This is a Validated Antibody Database (VAD) review about dog TBC1D4, based on 14 published articles (read how Labome selects the articles), using TBC1D4 antibody in all methods. It is aimed to help Labome visitors find the most suited TBC1D4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TBC1D4 synonym: TBC1 domain family member 4

EMD Millipore
rabbit polyclonal
  • western blot; human; loading ...; fig 6d
In order to analyze pro- and anti-lipolytic signaling pathways in adipocytes after in vivo endotoxin exposure, EMD Millipore TBC1D4 antibody (Upstate, 07-741) was used in western blot on human samples (fig 6d). PLoS ONE (2016) ncbi
rabbit polyclonal
  • western blot; rat; fig 2
EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on rat samples (fig 2). Physiol Rep (2016) ncbi
rabbit polyclonal
  • western blot; mouse; fig 5
EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on mouse samples (fig 5). PLoS ONE (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:5000; loading ...; fig 1d
EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on mouse samples at 1:5000 (fig 1d). Diabetes (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
In order to research suppression of obesity in leptin-deficient mice by Tbc1d1 deletion, EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on mouse samples at 1:1000. Int J Obes (Lond) (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; mouse; 1:100; fig 5c
  • western blot; mouse; 1:200; loading ...; fig 5a
In order to use Kcne3 knockout mice to investigate atrial electrophysiology and the development of aldosterone-dependent atrial fibrillation, EMD Millipore TBC1D4 antibody (Millipore, ABS54) was used in immunocytochemistry on mouse samples at 1:100 (fig 5c) and in western blot on mouse samples at 1:200 (fig 5a). FASEB J (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 6
In order to assess the effect of Roux-en-Y gastric bypass surgery on expression and regulation of proteins involved in regulation of peripheral glucose metabolism, EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on human samples (fig 6). Am J Physiol Regul Integr Comp Physiol (2015) ncbi
rabbit polyclonal
  • western blot; mouse
In order to determine that PKB-mediated phosphorylation of AS160/TBC1D4 is one of the major PAS-binding signals in the heart in response to insulin, EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on mouse samples . PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 4
In order to study how acute environmental hypoxia regulates blood glucose and downstream intramuscular insulin signaling after humans eat a meal, EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on human samples (fig 4). Eur J Appl Physiol (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig 3
In order to characterize how insulin resistance is induced and alteration of substrate utilization in vivo due to acute mTOR inhibition, EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on mouse samples (fig 3). Mol Metab (2014) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
In order to investigate the role of Tbc1d1 in insulin- and AICAR-stimulated glucose uptake in skeletal muscle, EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on mouse samples at 1:1000. Endocrinology (2013) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse
  • western blot; mouse
In order to study the role of AS160 in the insulin responses in multiple tissues, EMD Millipore TBC1D4 antibody (Upstate / Millipore, 07-741) was used in immunoprecipitation on mouse samples and in western blot on mouse samples . Biochem J (2013) ncbi
rabbit polyclonal
  • western blot; rat
EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on rat samples . J Appl Physiol (1985) (2012) ncbi
rabbit polyclonal
  • immunoprecipitation; rat; 2 ug
EMD Millipore TBC1D4 antibody (Millipore, ABS54) was used in immunoprecipitation on rat samples at 2 ug. J Appl Physiol (1985) (2012) ncbi
rabbit polyclonal
  • western blot; rat
In order to examine the effect of Akt2 phosphorylation on on glucose uptake in skeletal muscle, EMD Millipore TBC1D4 antibody (Millipore, 07-741) was used in western blot on rat samples . Biochim Biophys Acta (2012) ncbi
Articles Reviewed
  1. Rittig N, Bach E, Thomsen H, Pedersen S, Nielsen T, Jørgensen J, et al. Regulation of Lipolysis and Adipose Tissue Signaling during Acute Endotoxin-Induced Inflammation: A Human Randomized Crossover Trial. PLoS ONE. 2016;11:e0162167 pubmed publisher
  2. Kawamoto E, Koshinaka K, Yoshimura T, Masuda H, Kawanaka K. Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylation. Physiol Rep. 2016;4: pubmed publisher
  3. Møller C, Kjøbsted R, Enriori P, Jensen T, Garcia Rudaz C, Litwak S, et al. ?-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK. PLoS ONE. 2016;11:e0157027 pubmed publisher
  4. Vazirani R, Verma A, Sadacca L, Buckman M, Picatoste B, Beg M, et al. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016;65:1577-89 pubmed publisher
  5. Dokas J, Chadt A, Joost H, Al Hasani H. Tbc1d1 deletion suppresses obesity in leptin-deficient mice. Int J Obes (Lond). 2016;40:1242-9 pubmed publisher
  6. Lisewski U, Koehncke C, Wilck N, Buschmeyer B, Pieske B, Roepke T. Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice. FASEB J. 2016;30:2476-89 pubmed publisher
  7. Albers P, Bojsen Møller K, Dirksen C, Serup A, Kristensen D, Frystyk J, et al. Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery. Am J Physiol Regul Integr Comp Physiol. 2015;309:R510-24 pubmed publisher
  8. Quan C, Xie B, Wang H, Chen S. PKB-Mediated Thr649 Phosphorylation of AS160/TBC1D4 Regulates the R-Wave Amplitude in the Heart. PLoS ONE. 2015;10:e0124491 pubmed publisher
  9. D Hulst G, Sylow L, Hespel P, Deldicque L. Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle. Eur J Appl Physiol. 2015;115:1219-31 pubmed publisher
  10. Kleinert M, Sylow L, Fazakerley D, Krycer J, Thomas K, Oxbøll A, et al. Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Mol Metab. 2014;3:630-41 pubmed publisher
  11. Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath J, Joost H, et al. Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology. 2013;154:3502-14 pubmed publisher
  12. Wang H, Ducommun S, Quan C, Xie B, Li M, Wasserman D, et al. AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J. 2013;449:479-89 pubmed publisher
  13. Schweitzer G, Arias E, Cartee G. Sustained postexercise increases in AS160 Thr642 and Ser588 phosphorylation in skeletal muscle without sustained increases in kinase phosphorylation. J Appl Physiol (1985). 2012;113:1852-61 pubmed publisher
  14. Sharma N, Arias E, Sequea D, Cartee G. Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle. Biochim Biophys Acta. 2012;1822:1735-40 pubmed publisher