This is a Validated Antibody Database (VAD) review about dogs LMNA, based on 38 published articles (read how Labome selects the articles), using LMNA antibody in all methods. It is aimed to help Labome visitors find the most suited LMNA antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Knockout validation
MilliporeSigma
mouse monoclonal (4C11)
  • western blot knockout validation; mouse; loading ...; fig 1d
  • immunohistochemistry; mouse; loading ...; fig 2a
MilliporeSigma LMNA antibody (Sigma-Aldrich, SAB4200236) was used in western blot knockout validation on mouse samples (fig 1d) and in immunohistochemistry on mouse samples (fig 2a). Aging Cell (2020) ncbi
Abcam
mouse monoclonal (133A2)
  • western blot; mouse; loading ...; fig 3f
Abcam LMNA antibody (Abcam, ab8980) was used in western blot on mouse samples (fig 3f). Signal Transduct Target Ther (2021) ncbi
mouse monoclonal (131C3)
  • western blot; human; loading ...; fig 1h
Abcam LMNA antibody (Abcam, ab8984) was used in western blot on human samples (fig 1h). Science (2020) ncbi
mouse monoclonal (133A2)
  • immunocytochemistry; human; loading ...; fig s4b
Abcam LMNA antibody (Abcam, ab8980) was used in immunocytochemistry on human samples (fig s4b). Sci Adv (2019) ncbi
mouse monoclonal (131C3)
  • immunocytochemistry; human; loading ...; fig 3b
  • western blot; human; loading ...; fig s4j
Abcam LMNA antibody (abcam, ab8984) was used in immunocytochemistry on human samples (fig 3b) and in western blot on human samples (fig s4j). Nature (2019) ncbi
mouse monoclonal (131C3)
  • western blot; human; loading ...; fig 1h
Abcam LMNA antibody (Abcam, ab8984) was used in western blot on human samples (fig 1h). Cell (2019) ncbi
mouse monoclonal (131C3)
  • immunocytochemistry; mouse; loading ...; fig s5d
Abcam LMNA antibody (Abcam, ab8984) was used in immunocytochemistry on mouse samples (fig s5d). Genome Biol (2018) ncbi
mouse monoclonal (131C3)
  • immunohistochemistry; human; 1:200; loading ...; fig 2c
  • western blot; human; 1:1000; loading ...; fig 4c
Abcam LMNA antibody (Abcam, ab8984) was used in immunohistochemistry on human samples at 1:200 (fig 2c) and in western blot on human samples at 1:1000 (fig 4c). Nat Commun (2018) ncbi
mouse monoclonal (133A2)
  • immunocytochemistry; human; 1:1000; loading ...; fig 1a
In order to investigate the effect of actomyosin on cell nuclear morphology and genome stability, Abcam LMNA antibody (Abcam, ab8980) was used in immunocytochemistry on human samples at 1:1000 (fig 1a). Nat Commun (2017) ncbi
mouse monoclonal (131C3)
  • immunocytochemistry; human; 1:200; loading ...; fig s6
In order to screen for genes involved in mitochondrial DNA maintenance, Abcam LMNA antibody (Abcam, ab8984) was used in immunocytochemistry on human samples at 1:200 (fig s6). Nat Chem Biol (2016) ncbi
mouse monoclonal (131C3)
  • western blot; human; 1:1000; fig 5
In order to determine regulation of expression of Epstein-Barr virus BART microRNAs and long noncoding RNAs in nasopharyngeal carcinoma via NF-kappaB signaling, Abcam LMNA antibody (Abcam, ab8984) was used in western blot on human samples at 1:1000 (fig 5). J Virol (2016) ncbi
mouse monoclonal (133A2)
  • immunocytochemistry; human; 1:500; fig 1
In order to test if progerin elicits spatiotemporal deviations in mitotic processes in Hutchinson-Gilford progeria syndrome fibroblasts, Abcam LMNA antibody (Abcam, ab8980) was used in immunocytochemistry on human samples at 1:500 (fig 1). Oncotarget (2016) ncbi
mouse monoclonal (133A2)
  • immunocytochemistry; human; 1:1000; fig s1
Abcam LMNA antibody (Abcam, ab8980) was used in immunocytochemistry on human samples at 1:1000 (fig s1). Nat Commun (2015) ncbi
mouse monoclonal (133A2)
  • western blot; human; fig 3
Abcam LMNA antibody (Abcam, 133A2) was used in western blot on human samples (fig 3). Oncotarget (2016) ncbi
mouse monoclonal (131C3)
  • immunocytochemistry; human; 1:500; fig 1
Abcam LMNA antibody (Abcam, ab8984) was used in immunocytochemistry on human samples at 1:500 (fig 1). Nat Commun (2015) ncbi
mouse monoclonal (131C3)
  • western blot; human; 1:2000; fig 1
Abcam LMNA antibody (abcam, ab8984) was used in western blot on human samples at 1:2000 (fig 1). Sci Rep (2015) ncbi
mouse monoclonal (133A2)
  • immunocytochemistry; human
Abcam LMNA antibody (Abcam, Ab8980) was used in immunocytochemistry on human samples . Cell Death Differ (2016) ncbi
mouse monoclonal (131C3)
  • western blot; mouse; 1:1000; fig 1
Abcam LMNA antibody (abcam, ab8984) was used in western blot on mouse samples at 1:1000 (fig 1). PLoS ONE (2015) ncbi
mouse monoclonal (133A2)
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1
  • immunocytochemistry; human; 1:100; loading ...; fig 4
  • western blot; human; 1:250; loading ...; fig 3b
Abcam LMNA antibody (Abcam, ab8980) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 1), in immunocytochemistry on human samples at 1:100 (fig 4) and in western blot on human samples at 1:250 (fig 3b). Pathol Res Pract (2015) ncbi
mouse monoclonal (131C3)
  • immunocytochemistry; human; 1:200; loading ...
Abcam LMNA antibody (Abcam, ab8984) was used in immunocytochemistry on human samples at 1:200. Mol Hum Reprod (2015) ncbi
mouse monoclonal (133A2)
  • immunocytochemistry; human; 1:100; loading ...
Abcam LMNA antibody (Abcam, ab8980) was used in immunocytochemistry on human samples at 1:100. Mol Hum Reprod (2015) ncbi
mouse monoclonal (131C3)
  • western blot; human; 1:1000
In order to study the expression and the nuclear localization of VPAC1 and VPAC2 in glioma, Abcam LMNA antibody (Abcam, ab8984) was used in western blot on human samples at 1:1000. Biochem Biophys Res Commun (2014) ncbi
mouse monoclonal (133A2)
  • western blot; human; 1:2000; loading ...; fig 4b
Abcam LMNA antibody (abcam, ab8980) was used in western blot on human samples at 1:2000 (fig 4b). Nat Cell Biol (2014) ncbi
mouse monoclonal (133A2)
  • western blot; human; 1:1000
Abcam LMNA antibody (Abcam, ab8980) was used in western blot on human samples at 1:1000. J Pharm Pharmacol (2014) ncbi
Invitrogen
mouse monoclonal (131C3)
  • immunocytochemistry; human; 1:200; loading ...; fig 4
In order to demonstrate that nuclear envelope rupture in cancer cells relies on the assembly of contractile actin bundles that interact with the nucleus via the linker of nucleoskeleton and cytoskeleton complex, Invitrogen LMNA antibody (Thermo Fischer Scientific, 131C3) was used in immunocytochemistry on human samples at 1:200 (fig 4). J Cell Biol (2016) ncbi
MilliporeSigma
mouse monoclonal (4C11)
  • immunocytochemistry; human; loading ...; fig 5a
MilliporeSigma LMNA antibody (Sigma, SAB4200236) was used in immunocytochemistry on human samples (fig 5a). Cells (2020) ncbi
mouse monoclonal (4C11)
  • western blot knockout validation; mouse; loading ...; fig 1d
  • immunohistochemistry; mouse; loading ...; fig 2a
MilliporeSigma LMNA antibody (Sigma-Aldrich, SAB4200236) was used in western blot knockout validation on mouse samples (fig 1d) and in immunohistochemistry on mouse samples (fig 2a). Aging Cell (2020) ncbi
mouse monoclonal (4C11)
  • western blot; human; 1:5000; loading ...; fig 5a
MilliporeSigma LMNA antibody (Sigma-Aldrich, SAB4200236) was used in western blot on human samples at 1:5000 (fig 5a). Oncol Rep (2019) ncbi
mouse monoclonal (4C11)
  • western blot; hamsters; loading ...; fig s19a
In order to propose that local stresses applied to integrins propagate from the tensed actin cytoskeleton to the LINC complex and then through lamina-chromatin interactions to directly stretch chromatin and upregulate transcription, MilliporeSigma LMNA antibody (Sigma, SAB4200236) was used in western blot on hamsters samples (fig s19a). Nat Mater (2016) ncbi
mouse monoclonal (4C11)
  • western blot; mouse; 1:10,000; fig 1
MilliporeSigma LMNA antibody (Sigma, SAB200236) was used in western blot on mouse samples at 1:10,000 (fig 1). Mol Vis (2016) ncbi
mouse monoclonal (4C11)
  • immunocytochemistry; mouse; 1:2000; fig 5
MilliporeSigma LMNA antibody (Sigma Aldrich, 4C11) was used in immunocytochemistry on mouse samples at 1:2000 (fig 5). Nat Commun (2016) ncbi
mouse monoclonal (4C11)
  • immunocytochemistry; mouse; fig 7
In order to assess induced Bax-regulated nuclear rupture and bubble budding followed by release of nuclear proteins due to cellular stress, MilliporeSigma LMNA antibody (Sigma, SAB4200236) was used in immunocytochemistry on mouse samples (fig 7). Nucleus (2014) ncbi
mouse monoclonal (4C11)
  • western blot; human; 1:1000
MilliporeSigma LMNA antibody (Sigma, 4C11) was used in western blot on human samples at 1:1000. EMBO J (2014) ncbi
mouse monoclonal (4C11)
  • western blot; human
MilliporeSigma LMNA antibody (Sigma-Aldrich, SAB4200236) was used in western blot on human samples . PLoS ONE (2014) ncbi
BD Biosciences
mouse monoclonal (14/LaminAC)
  • western blot; human; 1:1000; loading ...; fig 2g
BD Biosciences LMNA antibody (BD Biosciences, 612162) was used in western blot on human samples at 1:1000 (fig 2g). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (14/LaminAC)
  • western blot; human; loading ...; fig s1h
In order to study long noncoding RNA UPAT, colon tumorigenesis, and UHRF1, BD Biosciences LMNA antibody (BD Biosciences, 612162) was used in western blot on human samples (fig s1h). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (14/LaminAC)
  • western blot; human; fig 2
In order to assess negative regulation of the NF-kappaB-mediated signaling pathway through stabilization of Cactin by TRIM39, BD Biosciences LMNA antibody (BD Pharmingen, 612162) was used in western blot on human samples (fig 2). Cell Mol Life Sci (2016) ncbi
mouse monoclonal (14/LaminAC)
  • western blot; human
In order to study OGR1-mediated, pH-dependent signaling pathways in intestinal epithelial cells, BD Biosciences LMNA antibody (BD Biosciences, 612162) was used in western blot on human samples . Am J Physiol Gastrointest Liver Physiol (2015) ncbi
mouse monoclonal (14/LaminAC)
  • western blot; human; fig 6
BD Biosciences LMNA antibody (BD Biosciences, 612162) was used in western blot on human samples (fig 6). J Pathol (2014) ncbi
mouse monoclonal (14/LaminAC)
  • western blot; human
BD Biosciences LMNA antibody (BD Biosciences, 612162) was used in western blot on human samples . Neurobiol Dis (2014) ncbi
Articles Reviewed
  1. Yu Z, Li X, Yang M, Huang J, Fang Q, Jia J, et al. TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO. Signal Transduct Target Ther. 2021;6:90 pubmed publisher
  2. Svobodová Kovaříková A, Bartova E, Kovarik A, Lukasova E. Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in γ-Irradiation-Induced Senescent Cells. Cells. 2020;9: pubmed publisher
  3. Topalian S, Taube J, Pardoll D. Neoadjuvant checkpoint blockade for cancer immunotherapy. Science. 2020;367: pubmed publisher
  4. Wang W, Wang J, Lin W, Kao C, Hung M, Teng Y, et al. Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020;19:e13090 pubmed publisher
  5. Yokoi A, Villar Prados A, Oliphint P, Zhang J, Song X, De Hoff P, et al. Mechanisms of nuclear content loading to exosomes. Sci Adv. 2019;5:eaax8849 pubmed publisher
  6. Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam C, Garg P, et al. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019;572:335-340 pubmed publisher
  7. Peng J, Liang S, Li L. sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2019;41:224-234 pubmed publisher
  8. Mirza A, McKellar S, Urman N, Brown A, Hollmig T, Aasi S, et al. LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Cell. 2019;176:198-212.e15 pubmed publisher
  9. Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018;19:189 pubmed publisher
  10. Zhang Y, Wang J, Huang W, Cai J, Ba J, Wang Y, et al. Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation. Nat Commun. 2018;9:3613 pubmed publisher
  11. Takaki T, Montagner M, Serres M, Le Berre M, Russell M, Collinson L, et al. Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Nat Commun. 2017;8:16013 pubmed publisher
  12. Coccia M, Rossi A, Riccio A, Trotta E, Santoro M. Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance. Proc Natl Acad Sci U S A. 2017;114:1045-1050 pubmed publisher
  13. Hatch E, Hetzer M. Nuclear envelope rupture is induced by actin-based nucleus confinement. J Cell Biol. 2016;215:27-36 pubmed
  14. Tajik A, Zhang Y, Wei F, Sun J, Jia Q, Zhou W, et al. Transcription upregulation via force-induced direct stretching of chromatin. Nat Mater. 2016;15:1287-1296 pubmed publisher
  15. Uribe M, Haro C, Ventero M, Campello L, Cruces J, Martín Nieto J. Expression pattern in retinal photoreceptors of POMGnT1, a protein involved in muscle-eye-brain disease. Mol Vis. 2016;22:658-73 pubmed
  16. Wisnovsky S, Jean S, Kelley S. Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes. Nat Chem Biol. 2016;12:567-73 pubmed publisher
  17. Verhoeven R, Tong S, Zhang G, Zong J, Chen Y, Jin D, et al. NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma. J Virol. 2016;90:6475-88 pubmed publisher
  18. Eisch V, Lu X, Gabriel D, Djabali K. Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts. Oncotarget. 2016;7:24700-18 pubmed publisher
  19. Thiam H, Vargas P, Carpi N, Crespo C, Raab M, Terriac E, et al. Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Nat Commun. 2016;7:10997 pubmed publisher
  20. Taniue K, Kurimoto A, Sugimasa H, Nasu E, Takeda Y, Iwasaki K, et al. Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1. Proc Natl Acad Sci U S A. 2016;113:1273-8 pubmed publisher
  21. Dvash E, Har Tal M, Barak S, Meir O, Rubinstein M. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Nat Commun. 2015;6:10112 pubmed publisher
  22. Safavi S, Järnum S, Vannas C, Udhane S, Jonasson E, Tomić T, et al. HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo. Oncotarget. 2016;7:433-45 pubmed publisher
  23. Suzuki M, Watanabe M, Nakamaru Y, Takagi D, Takahashi H, Fukuda S, et al. TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin. Cell Mol Life Sci. 2016;73:1085-101 pubmed publisher
  24. Chaumet A, Wright G, Seet S, Tham K, Gounko N, Bard F. Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. Nat Commun. 2015;6:8218 pubmed publisher
  25. Matsui M, Li L, Janowski B, Corey D. Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors. Sci Rep. 2015;5:12855 pubmed publisher
  26. de Vallière C, Vidal S, Clay I, Jurisic G, Tcymbarevich I, Lang S, et al. The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment. Am J Physiol Gastrointest Liver Physiol. 2015;309:G475-90 pubmed publisher
  27. Yoon S, Bogdanov K, Kovalenko A, Wallach D. Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ. 2016;23:253-60 pubmed publisher
  28. Cardona M, López J, Serafín A, Rongvaux A, Inserte J, García Dorado D, et al. Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart. PLoS ONE. 2015;10:e0131411 pubmed publisher
  29. Gong G, Chen P, Li L, Tan H, Zhou J, Zhou Y, et al. Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis. Pathol Res Pract. 2015;211:175-82 pubmed publisher
  30. Lindenboim L, Sasson T, Worman H, Borner C, Stein R. Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release. Nucleus. 2014;5:527-41 pubmed publisher
  31. Elkhatib R, Longepied G, Paci M, Achard V, Grillo J, Levy N, et al. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. Mol Hum Reprod. 2015;21:225-36 pubmed publisher
  32. Barbarin A, Séité P, Godet J, Bensalma S, Muller J, Chadéneau C. Atypical nuclear localization of VIP receptors in glioma cell lines and patients. Biochem Biophys Res Commun. 2014;454:524-30 pubmed publisher
  33. Jurkin J, Henkel T, Nielsen A, Minnich M, Popow J, Kaufmann T, et al. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J. 2014;33:2922-36 pubmed publisher
  34. Otani K, Dong Y, Li X, Lu J, Zhang N, Xu L, et al. Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer. J Pathol. 2014;234:302-15 pubmed publisher
  35. Hamada K, Osaka M, Yoshida M. Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium. PLoS ONE. 2014;9:e90502 pubmed publisher
  36. Piao H, Yuan Y, Wang M, Sun Y, Liang H, Ma L. ?-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014;16:245-54 pubmed publisher
  37. Dannoura A, Giraldo A, Pereira I, Gibbins J, Dash P, Bicknell K, et al. Ibuprofen inhibits migration and proliferation of human coronary artery smooth muscle cells by inducing a differentiated phenotype: role of peroxisome proliferator-activated receptor ?. J Pharm Pharmacol. 2014;66:779-92 pubmed publisher
  38. Gómez Sánchez R, Gegg M, Bravo San Pedro J, Niso Santano M, Alvarez Erviti L, Pizarro Estrella E, et al. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression. Neurobiol Dis. 2014;62:426-40 pubmed publisher