This is a Validated Antibody Database (VAD) review about guinea pig Atp2a2, based on 38 published articles (read how Labome selects the articles), using Atp2a2 antibody in all methods. It is aimed to help Labome visitors find the most suited Atp2a2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Atp2a2 synonym: SERCA2

Invitrogen
mouse monoclonal (2A7-A1)
  • immunocytochemistry; human; 1:100; loading ...; fig 1e
Invitrogen Atp2a2 antibody (Invitrogen, MA3-919) was used in immunocytochemistry on human samples at 1:100 (fig 1e). EMBO Mol Med (2021) ncbi
mouse monoclonal (2A7-A1)
  • western blot; African green monkey; 1:1000; loading ...; fig s11
Invitrogen Atp2a2 antibody (Thermo Fisher, MA3-919) was used in western blot on African green monkey samples at 1:1000 (fig s11). Commun Biol (2021) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; loading ...; fig 3g
Invitrogen Atp2a2 antibody (Thermo Fisher, MA3-919) was used in western blot on mouse samples (fig 3g). Neuron (2021) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:2000; loading ...
Invitrogen Atp2a2 antibody (Thermo Fisher Scientific, MA3-919) was used in western blot on mouse samples at 1:2000. Int J Mol Sci (2020) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:1000; loading ...; fig 4a
Invitrogen Atp2a2 antibody (ThermoFisher, MA3-919) was used in western blot on mouse samples at 1:1000 (fig 4a). elife (2019) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; loading ...; fig 1g
Invitrogen Atp2a2 antibody (Thermo Fisher Scientific, MA3-919) was used in western blot on mouse samples (fig 1g). Hum Mol Genet (2018) ncbi
mouse monoclonal (2A7-A1)
Invitrogen Atp2a2 antibody (Fisher Scientific, MA3-919) was used . Nat Commun (2017) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; loading ...; fig 7a
In order to test if in utero particulate matter exposure alters cardiac structure and function at adulthood, Invitrogen Atp2a2 antibody (Thermo Fisher, MA3-919) was used in western blot on mouse samples (fig 7a). J Am Heart Assoc (2017) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:1000; loading ...; fig s2f
In order to elucidate the mechanism by which the I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel results in disease, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in western blot on mouse samples at 1:1000 (fig s2f). Nat Commun (2017) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; loading ...; fig 2c
In order to report the physiological role of sarcolipin upregulation in muscle myopathy, Invitrogen Atp2a2 antibody (Pierce Antibodies, MA3-919) was used in western blot on mouse samples (fig 2c). PLoS ONE (2017) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:1000; loading ...; fig 3e
In order to test the ability of the Notch inhibitor DAPT to convert murine fibroblasts into cardiomyocytes, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in western blot on mouse samples at 1:1000 (fig 3e). Stem Cell Reports (2017) ncbi
mouse monoclonal (2A7-A1)
  • western blot; rat; loading ...; fig 2e
In order to assess the role of redox stress in PH-induced diaphragm weakness, Invitrogen Atp2a2 antibody (Thermo, MA3-919) was used in western blot on rat samples (fig 2e). PLoS ONE (2017) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:1000; loading ...; fig 2c
In order to evaluate the impacts of high fat diet on the insulin-adrenergic receptor signal network in hearts, Invitrogen Atp2a2 antibody (Thermo, 2A7-A1) was used in western blot on mouse samples at 1:1000 (fig 2c). J Physiol (2017) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; loading ...; fig 10
In order to study mouse models of dilated cardiomyopathy to study calcium signaling, Invitrogen Atp2a2 antibody (Affinity BioReagents, MA3-919) was used in western blot on mouse samples (fig 10). PLoS ONE (2016) ncbi
mouse monoclonal (2A7-A1)
  • immunohistochemistry; mouse; 1:200; loading ...; fig 4a
  • western blot; mouse; 1:200; loading ...; fig 4c
In order to test if modulation of SERCA2 improves outcome in sepsis, Invitrogen Atp2a2 antibody (Thermo Fischer, MA3-919) was used in immunohistochemistry on mouse samples at 1:200 (fig 4a) and in western blot on mouse samples at 1:200 (fig 4c). Sci Rep (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; fig 4c
In order to test if BGP-15 ameliorate established disease in a mouse model of Duchenne muscular dystrophy, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in western blot on mouse samples (fig 4c). Am J Pathol (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; human; 1:1000; loading ...; fig 1a
In order to discuss how mutations in sarcomere genes may result in altered calcium signaling and heart defects, Invitrogen Atp2a2 antibody (Thermo Pierce, MA3-919) was used in western blot on human samples at 1:1000 (fig 1a). Circulation (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; rat; fig 8
In order to determine the role of protein O-GlcNAcylation in skeletal muscle, Invitrogen Atp2a2 antibody (Thermo, MA3-919) was used in western blot on rat samples (fig 8). Physiol Rep (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; human; 1:1000; fig s2
In order to characterize engineered heart tissues derived from human induced pluripotent stem cell-derived cardiomyocytes, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in western blot on human samples at 1:1000 (fig s2). Stem Cell Reports (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:2000; fig 1
In order to study slow-twitch type 1 muscle fibers and diaphragm assessment in mice overexpressing phospholamban, Invitrogen Atp2a2 antibody (Pierce Antibodies, 2A7-A1) was used in western blot on mouse samples at 1:2000 (fig 1). Brain Behav (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; rat; 1:2500; fig s1
In order to investigate left ventricular cardiomyocytes from post-infaction rats with and without heart failure after beta-adrenoceptor stimulation to revela Ca2+ waves and sarcoplasmic reticulum Ca2+ depletion, Invitrogen Atp2a2 antibody (Thermo Fisher Scientific, MA3-919) was used in western blot on rat samples at 1:2500 (fig s1). PLoS ONE (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; human; fig 3
In order to elucidate the induction by phosphorylation-mediated ubiquitination and inhibition by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase due to phospholamban degradation, Invitrogen Atp2a2 antibody (Affinity BioReagents, 2A7-A1) was used in western blot on human samples (fig 3). Biochem Biophys Res Commun (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:2000; loading ...; fig s8a
In order to elucidate how DWORF activates the SERCA pump, Invitrogen Atp2a2 antibody (Pierce, 2A7-A1) was used in western blot on mouse samples at 1:2000 (fig s8a). Science (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; domestic sheep; fig 1
In order to assess the importance of SERCA2a to the fibrotic response in small and large myocardial infarct, Invitrogen Atp2a2 antibody (Fisher Scientific, MA3- 919) was used in western blot on domestic sheep samples (fig 1). J Thorac Cardiovasc Surg (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; rat; fig 2
In order to study the effects of ascending aortic banding on calcium handling in rat isolated atrial myocytes, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in western blot on rat samples (fig 2). PLoS ONE (2015) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; fig 4
In order to determine the impact of ALDH2 overexpression on doxorubicin-induced myocardial damage and mitochondria, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in western blot on mouse samples (fig 4). Biochim Biophys Acta (2016) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse
  • western blot; human
In order to study SERCA dysfunction in mice overexpressing phospholamban, Invitrogen Atp2a2 antibody (Pierce Antibodies, 2A7-A1) was used in western blot on mouse samples and in western blot on human samples . Dis Model Mech (2015) ncbi
mouse monoclonal (2A7-A1)
  • western blot; rat; 1:1000; fig 5
In order to determine the relationship between ACE and ACE2 activity, left ventricular function, and gender in spontaneously hypertensive rats, Invitrogen Atp2a2 antibody (Affinity BioReagents, MA3-919) was used in western blot on rat samples at 1:1000 (fig 5). PLoS ONE (2015) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; fig 3.e,f
In order to investigate the mechanism by which cysteine-rich free radical scavenger metallothionein regulates ER stress-induced myocardial contractile defect, Invitrogen Atp2a2 antibody (Affinity BioReagent, MA3- 919) was used in western blot on mouse samples (fig 3.e,f). Free Radic Res (2015) ncbi
mouse monoclonal (2A7-A1)
  • western blot; human
In order to study the role and mechanism of nitric oxide on Ca(2+) release, Invitrogen Atp2a2 antibody (thermo, ma3-919) was used in western blot on human samples . Arch Biochem Biophys (2015) ncbi
mouse monoclonal (2A7-A1)
  • immunoprecipitation; domestic rabbit
  • western blot; domestic rabbit
In order to study the effect of progesterone on SERCA2a regulation in isolated cardiomyocytes, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in immunoprecipitation on domestic rabbit samples and in western blot on domestic rabbit samples . Am J Physiol Cell Physiol (2014) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; fig 6
In order to suggest that the inability to enhance myofilament relaxation through cTnI phosphorylation predisposes the heart to hypertrophic cardiomyopathy, Invitrogen Atp2a2 antibody (Pierce, MA3-919) was used in western blot on mouse samples (fig 6). J Biol Chem (2014) ncbi
mouse monoclonal (2A7-A1)
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
  • western blot; human
  • immunocytochemistry; domestic rabbit
  • immunohistochemistry; domestic rabbit
In order to study the contribution of nuclear Ca(2+) handling on the development and progression of heart failure, Invitrogen Atp2a2 antibody (Thermo Scientific, MA3-919) was used in immunocytochemistry on mouse samples , in immunohistochemistry on mouse samples , in western blot on human samples , in immunocytochemistry on domestic rabbit samples and in immunohistochemistry on domestic rabbit samples . Circulation (2014) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; 1:1000; fig 6f
In order to elucidate the critical role of TRPV2 in maintenance of cardiac function and structure in mice, Invitrogen Atp2a2 antibody (Thermo, MA3919) was used in western blot on mouse samples at 1:1000 (fig 6f). Nat Commun (2014) ncbi
mouse monoclonal (2A7-A1)
  • immunohistochemistry - frozen section; human; 1:1000; fig 4
  • immunoprecipitation; human; fig 6
  • western blot; human; 1:2000; fig 3
In order to determine if sarcolipin and phospholamban regulate SERCA1a, SERCA2a, or both in skeletal muscle, Invitrogen Atp2a2 antibody (Pierce, 2A7-A1) was used in immunohistochemistry - frozen section on human samples at 1:1000 (fig 4), in immunoprecipitation on human samples (fig 6) and in western blot on human samples at 1:2000 (fig 3). PLoS ONE (2013) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse; fig 7
In order to quantify the relative contribution of calcium cycling to resting metabolic rate in mouse fast and slow twitch skeletal muscle, Invitrogen Atp2a2 antibody (Affinity Bioreagents, 2A7-A1) was used in western blot on mouse samples (fig 7). PLoS ONE (2013) ncbi
mouse monoclonal (2A7-A1)
  • western blot; mouse
In order to study the cardiac effects of neuregulin in cMLCK knockout mice, Invitrogen Atp2a2 antibody (Pierce, MA3-919) was used in western blot on mouse samples . PLoS ONE (2013) ncbi
mouse monoclonal (2A7-A1)
  • western blot; human
In order to investigate the abnormalities of calcium handling proteins in skeletal and heart muscle during heart failure, Invitrogen Atp2a2 antibody (Pierce, 2A7-A1) was used in western blot on human samples . J Card Fail (2012) ncbi
Articles Reviewed
  1. Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, et al. Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. EMBO Mol Med. 2021;13:e13074 pubmed publisher
  2. Liu M, Li N, Qu C, Gao Y, Wu L, Hu L. Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates. Commun Biol. 2021;4:188 pubmed publisher
  3. Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht M, et al. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron. 2021;109:299-313.e9 pubmed publisher
  4. Feng D, Xu D, Murakoshi N, Tajiri K, Qin R, Yonebayashi S, et al. Nicotinamide Phosphoribosyltransferase (Nampt)/Nicotinamide Adenine Dinucleotide (NAD) Axis Suppresses Atrial Fibrillation by Modulating the Calcium Handling Pathway. Int J Mol Sci. 2020;21: pubmed publisher
  5. Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed publisher
  6. Fajardo V, Chambers P, Juracic E, Rietze B, Gamu D, Bellissimo C, et al. Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology. Hum Mol Genet. 2018;27:4094-4102 pubmed publisher
  7. Huet Calderwood C, Rivera Molina F, Iwamoto D, Kromann E, Toomre D, Calderwood D. Novel ecto-tagged integrins reveal their trafficking in live cells. Nat Commun. 2017;8:570 pubmed publisher
  8. Tanwar V, Gorr M, Velten M, Eichenseer C, Long V, Bonilla I, et al. In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood. J Am Heart Assoc. 2017;6: pubmed publisher
  9. Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
  10. Fajardo V, Gamu D, Mitchell A, Bloemberg D, Bombardier E, Chambers P, et al. Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice. PLoS ONE. 2017;12:e0173708 pubmed publisher
  11. Abad M, Hashimoto H, Zhou H, Morales M, Chen B, Bassel Duby R, et al. Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity. Stem Cell Reports. 2017;8:548-560 pubmed publisher
  12. Himori K, Abe M, Tatebayashi D, Lee J, Westerblad H, Lanner J, et al. Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension. PLoS ONE. 2017;12:e0169146 pubmed publisher
  13. Fu Q, Hu Y, Wang Q, Liu Y, Li N, Xu B, et al. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J Physiol. 2017;595:1973-1986 pubmed publisher
  14. Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed publisher
  15. Martin L, Horst K, Chiazza F, Oggero S, Collino M, Brandenburg K, et al. The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci Rep. 2016;6:37277 pubmed publisher
  16. Kennedy T, Swiderski K, Murphy K, Gehrig S, Curl C, Chandramouli C, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016;186:3246-3260 pubmed publisher
  17. Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed
  18. Hortemo K, Lunde P, Anonsen J, Kvaløy H, Munkvik M, Rehn T, et al. Exercise training increases protein O-GlcNAcylation in rat skeletal muscle. Physiol Rep. 2016;4: pubmed
  19. Mannhardt I, Breckwoldt K, Letuffe Brenière D, Schaaf S, Schulz H, Neuber C, et al. Human Engineered Heart Tissue: Analysis of Contractile Force. Stem Cell Reports. 2016;7:29-42 pubmed publisher
  20. Fajardo V, Smith I, Bombardier E, Chambers P, Quadrilatero J, Tupling A. Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers. Brain Behav. 2016;6:e00470 pubmed publisher
  21. Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed publisher
  22. Nakagawa T, Yokoe S, Asahi M. Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase. Biochem Biophys Res Commun. 2016;472:523-30 pubmed publisher
  23. Nelson B, Makarewich C, Anderson D, Winders B, Troupes C, Wu F, et al. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science. 2016;351:271-5 pubmed publisher
  24. Katz M, Brandon Warner E, Fargnoli A, Williams R, Kendle A, Hajjar R, et al. Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression. J Thorac Cardiovasc Surg. 2016;151:1191-200.e3 pubmed publisher
  25. Zhang H, Cannell M, Kim S, Watson J, Norman R, Calaghan S, et al. Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload. PLoS ONE. 2015;10:e0144309 pubmed publisher
  26. Ge W, Yuan M, Ceylan A, Wang X, Ren J. Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. Biochim Biophys Acta. 2016;1862:622-634 pubmed publisher
  27. Fajardo V, Bombardier E, McMillan E, TRAN K, Wadsworth B, Gamu D, et al. Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype. Dis Model Mech. 2015;8:999-1009 pubmed publisher
  28. Dalpiaz P, Lamas A, Caliman I, Ribeiro R, Abreu G, Moyses M, et al. Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats. PLoS ONE. 2015;10:e0127515 pubmed publisher
  29. Yang L, Wang J, Yang J, Schamber R, Hu N, Nair S, et al. Antioxidant metallothionein alleviates endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction. Free Radic Res. 2015;49:1187-98 pubmed publisher
  30. Tang Y, Yin Y, Miao L, Wei B, Zhai K, Ji G. Nitric oxide enhances extracellular ATP induced Ca²⁺ oscillation in HeLa cells. Arch Biochem Biophys. 2015;565:68-75 pubmed publisher
  31. Moshal K, Zhang Z, Roder K, Kim T, Cooper L, Patedakis Litvinov B, et al. Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes. Am J Physiol Cell Physiol. 2014;307:C1050-7 pubmed publisher
  32. Dweck D, Sanchez Gonzalez M, Chang A, Dulce R, Badger C, Koutnik A, et al. Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy. J Biol Chem. 2014;289:23097-111 pubmed publisher
  33. Ljubojević S, Radulovic S, Leitinger G, Sedej S, Sacherer M, Holzer M, et al. Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure. Circulation. 2014;130:244-55 pubmed publisher
  34. Katanosaka Y, Iwasaki K, Ujihara Y, Takatsu S, Nishitsuji K, Kanagawa M, et al. TRPV2 is critical for the maintenance of cardiac structure and function in mice. Nat Commun. 2014;5:3932 pubmed publisher
  35. Fajardo V, Bombardier E, Vigna C, Devji T, Bloemberg D, Gamu D, et al. Co-expression of SERCA isoforms, phospholamban and sarcolipin in human skeletal muscle fibers. PLoS ONE. 2013;8:e84304 pubmed publisher
  36. Smith I, Bombardier E, Vigna C, Tupling A. ATP consumption by sarcoplasmic reticulum Ca²? pumps accounts for 40-50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle. PLoS ONE. 2013;8:e68924 pubmed publisher
  37. Chang A, Huang J, Battiprolu P, Hill J, Kamm K, Stull J. The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts. PLoS ONE. 2013;8:e66720 pubmed publisher
  38. Middlekauff H, Vigna C, Verity M, Fonarow G, Horwich T, Hamilton M, et al. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?. J Card Fail. 2012;18:724-33 pubmed publisher