W, Andersson D, John S, et al. Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nat Med. 2015;21:1262-1271 pubmed publisher
  19. Rajagopal V, Bass G, Walker C, Crossman D, Petzer A, Hickey A, et al. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes. PLoS Comput Biol. 2015;11:e1004417 pubmed publisher
  20. Li H, Lichter J, Seidel T, Tomaselli G, Bridge J, Sachse F. Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure. Circ Heart Fail. 2015;8:1105-14 pubmed publisher
  21. Bryant S, Kong C, Watson J, Cannell M, James A, Orchard C. Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts. J Mol Cell Cardiol. 2015;86:23-31 pubmed publisher
  22. Crossman D, Hou Y, Jayasinghe I, Baddeley D, Soeller C. Combining confocal and single molecule localisation microscopy: A correlative approach to multi-scale tissue imaging. Methods. 2015;88:98-108 pubmed publisher
  23. Liu J, Xin L, Benson V, Allen D, Ju Y. Store-operated calcium entry and the localization of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells. Front Physiol. 2015;6:69 pubmed publisher
  24. Hou Y, Jayasinghe I, Crossman D, Baddeley D, Soeller C. Nanoscale analysis of ryanodine receptor clusters in dyadic couplings of rat cardiac myocytes. J Mol Cell Cardiol. 2015;80:45-55 pubmed publisher
  25. Chiang D, Kongchan N, Beavers D, Alsina K, Voigt N, Neilson J, et al. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014;7:1214-22 pubmed publisher
  26. Ljubojević S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, et al. Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure. Circulation. 2014;130:244-55 pubmed publisher
  27. Shilling D, Müller M, Takano H, Mak D, Abel T, Coulter D, et al. Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis. J Neurosci. 2014;34:6910-23 pubmed publisher
  28. Yi T, Vick J, Vecchio M, Begin K, Bell S, Delay R, et al. Identifying cellular mechanisms of zinc-induced relaxation in isolated cardiomyocytes. Am J Physiol Heart Circ Physiol. 2013;305:H706-15 pubmed publisher
  29. Yi T, Cheema Y, Tremble S, Bell S, Chen Z, Subramanian M, et al. Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoform. Cardiovasc Diabetol. 2012;11:135 pubmed publisher
  30. Ding J, Xu X, Yang D, Chu P, Dalton N, Ye Z, et al. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J. 2004;23:885-96 pubmed