This is a Validated Antibody Database (VAD) review about dog RAC1, based on 42 published articles (read how Labome selects the articles), using RAC1 antibody in all methods. It is aimed to help Labome visitors find the most suited RAC1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
RAC1 synonym: RAC2; ras-related C3 botulinum toxin substrate 1; Rac 1b; p21-Rac1; rac2 GTP-binding protein; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

Knockout validation
BD Biosciences
mouse monoclonal (102/Rac1)
  • western blot knockout validation; mouse; loading ...; fig 3a
BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in western blot knockout validation on mouse samples (fig 3a). J Biol Chem (2018) ncbi
BD Biosciences
mouse monoclonal (102/Rac1)
  • western blot knockout validation; mouse; fig 1
BD Biosciences RAC1 antibody (BD, 61051) was used in western blot knockout validation on mouse samples (fig 1). Arterioscler Thromb Vasc Biol (2012) ncbi
BD Biosciences
mouse monoclonal (102/Rac1)
  • immunohistochemistry knockout validation; mouse; 1:200; fig 1e
  • western blot knockout validation; mouse; fig 1c
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 1e
In order to study the role of the Rac1 GTPase the shaping of the ocular lens, BD Biosciences RAC1 antibody (BD, 610651) was used in immunohistochemistry knockout validation on mouse samples at 1:200 (fig 1e), in western blot knockout validation on mouse samples (fig 1c) and in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig 1e). Dev Biol (2011) ncbi
BD Biosciences
mouse monoclonal (102/Rac1)
  • western blot; human; loading ...; fig s1a
BD Biosciences RAC1 antibody (BD Transduction Laboratories, 10650) was used in western blot on human samples (fig s1a). Cancers (Basel) (2019) ncbi
mouse monoclonal (102/Rac1)
  • western blot; mouse; loading ...; fig 4c
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on mouse samples (fig 4c). Sci Signal (2018) ncbi
mouse monoclonal (102/Rac1)
  • western blot knockout validation; mouse; loading ...; fig 3a
BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in western blot knockout validation on mouse samples (fig 3a). J Biol Chem (2018) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; 1:1000; loading ...; fig 3c
BD Biosciences RAC1 antibody (BD Biosciences, 102) was used in western blot on human samples at 1:1000 (fig 3c). Nature (2017) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; loading ...; fig 3a
BD Biosciences RAC1 antibody (BD Transduction Laboratories, 610650) was used in western blot on human samples (fig 3a). Hum Mol Genet (2017) ncbi
mouse monoclonal (102/Rac1)
  • immunocytochemistry; human
  • western blot; human; loading ...; fig 1d
In order to investigate Rac1 activity and inhibition in gastric adenocarcinoma cells and mouse xenograft models for epithelial-to-mesenchymal transition and cancer stem-like cell phenotypes, BD Biosciences RAC1 antibody (BD Biosciences, 61065) was used in immunocytochemistry on human samples and in western blot on human samples (fig 1d). Mol Cancer Res (2017) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; loading ...; fig 1b
BD Biosciences RAC1 antibody (BD Transduction Laboratories, 102) was used in western blot on human samples (fig 1b). Front Cell Infect Microbiol (2017) ncbi
mouse monoclonal (102/Rac1)
  • western blot; mouse; loading ...; fig 7D
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on mouse samples (fig 7D). elife (2017) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; loading ...; fig 6a
BD Biosciences RAC1 antibody (BD, 102/Rac1) was used in western blot on human samples (fig 6a). PLoS ONE (2017) ncbi
mouse monoclonal (102/Rac1)
  • western blot; rat; loading ...; fig 3c
In order to perform whole exome sequencing to identify recessive causes of steroid-resistant nephrotic syndrome, BD Biosciences RAC1 antibody (BD Transduction Laboratories, 610650) was used in western blot on rat samples (fig 3c). J Clin Invest (2017) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; 1:1000; loading ...; fig 6b
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on human samples at 1:1000 (fig 6b). J Cell Biol (2017) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; loading ...; fig s3c
In order to report that frizzled family proteins are receptors for Clostridium difficile toxin B, BD Biosciences RAC1 antibody (BD Biosciences, 102) was used in western blot on human samples (fig s3c). Nature (2016) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; loading ...; fig 5b
BD Biosciences RAC1 antibody (BD Biosciences, 102) was used in western blot on human samples (fig 5b). Oncogene (2017) ncbi
mouse monoclonal (102/Rac1)
  • immunocytochemistry; mouse; 1:200; fig s4
In order to determine regulation of metastasis and cell invasion through the phosphorylation of paxillin due to cytoplasmic cyclin D1, BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in immunocytochemistry on mouse samples at 1:200 (fig s4). Nat Commun (2016) ncbi
mouse monoclonal (102/Rac1)
  • western blot; mouse; fig 3A
BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in western blot on mouse samples (fig 3A). PLoS ONE (2016) ncbi
mouse monoclonal (102/Rac1)
  • immunohistochemistry - frozen section; mouse; fig 4
BD Biosciences RAC1 antibody (BD Biosciences, 61065) was used in immunohistochemistry - frozen section on mouse samples (fig 4). PLoS ONE (2016) ncbi
mouse monoclonal (102/Rac1)
  • immunocytochemistry; human; fig 7
  • western blot; human; fig 7
In order to study inhibition of Rac1 trafficking to the cell border by RhoB control of the endothelial barrier recovery, BD Biosciences RAC1 antibody (BD, 610650) was used in immunocytochemistry on human samples (fig 7) and in western blot on human samples (fig 7). J Cell Biol (2016) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; 1:1000; fig 5
In order to research the drive of early signaling and vesicle dynamics during T-cell activation by Aurora A, BD Biosciences RAC1 antibody (BD Pharmingen, 610651) was used in western blot on human samples at 1:1000 (fig 5). Nat Commun (2016) ncbi
mouse monoclonal (102/Rac1)
  • western blot; mouse; 1:1000; fig 1
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2016) ncbi
mouse monoclonal (102/Rac1)
  • western blot; mouse; fig s3
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on mouse samples (fig s3). J Cell Biol (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; hamsters; loading ...; fig 3e
BD Biosciences RAC1 antibody (BD Biosciences, 61051) was used in western blot on hamsters samples (fig 3e). Blood (2016) ncbi
mouse monoclonal (102/Rac1)
  • flow cytometry; human; fig 8
  • immunocytochemistry; human; fig 3
BD Biosciences RAC1 antibody (BD Transduction, 610650) was used in flow cytometry on human samples (fig 8) and in immunocytochemistry on human samples (fig 3). PLoS ONE (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human
In order to report that inhibition of eIF5A reduces pancreatic ductal adenocarcinoma cell migration, invasion, and metastasis in vitro and in vivo, BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in western blot on human samples . J Biol Chem (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human
BD Biosciences RAC1 antibody (BD Transduction Laboratories, 610650) was used in western blot on human samples . J Cell Sci (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; fig 5
In order to study the role of autophagy factors in cancer progression and treatment response, BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in western blot on human samples (fig 5). Nat Commun (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human
In order to assess the contribution of tissue damage and extracellular matrix fragmentation during inflammation, BD Biosciences RAC1 antibody (BD Transduction Labs, 610650) was used in western blot on human samples . Sci Adv (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; fig 7
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on human samples (fig 7). J Cell Biol (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; 1:1000; fig 4
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on human samples at 1:1000 (fig 4). Nat Commun (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; fig  3
BD Biosciences RAC1 antibody (BD Transduction Laboratories, 610651) was used in western blot on human samples (fig  3). Hum Genet (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; fig 4
BD Biosciences RAC1 antibody (BD, 610651) was used in western blot on human samples (fig 4). J Cell Biol (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human
BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in western blot on human samples . PLoS ONE (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; mouse; 1:1000; fig 4
BD Biosciences RAC1 antibody (BD Bioscience, 610651) was used in western blot on mouse samples at 1:1000 (fig 4). Nat Commun (2015) ncbi
mouse monoclonal (102/Rac1)
  • immunocytochemistry; human; fig 6
  • western blot; human; fig 7
BD Biosciences RAC1 antibody (BD Transduction Laboratories, 610651) was used in immunocytochemistry on human samples (fig 6) and in western blot on human samples (fig 7). PLoS ONE (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; fig 1
BD Biosciences RAC1 antibody (BD, 610650) was used in western blot on human samples (fig 1). Cell Res (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; mouse; 1:1000
BD Biosciences RAC1 antibody (BD Transduction Laboratories, 610650) was used in western blot on mouse samples at 1:1000. Nat Neurosci (2015) ncbi
mouse monoclonal (102/Rac1)
  • immunoprecipitation; human
BD Biosciences RAC1 antibody (BD Transduction Labs, 610650) was used in immunoprecipitation on human samples . Comb Chem High Throughput Screen (2015) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human
BD Biosciences RAC1 antibody (BD Transduction, #610650) was used in western blot on human samples . Free Radic Res (2014) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; fig s1
BD Biosciences RAC1 antibody (BD Biosciences, 610650) was used in western blot on human samples (fig s1). EMBO J (2014) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human; fig 5
BD Biosciences RAC1 antibody (BD, 610651) was used in western blot on human samples (fig 5). J Biol Chem (2014) ncbi
mouse monoclonal (102/Rac1)
  • western blot; human
BD Biosciences RAC1 antibody (BD Bioscience, #610650) was used in western blot on human samples . Mol Cancer Res (2014) ncbi
mouse monoclonal (102/Rac1)
  • western blot knockout validation; mouse; fig 1
BD Biosciences RAC1 antibody (BD, 61051) was used in western blot knockout validation on mouse samples (fig 1). Arterioscler Thromb Vasc Biol (2012) ncbi
mouse monoclonal (102/Rac1)
  • immunohistochemistry knockout validation; mouse; 1:200; fig 1e
  • western blot knockout validation; mouse; fig 1c
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 1e
In order to study the role of the Rac1 GTPase the shaping of the ocular lens, BD Biosciences RAC1 antibody (BD, 610651) was used in immunohistochemistry knockout validation on mouse samples at 1:200 (fig 1e), in western blot knockout validation on mouse samples (fig 1c) and in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig 1e). Dev Biol (2011) ncbi
Articles Reviewed
  1. Ungefroren H, Otterbein H, Fiedler C, Mihara K, Hollenberg M, Gieseler F, et al. RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5. Cancers (Basel). 2019;11: pubmed publisher
  2. Roy N, MacKay J, Robertson T, Hammer D, Burkhardt J. Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. Sci Signal. 2018;11: pubmed publisher
  3. Ge J, Burnier L, Adamopoulou M, Kwa M, Schaks M, Rottner K, et al. RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem. 2018;293:9358-9369 pubmed publisher
  4. Polacheck W, Kutys M, Yang J, Eyckmans J, Wu Y, Vasavada H, et al. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017;552:258-262 pubmed publisher
  5. Barbiero I, Peroni D, Tramarin M, Chandola C, Rusconi L, Landsberger N, et al. The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex. Hum Mol Genet. 2017;26:3520-3530 pubmed publisher
  6. Yoon C, Cho S, Chang K, Park D, Ryeom S, Yoon S. Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma. Mol Cancer Res. 2017;15:1106-1116 pubmed publisher
  7. Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, et al. Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB. Front Cell Infect Microbiol. 2017;7:67 pubmed publisher
  8. Jeannot P, Nowosad A, Perchey R, Callot C, Bennana E, Katsube T, et al. p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. elife. 2017;6: pubmed publisher
  9. Eppler F, Quast T, Kolanus W. Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS ONE. 2017;12:e0172443 pubmed publisher
  10. Lovric S, Gonçalves S, Gee H, Oskouian B, Srinivas H, Choi W, et al. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017;127:912-928 pubmed publisher
  11. Rafiq N, Lieu Z, Jiang T, Yu C, Matsudaira P, Jones G, et al. Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J Cell Biol. 2017;216:181-197 pubmed publisher
  12. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, et al. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016;538:350-355 pubmed publisher
  13. Frank S, Köllmann C, van Lidth de Jeude J, Thiagarajah J, Engelholm L, Frödin M, et al. The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene. 2017;36:1816-1828 pubmed publisher
  14. Fusté N, Fernández Hernández R, Cemeli T, Mirantes C, Pedraza N, Rafel M, et al. Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin. Nat Commun. 2016;7:11581 pubmed publisher
  15. Chen L, DeWispelaere A, Dastvan F, Osborne W, Blechner C, Windhorst S, et al. Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity. PLoS ONE. 2016;11:e0155726 pubmed publisher
  16. Takenaka N, Nihata Y, Satoh T. Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle. PLoS ONE. 2016;11:e0155292 pubmed publisher
  17. Marcos Ramiro B, García Weber D, Barroso S, Feito J, Ortega M, Cernuda Morollón E, et al. RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border. J Cell Biol. 2016;213:385-402 pubmed publisher
  18. Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed publisher
  19. Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, et al. Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nat Commun. 2016;7:10664 pubmed publisher
  20. Giampietro C, Disanza A, Bravi L, Barrios Rodiles M, Corada M, Frittoli E, et al. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol. 2015;211:1177-92 pubmed publisher
  21. Estevez B, Kim K, Delaney M, Stojanovic Terpo A, Shen B, Ruan C, et al. Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation. Blood. 2016;127:626-36 pubmed publisher
  22. Oprea T, Sklar L, Agola J, Guo Y, Silberberg M, Roxby J, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS ONE. 2015;10:e0142182 pubmed publisher
  23. Fujimura K, Choi S, Wyse M, Strnadel J, Wright T, Klemke R. Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. J Biol Chem. 2015;290:29907-19 pubmed publisher
  24. Jamieson C, Lui C, Brocardo M, Martino Echarri E, Henderson B. Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import. J Cell Sci. 2015;128:3933-46 pubmed publisher
  25. He S, Zhao Z, Yang Y, O Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed publisher
  26. Hahn C, Scott D, Xu X, Roda M, Payne G, Wells J, et al. The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability. Sci Adv. 2015;1: pubmed
  27. Newell Litwa K, Badoual M, Asmussen H, Patel H, Whitmore L, Horwitz A. ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity. J Cell Biol. 2015;210:225-42 pubmed publisher
  28. Whalley H, Porter A, Diamantopoulou Z, White G, Castañeda Saucedo E, Malliri A. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation. Nat Commun. 2015;6:7437 pubmed publisher
  29. Hwang D, Kohl S, Fan X, Vivante A, Chan S, Dworschak G, et al. Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract. Hum Genet. 2015;134:905-16 pubmed publisher
  30. Grikscheit K, Frank T, Wang Y, Grosse R. Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol. 2015;209:367-76 pubmed publisher
  31. Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y. The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. PLoS ONE. 2015;10:e0124259 pubmed publisher
  32. Lu J, Luo C, Bali K, Xie R, Mains R, Eipper B, et al. A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses. Nat Commun. 2015;6:6820 pubmed publisher
  33. Giehl K, Keller C, Muehlich S, Goppelt Struebe M. Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells. PLoS ONE. 2015;10:e0121589 pubmed publisher
  34. Yuan P, Zhang H, Cai C, Zhu S, Zhou Y, Yang X, et al. Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B. Cell Res. 2015;25:157-68 pubmed publisher
  35. Delloye Bourgeois C, Jacquier A, Charoy C, Reynaud F, Nawabi H, Thoinet K, et al. PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci. 2015;18:36-45 pubmed publisher
  36. van Adrichem A, Fagerholm A, Turunen L, Lehto A, Saarela J, Koskinen A, et al. Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP. Comb Chem High Throughput Screen. 2015;18:3-17 pubmed
  37. Kovacs I, Horvath M, Kovacs T, Somogyi K, Tretter L, Geiszt M, et al. Comparison of proton channel, phagocyte oxidase, and respiratory burst levels between human eosinophil and neutrophil granulocytes. Free Radic Res. 2014;48:1190-9 pubmed publisher
  38. Takeda A, Oberoi Khanuja T, Glatz G, Schulenburg K, Scholz R, Carpy A, et al. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014;33:1784-801 pubmed publisher
  39. Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, et al. DNA damage induces the accumulation of Tiam1 by blocking ?-TrCP-dependent degradation. J Biol Chem. 2014;289:15482-94 pubmed publisher
  40. Zhong J, Bach C, Shum M, O Neill G. NEDD9 regulates 3D migratory activity independent of the Rac1 morphology switch in glioma and neuroblastoma. Mol Cancer Res. 2014;12:264-73 pubmed publisher
  41. Delaney M, Liu J, Zheng Y, Berndt M, Du X. The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Arterioscler Thromb Vasc Biol. 2012;32:2761-8 pubmed publisher
  42. Maddala R, Chauhan B, Walker C, Zheng Y, Robinson M, Lang R, et al. Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol. 2011;360:30-43 pubmed publisher