This is a Validated Antibody Database (VAD) review about dogs AGFG1, based on 64 published articles (read how Labome selects the articles), using AGFG1 antibody in all methods. It is aimed to help Labome visitors find the most suited AGFG1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
AGFG1 synonym: HRB

Knockout validation
BD Biosciences
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; loading ...; fig 3c
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot knockout validation on mouse samples (fig 3c). Proc Natl Acad Sci U S A (2017) ncbi
BD Biosciences
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; loading ...; fig 1h
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot knockout validation on mouse samples (fig 1h). J Clin Invest (2017) ncbi
BD Biosciences
mouse monoclonal (38/RIP)
  • western blot knockout validation; human; loading ...; fig 4d
  • western blot; mouse; loading ...; fig 3d
BD Biosciences AGFG1 antibody (BD Transduction Laboratories, 610458) was used in western blot knockout validation on human samples (fig 4d) and in western blot on mouse samples (fig 3d). Cell Death Differ (2017) ncbi
BD Biosciences
mouse monoclonal (38/RIP)
  • western blot knockout validation; human; 1:1000; loading ...; fig 4b
BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot knockout validation on human samples at 1:1000 (fig 4b). Cell Death Dis (2017) ncbi
BD Biosciences
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; loading ...; fig s4a
  • immunoprecipitation; mouse; loading ...; fig 2a
BD Biosciences AGFG1 antibody (BD, 610459) was used in western blot knockout validation on mouse samples (fig s4a) and in immunoprecipitation on mouse samples (fig 2a). Nature (2016) ncbi
BD Biosciences
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; fig 9
BD Biosciences AGFG1 antibody (BD biosciences, 610459) was used in western blot knockout validation on mouse samples (fig 9). Nat Commun (2015) ncbi
BD Biosciences
mouse monoclonal (38/RIP)
  • western blot; human; 1:1000; loading ...; fig 6b
BD Biosciences AGFG1 antibody (BD Bioscience, 610459) was used in western blot on human samples at 1:1000 (fig 6b). EMBO Mol Med (2022) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; 1:1000; loading ...; fig 3b
BD Biosciences AGFG1 antibody (BD Pharmingen, 610458) was used in western blot on human samples at 1:1000 (fig 3b). Mol Med Rep (2021) ncbi
mouse monoclonal (38/RIP)
  • immunohistochemistry; human; loading ...; fig 2b
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in immunohistochemistry on human samples (fig 2b). Sci Rep (2021) ncbi
mouse monoclonal (38/RIP)
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 1k
  • immunocytochemistry; rat; 1:200; loading ...; fig 1m
  • western blot; rat; 1:1000; loading ...; fig 2e
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in immunohistochemistry - paraffin section on rat samples at 1:200 (fig 1k), in immunocytochemistry on rat samples at 1:200 (fig 1m) and in western blot on rat samples at 1:1000 (fig 2e). Front Cell Dev Biol (2021) ncbi
mouse monoclonal (38/RIP)
  • immunocytochemistry; human; loading ...; fig 4a, 4b
  • western blot; human; loading ...; fig 5a, 5c
BD Biosciences AGFG1 antibody (BD, 610459) was used in immunocytochemistry on human samples (fig 4a, 4b) and in western blot on human samples (fig 5a, 5c). Front Cell Dev Biol (2020) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; loading ...; fig 3d
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on human samples (fig 3d). Cell Commun Signal (2020) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; 1:6000; loading ...; fig 2c
BD Biosciences AGFG1 antibody (BD-Biosciences, 610459) was used in western blot on human samples at 1:6000 (fig 2c). Cell Death Dis (2020) ncbi
mouse monoclonal (38/RIP)
  • immunohistochemistry; mouse; 1:200; loading ...; fig s12c
  • western blot; mouse; 1:1000; loading ...; fig s12b
BD Biosciences AGFG1 antibody (BD bioscience, 610459) was used in immunohistochemistry on mouse samples at 1:200 (fig s12c) and in western blot on mouse samples at 1:1000 (fig s12b). Nat Commun (2020) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; fig 1h
BD Biosciences AGFG1 antibody (BD Transduction, 610459) was used in western blot on human samples (fig 1h). Nature (2020) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; loading ...; fig 3d
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples (fig 3d). elife (2019) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; loading ...; fig s7e
BD Biosciences AGFG1 antibody (BD, 610458) was used in western blot on mouse samples (fig s7e). Sci Adv (2019) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:3000; loading ...; fig 4a
BD Biosciences AGFG1 antibody (BD Transduction Laboratories, 610458) was used in western blot on mouse samples at 1:3000 (fig 4a). J Cell Sci (2019) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; loading ...; fig 4c
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples (fig 4c). Cell Death Differ (2019) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:1000; loading ...; fig 3i
BD Biosciences AGFG1 antibody (BD Bioscience, 610459) was used in western blot on mouse samples at 1:1000 (fig 3i). Cell Death Differ (2019) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:500; loading ...; fig 4g
BD Biosciences AGFG1 antibody (BD Transduction, 38) was used in western blot on mouse samples at 1:500 (fig 4g). Sci Adv (2019) ncbi
mouse monoclonal (38/RIP)
  • proximity ligation assay; mouse; 1:50; loading ...; fig 1f
  • western blot; mouse; 1:1000; loading ...; fig 1b
  • proximity ligation assay; human; 1:50; loading ...; fig 1d
  • immunoprecipitation; human; loading ...; fig 2a
  • western blot; human; 1:1000; loading ...; fig 1a
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in proximity ligation assay on mouse samples at 1:50 (fig 1f), in western blot on mouse samples at 1:1000 (fig 1b), in proximity ligation assay on human samples at 1:50 (fig 1d), in immunoprecipitation on human samples (fig 2a) and in western blot on human samples at 1:1000 (fig 1a). Mol Cell (2019) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; fig 3f
BD Biosciences AGFG1 antibody (BD, 610458) was used in western blot on human samples (fig 3f). Cell Death Differ (2019) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; loading ...; fig 3b
BD Biosciences AGFG1 antibody (BD, 610459) was used in western blot on mouse samples (fig 3b). Cell Death Dis (2018) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; loading ...; fig 2b
BD Biosciences AGFG1 antibody (BD, 610459) was used in western blot on mouse samples (fig 2b). Nature (2018) ncbi
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; loading ...; fig 3c
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot knockout validation on mouse samples (fig 3c). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; loading ...; fig 1h
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot knockout validation on mouse samples (fig 1h). J Clin Invest (2017) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; loading ...; fig 6g
  • western blot; human; loading ...; fig 8b
BD Biosciences AGFG1 antibody (BD Bioscience, 610459) was used in western blot on mouse samples (fig 6g) and in western blot on human samples (fig 8b). EMBO J (2017) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; loading ...; fig s3
In order to test if TRAIL/TRAIL-R signaling in cancer cells alters the immune microenvironment, BD Biosciences AGFG1 antibody (BD Bioscience, 610458) was used in western blot on human samples (fig s3). Mol Cell (2017) ncbi
mouse monoclonal (38/RIP)
  • western blot knockout validation; human; loading ...; fig 4d
  • western blot; mouse; loading ...; fig 3d
BD Biosciences AGFG1 antibody (BD Transduction Laboratories, 610458) was used in western blot knockout validation on human samples (fig 4d) and in western blot on mouse samples (fig 3d). Cell Death Differ (2017) ncbi
mouse monoclonal (38/RIP)
  • western blot knockout validation; human; 1:1000; loading ...; fig 4b
BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot knockout validation on human samples at 1:1000 (fig 4b). Cell Death Dis (2017) ncbi
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; loading ...; fig s4a
  • immunoprecipitation; mouse; loading ...; fig 2a
BD Biosciences AGFG1 antibody (BD, 610459) was used in western blot knockout validation on mouse samples (fig s4a) and in immunoprecipitation on mouse samples (fig 2a). Nature (2016) ncbi
mouse monoclonal (38/RIP)
  • immunoprecipitation; mouse; fig 4
  • western blot; mouse; fig 1
In order to elucidate the mechanism by which RIPK1 counteracts RIPK3-MLKL-mediated necroptosis, BD Biosciences AGFG1 antibody (BD, 610459) was used in immunoprecipitation on mouse samples (fig 4) and in western blot on mouse samples (fig 1). Nature (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; loading ...; fig s1b
BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on human samples (fig s1b). Open Biol (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; 1:1000; fig s15
BD Biosciences AGFG1 antibody (BD Transduction, 610458) was used in western blot on human samples at 1:1000 (fig s15). Nat Commun (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; fig 1
BD Biosciences AGFG1 antibody (BD, 610459) was used in western blot on human samples (fig 1). Cell Rep (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; fig 5
BD Biosciences AGFG1 antibody (BD, 610458) was used in western blot on human samples (fig 5). EMBO J (2016) ncbi
mouse monoclonal (38/RIP)
  • immunoprecipitation; mouse; loading ...; fig s1
  • western blot; mouse; loading ...; fig 2a
BD Biosciences AGFG1 antibody (BD, 610458) was used in immunoprecipitation on mouse samples (fig s1) and in western blot on mouse samples (fig 2a). Cell Death Differ (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; fig 5
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples (fig 5). Cell Rep (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; fig 2
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on human samples (fig 2). Biochem Biophys Res Commun (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; fig 1
In order to analyze induction of efficient anti-tumor immunity by vaccination with necroptotic cancer cells, BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples (fig 1). Cell Rep (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; fig 6j
BD Biosciences AGFG1 antibody (BD, 610459) was used in western blot on mouse samples (fig 6j). Immunity (2016) ncbi
mouse monoclonal (38/RIP)
  • proximity ligation assay; mouse; fig 7
  • western blot; mouse; 1:1000; fig 8
  • proximity ligation assay; human; fig 7
  • western blot; human; 1:1000; fig 6
BD Biosciences AGFG1 antibody (BD Bioscience, 610459) was used in proximity ligation assay on mouse samples (fig 7), in western blot on mouse samples at 1:1000 (fig 8), in proximity ligation assay on human samples (fig 7) and in western blot on human samples at 1:1000 (fig 6). Nat Commun (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; fig 7
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples (fig 7). Nat Commun (2016) ncbi
mouse monoclonal (38/RIP)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, BD Biosciences AGFG1 antibody (BD, 38) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; fig 3
BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on mouse samples (fig 3). Cell Death Dis (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; rat; 1:1000; fig 3
In order to investigate the molecular mechanisms that regulate cardiomyocyte necroptosis, BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on rat samples at 1:1000 (fig 3). Nat Med (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:500; fig 6
In order to characterize TAK1 and modulation of skeletal muscle repair and satelline stem cell homeostasis, BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on mouse samples at 1:500 (fig 6). Nat Commun (2015) ncbi
mouse monoclonal (38/RIP)
  • immunocytochemistry; human; fig s9
  • western blot; human; fig 5b
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in immunocytochemistry on human samples (fig s9) and in western blot on human samples (fig 5b). Oncotarget (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse
  • western blot; human
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples and in western blot on human samples . Cell Death Differ (2016) ncbi
mouse monoclonal (38/RIP)
  • western blot knockout validation; mouse; fig 9
BD Biosciences AGFG1 antibody (BD biosciences, 610459) was used in western blot knockout validation on mouse samples (fig 9). Nat Commun (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; loading ...; fig 3f
BD Biosciences AGFG1 antibody (Becton, Dickinson, 610459) was used in western blot on mouse samples (fig 3f). Cell Death Differ (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; human
BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on human samples . Cell Death Dis (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; loading ...; fig 1a,2a,3
BD Biosciences AGFG1 antibody (BD Transduction Laboratories, 610458) was used in western blot on human samples (fig 1a,2a,3). BMC Cancer (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; human; fig 4a
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on human samples (fig 4a). Cell Commun Signal (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:2000; fig 4
In order to study TLR3-mediated pro-inflammatory cytokine production regulated by glycogen synthase kinase 3-beta ubiquitination by TRAF6, BD Biosciences AGFG1 antibody (BD Pharmingen, 610459) was used in western blot on mouse samples at 1:2000 (fig 4). Nat Commun (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; human
In order to determine the role of PCTAIRE1 in apoptosis, BD Biosciences AGFG1 antibody (BD Transduction Lab, 610458) was used in western blot on human samples . PLoS ONE (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:1000; fig 2
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples at 1:1000 (fig 2). Front Cell Dev Biol (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:1000; fig 5
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples at 1:1000 (fig 5). Nat Cell Biol (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; 1:1000; fig 4e
BD Biosciences AGFG1 antibody (BD Transduction Laboratories, 610458) was used in western blot on mouse samples at 1:1000 (fig 4e). Nat Commun (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; human
In order to investigate if Chal-24 can be combined with cisplatin for better cancer therapy, BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on human samples . Oncotarget (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; human
BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on human samples . J Biol Chem (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; fig 2
BD Biosciences AGFG1 antibody (BD Transduction Laboratories, 610459) was used in western blot on mouse samples (fig 2). Cell Death Dis (2015) ncbi
mouse monoclonal (38/RIP)
  • immunoprecipitation; mouse; fig 2a
  • western blot; mouse; fig 2d
BD Biosciences AGFG1 antibody (BD Transduction Laboratories, 610458) was used in immunoprecipitation on mouse samples (fig 2a) and in western blot on mouse samples (fig 2d). Apoptosis (2015) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse; fig 3
In order to show that RIPK1 regulates homeostasis and prevents inflammation in barrier tissues by inhibiting epithelial cell apoptosis and necroptosis, BD Biosciences AGFG1 antibody (BDBiosciences, 610459) was used in western blot on mouse samples (fig 3). Nature (2014) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse
BD Biosciences AGFG1 antibody (BD Biosciences, 610459) was used in western blot on mouse samples . Biomed Res Int (2014) ncbi
mouse monoclonal (38/RIP)
  • western blot; mouse
BD Biosciences AGFG1 antibody (BD, 610458) was used in western blot on mouse samples . J Immunol (2014) ncbi
mouse monoclonal (38/RIP)
  • western blot; human
In order to study the role of receptor-interacting protein 1 in cancer's response to chemotherapy, BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on human samples . Oncotarget (2014) ncbi
mouse monoclonal (38/RIP)
  • western blot; human
In order to identify a novel anticancer mechanism that functions through autophagy-mediated necroptosis, BD Biosciences AGFG1 antibody (BD Biosciences, 610458) was used in western blot on human samples . Oncogene (2014) ncbi
mouse monoclonal (38/RIP)
  • western blot; human
BD Biosciences AGFG1 antibody (BD Bioscience, 610458) was used in western blot on human samples . Mol Cancer Res (2013) ncbi
Articles Reviewed
  1. Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth T, et al. Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS. EMBO Mol Med. 2022;14:e14901 pubmed publisher
  2. Kim S, Lee H, Lim J, Kim H. Astaxanthin induces NADPH oxidase activation and receptor‑interacting protein kinase 1‑mediated necroptosis in gastric cancer AGS cells. Mol Med Rep. 2021;24: pubmed publisher
  3. Lomphithak T, Akara Amornthum P, Murakami K, Hashimoto M, Usubuchi H, Iwabuchi E, et al. Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma. Sci Rep. 2021;11:11743 pubmed publisher
  4. Cheng J, Duan X, Fu X, Jiang Y, Yang P, Cao C, et al. RIP1 Perturbation Induces Chondrocyte Necroptosis and Promotes Osteoarthritis Pathogenesis via Targeting BMP7. Front Cell Dev Biol. 2021;9:638382 pubmed publisher
  5. Hu H, Wu G, Shu Z, Yu D, Nan N, Yuan F, et al. ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling. Front Cell Dev Biol. 2020;8:595253 pubmed publisher
  6. Lomphithak T, Choksi S, Mutirangura A, Tohtong R, Tencomnao T, Usubuchi H, et al. Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma. Cell Commun Signal. 2020;18:161 pubmed publisher
  7. Wu Y, Chou T, Young L, Hsieh F, Pan H, Mo S, et al. Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation. Cell Death Dis. 2020;11:305 pubmed publisher
  8. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, et al. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun. 2020;11:507 pubmed publisher
  9. Lalaoui N, Boyden S, Oda H, Wood G, Stone D, Chau D, et al. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2020;577:103-108 pubmed publisher
  10. Lim J, Park H, Heisler J, Maculins T, Roose Girma M, Xu M, et al. Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins. elife. 2019;8: pubmed publisher
  11. Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed publisher
  12. Wang Z, Feng J, Yu J, Chen G. FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. J Cell Sci. 2019;132: pubmed publisher
  13. Krishna Subramanian S, Singer S, Armaka M, Banales J, Hölzer K, Schirmacher P, et al. RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ. 2019;: pubmed publisher
  14. Frank T, Tuppi M, Hugle M, Dötsch V, van Wijk S, Fulda S. Cell cycle arrest in mitosis promotes interferon-induced necroptosis. Cell Death Differ. 2019;: pubmed publisher
  15. Daruich A, Le Rouzic Q, Jonet L, Naud M, Kowalczuk L, Pournaras J, et al. Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection. Sci Adv. 2019;5:eaau9940 pubmed publisher
  16. Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand A, Robertson D, et al. RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell. 2019;73:413-428.e7 pubmed publisher
  17. Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
  18. Siegmund D, Ehrenschwender M, Wajant H. TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling. Cell Death Dis. 2018;9:921 pubmed publisher
  19. Peltzer N, Darding M, Montinaro A, Dráber P, Draberova H, Kupka S, et al. LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature. 2018;557:112-117 pubmed publisher
  20. Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar A, et al. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A. 2017;114:11944-11949 pubmed publisher
  21. Van T, Polykratis A, Straub B, Kondylis V, Papadopoulou N, Pasparakis M. Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Invest. 2017;127:2662-2677 pubmed publisher
  22. Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  23. Hartwig T, Montinaro A, von Karstedt S, Sevko A, Surinova S, Chakravarthy A, et al. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell. 2017;65:730-742.e5 pubmed publisher
  24. Tanzer M, Khan N, Rickard J, Etemadi N, Lalaoui N, Spall S, et al. Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell Death Differ. 2017;24:481-491 pubmed publisher
  25. Guicciardi M, Krishnan A, Bronk S, Hirsova P, Griffith T, Gores G. Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice. Cell Death Dis. 2017;8:e2535 pubmed publisher
  26. Newton K, Wickliffe K, Maltzman A, Dugger D, Strasser A, Pham V, et al. RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016;540:129-133 pubmed publisher
  27. Lin J, Kumari S, Kim C, Van T, Wachsmuth L, Polykratis A, et al. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016;540:124-128 pubmed publisher
  28. Samson A, Ho B, Au A, Schoenwaelder S, Smyth M, Bottomley S, et al. Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells. Open Biol. 2016;6: pubmed
  29. Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  30. Kupka S, De Miguel D, Dráber P, Martino L, Surinova S, Rittinger K, et al. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep. 2016;16:2271-80 pubmed publisher
  31. Wagner S, Satpathy S, Beli P, Choudhary C. SPATA2 links CYLD to the TNF-? receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016;35:1868-84 pubmed publisher
  32. Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed publisher
  33. Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
  34. Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher
  35. Aaes T, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, et al. Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Rep. 2016;15:274-87 pubmed publisher
  36. Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, et al. NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions. Immunity. 2016;44:553-567 pubmed publisher
  37. Orme M, Liccardi G, Moderau N, Feltham R, Wicky John S, Tenev T, et al. The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles. Nat Commun. 2016;7:10972 pubmed publisher
  38. Thornton T, Delgado P, Chen L, Salas B, Krementsov D, Fernández M, et al. Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nat Commun. 2016;7:10553 pubmed publisher
  39. Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  40. Jacobsen A, Lowes K, Tanzer M, Lucet I, Hildebrand J, Petrie E, et al. HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell Death Dis. 2016;7:e2051 pubmed publisher
  41. Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, et al. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med. 2016;22:175-82 pubmed publisher
  42. Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  43. Kharaziha P, Chioureas D, Baltatzis G, Fonseca P, Rodriguez P, Gogvadze V, et al. Sorafenib-induced defective autophagy promotes cell death by necroptosis. Oncotarget. 2015;6:37066-82 pubmed publisher
  44. Yoon S, Bogdanov K, Kovalenko A, Wallach D. Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ. 2016;23:253-60 pubmed publisher
  45. Kang S, Fernandes Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, et al. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015;6:7515 pubmed publisher
  46. Boutaffala L, Bertrand M, Remouchamps C, Seleznik G, Reisinger F, Janas M, et al. NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis. Cell Death Differ. 2015;22:2020-33 pubmed publisher
  47. Fauster A, Rebsamen M, Huber K, Bigenzahn J, Stukalov A, Lardeau C, et al. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis. 2015;6:e1767 pubmed publisher
  48. Selmi T, Alecci C, dell Aquila M, Montorsi L, Martello A, Guizzetti F, et al. ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly. BMC Cancer. 2015;15:357 pubmed publisher
  49. Philipp S, Sosna J, Plenge J, Kalthoff H, Adam D. Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal. 2015;13:25 pubmed publisher
  50. Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed publisher
  51. Yanagi T, Shi R, Aza Blanc P, Reed J, Matsuzawa S. PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines. PLoS ONE. 2015;10:e0119404 pubmed publisher
  52. Dowling J, Nair A, Zhang J. A novel function of RIP1 in postnatal development and immune homeostasis by protecting against RIP3-dependent necroptosis and FADD-mediated apoptosis. Front Cell Dev Biol. 2015;3:12 pubmed publisher
  53. Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, et al. Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol. 2015;17:434-44 pubmed publisher
  54. Lawlor K, Khan N, Mildenhall A, Gerlic M, Croker B, D Cruz A, et al. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun. 2015;6:6282 pubmed publisher
  55. Shi S, Wang Q, Xu J, Jang J, Padilla M, Nyunoya T, et al. Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget. 2015;6:1640-51 pubmed
  56. Wang Y, Tan B, Mu R, Chang Y, Wu M, Tu H, et al. Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling. J Biol Chem. 2015;290:10395-405 pubmed publisher
  57. Saveljeva S, Mc Laughlin S, Vandenabeele P, Samali A, Bertrand M. Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death Dis. 2015;6:e1587 pubmed publisher
  58. Chen G, Cheng X, Zhao M, Lin S, Lu J, Kang J, et al. RIP1-dependent Bid cleavage mediates TNFα-induced but Caspase-3-independent cell death in L929 fibroblastoma cells. Apoptosis. 2015;20:92-109 pubmed publisher
  59. Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, et al. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014;513:90-4 pubmed publisher
  60. Liu S, Wang X, Li Y, Xu L, Yu X, Ge L, et al. Necroptosis mediates TNF-induced toxicity of hippocampal neurons. Biomed Res Int. 2014;2014:290182 pubmed publisher
  61. McComb S, Shutinoski B, Thurston S, Cessford E, Kumar K, Sad S. Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. J Immunol. 2014;192:5671-8 pubmed publisher
  62. Wang Q, Shi S, He W, Padilla M, Zhang L, Wang X, et al. Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition. Oncotarget. 2014;5:1304-14 pubmed
  63. He W, Wang Q, Srinivasan B, Xu J, Padilla M, Li Z, et al. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene. 2014;33:3004-13 pubmed publisher
  64. Han J, Soletti R, Sadarangani A, Sridevi P, Ramirez M, Eckmann L, et al. Nuclear expression of ?-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013;11:207-18 pubmed publisher